| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming-Chyi Huang, Lian-Yu Chen, Chih-Ken Chen, Shih-Ku Li. Potential benefit of lamotrigine in managing ketamine use disorder. Medical hypotheses. vol 87. 2016-10-31. PMID:26632202. |
limiting evidence showed that lamotrigine, which inhibits glutamate release, is effective to reduce cocaine craving. |
2016-10-31 |
2023-08-13 |
Not clear |
| Jakub Jedynak, Matthew Hearing, Anna Ingebretson, Stephanie R Ebner, Matthew Kelly, Rachel A Fischer, Saïd Kourrich, Mark J Thoma. Cocaine and Amphetamine Induce Overlapping but Distinct Patterns of AMPAR Plasticity in Nucleus Accumbens Medium Spiny Neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 2. 2016-09-20. PMID:26068728. |
synaptic transmission mediated by ampa-type glutamate receptors was potentiated in the nac shell 10-14 days following repeated amphetamine or cocaine treatment. |
2016-09-20 |
2023-08-13 |
mouse |
| Pedro H Gobira, Luciano R Vilela, Bruno D C Gonçalves, Rebeca P M Santos, Antonio C de Oliveira, Luciene B Vieira, Daniele C Aguiar, José A Crippa, Fabricio A Moreir. Cannabidiol, a Cannabis sativa constituent, inhibits cocaine-induced seizures in mice: Possible role of the mTOR pathway and reduction in glutamate release. Neurotoxicology. vol 50. 2016-08-24. PMID:26283212. |
synaptosome studies with the hippocampus of drug-treated animals revealed that cocaine increases glutamate release, whereas cbd induces the opposite effect. |
2016-08-24 |
2023-08-13 |
mouse |
| Jieun Kim, In Soo Ryu, Su Yeon Seo, Eun Sang Cho. Activation of Protein Kinases and Phosphatases Coupled to Glutamate Receptors Regulates the Phosphorylation State of DARPP32 at Threonine 75 After Repeated Exposure to Cocaine in the Rat Dorsal Striatum in a Ca2+-Dependent Manner. The international journal of neuropsychopharmacology. vol 18. issue 12. 2016-08-10. PMID:26142455. |
activation of protein kinases and phosphatases coupled to glutamate receptors regulates the phosphorylation state of darpp32 at threonine 75 after repeated exposure to cocaine in the rat dorsal striatum in a ca2+-dependent manner. |
2016-08-10 |
2023-08-13 |
rat |
| Jieun Kim, In Soo Ryu, Su Yeon Seo, Eun Sang Cho. Activation of Protein Kinases and Phosphatases Coupled to Glutamate Receptors Regulates the Phosphorylation State of DARPP32 at Threonine 75 After Repeated Exposure to Cocaine in the Rat Dorsal Striatum in a Ca2+-Dependent Manner. The international journal of neuropsychopharmacology. vol 18. issue 12. 2016-08-10. PMID:26142455. |
in this study, mechanisms underlying repeated cocaine-stimulated phosphorylation of darpp32 at threonine 75 (pdarpp32-thr75) were determined by investigating the hypothesis that activation of protein kinases and phosphatases coupled to glutamate signaling is necessary for the regulation of pdarpp32-thr75 after repeated cocaine administration. |
2016-08-10 |
2023-08-13 |
rat |
| Chiung-Chun Huang, Ying-Ching Liang, Cheng-Che Lee, Kuei-Sen Hs. Cocaine Withdrawal Impairs mGluR5-Dependent Long-Term Depression in Nucleus Accumbens Shell Neurons of Both Direct and Indirect Pathways. Molecular neurobiology. vol 52. issue 3. 2016-08-08. PMID:25319571. |
we previously reported that animals withdrawn from repeated cocaine exposure exhibited a selective deficit in the ability to elicit metabotropic glutamate receptor 5 (mglur5)-dependent long-term depression (ltd) in the nucleus accumbens (nac) shell. |
2016-08-08 |
2023-08-13 |
mouse |
| D Y Sakae, F Marti, S Lecca, F Vorspan, E Martín-García, L J Morel, A Henrion, J Gutiérrez-Cuesta, A Besnard, N Heck, E Herzog, S Bolte, V F Prado, M A M Prado, F Bellivier, C B Eap, S Crettol, P Vanhoutte, J Caboche, A Gratton, L Moquin, B Giros, R Maldonado, S Daumas, M Mameli, S Jamain, S El Mestikaw. The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens. Molecular psychiatry. vol 20. issue 11. 2016-08-02. PMID:26239290. |
the absence of vglut3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens. |
2016-08-02 |
2023-08-13 |
mouse |
| D Y Sakae, F Marti, S Lecca, F Vorspan, E Martín-García, L J Morel, A Henrion, J Gutiérrez-Cuesta, A Besnard, N Heck, E Herzog, S Bolte, V F Prado, M A M Prado, F Bellivier, C B Eap, S Crettol, P Vanhoutte, J Caboche, A Gratton, L Moquin, B Giros, R Maldonado, S Daumas, M Mameli, S Jamain, S El Mestikaw. The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens. Molecular psychiatry. vol 20. issue 11. 2016-08-02. PMID:26239290. |
our study shows that tans use glutamate to reduce da release and decrease reinforcing properties of cocaine in mice. |
2016-08-02 |
2023-08-13 |
mouse |
| María Mercedes Odeon, Marcela Andreu, Laura Yamauchi, Mauricio Grosman, Gabriela Beatriz Acost. Chronic postnatal stress induces voluntary alcohol intake and modifies glutamate transporters in adolescent rats. Stress (Amsterdam, Netherlands). vol 18. issue 4. 2016-07-13. PMID:26037264. |
several drugs of abuse, including alcohol and cocaine, alter glutamate transport (glut). |
2016-07-13 |
2023-08-13 |
rat |
| Huikun Wang, Tyler Treadway, Daniel P Covey, Joseph F Cheer, Carl R Lupic. Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area. Cell reports. vol 12. issue 12. 2016-07-06. PMID:26365195. |
cocaine mobilizes 2-ag via inhibition of norepinephrine uptake and promotion of a cooperative interaction between gq/11-coupled type-1 metabotropic glutamate and α1-adrenergic receptors to stimulate internal calcium stores and activate phospholipase c. the disinhibition of da neurons by cocaine-mobilized 2-ag is also functionally relevant because it augments da release in the nucleus accumbens in vivo. |
2016-07-06 |
2023-08-13 |
rat |
| Michael D Scofield, Heather A Boger, Rachel J Smith, Hao Li, Philip G Haydon, Peter W Kaliva. Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking. Biological psychiatry. vol 78. issue 7. 2016-06-14. PMID:25861696. |
gq-dreadd selectively initiates glial glutamate release and inhibits cue-induced cocaine seeking. |
2016-06-14 |
2023-08-13 |
Not clear |
| Polymnia Georgiou, Panos Zanos, Mazdak Ehteramyan, Susanna Hourani, Ian Kitchen, Rafael Maldonado, Alexis Baile. Differential regulation of mGlu5 R and ΜOPr by priming- and cue-induced reinstatement of cocaine-seeking behaviour in mice. Addiction biology. vol 20. issue 5. 2016-06-01. PMID:25522112. |
given the evidence implicating the metabotropic glutamate receptor 5 (mglu5 r), μ-opioid receptor (mopr), κ-opioid receptor (Κopr) and oxytocin receptor (otr) systems in cocaine addiction and relapse, our aim was to assess the modulation of these receptors using a mouse model of cue- and priming-induced reinstatement of cocaine seeking. |
2016-06-01 |
2023-08-13 |
mouse |
| Sunil Goodwani, P S S Rao, Richard L Bell, Youssef Sar. Amoxicillin and amoxicillin/clavulanate reduce ethanol intake and increase GLT-1 expression as well as AKT phosphorylation in mesocorticolimbic regions. Brain research. vol 1622. 2016-06-01. PMID:26168897. |
studies have shown that administration of the β-lactam antibiotic ceftriaxone (cef) attenuates ethanol consumption and cocaine seeking behavior as well as prevents ethanol-induced downregulation of glutamate transporter 1 (glt-1) expression in central reward brain regions. |
2016-06-01 |
2023-08-13 |
rat |
| Elena V Romanova, Stanislav S Rubakhin, John R Ossyra, Jonathan A Zombeck, Michael R Nosek, Jonathan V Sweedler, Justin S Rhode. Differential peptidomics assessment of strain and age differences in mice in response to acute cocaine administration. Journal of neurochemistry. vol 135. issue 5. 2016-05-16. PMID:26223348. |
neuropeptides in the lh affected by acute cocaine administration included pro-opiomelanocortin-, myelin basic protein-, and glutamate transporter-derived peptides. |
2016-05-16 |
2023-08-13 |
mouse |
| Paul F Kramer, John T William. Cocaine Decreases Metabotropic Glutamate Receptor mGluR1 Currents in Dopamine Neurons by Activating mGluR5. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 10. 2016-05-09. PMID:25829143. |
cocaine decreases metabotropic glutamate receptor mglur1 currents in dopamine neurons by activating mglur5. |
2016-05-09 |
2023-08-13 |
Not clear |
| A Fole, M Miguens, A Higuera-Matas, L F Alguacil, E Ambrosio, N Del Olm. Cocaine facilitates protein synthesis-dependent LTP: the role of metabotropic glutamate receptors. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 4. 2016-05-06. PMID:24268515. |
cocaine facilitates protein synthesis-dependent ltp: the role of metabotropic glutamate receptors. |
2016-05-06 |
2023-08-12 |
Not clear |
| Xia Li, Athina Marko. Metabotropic Glutamate Receptor 7 (mGluR7) as a Target for the Treatment of Psychostimulant Dependence. CNS & neurological disorders drug targets. vol 14. issue 6. 2016-03-23. PMID:26022263. |
in vivo microdialysis results indicated that a nucleus accumbens-ventral pallidum γ-aminobutyric acid-ergic mechanism may underlie amn082-induced antagonism of the reinforcing effects of cocaine, whereas a glutamate mglu2/3 receptor mechanism underlies the amn082-induced blockade of cocaine seeking. |
2016-03-23 |
2023-08-13 |
Not clear |
| Douglas J Roberts-Wolfe, Peter W Kaliva. Glutamate Transporter GLT-1 as a Therapeutic Target for Substance Use Disorders. CNS & neurological disorders drug targets. vol 14. issue 6. 2016-03-23. PMID:26022265. |
cocaine, opioids, ethanol, nicotine, amphetamines, and cannabinoids each affect glt-1 expression and glutamate uptake, and restoring glt-1 expression with n-acetylcysteine or ceftriaxone shows promise in correcting pre-clinical and clinical manifestations of drug addiction. |
2016-03-23 |
2023-08-13 |
Not clear |
| Kalindi Bakshi, Raminder Parihar, Satindra K Goswami, Melissa Walsh, Eitan Friedman, Hoau-Yan Wan. Prenatal cocaine exposure uncouples mGluR1 from Homer1 and Gq Proteins. PloS one. vol 9. issue 3. 2016-01-14. PMID:24626340. |
although cocaine profoundly disrupts glutamatergic neurotransmission and in utero cocaine exposure negatively affects metabotropic glutamate receptor-type 1 (mglur1) activity, the effect of prenatal cocaine exposure on mglur1 signaling and the underlying mechanism responsible for the prenatal cocaine effect remain elusive. |
2016-01-14 |
2023-08-12 |
rat |
| Jee Hyun Kim, Christina Perry, Sophia Luikinga, Isabel Zbukvic, Robyn M Brown, Andrew J Lawrenc. Extinction of a cocaine-taking context that protects against drug-primed reinstatement is dependent on the metabotropic glutamate 5 receptor. Addiction biology. vol 20. issue 3. 2016-01-01. PMID:24712397. |
we investigated the effects of extinguishing action-reward versus context-reward associations on drug-primed reinstatement, and the potential role of the metabotropic glutamate 5 receptor (mglu5) in these different types of extinction in rats that self-administer cocaine. |
2016-01-01 |
2023-08-13 |
rat |