| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B M Siemsen, G Giannotti, J A McFaddin, M D Scofield, Jacqueline F McGint. Biphasic effect of abstinence duration following cocaine self-administration on spine morphology and plasticity-related proteins in prelimbic cortical neurons projecting to the nucleus accumbens core. Brain structure & function. vol 224. issue 2. 2019-07-01. PMID:30498893. |
cocaine self-administration (sa) in rats dysregulates glutamatergic signaling in the prelimbic (prl) cortex and glutamate release in the nucleus accumbens (na) core, promoting cocaine seeking. |
2019-07-01 |
2023-08-13 |
rat |
| M P García-Pardo, C Calpe-López, J Miñarro, M A Aguila. Role of N-methyl-D-aspartate receptors in the long-term effects of repeated social defeat stress on the rewarding and psychomotor properties of cocaine in mice. Behavioural brain research. vol 361. 2019-06-04. PMID:30557580. |
the aim of this work is to determine the role of n-methyl-d-aspartate (nmda) glutamate receptors in the influence of social stress on the conditioned place preference and locomotor sensitization induced by cocaine. |
2019-06-04 |
2023-08-13 |
mouse |
| M P García-Pardo, C Calpe-López, J Miñarro, M A Aguila. Role of N-methyl-D-aspartate receptors in the long-term effects of repeated social defeat stress on the rewarding and psychomotor properties of cocaine in mice. Behavioural brain research. vol 361. 2019-06-04. PMID:30557580. |
our results show that glutamate nmda receptors are involved in the higher vulnerability to cocaine effects provoked by exposure to social defeat. |
2019-06-04 |
2023-08-13 |
mouse |
| Gerard M J Beaudoin, Jorge A Gomez, Jessica Perkins, Julie L Bland, Alyssa K Petko, Carlos A Paladin. Cocaine Selectively Reorganizes Excitatory Inputs to Substantia Nigra Pars Compacta Dopamine Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 5. 2019-05-29. PMID:29263240. |
this contrasts with ventral tegmental area (vta) dopamine neurons, whose glutamate afferents react robustly to cocaine. |
2019-05-29 |
2023-08-13 |
mouse |
| Gerard M J Beaudoin, Jorge A Gomez, Jessica Perkins, Julie L Bland, Alyssa K Petko, Carlos A Paladin. Cocaine Selectively Reorganizes Excitatory Inputs to Substantia Nigra Pars Compacta Dopamine Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 5. 2019-05-29. PMID:29263240. |
we used an optogenetic strategy to isolate identified snc inputs and determine whether cocaine sensitivity in the mouse snc circuit is conferred at the level of three glutamate afferents: dorsal raphé nucleus (dr), pedunculopontine nucleus (ppn), and subthalamic nucleus (stn). |
2019-05-29 |
2023-08-13 |
mouse |
| Bart de Laat, Akila Weerasekera, Gil Leurquin-Sterk, Guy Bormans, Uwe Himmelreich, Cindy Casteels, Koen Van Laer. Glutamatergic Biomarkers for Cocaine Addiction: A Longitudinal Study Using MR Spectroscopy and mGluR5 PET in Self-Administering Rats. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 59. issue 6. 2019-05-01. PMID:29496988. |
we present findings on a rat model of cocaine self-administration that was followed up longitudinally using the metabotropic glutamate receptor type 5 (mglur5) tracer |
2019-05-01 |
2023-08-13 |
rat |
| Erin M Miller, Jorge E Quintero, Francois Pomerleau, Peter Huettl, Greg A Gerhardt, Paul E A Glase. Chronic Methylphenidate Alters Tonic and Phasic Glutamate Signaling in the Frontal Cortex of a Freely-Moving Rat Model of ADHD. Neurochemical research. vol 44. issue 1. 2019-03-14. PMID:29397534. |
glutamate dysfunction has been implicated in a number of substance of abuse studies, including cocaine and methamphetamine. |
2019-03-14 |
2023-08-13 |
rat |
| Marian T Sepulveda-Orengo, Kati L Healey, Ronald Kim, Alyson C Auriemma, Jennifer Rojas, Nicholas Woronoff, Rachel Hyppolite, Kathryn J Reissne. Riluzole Impairs Cocaine Reinstatement and Restores Adaptations in Intrinsic Excitability and GLT-1 Expression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 6. 2019-03-04. PMID:28990593. |
adaptations in glutamate signaling within the brain's reward circuitry are observed following withdrawal from several abused drugs, including cocaine. |
2019-03-04 |
2023-08-13 |
rat |
| Marian T Sepulveda-Orengo, Kati L Healey, Ronald Kim, Alyson C Auriemma, Jennifer Rojas, Nicholas Woronoff, Rachel Hyppolite, Kathryn J Reissne. Riluzole Impairs Cocaine Reinstatement and Restores Adaptations in Intrinsic Excitability and GLT-1 Expression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 6. 2019-03-04. PMID:28990593. |
here, we tested the hypothesis that administration of the compound riluzole, which regulates glutamate dynamics in several ways, would reduce cocaine seeking in the rat self-administration and reinstatement model of addiction. |
2019-03-04 |
2023-08-13 |
rat |
| Marian T Sepulveda-Orengo, Kati L Healey, Ronald Kim, Alyson C Auriemma, Jennifer Rojas, Nicholas Woronoff, Rachel Hyppolite, Kathryn J Reissne. Riluzole Impairs Cocaine Reinstatement and Restores Adaptations in Intrinsic Excitability and GLT-1 Expression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 6. 2019-03-04. PMID:28990593. |
glt-1 is responsible for the majority of glutamate uptake in the brain, and has been previously reported to be downregulated by cocaine. |
2019-03-04 |
2023-08-13 |
rat |
| Marian T Sepulveda-Orengo, Kati L Healey, Ronald Kim, Alyson C Auriemma, Jennifer Rojas, Nicholas Woronoff, Rachel Hyppolite, Kathryn J Reissne. Riluzole Impairs Cocaine Reinstatement and Restores Adaptations in Intrinsic Excitability and GLT-1 Expression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 6. 2019-03-04. PMID:28990593. |
these results demonstrate that riluzole impairs cocaine reinstatement while rectifying several cellular adaptations in glutamatergic signaling within the brain's reward circuitry, and support the hypothesis that regulators of glutamate homeostasis represent viable candidates for pharmacotherapeutic treatment of psychostimulant relapse. |
2019-03-04 |
2023-08-13 |
rat |
| Akiko Shimamoto, Virginie Rappeneau, Havisha Munjal, Tonie Farris, Christopher Davis, Alicia Wilson, Malcolm Edwards, Cindy Moore, Collin Reynolds, Charles K Meshu. Glutamate-Glutamine Transfer and Chronic Stress-Induced Sex Differences in Cocaine Responses. Neuroscience. vol 391. 2019-02-27. PMID:30240589. |
the current study investigated the role of a gln transporter called sodium-coupled neutral amino acid transporter subtype 1/2 (snat 1/2), phosphate-activated glutaminase (pag), and astrocytic glutamate transporter-1 (glt-1) on csds animals exposed to cocaine. |
2019-02-27 |
2023-08-13 |
rat |
| Lucia Caffino, Giulia Messa, Fabio Fumagall. A single cocaine administration alters dendritic spine morphology and impairs glutamate receptor synaptic retention in the medial prefrontal cortex of adolescent rats. Neuropharmacology. vol 140. 2019-02-20. PMID:30092246. |
a single cocaine administration alters dendritic spine morphology and impairs glutamate receptor synaptic retention in the medial prefrontal cortex of adolescent rats. |
2019-02-20 |
2023-08-13 |
rat |
| Lucia Caffino, Giulia Messa, Fabio Fumagall. A single cocaine administration alters dendritic spine morphology and impairs glutamate receptor synaptic retention in the medial prefrontal cortex of adolescent rats. Neuropharmacology. vol 140. 2019-02-20. PMID:30092246. |
we investigated the effect of a single cocaine exposure on dendritic spine structure and glutamate dynamics in the medial prefrontal cortex (mpfc) of adolescent rats 7 days after a single cocaine administration. |
2019-02-20 |
2023-08-13 |
rat |
| Lucia Caffino, Giulia Messa, Fabio Fumagall. A single cocaine administration alters dendritic spine morphology and impairs glutamate receptor synaptic retention in the medial prefrontal cortex of adolescent rats. Neuropharmacology. vol 140. 2019-02-20. PMID:30092246. |
notably, neither these critical glutamate determinants nor the density and morphology of the dendritic spines were altered in the mpfc of adult animals, suggesting that a single cocaine exposure selectively impairs the developmental trajectory of the glutamate synapse. |
2019-02-20 |
2023-08-13 |
rat |
| Lucia Caffino, Giulia Messa, Fabio Fumagall. A single cocaine administration alters dendritic spine morphology and impairs glutamate receptor synaptic retention in the medial prefrontal cortex of adolescent rats. Neuropharmacology. vol 140. 2019-02-20. PMID:30092246. |
these results indicate a dynamic impairment of mpfc glutamate homeostasis during a critical developmental window that persists for at least one week after a single cocaine administration. |
2019-02-20 |
2023-08-13 |
rat |
| Lucia Caffino, Giulia Messa, Fabio Fumagall. A single cocaine administration alters dendritic spine morphology and impairs glutamate receptor synaptic retention in the medial prefrontal cortex of adolescent rats. Neuropharmacology. vol 140. 2019-02-20. PMID:30092246. |
our results identify dysfunctional glutamate synapse as a major contributor to the mechanisms that distinguish adolescent vs. adult outcomes of a single cocaine exposure. |
2019-02-20 |
2023-08-13 |
rat |
| Vívian T da Silveira, Jivago Röpke, Ana L Matosinhos, Ana C Issy, Elaine A Del Bel, Antônio C de Oliveira, Fabrício A Moreir. Effects of the monoamine stabilizer (-)-OSU6162 on locomotor and sensorimotor responses predictive of antipsychotic activity. Naunyn-Schmiedeberg's archives of pharmacology. vol 391. issue 7. 2018-11-26. PMID:29691608. |
next, in independent experiments, this compound was evaluated for its efficacy to prevent hyperlocomotion induced by cocaine (10 mg/kg; dopamine transporter inhibitor) or ketamine (60 mg/kg; glutamate nmda channel blocker) in the open field. |
2018-11-26 |
2023-08-13 |
mouse |
| Zuzana Hajasova, Corinne Canestrelli, Francine Acher, Florence Noble, Nicolas Mari. Role of mGlu7 receptor in morphine rewarding effects is uncovered by a novel orthosteric agonist. Neuropharmacology. vol 131. 2018-11-19. PMID:29307544. |
group iii metabotropic glutamate (mglu) receptors has received much attention as a putative target in ethanol and cocaine addiction, but no data on opiate addiction exist. |
2018-11-19 |
2023-08-13 |
Not clear |
| M P García-Pardo, J Miñarro, M A Aguila. Role of AMPA glutamate receptors in the conditioned rewarding effects of MDMA in mice. Behavioural brain research. vol 347. 2018-11-05. PMID:29526785. |
previously, we showed that blockade of glutamate nmda and ampa receptors impairs the conditioned rewarding effects of mdma and cocaine, respectively. |
2018-11-05 |
2023-08-13 |
mouse |