| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Garcia-Keller, Y M Kupchik, C D Gipson, R M Brown, S Spencer, F Bollati, M A Esparza, D J Roberts-Wolfe, J A Heinsbroek, A-C Bobadilla, L M Cancela, P W Kaliva. Glutamatergic mechanisms of comorbidity between acute stress and cocaine self-administration. Molecular psychiatry. vol 21. issue 8. 2017-09-25. PMID:26821978. |
importantly, by restoring glutamate transport in the accumbens core with ceftriaxone the capacity of acute stress to augment the acquisition of cocaine self-administration was abolished. |
2017-09-25 |
2023-08-13 |
rat |
| C Garcia-Keller, Y M Kupchik, C D Gipson, R M Brown, S Spencer, F Bollati, M A Esparza, D J Roberts-Wolfe, J A Heinsbroek, A-C Bobadilla, L M Cancela, P W Kaliva. Glutamatergic mechanisms of comorbidity between acute stress and cocaine self-administration. Molecular psychiatry. vol 21. issue 8. 2017-09-25. PMID:26821978. |
reversing acute stress-induced vulnerability to self-administer cocaine by normalizing glutamate transport poses a novel treatment possibility for reducing comorbid suds in stress disorders. |
2017-09-25 |
2023-08-13 |
rat |
| Frank J Meye, Mariano Soiza-Reilly, Tamar Smit, Marco A Diana, Martin K Schwarz, Manuel Mamel. Shifted pallidal co-release of GABA and glutamate in habenula drives cocaine withdrawal and relapse. Nature neuroscience. vol 19. issue 8. 2017-08-18. PMID:27348214. |
shifted pallidal co-release of gaba and glutamate in habenula drives cocaine withdrawal and relapse. |
2017-08-18 |
2023-08-13 |
mouse |
| Amber L LaCrosse, Sinead M O'Donovan, Marian T Sepulveda-Orengo, Robert E McCullumsmith, Kathryn J Reissner, Marek Schwendt, Lori A Knacksted. Contrasting the Role of xCT and GLT-1 Upregulation in the Ability of Ceftriaxone to Attenuate the Cue-Induced Reinstatement of Cocaine Seeking and Normalize AMPA Receptor Subunit Expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 24. 2017-08-18. PMID:28495973. |
long-term treatment with ceftriaxone attenuates the reinstatement of cocaine seeking while increasing the function of the glutamate transporter 1 (glt-1) and system xc- (sxc) in the nucleus accumbens core (nac). |
2017-08-18 |
2023-08-13 |
rat |
| Lucyna Pomierny-Chamiolo, Joanna Miszkiel, Malgorzata Frankowska, Beata Bystrowska, Malgorzata Fili. Cocaine self-administration, extinction training and drug-induced relapse change metabotropic glutamate mGlu5 receptors expression: Evidence from radioligand binding and immunohistochemistry assays. Brain research. vol 1655. 2017-08-08. PMID:27871824. |
cocaine self-administration, extinction training and drug-induced relapse change metabotropic glutamate mglu5 receptors expression: evidence from radioligand binding and immunohistochemistry assays. |
2017-08-08 |
2023-08-13 |
Not clear |
| Michael D Scofield, Hao Li, Benjamin M Siemsen, Kati L Healey, Phuong K Tran, Nicholas Woronoff, Heather A Boger, Peter W Kalivas, Kathryn J Reissne. Cocaine Self-Administration and Extinction Leads to Reduced Glial Fibrillary Acidic Protein Expression and Morphometric Features of Astrocytes in the Nucleus Accumbens Core. Biological psychiatry. vol 80. issue 3. 2017-08-07. PMID:26946381. |
while it has been shown that cocaine experience impairs astroglial glutamate uptake and release in the nucleus accumbens (nac), few studies have explored effects of self-administration on the structure and physiology of astrocytes. |
2017-08-07 |
2023-08-13 |
Not clear |
| Alexander C W Smith, Michael D Scofield, Jasper A Heinsbroek, Cassandra D Gipson, Daniela Neuhofer, Doug J Roberts-Wolfe, Sade Spencer, Constanza Garcia-Keller, Neringa M Stankeviciute, Rachel J Smith, Nicholas P Allen, Melissa R Lorang, William C Griffin, Heather A Boger, Peter W Kaliva. Accumbens nNOS Interneurons Regulate Cocaine Relapse. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 4. 2017-08-01. PMID:28123012. |
we used a rodent self-administration/reinstatement model of relapse to show that cue-induced t-sp and reinstated cocaine seeking result from glutamate spillover, initiating a metabotropic glutamate receptor 5 (mglur5)-dependent increase in nitric oxide (no) production. |
2017-08-01 |
2023-08-13 |
Not clear |
| Matheus Figueiredo Sathler, Bernardo Stutz, Robertta Silva Martins, Maurício Dos Santos Pereira, Ney Roner Pecinalli, Luis E Santos, Rosilane Taveira-da-Silva, Jennifer Lowe, Isis Grigorio de Freitas, Ricardo Augusto de Melo Reis, Alex C Manhães, Regina C C Kubrusl. Single exposure to cocaine impairs aspartate uptake in the pre-frontal cortex via dopamine D1-receptor dependent mechanisms. Neuroscience. vol 329. 2017-07-26. PMID:27208619. |
dopamine and glutamate play critical roles in the reinforcing effects of cocaine. |
2017-07-26 |
2023-08-13 |
Not clear |
| Avani Shukla, Anna Beroun, Myrto Panopoulou, Peter A Neumann, Seth Gn Grant, M Foster Olive, Yan Dong, Oliver M Schlüte. Calcium-permeable AMPA receptors and silent synapses in cocaine-conditioned place preference. The EMBO journal. vol 36. issue 4. 2017-07-10. PMID:28077487. |
exposure to cocaine generates silent synapses in the nucleus accumbens (nac), whose eventual unsilencing/maturation by recruitment of calcium-permeable ampa-type glutamate receptors (cp-ampars) after drug withdrawal results in profound remodeling of nac neuro-circuits. |
2017-07-10 |
2023-08-13 |
mouse |
| Anthony Purgianto, Jessica A Loweth, Julia J Miao, Mike Milovanovic, Marina E Wol. Surface expression of GABAA receptors in the rat nucleus accumbens is increased in early but not late withdrawal from extended-access cocaine self-administration. Brain research. vol 1642. 2017-05-23. PMID:27060767. |
it is well established that cocaine-induced changes in glutamate receptor expression in the nucleus accumbens (nac) play a significant role in animal models of cocaine addiction. |
2017-05-23 |
2023-08-13 |
rat |
| Zuzana Justinova, Bernard Le Foll, Godfrey H Redhi, Athina Markou, Steven R Goldber. Differential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on nicotine versus cocaine self-administration and relapse in squirrel monkeys. Psychopharmacology. vol 233. issue 10. 2017-02-22. PMID:26149611. |
differential effects of the metabotropic glutamate 2/3 receptor agonist ly379268 on nicotine versus cocaine self-administration and relapse in squirrel monkeys. |
2017-02-22 |
2023-08-13 |
human |
| Jae Kim, Joel John, Dianne Langford, Ellen Walker, Sara Ward, Scott M Rawl. Clavulanic acid enhances glutamate transporter subtype I (GLT-1) expression and decreases reinforcing efficacy of cocaine in mice. Amino acids. vol 48. issue 3. 2016-12-13. PMID:26543027. |
clavulanic acid enhances glutamate transporter subtype i (glt-1) expression and decreases reinforcing efficacy of cocaine in mice. |
2016-12-13 |
2023-08-13 |
mouse |
| Jae Kim, Joel John, Dianne Langford, Ellen Walker, Sara Ward, Scott M Rawl. Clavulanic acid enhances glutamate transporter subtype I (GLT-1) expression and decreases reinforcing efficacy of cocaine in mice. Amino acids. vol 48. issue 3. 2016-12-13. PMID:26543027. |
the β-lactam antibiotic ceftriaxone (ctx) reduces cocaine reinforcement and relapse in preclinical assays through a mechanism involving activation of glutamate transporter subtype 1 (glt-1). |
2016-12-13 |
2023-08-13 |
mouse |
| Jae Kim, Joel John, Dianne Langford, Ellen Walker, Sara Ward, Scott M Rawl. Clavulanic acid enhances glutamate transporter subtype I (GLT-1) expression and decreases reinforcing efficacy of cocaine in mice. Amino acids. vol 48. issue 3. 2016-12-13. PMID:26543027. |
these findings suggest that the β-lactamase inhibitor ca can activate the cellular glutamate reuptake system in the brain reward circuit and reduce cocaine's reinforcing efficacy at 100-fold lower doses than ctx. |
2016-12-13 |
2023-08-13 |
mouse |
| Christina J Perry, Felicia Reed, Isabel C Zbukvic, Jee Hyun Kim, Andrew J Lawrenc. The metabotropic glutamate 5 receptor is necessary for extinction of cocaine-associated cues. British journal of pharmacology. vol 173. issue 6. 2016-12-13. PMID:26784278. |
antagonism of the metabotropic glutamate 5 (mglu5 ) receptor has emerged as a potential treatment, by reducing the reinforcing properties of cocaine. |
2016-12-13 |
2023-08-13 |
Not clear |
| Eduardo Blanco, Pablo Galeano, Ana Palomino, Francisco J Pavón, Patricia Rivera, Antonia Serrano, Francisco Alen, Leticia Rubio, Antonio Vargas, Estela Castilla-Ortega, Juan Decara, Ainhoa Bilbao, Fernando Rodríguez de Fonseca, Juan Suáre. Cocaine-induced behavioral sensitization decreases the expression of endocannabinoid signaling-related proteins in the mouse hippocampus. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 3. 2016-12-13. PMID:26811312. |
in the present work, we studied whether the hippocampal gene/protein expression of relevant glutamate signaling components, including glutamate-synthesizing enzymes and metabotropic and ionotropic receptors, and the hippocampal gene/protein expression of cannabinoid type 1 (cb1) receptor and endocannabinoid metabolic enzymes were altered following acute and/or repeated cocaine administration resulting in conditioned locomotion and locomotor sensitization. |
2016-12-13 |
2023-08-13 |
mouse |
| Eduardo Blanco, Pablo Galeano, Ana Palomino, Francisco J Pavón, Patricia Rivera, Antonia Serrano, Francisco Alen, Leticia Rubio, Antonio Vargas, Estela Castilla-Ortega, Juan Decara, Ainhoa Bilbao, Fernando Rodríguez de Fonseca, Juan Suáre. Cocaine-induced behavioral sensitization decreases the expression of endocannabinoid signaling-related proteins in the mouse hippocampus. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 3. 2016-12-13. PMID:26811312. |
in contrast, locomotor sensitization to cocaine produced an up-regulation of several glutamate receptor-related genes and, specifically, an increased protein expression of the glun1 receptor subunit. |
2016-12-13 |
2023-08-13 |
mouse |
| Lea M Hulka, Milan Scheidegger, Matthias Vonmoos, Katrin H Preller, Markus R Baumgartner, Marcus Herdener, Erich Seifritz, Anke Henning, Boris B Quedno. Glutamatergic and neurometabolic alterations in chronic cocaine users measured with (1) H-magnetic resonance spectroscopy. Addiction biology. vol 21. issue 1. 2016-11-01. PMID:25600822. |
therefore, we investigated potential differences of glutamate, glutamine and further metabolite levels in the pregenual anterior cingulate cortex (pgacc) and the right dorsolateral prefrontal cortex (rdlpfc) of chronic cocaine users and controls using the prior knowledge fitting 2.0 tool in combination with two-dimensional j-resolved single-voxel (1) h-magnetic resonance spectroscopy at 3t and voxel tissue composition and relaxation correction. |
2016-11-01 |
2023-08-13 |
Not clear |
| Lea M Hulka, Milan Scheidegger, Matthias Vonmoos, Katrin H Preller, Markus R Baumgartner, Marcus Herdener, Erich Seifritz, Anke Henning, Boris B Quedno. Glutamatergic and neurometabolic alterations in chronic cocaine users measured with (1) H-magnetic resonance spectroscopy. Addiction biology. vol 21. issue 1. 2016-11-01. PMID:25600822. |
glutamate and glutamine levels did not differ between cocaine users and controls, but higher weekly cocaine use and higher cocaine hair concentrations were associated with lower glutamine/creatine ratios in the pgacc. |
2016-11-01 |
2023-08-13 |
Not clear |
| Lea M Hulka, Milan Scheidegger, Matthias Vonmoos, Katrin H Preller, Markus R Baumgartner, Marcus Herdener, Erich Seifritz, Anke Henning, Boris B Quedno. Glutamatergic and neurometabolic alterations in chronic cocaine users measured with (1) H-magnetic resonance spectroscopy. Addiction biology. vol 21. issue 1. 2016-11-01. PMID:25600822. |
finally, cocaine use over the past 6 months appears to decrease cortical glutamine levels indicating changes in glutamate cycling. |
2016-11-01 |
2023-08-13 |
Not clear |