| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Weiland, Steven Garcia, Lori A Knacksted. Ceftriaxone and cefazolin attenuate the cue-primed reinstatement of alcohol-seeking. Frontiers in pharmacology. vol 6. 2015-03-25. PMID:25805996. |
cefaz had no effect on cocaine reinstatement, a behavior that has been strongly tied to altered glutamate homeostasis in the nucleus accumbens. |
2015-03-25 |
2023-08-13 |
rat |
| M S Milella, L Marengo, K Larcher, A Fotros, A Dagher, P Rosa-Neto, C Benkelfat, M Leyto. Limbic system mGluR5 availability in cocaine dependent subjects: a high-resolution PET [(11)C]ABP688 study. NeuroImage. vol 98. 2015-03-09. PMID:24795154. |
cocaine self-administration decreases type 5 metabotropic glutamate receptor (mglur5) tissue concentrations in laboratory rats during early abstinence. |
2015-03-09 |
2023-08-13 |
human |
| M Behnam Ghasemzadeh, Preethi Vasudevan, Christopher R Mueller, Chad Seubert, John R Mantsc. Region-specific alterations in glutamate receptor expression and subcellular distribution following extinction of cocaine self-administration. Brain research. vol 1267. 2015-02-23. PMID:19368820. |
region-specific alterations in glutamate receptor expression and subcellular distribution following extinction of cocaine self-administration. |
2015-02-23 |
2023-08-12 |
rat |
| M Behnam Ghasemzadeh, Preethi Vasudevan, Christopher R Mueller, Chad Seubert, John R Mantsc. Region-specific alterations in glutamate receptor expression and subcellular distribution following extinction of cocaine self-administration. Brain research. vol 1267. 2015-02-23. PMID:19368820. |
the effects of extinction following cocaine self-administration on the expression and synaptosomal distribution of glur1 and nmdar1 glutamate receptor subunits in the na shell and core and the dorsolateral striatum were examined. |
2015-02-23 |
2023-08-12 |
rat |
| Laura H Corbit, Billy C Chieng, Bernard W Ballein. Effects of repeated cocaine exposure on habit learning and reversal by N-acetylcysteine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 8. 2015-02-12. PMID:24531561. |
we then administered n-acetylcysteine (nac) in an attempt to normalize glutamate homeostasis and hence reverse the cellular and behavioral effects of cocaine exposure. |
2015-02-12 |
2023-08-12 |
human |
| L M Hulka, V Treyer, M Scheidegger, K H Preller, M Vonmoos, M R Baumgartner, A Johayem, S M Ametamey, A Buck, E Seifritz, B B Quedno. Smoking but not cocaine use is associated with lower cerebral metabotropic glutamate receptor 5 density in humans. Molecular psychiatry. vol 19. issue 5. 2015-01-19. PMID:23628984. |
smoking but not cocaine use is associated with lower cerebral metabotropic glutamate receptor 5 density in humans. |
2015-01-19 |
2023-08-12 |
human |
| Jeremy M Reimers, Jessica A Loweth, Marina E Wol. BDNF contributes to both rapid and homeostatic alterations in AMPA receptor surface expression in nucleus accumbens medium spiny neurons. The European journal of neuroscience. vol 39. issue 7. 2014-12-18. PMID:24712995. |
brain-derived neurotrophic factor (bdnf) plays a critical role in plasticity at glutamate synapses and in the effects of repeated cocaine exposure. |
2014-12-18 |
2023-08-13 |
mouse |
| Diana Martinez, Mark Slifstein, Nabeel Nabulsi, Alexander Grassetti, Nina B L Urban, Audrey Perez, Fei Liu, Shu-Fei Lin, Jim Ropchan, Xiangling Mao, Lawrence S Kegeles, Dikoma C Shungu, Richard E Carson, Yiyun Huan. Imaging glutamate homeostasis in cocaine addiction with the metabotropic glutamate receptor 5 positron emission tomography radiotracer [(11)C]ABP688 and magnetic resonance spectroscopy. Biological psychiatry. vol 75. issue 2. 2014-11-18. PMID:24035345. |
imaging glutamate homeostasis in cocaine addiction with the metabotropic glutamate receptor 5 positron emission tomography radiotracer [(11)c]abp688 and magnetic resonance spectroscopy. |
2014-11-18 |
2023-08-12 |
human |
| Diana Martinez, Mark Slifstein, Nabeel Nabulsi, Alexander Grassetti, Nina B L Urban, Audrey Perez, Fei Liu, Shu-Fei Lin, Jim Ropchan, Xiangling Mao, Lawrence S Kegeles, Dikoma C Shungu, Richard E Carson, Yiyun Huan. Imaging glutamate homeostasis in cocaine addiction with the metabotropic glutamate receptor 5 positron emission tomography radiotracer [(11)C]ABP688 and magnetic resonance spectroscopy. Biological psychiatry. vol 75. issue 2. 2014-11-18. PMID:24035345. |
preclinical studies demonstrate that glutamate homeostasis in the striatum is disrupted following cocaine exposure, including a decrease in metabotropic glutamate receptor type 5 (mglur5) expression and reduced glutamate turnover. |
2014-11-18 |
2023-08-12 |
human |
| Diana Martinez, Mark Slifstein, Nabeel Nabulsi, Alexander Grassetti, Nina B L Urban, Audrey Perez, Fei Liu, Shu-Fei Lin, Jim Ropchan, Xiangling Mao, Lawrence S Kegeles, Dikoma C Shungu, Richard E Carson, Yiyun Huan. Imaging glutamate homeostasis in cocaine addiction with the metabotropic glutamate receptor 5 positron emission tomography radiotracer [(11)C]ABP688 and magnetic resonance spectroscopy. Biological psychiatry. vol 75. issue 2. 2014-11-18. PMID:24035345. |
the goal of this study was to use imaging of the human brain to investigate alterations in the glutamate signaling in cocaine addiction. |
2014-11-18 |
2023-08-12 |
human |
| Jeffrey L Barr, Gina L Forster, Ellen M Unterwal. Repeated cocaine enhances ventral hippocampal-stimulated dopamine efflux in the nucleus accumbens and alters ventral hippocampal NMDA receptor subunit expression. Journal of neurochemistry. vol 130. issue 4. 2014-09-29. PMID:24832868. |
together, these results suggest that repeated exposure to cocaine produces maladaptive ventral hippocampal-nucleus accumbens communication, in part through changes in glutamate receptor composition. |
2014-09-29 |
2023-08-13 |
rat |
| Courtney L Williams, William C Buchta, Arthur C Riege. CRF-R2 and the heterosynaptic regulation of VTA glutamate during reinstatement of cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 31. 2014-09-29. PMID:25080599. |
crf-r2 and the heterosynaptic regulation of vta glutamate during reinstatement of cocaine seeking. |
2014-09-29 |
2023-08-13 |
rat |
| Courtney L Williams, William C Buchta, Arthur C Riege. CRF-R2 and the heterosynaptic regulation of VTA glutamate during reinstatement of cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 31. 2014-09-29. PMID:25080599. |
stress can reinstate cocaine seeking through an interaction between the stress hormone corticotropin releasing factor (crf) and glutamate release onto dopamine neurons in the ventral tegmental area (vta). |
2014-09-29 |
2023-08-13 |
rat |
| Courtney L Williams, William C Buchta, Arthur C Riege. CRF-R2 and the heterosynaptic regulation of VTA glutamate during reinstatement of cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 31. 2014-09-29. PMID:25080599. |
after chronic cocaine self-administration and extinction training, the sensitivity of glutamate and gaba receptors was unchanged. |
2014-09-29 |
2023-08-13 |
rat |
| Lisa A Briand, Blake A Kimmey, Pavel I Ortinski, Richard L Huganir, R Christopher Pierc. Disruption of glutamate receptor-interacting protein in nucleus accumbens enhances vulnerability to cocaine relapse. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 3. 2014-09-10. PMID:24126453. |
disruption of glutamate receptor-interacting protein in nucleus accumbens enhances vulnerability to cocaine relapse. |
2014-09-10 |
2023-08-12 |
Not clear |
| Lisa A Briand, Blake A Kimmey, Pavel I Ortinski, Richard L Huganir, R Christopher Pierc. Disruption of glutamate receptor-interacting protein in nucleus accumbens enhances vulnerability to cocaine relapse. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 3. 2014-09-10. PMID:24126453. |
glutamate receptor-interacting protein (grip) is a neuronal scaffolding protein that stabilizes glua2 ampars at synapses but its role in cocaine addiction has not been examined. |
2014-09-10 |
2023-08-12 |
Not clear |
| R Picetti, S D Schlussman, Y Zhou, B Ray, E Ducat, V Yuferov, M J Kree. Addictions and stress: clues for cocaine pharmacotherapies. Current pharmaceutical design. vol 19. issue 40. 2014-08-29. PMID:23574443. |
several neurobiological systems have been implicated with cocaine addiction, including dopamine, serotonin and glutamate systems, opioid receptor and opioid neuropeptide gene systems, stress-responsive systems including crf, vasopressin and orexin. |
2014-08-29 |
2023-08-12 |
Not clear |
| Qingyao Kong, Dan Song, Long-Chuan Y. Region-specific alterations in glutamate receptor 1 phosphorylation during context-induced drug seeking after withdrawal from morphine self-administration. Neuroreport. vol 25. issue 2. 2014-08-26. PMID:24201449. |
adaptations in glutamate receptor 1 (glur1) phosphorylation in limbic brain regions have been shown to occur during withdrawal from addictive drugs, such as cocaine, methamphetamine, and heroin. |
2014-08-26 |
2023-08-12 |
rat |
| Kathryn J Reissner, Robyn M Brown, Sade Spencer, Phuong K Tran, Charles A Thomas, Peter W Kaliva. Chronic administration of the methylxanthine propentofylline impairs reinstatement to cocaine by a GLT-1-dependent mechanism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 2. 2014-08-21. PMID:23985782. |
ppf restored the cocaine-induced decrease in glt-1 in the accumbens core; then, using an antisense strategy against glutamate transporter glt-1, we found that restored transporter expression was necessary for ppf to inhibit cue-primed cocaine seeking. |
2014-08-21 |
2023-08-12 |
rat |
| Kathryn J Reissner, Robyn M Brown, Sade Spencer, Phuong K Tran, Charles A Thomas, Peter W Kaliva. Chronic administration of the methylxanthine propentofylline impairs reinstatement to cocaine by a GLT-1-dependent mechanism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 2. 2014-08-21. PMID:23985782. |
these findings indicate that modulating glial physiology with atypical xanthine derivatives like ppf is a potential avenue for developing new medications for cocaine abuse, and support the hypothesis that neuron-glial interactions contribute to mechanisms of psychostimulant addiction, particularly via expression and function of astroglial glutamate transporters. |
2014-08-21 |
2023-08-12 |
rat |