| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Russell J Amato, Andrew S Felts, Alice L Rodriguez, Daryl F Venable, Ryan D Morrison, Frank W Byers, J Scott Daniels, Colleen M Niswender, P Jeffrey Conn, Craig W Lindsley, Carrie K Jones, Kyle A Emmitt. Substituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addiction. ACS chemical neuroscience. vol 4. issue 8. 2014-04-01. PMID:23682684. |
evidence has continued to accumulate that indicates a critical role for the metabotropic glutamate receptor subtype 5 (mglu5) in the modulation of neural circuitry associated with the addictive properties of cocaine. |
2014-04-01 |
2023-08-12 |
rat |
| Briac Halbout, Rick E Bernardi, Anita C Hansson, Rainer Spanage. Incubation of cocaine seeking following brief cocaine experience in mice is enhanced by mGluR1 blockade. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 5. 2014-04-01. PMID:24478360. |
in contrast to most studies that use multiple cocaine-cue conditioning sessions, the present study tested mice with limited cocaine experience (i.e., a single conditioning session) in the incubation of cue-mediated cocaine seeking and its associated changes in the glutamate system. |
2014-04-01 |
2023-08-12 |
mouse |
| Briac Halbout, Rick E Bernardi, Anita C Hansson, Rainer Spanage. Incubation of cocaine seeking following brief cocaine experience in mice is enhanced by mGluR1 blockade. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 5. 2014-04-01. PMID:24478360. |
these results suggest that limited cocaine experience is sufficient to induce neurobiological changes that enable an initially neutral cue to acquire motivational value that increases over time, an effect that likely involves glutamate signaling through mglur1. |
2014-04-01 |
2023-08-12 |
mouse |
| Kristin M Timmer, Jeffery D Stekete. Group I metabotropic glutamate receptors in the medial prefrontal cortex: role in mesocorticolimbic glutamate release in cocaine sensitization. Synapse (New York, N.Y.). vol 67. issue 12. 2014-03-25. PMID:23913407. |
group i metabotropic glutamate receptors in the medial prefrontal cortex: role in mesocorticolimbic glutamate release in cocaine sensitization. |
2014-03-25 |
2023-08-12 |
rat |
| Benjamin D Hobson, Casey E O'Neill, Sophia C Levis, Lisa M Monteggia, Rachael L Neve, David W Self, Ryan K Bachtel. Adenosine A1 and dopamine d1 receptor regulation of AMPA receptor phosphorylation and cocaine-seeking behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 10. 2014-03-24. PMID:23598433. |
ampar (α-amino-3-hydroxy-5-methylisoxazole-4-propionate glutamate receptor) stimulation in the nucleus accumbens (nac) is critical in cocaine seeking. |
2014-03-24 |
2023-08-12 |
Not clear |
| Benjamin D Hobson, Casey E O'Neill, Sophia C Levis, Lisa M Monteggia, Rachael L Neve, David W Self, Ryan K Bachtel. Adenosine A1 and dopamine d1 receptor regulation of AMPA receptor phosphorylation and cocaine-seeking behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 10. 2014-03-24. PMID:23598433. |
a1ar stimulation inhibits both the facilitation of ampar function and subsequent cocaine seeking, suggesting that reducing ampa glutamate neurotransmission in direct pathway neurons may restore inhibitory control and reduce cocaine relapse. |
2014-03-24 |
2023-08-12 |
Not clear |
| Laura A Gabach, Valeria P Carlini, María C Monti, Laura E Maglio, Susana Rubiales De Barioglio, Mariela F Pere. Involvement of nNOS/NO/sGC/cGMP signaling pathway in cocaine sensitization and in the associated hippocampal alterations: does phosphodiesterase 5 inhibition help to drug vulnerability? Psychopharmacology. vol 229. issue 1. 2014-03-21. PMID:23579428. |
moreover, cocaine and other drugs of abuse can affect the strength of glutamate synapses in this structure, lastly modifying neuronal activity in main regions of the reward circuitry. |
2014-03-21 |
2023-08-12 |
rat |
| Ana Palomino, Francisco-Javier Pavón, Eduardo Blanco-Calvo, Antonia Serrano, Sergio Arrabal, Patricia Rivera, Francisco Alén, Antonio Vargas, Ainhoa Bilbao, Leticia Rubio, Fernando Rodríguez de Fonseca, Juan Suáre. Effects of acute versus repeated cocaine exposure on the expression of endocannabinoid signaling-related proteins in the mouse cerebellum. Frontiers in integrative neuroscience. vol 8. 2014-03-17. PMID:24634647. |
here, we examined the impact of acute and repeated cocaine exposure on the two main signaling systems in the mouse cerebellum: the endocannabinoid (ecb) and glutamate systems. |
2014-03-17 |
2023-08-12 |
mouse |
| Ana Palomino, Francisco-Javier Pavón, Eduardo Blanco-Calvo, Antonia Serrano, Sergio Arrabal, Patricia Rivera, Francisco Alén, Antonio Vargas, Ainhoa Bilbao, Leticia Rubio, Fernando Rodríguez de Fonseca, Juan Suáre. Effects of acute versus repeated cocaine exposure on the expression of endocannabinoid signaling-related proteins in the mouse cerebellum. Frontiers in integrative neuroscience. vol 8. 2014-03-17. PMID:24634647. |
repeated cocaine also increased lga gene expression but had no effect on glutamate receptors. |
2014-03-17 |
2023-08-12 |
mouse |
| Ana Palomino, Francisco-Javier Pavón, Eduardo Blanco-Calvo, Antonia Serrano, Sergio Arrabal, Patricia Rivera, Francisco Alén, Antonio Vargas, Ainhoa Bilbao, Leticia Rubio, Fernando Rodríguez de Fonseca, Juan Suáre. Effects of acute versus repeated cocaine exposure on the expression of endocannabinoid signaling-related proteins in the mouse cerebellum. Frontiers in integrative neuroscience. vol 8. 2014-03-17. PMID:24634647. |
these findings indicate that acute cocaine modulates the expression of the ecb and glutamate systems. |
2014-03-17 |
2023-08-12 |
mouse |
| Ana Palomino, Francisco-Javier Pavón, Eduardo Blanco-Calvo, Antonia Serrano, Sergio Arrabal, Patricia Rivera, Francisco Alén, Antonio Vargas, Ainhoa Bilbao, Leticia Rubio, Fernando Rodríguez de Fonseca, Juan Suáre. Effects of acute versus repeated cocaine exposure on the expression of endocannabinoid signaling-related proteins in the mouse cerebellum. Frontiers in integrative neuroscience. vol 8. 2014-03-17. PMID:24634647. |
repeated cocaine results in normalization of glutamate receptor expression, although sustained changes in ecb is observed. |
2014-03-17 |
2023-08-12 |
mouse |
| Jessica A Loweth, Kuei Y Tseng, Marina E Wol. Using metabotropic glutamate receptors to modulate cocaine's synaptic and behavioral effects: mGluR1 finds a niche. Current opinion in neurobiology. vol 23. issue 4. 2014-02-27. PMID:23385114. |
using metabotropic glutamate receptors to modulate cocaine's synaptic and behavioral effects: mglur1 finds a niche. |
2014-02-27 |
2023-08-12 |
Not clear |
| Bankole A Johnson, Nassima Ait-Daoud, Xin-Qun Wang, J Kim Penberthy, Martin A Javors, Chamindi Seneviratne, Lei Li. Topiramate for the treatment of cocaine addiction: a randomized clinical trial. JAMA psychiatry. vol 70. issue 12. 2014-02-24. PMID:24132249. |
we hypothesized that dual modulation of the mesocorticolimbic dopamine system by topiramate-a glutamate receptor antagonist and γ-aminobutyric acid receptor agonist-would result in efficacious treatment for cocaine dependence compared with placebo. |
2014-02-24 |
2023-08-12 |
Not clear |
| Ryan H Purcell, Ligia A Papale, Christopher D Makinson, Nikki T Sawyer, Jason P Schroeder, Andrew Escayg, David Weinshenke. Effects of an epilepsy-causing mutation in the SCN1A sodium channel gene on cocaine-induced seizure susceptibility in mice. Psychopharmacology. vol 228. issue 2. 2014-02-10. PMID:23494229. |
several mechanisms have been proposed for the induction of seizures by cocaine, including enhanced monoaminergic signaling, blockade of ion channels, and alterations in gaba and glutamate transmission. |
2014-02-10 |
2023-08-12 |
mouse |
| Rose Chesworth, Robyn M Brown, Jee Hyun Kim, Andrew J Lawrenc. The metabotropic glutamate 5 receptor modulates extinction and reinstatement of methamphetamine-seeking in mice. PloS one. vol 8. issue 7. 2014-02-03. PMID:23861896. |
we sought to assess the involvement of the metabotropic glutamate 5 receptor (mglu5) in behaviours relevant to meth addiction because this receptor has been implicated in the actions of other drugs of abuse, including alcohol, cocaine and opiates. |
2014-02-03 |
2023-08-12 |
mouse |
| Christoph Abé, Anderson Mon, Timothy C Durazzo, David L Pennington, Thomas P Schmidt, Dieter J Meyerhof. Polysubstance and alcohol dependence: unique abnormalities of magnetic resonance-derived brain metabolite levels. Drug and alcohol dependence. vol 130. issue 1-3. 2014-01-27. PMID:23122599. |
brain magnetic resonance spectroscopy studies of mono-substance use disorders (e.g., alcohol or cocaine) reveal abnormal levels of cortical metabolites (reflecting neuronal integrity, cell membrane turnover/synthesis, cellular bioenergetics, gliosis) and altered concentrations of glutamate and γ-aminobutyric acid (gaba). |
2014-01-27 |
2023-08-12 |
Not clear |
| Fei Yu, Peng Zhong, Xiaojie Liu, Dalong Sun, Hai-Qing Gao, Qing-Song Li. Metabotropic glutamate receptor I (mGluR1) antagonism impairs cocaine-induced conditioned place preference via inhibition of protein synthesis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 7. 2014-01-24. PMID:23348064. |
antagonism of group i metabotropic glutamate receptors (mglur1 and mglur5) reduces behavioral effects of drugs of abuse, including cocaine. |
2014-01-24 |
2023-08-12 |
rat |
| Patricia Rivera, Miguel Miguéns, Santiago M Coria, Leticia Rubio, Alejandro Higuera-Matas, Francisco J Bermúdez-Silva, Fernando Rodríguez de Fonseca, Juan Suárez, Emilio Ambrosi. Cocaine self-administration differentially modulates the expression of endogenous cannabinoid system-related proteins in the hippocampus of Lewis vs. Fischer 344 rats. The international journal of neuropsychopharmacology. vol 16. issue 6. 2014-01-15. PMID:23217608. |
the endocannabinoids anandamide and 2-arachidonyl glycerol (2-ag) are modulators of glutamate and γ-aminobutyric acid (gaba), two transmitters involved in cocaine addiction. |
2014-01-15 |
2023-08-12 |
rat |
| Miguel Miguéns, Fanny Botreau, Oscar Olías, Nuria Del Olmo, Santiago M Coria, Alejandro Higuera-Matas, Emilio Ambrosi. Genetic differences in the modulation of accumbal glutamate and γ-amino butyric acid levels after cocaine-induced reinstatement. Addiction biology. vol 18. issue 4. 2013-10-29. PMID:22004520. |
to investigate this, we measured by in vivo microdialysis extracellular glutamate and gaba levels in the core division of the nucleus accumbens after extinction of cocaine self-administration and during cocaine-induced reinstatement (7.5mg/kg, i.p.) |
2013-10-29 |
2023-08-12 |
rat |
| Miguel Miguéns, Fanny Botreau, Oscar Olías, Nuria Del Olmo, Santiago M Coria, Alejandro Higuera-Matas, Emilio Ambrosi. Genetic differences in the modulation of accumbal glutamate and γ-amino butyric acid levels after cocaine-induced reinstatement. Addiction biology. vol 18. issue 4. 2013-10-29. PMID:22004520. |
after extinction, f344 rats that self-administered cocaine had less gaba than the saline controls, while the glutamate levels remained constant in both strains. |
2013-10-29 |
2023-08-12 |
rat |