| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard M Allen, Bruce H Mandt, Jillian Jaskunas, Amanda Hackley, Alyssa Shickedanz, David Bergkam. Continuous exposure to dizocilpine facilitates the acquisition and escalation of cocaine consumption in male Sprague-Dawley rats. Drug and alcohol dependence. vol 147. 2015-12-30. PMID:25523326. |
blocking n-methyl-d-aspartate (nmda) glutamate receptors (nmdars) prevents cocaine locomotor sensitization, but facilitates escalation of cocaine self-administration and produces ambiguous effects on acquisition of cocaine self-administration. |
2015-12-30 |
2023-08-13 |
rat |
| Heath D Schmidt, Blake A Kimmey, Adrian C Arreola, R Christopher Pierc. Group I metabotropic glutamate receptor-mediated activation of PKC gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking. Addiction biology. vol 20. issue 2. 2015-10-21. PMID:24506432. |
group i metabotropic glutamate receptor-mediated activation of pkc gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking. |
2015-10-21 |
2023-08-12 |
rat |
| Heath D Schmidt, Blake A Kimmey, Adrian C Arreola, R Christopher Pierc. Group I metabotropic glutamate receptor-mediated activation of PKC gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking. Addiction biology. vol 20. issue 2. 2015-10-21. PMID:24506432. |
emerging evidence indicates that type i metabotropic glutamate receptors (mglurs) in the nucleus accumbens play a critical role in cocaine seeking. |
2015-10-21 |
2023-08-12 |
rat |
| Kathryn J Reissner, Cassandra D Gipson, Phuong K Tran, Lori A Knackstedt, Michael D Scofield, Peter W Kaliva. Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement. Addiction biology. vol 20. issue 2. 2015-10-21. PMID:24612076. |
glutamate transporter glt-1 mediates n-acetylcysteine inhibition of cocaine reinstatement. |
2015-10-21 |
2023-08-12 |
rat |
| Kathryn J Reissner, Cassandra D Gipson, Phuong K Tran, Lori A Knackstedt, Michael D Scofield, Peter W Kaliva. Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement. Addiction biology. vol 20. issue 2. 2015-10-21. PMID:24612076. |
cocaine self-administration in rats reduces both cystine-glutamate exchange and glutamate transport via glt-1 in the nucleus accumbens, and nac treatment normalizes these two glial processes critical for maintaining glutamate homeostasis. |
2015-10-21 |
2023-08-12 |
rat |
| Wei-Lun Sun, Sarah A Eisenstein, Agnieszka Zelek-Molik, Jacqueline F McGint. A single brain-derived neurotrophic factor infusion into the dorsomedial prefrontal cortex attenuates cocaine self-administration-induced phosphorylation of synapsin in the nucleus accumbens during early withdrawal. The international journal of neuropsychopharmacology. vol 18. issue 1. 2015-09-30. PMID:25522393. |
we have previously demonstrated that one intra-dorsomedial prefrontal cortex brain-derived neurotrophic factor (bdnf) infusion immediately following the last cocaine self-administration session caused a long-lasting inhibition of cocaine-seeking and normalized the cocaine-induced disturbance of glutamate transmission in the nucleus accumbens after extinction and a cocaine prime. |
2015-09-30 |
2023-08-13 |
Not clear |
| Luyi Zhou, Wei-Lun Sun, Amy B Young, Kunhee Lee, Jacqueline F McGinty, Ronald E Se. Oxytocin reduces cocaine seeking and reverses chronic cocaine-induced changes in glutamate receptor function. The international journal of neuropsychopharmacology. vol 18. issue 1. 2015-09-30. PMID:25539504. |
oxytocin reduces cocaine seeking and reverses chronic cocaine-induced changes in glutamate receptor function. |
2015-09-30 |
2023-08-13 |
Not clear |
| M Jenda, K Gawel, M Marszalek, L Komsta, J H Kotlinsk. AMN082, a metabotropic glutamate receptor 7 allosteric agonist, attenuates locomotor sensitization and cross-sensitization induced by cocaine and morphine in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 57. 2015-08-13. PMID:25448778. |
amn082, a metabotropic glutamate receptor 7 allosteric agonist, attenuates locomotor sensitization and cross-sensitization induced by cocaine and morphine in mice. |
2015-08-13 |
2023-08-13 |
mouse |
| Victoria Lutgen, Linghai Kong, Kristen S Kau, Aric Madayag, John R Mantsch, David A Bake. Time course of cocaine-induced behavioral and neurochemical plasticity. Addiction biology. vol 19. issue 4. 2015-04-20. PMID:22970924. |
in this study, we examined the impact of withdrawal period duration and cocaine intake on the magnitude of cocaine-primed reinstatement and extracellular glutamate in the nucleus accumbens, which has been shown to be required for cocaine-primed reinstatement. |
2015-04-20 |
2023-08-12 |
rat |
| Victoria Lutgen, Linghai Kong, Kristen S Kau, Aric Madayag, John R Mantsch, David A Bake. Time course of cocaine-induced behavioral and neurochemical plasticity. Addiction biology. vol 19. issue 4. 2015-04-20. PMID:22970924. |
after 1, 21 or 60 days of withdrawal, drug seeking and extracellular glutamate levels in the nucleus accumbens were measured before and after a cocaine injection. |
2015-04-20 |
2023-08-12 |
rat |
| Melissa L Perreault, Brian F O'Dowd, Susan R Georg. Dopamine D₁-D₂ receptor heteromer regulates signaling cascades involved in addiction: potential relevance to adolescent drug susceptibility. Developmental neuroscience. vol 36. issue 3-4. 2015-04-17. PMID:24820626. |
the d1-d2 receptor heteromer, for instance, has been associated with calcium calmodulin kinase iiα, brain-derived neurotrophic factor and glycogen synthase kinase 3 (gsk-3) signaling, three proteins highly implicated in the regulation of glutamate transmission and synaptic plasticity and which regulate addiction to amphetamine, opioids and cocaine. |
2015-04-17 |
2023-08-13 |
Not clear |
| Lucia Caffino, Małgorzata Frankowska, Giuseppe Giannotti, Joanna Miszkiel, Anna Sadakierska-Chudy, Giorgio Racagni, Małgorzata Filip, Fabio Fumagall. Cocaine-induced glutamate receptor trafficking is abrogated by extinction training in the rat hippocampus. Pharmacological reports : PR. vol 66. issue 2. 2015-03-30. PMID:24911070. |
since glutamate appears to be critical for context-induced drug seeking behaviors, the major aim of our work was to investigate the expression of hippocampal ampa and nmda glutamate receptors following repeated cocaine exposure and during extinction training. |
2015-03-30 |
2023-08-13 |
rat |
| Magdalena Zaniewska, Edmund Przegaliński, Małgorzata Filip, Andrzej Pilc, Darío Dolle. Inhibitory actions of mGlu4 receptor ligands on cocaine-, but not nicotine-, induced sensitizing and conditioning locomotor responses in rats. Pharmacological reports : PR. vol 66. issue 2. 2015-03-30. PMID:24911071. |
male wistar rats were used to verify the hypothesis that metabotropic glutamate 4 (mglu4) receptor ligands may modulate the locomotor effects evoked by cocaine or nicotine. |
2015-03-30 |
2023-08-13 |
rat |
| Vinay Parikh, Sean X Naughton, Xiangdang Shi, Leslie K Kelley, Brittney Yegla, Christopher S Tallarida, Scott M Rawls, Ellen M Unterwal. Cocaine-induced neuroadaptations in the dorsal striatum: glutamate dynamics and behavioral sensitization. Neurochemistry international. vol 75. 2015-03-30. PMID:24911954. |
recent evidence suggests that diminished ability to control cocaine seeking arises from perturbations in glutamate homeostasis in the nucleus accumbens. |
2015-03-30 |
2023-08-13 |
rat |
| Vinay Parikh, Sean X Naughton, Xiangdang Shi, Leslie K Kelley, Brittney Yegla, Christopher S Tallarida, Scott M Rawls, Ellen M Unterwal. Cocaine-induced neuroadaptations in the dorsal striatum: glutamate dynamics and behavioral sensitization. Neurochemistry international. vol 75. 2015-03-30. PMID:24911954. |
we employed glutamate-sensitive microelectrodes and amperometry to study the impact of repeated cocaine administration on glutamate dynamics in the dorsolateral striatum of awake freely-moving rats. |
2015-03-30 |
2023-08-13 |
rat |
| Vinay Parikh, Sean X Naughton, Xiangdang Shi, Leslie K Kelley, Brittney Yegla, Christopher S Tallarida, Scott M Rawls, Ellen M Unterwal. Cocaine-induced neuroadaptations in the dorsal striatum: glutamate dynamics and behavioral sensitization. Neurochemistry international. vol 75. 2015-03-30. PMID:24911954. |
depolarization-evoked glutamate release was robustly increased in cocaine-pretreated rats challenged with cocaine. |
2015-03-30 |
2023-08-13 |
rat |
| Vinay Parikh, Sean X Naughton, Xiangdang Shi, Leslie K Kelley, Brittney Yegla, Christopher S Tallarida, Scott M Rawls, Ellen M Unterwal. Cocaine-induced neuroadaptations in the dorsal striatum: glutamate dynamics and behavioral sensitization. Neurochemistry international. vol 75. 2015-03-30. PMID:24911954. |
repeated cocaine exposure also reduced the neuronal tone of striatal glutamate. |
2015-03-30 |
2023-08-13 |
rat |
| Vinay Parikh, Sean X Naughton, Xiangdang Shi, Leslie K Kelley, Brittney Yegla, Christopher S Tallarida, Scott M Rawls, Ellen M Unterwal. Cocaine-induced neuroadaptations in the dorsal striatum: glutamate dynamics and behavioral sensitization. Neurochemistry international. vol 75. 2015-03-30. PMID:24911954. |
ceftriaxone, a β-lactam antibiotic that activates the astrocytic glutamate transporter, attenuated the effects of repeated cocaine exposure on synaptic glutamate release and glutamate clearance kinetics. |
2015-03-30 |
2023-08-13 |
rat |
| Vinay Parikh, Sean X Naughton, Xiangdang Shi, Leslie K Kelley, Brittney Yegla, Christopher S Tallarida, Scott M Rawls, Ellen M Unterwal. Cocaine-induced neuroadaptations in the dorsal striatum: glutamate dynamics and behavioral sensitization. Neurochemistry international. vol 75. 2015-03-30. PMID:24911954. |
finally, the antagonism of ampa glutamate receptors in the dorsolateral striatum blocked the development of behavioral sensitization to repeated cocaine administration. |
2015-03-30 |
2023-08-13 |
rat |
| Vinay Parikh, Sean X Naughton, Xiangdang Shi, Leslie K Kelley, Brittney Yegla, Christopher S Tallarida, Scott M Rawls, Ellen M Unterwal. Cocaine-induced neuroadaptations in the dorsal striatum: glutamate dynamics and behavioral sensitization. Neurochemistry international. vol 75. 2015-03-30. PMID:24911954. |
collectively, these data suggest that repeated cocaine exposure disrupts presynaptic glutamate transmission and transporter-mediated clearance mechanisms in the dorsal striatum. |
2015-03-30 |
2023-08-13 |
rat |