| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K K Szumlinski, C B Shi. Kinase interest you in treating incubated cocaine-craving? A hypothetical model for treatment intervention during protracted withdrawal from cocaine. Genes, brain, and behavior. vol 17. issue 3. 2018-10-01. PMID:29152855. |
rodent models of cocaine addiction indicate that a history of excessive cocaine-taking impacts excitatory glutamate signaling within the prefrontal cortex to drive drug-seeking behavior during protracted withdrawal. |
2018-10-01 |
2023-08-13 |
rat |
| José I Pena-Bravo, Carmela M Reichel, Antonieta Lavi. Abstinence from Cocaine-Induced Conditioned Place Preference Produces Discrete Changes in Glutamatergic Synapses onto Deep Layer 5/6 Neurons from Prelimbic and Infralimbic Cortices. eNeuro. vol 4. issue 6. 2018-08-07. PMID:29242822. |
these results suggest that retention of cocaine-cpp requires differential modulation of glutamate transmission between pl- and il-mpfc neurons and that these adaptations are dependent on the abstinence interval and reexposure to the cocaine context. |
2018-08-07 |
2023-08-13 |
rat |
| Lucyna Pomierny-Chamiolo, Joanna Miszkiel, Malgorzata Frankowska, Józef Mizera, Malgorzata Fili. Neuroadaptive changes in metabotropic glutamate mGlu2/3R expression during different phases of cocaine addiction in rats. Pharmacological reports : PR. vol 69. issue 5. 2018-07-30. PMID:28988614. |
neuroadaptive changes in metabotropic glutamate mglu2/3r expression during different phases of cocaine addiction in rats. |
2018-07-30 |
2023-08-13 |
rat |
| Evelyn H Schlenke. Sexual dimorphism of cardiopulmonary regulation in the arcuate nucleus of the hypothalamus. Respiratory physiology & neurobiology. vol 245. 2018-07-23. PMID:27756648. |
importantly, the anh exhibits structural and functional sexually dimorphic characteristics and contains numerous neuroactive substances and receptors including leptin, neuropeptide y, glutamate, acetylcholine, endorphins, orexin, kisspeptin, insulin, agouti-related protein, cocaine and amphetamine-regulated transcript, dopamine, somatostatin, components of renin-angiotensin system and gamma amino butyric acid that modulate physiological functions. |
2018-07-23 |
2023-08-13 |
Not clear |
| Anthony Purgianto, Michael E Weinfeld, Marina E Wol. Prolonged withdrawal from cocaine self-administration affects prefrontal cortex- and basolateral amygdala-nucleus accumbens core circuits but not accumbens GABAergic local interneurons. Addiction biology. vol 22. issue 6. 2018-07-16. PMID:27457780. |
overall, our results suggest that alterations in gaba transmission may accompany incubation of cocaine craving, but they are circuit specific and less pronounced than alterations in glutamate transmission. |
2018-07-16 |
2023-08-13 |
rat |
| Ronald Kim, Marian T Sepulveda-Orengo, Kati L Healey, Emily A Williams, Kathryn J Reissne. Regulation of glutamate transporter 1 (GLT-1) gene expression by cocaine self-administration and withdrawal. Neuropharmacology. vol 128. 2018-07-13. PMID:28919080. |
regulation of glutamate transporter 1 (glt-1) gene expression by cocaine self-administration and withdrawal. |
2018-07-13 |
2023-08-13 |
rat |
| Feipeng Zhu, Qihui Wu, Jie Li, Katarzyna Grycel, Bing Liu, Xiaoxuan Sun, Li Zhou, Ruiyin Jiao, Rui Song, Younus M Khan, Qinglong Wang, Lun Wang, Yongxin Xu, Jin Li, Bo Zhang, Zhuan Zho. A single dose of cocaine potentiates glutamatergic synaptic transmission onto locus coeruleus neurons. Cell calcium. vol 67. 2018-05-29. PMID:29029785. |
in addition, the single injection of cocaine did not affect presynaptic glutamate release probability measured by paired pulse ratio. |
2018-05-29 |
2023-08-13 |
mouse |
| Qiang Wang, Dongdong Li, Nancy Bubula, Matthew R Campioni, Daniel S McGehee, Paul Vezin. Sensitizing exposure to amphetamine increases AMPA receptor phosphorylation without increasing cell surface expression in the rat nucleus accumbens. Neuropharmacology. vol 117. 2018-05-03. PMID:28223211. |
rather than increase the number of surface and synaptic ampa receptors as with cocaine, this mechanism could increase nacc medium spiny neuron reactivity to glutamate afferents by increasing the phosphorylation state of critical regulatory sites in the ampa receptor glua1 subunit in the psd. |
2018-05-03 |
2023-08-13 |
rat |
| Alaa M Hammad, Yusuf S Althobaiti, Sujan C Das, Youssef Sar. Effects of repeated cocaine exposure and withdrawal on voluntary ethanol drinking, and the expression of glial glutamate transporters in mesocorticolimbic system of P rats. Molecular and cellular neurosciences. vol 82. 2018-04-24. PMID:28442364. |
effects of repeated cocaine exposure and withdrawal on voluntary ethanol drinking, and the expression of glial glutamate transporters in mesocorticolimbic system of p rats. |
2018-04-24 |
2023-08-13 |
rat |
| Alaa M Hammad, Yusuf S Althobaiti, Sujan C Das, Youssef Sar. Effects of repeated cocaine exposure and withdrawal on voluntary ethanol drinking, and the expression of glial glutamate transporters in mesocorticolimbic system of P rats. Molecular and cellular neurosciences. vol 82. 2018-04-24. PMID:28442364. |
cocaine exposure has been shown to induce a dysregulation in glutamate homeostasis and a decrease in the expression of glt-1 and xct in the nucleus accumbens (nac). |
2018-04-24 |
2023-08-13 |
rat |
| Alaa M Hammad, Yusuf S Althobaiti, Sujan C Das, Youssef Sar. Effects of repeated cocaine exposure and withdrawal on voluntary ethanol drinking, and the expression of glial glutamate transporters in mesocorticolimbic system of P rats. Molecular and cellular neurosciences. vol 82. 2018-04-24. PMID:28442364. |
our findings demonstrated that chronic cocaine exposure affects ethanol intake; and ethanol and cocaine co-abuse alters the expression of glial glutamate transporters. |
2018-04-24 |
2023-08-13 |
rat |
| Hong-Ju Yang, Hai-Ying Zhang, Guo-Hua Bi, Yi He, Jun-Tao Gao, Zheng-Xiong X. Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats. Cell reports. vol 20. issue 2. 2018-04-03. PMID:28700935. |
deletion of type 2 metabotropic glutamate receptor decreases sensitivity to cocaine reward in rats. |
2018-04-03 |
2023-08-13 |
rat |
| Hong-Ju Yang, Hai-Ying Zhang, Guo-Hua Bi, Yi He, Jun-Tao Gao, Zheng-Xiong X. Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats. Cell reports. vol 20. issue 2. 2018-04-03. PMID:28700935. |
cocaine users show reduced expression of the metabotropic glutamate receptor (mglur2), but it is not clear whether this is a predisposing trait for addiction or a consequence of drug exposure. |
2018-04-03 |
2023-08-13 |
rat |
| Hong-Ju Yang, Hai-Ying Zhang, Guo-Hua Bi, Yi He, Jun-Tao Gao, Zheng-Xiong X. Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats. Cell reports. vol 20. issue 2. 2018-04-03. PMID:28700935. |
mglur2 mutant rats also show a lower propensity to relapse after a period of cocaine abstinence, an effect associated with reduced cocaine-induced dopamine and glutamate overflow in the nucleus accumbens. |
2018-04-03 |
2023-08-13 |
rat |
| B Levi Bolin, Joseph L Alcorn, Joshua A Lile, Craig R Rush, Abner O Rayapati, Lon R Hays, William W Stoop. N-Acetylcysteine reduces cocaine-cue attentional bias and differentially alters cocaine self-administration based on dosing order. Drug and alcohol dependence. vol 178. 2018-04-03. PMID:28711811. |
disrupted glutamate homeostasis is thought to contribute to cocaine-use disorder, in particular, by enhancing the incentive salience of cocaine stimuli. |
2018-04-03 |
2023-08-13 |
Not clear |
| Rui Zhao, Jiaojiao Chen, Zhaoxiang Ren, Hui Shen, Xuechu Zhe. GSK-3β inhibitors reverse cocaine-induced synaptic transmission dysfunction in the nucleus accumbens. Synapse (New York, N.Y.). vol 70. issue 11. 2017-12-22. PMID:27377051. |
moreover, cocaine inhibited the presynaptic release of glutamate in the nac, and sb216763 reversed this effect. |
2017-12-22 |
2023-08-13 |
rat |
| Alaa M Hammad, Fawaz Alasmari, Yusuf S Althobaiti, Youssef Sar. Modulatory effects of Ampicillin/Sulbactam on glial glutamate transporters and metabotropic glutamate receptor 1 as well as reinstatement to cocaine-seeking behavior. Behavioural brain research. vol 332. 2017-12-12. PMID:28624317. |
studies have reported that chronic exposure to cocaine induces downregulation of glutamate transporter-1 (glt-1) and cystine/glutamate exchanger (xct) in the central reward brain regions. |
2017-12-12 |
2023-08-13 |
rat |
| Marco Antonio Nocito Echevarria, Tassio Andrade Reis, Giulianno Ruffo Capatti, Victor Siciliano Soares, Dartiu Xavier da Silveira, Thiago Marques Fidalg. N-acetylcysteine for treating cocaine addiction - A systematic review. Psychiatry research. vol 251. 2017-11-30. PMID:28213190. |
nac reverses the disruption of glutamate homeostasis caused by long-term cocaine use restoring function of the cystine-glutamate exchanger in glial cells and reversing the downregulated glt-1 receptor. |
2017-11-30 |
2023-08-13 |
human |
| Anushree N Karkhanis, Thomas J R Beveridge, Bruce E Blough, Sara R Jones, Mark J Ferri. The individual and combined effects of phenmetrazine and mgluR2/3 agonist LY379268 on the motivation to self-administer cocaine. Drug and alcohol dependence. vol 166. 2017-10-11. PMID:27394931. |
the us food and drug administration has not approved a treatment for cocaine addiction, possibly due in part to the fact that repeated cocaine use results in dysregulation of multiple neurotransmitter systems, including glutamate and dopamine, and an emergence of increased negative affective states and heightening motivation to take cocaine despite negative consequences. |
2017-10-11 |
2023-08-13 |
Not clear |
| Anushree N Karkhanis, Thomas J R Beveridge, Bruce E Blough, Sara R Jones, Mark J Ferri. The individual and combined effects of phenmetrazine and mgluR2/3 agonist LY379268 on the motivation to self-administer cocaine. Drug and alcohol dependence. vol 166. 2017-10-11. PMID:27394931. |
we used a combination therapy approach to assess whether modulation of both glutamate and dopamine transmission would reduce the motivation to self- administer cocaine compared to modulation of either system alone. |
2017-10-11 |
2023-08-13 |
Not clear |