| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cindy Achat-Mendes, Donna M Platt, Roger D Spealma. Antagonism of metabotropic glutamate 1 receptors attenuates behavioral effects of cocaine and methamphetamine in squirrel monkeys. The Journal of pharmacology and experimental therapeutics. vol 343. issue 1. 2012-11-26. PMID:22815535. |
antagonism of metabotropic glutamate 1 receptors attenuates behavioral effects of cocaine and methamphetamine in squirrel monkeys. |
2012-11-26 |
2023-08-12 |
monkey |
| Cindy Achat-Mendes, Donna M Platt, Roger D Spealma. Antagonism of metabotropic glutamate 1 receptors attenuates behavioral effects of cocaine and methamphetamine in squirrel monkeys. The Journal of pharmacology and experimental therapeutics. vol 343. issue 1. 2012-11-26. PMID:22815535. |
within the group i family of metabotropic glutamate receptors (mglurs), substantial evidence points to a role for mglur5 mechanisms in cocaine's abuse-related behavioral effects, but less is understood about the contribution of mglur1, which also belongs to the group i mglur family. |
2012-11-26 |
2023-08-12 |
monkey |
| Ken T Wakabayashi, Eugene A Kiyatki. Rapid changes in extracellular glutamate induced by natural arousing stimuli and intravenous cocaine in the nucleus accumbens shell and core. Journal of neurophysiology. vol 108. issue 1. 2012-11-20. PMID:22496525. |
rapid changes in extracellular glutamate induced by natural arousing stimuli and intravenous cocaine in the nucleus accumbens shell and core. |
2012-11-20 |
2023-08-12 |
rat |
| Y Li, G-Y Yan, J-Q Zhou, Q Bu, P-C Deng, Y-Z Yang, L Lv, Y Deng, J-X Zhao, X Shao, R-M Zhu, Y-N Huang, Y-L Zhao, X-B Ce. ¹H NMR-based metabonomics in brain nucleus accumbens and striatum following repeated cocaine treatment in rats. Neuroscience. vol 218. 2012-11-16. PMID:22609933. |
the increase of neurotransmitters glutamate and gamma-amino butyric acid (gaba) were observed in nac and striatum from the rats repeatedly treated with cocaine. |
2012-11-16 |
2023-08-12 |
rat |
| Heather Trantham-Davidson, Ryan T LaLumiere, Kathryn J Reissner, Peter W Kalivas, Lori A Knacksted. Ceftriaxone normalizes nucleus accumbens synaptic transmission, glutamate transport, and export following cocaine self-administration and extinction training. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 36. 2012-11-16. PMID:22956831. |
ceftriaxone normalizes nucleus accumbens synaptic transmission, glutamate transport, and export following cocaine self-administration and extinction training. |
2012-11-16 |
2023-08-12 |
human |
| Heather Trantham-Davidson, Ryan T LaLumiere, Kathryn J Reissner, Peter W Kalivas, Lori A Knacksted. Ceftriaxone normalizes nucleus accumbens synaptic transmission, glutamate transport, and export following cocaine self-administration and extinction training. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 36. 2012-11-16. PMID:22956831. |
decreased basal glutamate levels are observed in the rat nucleus accumbens (na) core following cocaine self-administration. |
2012-11-16 |
2023-08-12 |
human |
| Heather Trantham-Davidson, Ryan T LaLumiere, Kathryn J Reissner, Peter W Kalivas, Lori A Knacksted. Ceftriaxone normalizes nucleus accumbens synaptic transmission, glutamate transport, and export following cocaine self-administration and extinction training. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 36. 2012-11-16. PMID:22956831. |
here we used a (3)h-glutamate uptake assay and microdialysis to test the hypothesis that ceftriaxone restores the function of both glt-1 and xct (glutamate reuptake and export, respectively) in the na core following cocaine self-administration. |
2012-11-16 |
2023-08-12 |
human |
| Heather Trantham-Davidson, Ryan T LaLumiere, Kathryn J Reissner, Peter W Kalivas, Lori A Knacksted. Ceftriaxone normalizes nucleus accumbens synaptic transmission, glutamate transport, and export following cocaine self-administration and extinction training. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 36. 2012-11-16. PMID:22956831. |
we found that 5 d of ceftriaxone treatment following cocaine self-administration restores basal glutamate levels in the accumbens core, likely through an upregulation of system x(c)(-) function. |
2012-11-16 |
2023-08-12 |
human |
| Heather Trantham-Davidson, Ryan T LaLumiere, Kathryn J Reissner, Peter W Kalivas, Lori A Knacksted. Ceftriaxone normalizes nucleus accumbens synaptic transmission, glutamate transport, and export following cocaine self-administration and extinction training. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 36. 2012-11-16. PMID:22956831. |
these data indicate that ceftriaxone normalizes multiple aspects of glutamate homeostasis following cocaine self-administration and thus holds the potential to reduce relapse in human cocaine addicts. |
2012-11-16 |
2023-08-12 |
human |
| Luca Ferraro, Malgorzata Frankowska, Daniel Marcellino, Magdalena Zaniewska, Sarah Beggiato, Malgorzata Filip, Maria Cristina Tomasini, Tiziana Antonelli, Sergio Tanganelli, Kjell Fux. A novel mechanism of cocaine to enhance dopamine d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 8. 2012-11-13. PMID:22453136. |
intra-nucleus accumbens perfusion of the d(2)-liker agonist quinpirole (10 μm) reduced local dialysate glutamate levels, whereas cocaine (10 and 100 nm) was ineffective. |
2012-11-13 |
2023-08-12 |
rat |
| Luca Ferraro, Malgorzata Frankowska, Daniel Marcellino, Magdalena Zaniewska, Sarah Beggiato, Malgorzata Filip, Maria Cristina Tomasini, Tiziana Antonelli, Sergio Tanganelli, Kjell Fux. A novel mechanism of cocaine to enhance dopamine d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 8. 2012-11-13. PMID:22453136. |
at a low concentration (100 nm), cocaine significantly enhanced quinpirole-induced reduction of accumbal extracellular glutamate levels. |
2012-11-13 |
2023-08-12 |
rat |
| Luca Ferraro, Malgorzata Frankowska, Daniel Marcellino, Magdalena Zaniewska, Sarah Beggiato, Malgorzata Filip, Maria Cristina Tomasini, Tiziana Antonelli, Sergio Tanganelli, Kjell Fux. A novel mechanism of cocaine to enhance dopamine d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 8. 2012-11-13. PMID:22453136. |
these novel actions of cocaine may have relevance for understanding the actions of cocaine upon accumbal da, and/or glutamate transmission and thus its rewarding as well as relapsing effects. |
2012-11-13 |
2023-08-12 |
rat |
| Yonatan M Kupchik, Khaled Moussawi, Xing-Chun Tang, Xiusong Wang, Benjamin C Kalivas, Rosalia Kolokithas, Katelyn B Ogburn, Peter W Kaliva. The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine. Biological psychiatry. vol 71. issue 11. 2012-10-04. PMID:22137594. |
relapse to cocaine seeking has been linked with low glutamate in the nucleus accumbens core (nacore) causing potentiation of synaptic glutamate transmission from prefrontal cortex (pfc) afferents. |
2012-10-04 |
2023-08-12 |
Not clear |
| Yonatan M Kupchik, Khaled Moussawi, Xing-Chun Tang, Xiusong Wang, Benjamin C Kalivas, Rosalia Kolokithas, Katelyn B Ogburn, Peter W Kaliva. The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine. Biological psychiatry. vol 71. issue 11. 2012-10-04. PMID:22137594. |
systemic n-acetylcysteine (nac) has been shown to restore glutamate homeostasis, reduce relapse to cocaine seeking, and depotentiate pfc-nacore synapses. |
2012-10-04 |
2023-08-12 |
Not clear |
| Camilla Bellone, Christian Lüsche. Drug-evoked plasticity: do addictive drugs reopen a critical period of postnatal synaptic development? Frontiers in molecular neuroscience. vol 5. 2012-10-02. PMID:22715323. |
recent data suggest that a single injection of cocaine (or another drug of addiction) triggers glutamate receptor redistribution with the reappearance of the subunits typically present in immature synapses, as if addictive drugs reopen the developmental critical period. |
2012-10-02 |
2023-08-12 |
mouse |
| Osnat M Ben-Shahar, Karen K Szumlinski, Kevin D Lominac, Ami Cohen, Evan Gordon, Kyle L Ploense, Jeremy DeMartini, Nicholas Bernstein, Nicole M Rudy, Ahmad N Nabhan, Arianne Sacramento, Kelly Pagano, Giovanni A Carosso, Nick Woodwar. Extended access to cocaine self-administration results in reduced glutamate function within the medial prefrontal cortex. Addiction biology. vol 17. issue 4. 2012-10-01. PMID:22339852. |
extended access to cocaine self-administration results in reduced glutamate function within the medial prefrontal cortex. |
2012-10-01 |
2023-08-12 |
human |
| Osnat M Ben-Shahar, Karen K Szumlinski, Kevin D Lominac, Ami Cohen, Evan Gordon, Kyle L Ploense, Jeremy DeMartini, Nicholas Bernstein, Nicole M Rudy, Ahmad N Nabhan, Arianne Sacramento, Kelly Pagano, Giovanni A Carosso, Nick Woodwar. Extended access to cocaine self-administration results in reduced glutamate function within the medial prefrontal cortex. Addiction biology. vol 17. issue 4. 2012-10-01. PMID:22339852. |
therefore, in the present study, we monitored glutamate and dopamine content within the mpfc during, or 24 hours after, cocaine self-administration in animals that experienced various amounts of exposure to the drug. |
2012-10-01 |
2023-08-12 |
human |
| Osnat M Ben-Shahar, Karen K Szumlinski, Kevin D Lominac, Ami Cohen, Evan Gordon, Kyle L Ploense, Jeremy DeMartini, Nicholas Bernstein, Nicole M Rudy, Ahmad N Nabhan, Arianne Sacramento, Kelly Pagano, Giovanni A Carosso, Nick Woodwar. Extended access to cocaine self-administration results in reduced glutamate function within the medial prefrontal cortex. Addiction biology. vol 17. issue 4. 2012-10-01. PMID:22339852. |
naïve subjects showed decreased glutamate and increased dopamine levels within the mpfc during cocaine self-administration. |
2012-10-01 |
2023-08-12 |
human |
| Osnat M Ben-Shahar, Karen K Szumlinski, Kevin D Lominac, Ami Cohen, Evan Gordon, Kyle L Ploense, Jeremy DeMartini, Nicholas Bernstein, Nicole M Rudy, Ahmad N Nabhan, Arianne Sacramento, Kelly Pagano, Giovanni A Carosso, Nick Woodwar. Extended access to cocaine self-administration results in reduced glutamate function within the medial prefrontal cortex. Addiction biology. vol 17. issue 4. 2012-10-01. PMID:22339852. |
finally, exposure to 17 cocaine self-administration sessions, the last 10 of which being 6-hour sessions, resulted in diminished glutamatergic response to self-administered cocaine and reduced basal glutamate levels within the mpfc while normalizing (i.e. |
2012-10-01 |
2023-08-12 |
human |
| Osnat M Ben-Shahar, Karen K Szumlinski, Kevin D Lominac, Ami Cohen, Evan Gordon, Kyle L Ploense, Jeremy DeMartini, Nicholas Bernstein, Nicole M Rudy, Ahmad N Nabhan, Arianne Sacramento, Kelly Pagano, Giovanni A Carosso, Nick Woodwar. Extended access to cocaine self-administration results in reduced glutamate function within the medial prefrontal cortex. Addiction biology. vol 17. issue 4. 2012-10-01. PMID:22339852. |
these data demonstrate directly that the transition to escalated cocaine use involves progressive changes in dopamine and glutamate function within the mpfc. |
2012-10-01 |
2023-08-12 |
human |