| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E A Debler, A Hashim, A Lajtha, H Sershe. Ascorbic acid and striatal transport of [3H] 1-methyl-4-phenylpyridine (MPP+) and [3H] dopamine. Life sciences. vol 42. issue 25. 1988-08-03. PMID:3260319. |
the dopamine uptake blockers, gbr-12909, cocaine, and mazindol strongly inhibit (ic50 less than 1 um) both [3h] dopamine and [3h] mpp+ transport. |
1988-08-03 |
2023-08-11 |
mouse |
| P W Kalivas, B Webe. Amphetamine injection into the ventral mesencephalon sensitizes rats to peripheral amphetamine and cocaine. The Journal of pharmacology and experimental therapeutics. vol 245. issue 3. 1988-07-29. PMID:3385638. |
the daily administration of indirect dopamine agonists, including amphetamine and cocaine, results in a progressive increase in the behavioral stimulant effect of these drugs. |
1988-07-29 |
2023-08-11 |
rat |
| R J Wyatt, F Karoum, R Suddath, R Fawcet. Persistently decreased brain dopamine levels and cocaine. JAMA. vol 259. issue 20. 1988-06-20. PMID:3367471. |
persistently decreased brain dopamine levels and cocaine. |
1988-06-20 |
2023-08-11 |
Not clear |
| A Hughes, P Inkpen, P Seve. Action of dopamine on isolated human saphenous veins. Journal of cardiovascular pharmacology. vol 11. issue 3. 1988-06-17. PMID:2452932. |
contractile responses to dopamine (10(-7)-10(-3) m) in the presence of propranolol, cocaine, and 17 beta oestradiol were competitively antagonised by the alpha 2-selective adrenoceptor antagonist yohimbine (10(-8)-10(-6) m) but unaffected by the alpha 1 selective adrenoceptor antagonist doxazosin (10(-8)-10(-6) m), whereas the response to norepinephrine (ne) (10(-8)-10(-3) m) was antagonised by doxazosin (10(-8)-10(-6) m), thus demonstrating the presence of alpha 1-adrenoceptors in this preparation. |
1988-06-17 |
2023-08-11 |
human |
| J Bergman, R D Spealma. Behavioral effects of histamine H1 antagonists: comparison with other drugs and modification by haloperidol. The Journal of pharmacology and experimental therapeutics. vol 245. issue 2. 1988-06-16. PMID:2896793. |
the dopamine uptake inhibitors cocaine (0.01-1.0 mg/kg) and bupropion (0.1-10.0 mg/kg) had behavioral effects similar to those of chlorpheniramine, diphenhydramine, pyrilamine and tripelennamine, whereas the muscarinic antagonist atropine (0.03-1.0 mg/kg), the serotonin 5-hydroxytryptamine/5-hydroxytryptamine antagonist cyproheptadine (0.03-1.0 mg/kg), the norepinephrine uptake inhibitor desmethylimipramine (0.03-3.0 mg/kg) and the benzodiazepine diazepam (0.3-30.0 mg/kg) produced only dose-related decreases in response rate. |
1988-06-16 |
2023-08-11 |
human |
| P W Kalivas, P Duffy, L A DuMars, C Skinne. Behavioral and neurochemical effects of acute and daily cocaine administration in rats. The Journal of pharmacology and experimental therapeutics. vol 245. issue 2. 1988-06-16. PMID:3130474. |
acute injection of cocaine was found to significantly decrease the level of dopamine (da) metabolites in the nucleus accumbens, striatum and a10 da region. |
1988-06-16 |
2023-08-11 |
rat |
| L Hernandez, B G Hoebe. Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis. Life sciences. vol 42. issue 18. 1988-06-03. PMID:3362036. |
food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis. |
1988-06-03 |
2023-08-11 |
rat |
| L Hernandez, B G Hoebe. Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis. Life sciences. vol 42. issue 18. 1988-06-03. PMID:3362036. |
at the site in the nucleus accumbens where rats will administer amphetamine to themselves, injections of amphetamine or cocaine increased extracellular dopamine five-fold. |
1988-06-03 |
2023-08-11 |
rat |
| L Hernandez, B G Hoebe. Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis. Life sciences. vol 42. issue 18. 1988-06-03. PMID:3362036. |
thus amphetamine and cocaine increase dopamine in a behavior reinforcement system which is normally activated by eating. |
1988-06-03 |
2023-08-11 |
rat |
| P W Kalivas, P Duff. Effects of daily cocaine and morphine treatment on somatodendritic and terminal field dopamine release. Journal of neurochemistry. vol 50. issue 5. 1988-06-02. PMID:3361305. |
effects of daily cocaine and morphine treatment on somatodendritic and terminal field dopamine release. |
1988-06-02 |
2023-08-11 |
rat |
| P W Kalivas, P Duff. Effects of daily cocaine and morphine treatment on somatodendritic and terminal field dopamine release. Journal of neurochemistry. vol 50. issue 5. 1988-06-02. PMID:3361305. |
to evaluate a role for brain dopamine in behavioral sensitization to cocaine and morphine, tissue slices from the ventromedial mesencephalon (containing dopamine cell bodies), the nucleus accumbens, and striatum (dopamine terminal fields) were obtained from rats pretreated with daily cocaine, morphine, or saline 2-3 weeks earlier. |
1988-06-02 |
2023-08-11 |
rat |
| P W Kalivas, P Duff. Effects of daily cocaine and morphine treatment on somatodendritic and terminal field dopamine release. Journal of neurochemistry. vol 50. issue 5. 1988-06-02. PMID:3361305. |
in contrast, the release of dopamine from the nucleus accumbens and striatum was either unaltered or slightly enhanced in rats pretreated with cocaine and morphine. |
1988-06-02 |
2023-08-11 |
rat |
| H Sershen, P Berger, A E Jacobson, K C Rice, M E Reit. Metaphit prevents locomotor activation induced by various psychostimulants and interferes with the dopaminergic system in mice. Neuropharmacology. vol 27. issue 1. 1988-04-22. PMID:3352864. |
in ex vivo experiments 2 and 24 hr after the intravenous administration of metaphit, no changes were observed either in the binding of [3h]cocaine to striatal membranes or in the uptake of [3h]dopamine into synaptosomes or slices. |
1988-04-22 |
2023-08-11 |
mouse |
| H Sershen, P Berger, A E Jacobson, K C Rice, M E Reit. Metaphit prevents locomotor activation induced by various psychostimulants and interferes with the dopaminergic system in mice. Neuropharmacology. vol 27. issue 1. 1988-04-22. PMID:3352864. |
in these in vivo experiments, however, metaphit antagonized the locomotor stimulation induced by blockers of the uptake of dopamine (methylphenidate, mazindol, cocaine, gbr 12909) but not that induced by drugs that affect locomotion by other mechanisms (amphetamine, phencyclidine). |
1988-04-22 |
2023-08-11 |
mouse |
| G G Nomikos, C Spyrak. Cocaine-induced place conditioning: importance of route of administration and other procedural variables. Psychopharmacology. vol 94. issue 1. 1988-04-18. PMID:3126520. |
it has been shown that pretreatment with dopamine (da) receptor blockers disrupts the effect of intravenously (iv) and intracerebrally (icv), but not intraperitoneally (ip) administered cocaine on place preference conditioning (ppc). |
1988-04-18 |
2023-08-11 |
rat |
| L A DuMars, L D Rodger, P W Kaliva. Behavioral cross-sensitization between cocaine and enkephalin in the A10 dopamine region. Behavioural brain research. vol 27. issue 1. 1988-04-05. PMID:3342116. |
behavioral cross-sensitization between cocaine and enkephalin in the a10 dopamine region. |
1988-04-05 |
2023-08-11 |
rat |
| L A DuMars, L D Rodger, P W Kaliva. Behavioral cross-sensitization between cocaine and enkephalin in the A10 dopamine region. Behavioural brain research. vol 27. issue 1. 1988-04-05. PMID:3342116. |
the motor stimulant effect produced by cocaine and the injection of opioids onto a10 dopamine neurons is thought to be mediated by an increase in dopaminergic transmission in mesolimbic dopamine terminal fields such as the nucleus accumbens. |
1988-04-05 |
2023-08-11 |
rat |
| P A Broderic. Rat striatal dopamine release mechanisms of cocaine. NIDA research monograph. vol 75. 1988-03-18. PMID:3123952. |
rat striatal dopamine release mechanisms of cocaine. |
1988-03-18 |
2023-08-11 |
rat |
| P A Broderic. Rat striatal dopamine release mechanisms of cocaine. NIDA research monograph. vol 75. 1988-03-18. PMID:3123952. |
these findings show that cocaine produces a decrease in dopamine release from rat striatum and prevents the surge of dopamine release which occurs post-mortem. |
1988-03-18 |
2023-08-11 |
rat |
| L C Einhorn, P A Johansen, F J Whit. Electrophysiological effects of cocaine in the mesoaccumbens dopamine system: studies in the ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 8. issue 1. 1988-03-08. PMID:3339402. |
extracellular single-cell recording and microiontophoretic techniques were used to characterize the effects of cocaine on the activity of mesoaccumbens a10 dopamine (da) neurons in the rat ventral tegmental area (vta), which have been implicated in the rewarding effects of this and other drugs of abuse. |
1988-03-08 |
2023-08-11 |
rat |