| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marie L Gram, Julia M Warren, Emilie L Madsen, Jeppe C Nielsen, Claus J Loland, Mikael Bol. Is Cocaine Protonated When it Binds to the Dopamine Transporter? JACS Au. vol 5. issue 3. 2025-03-28. PMID:40151268. |
is cocaine protonated when it binds to the dopamine transporter? |
2025-03-28 |
2025-03-30 |
Not clear |
| Toshihiko Aki, Kana Unum. Cocaine abuse and its impact on the thymus and spleen. Histology and histopathology. 2025-03-27. PMID:40145263. |
cocaine enhances and prolongs the neurotransmission of monoamines, such as dopamine, serotonin, and adrenaline, which are responsible not only for cocaine's euphoric effects, but also its cardiovascular toxicity. |
2025-03-27 |
2025-03-30 |
Not clear |
| Sun Mi Gu, Daejin Park, Sowoon Seo, Sanghyeon Kim, Young Eun Kim, Maree J Webster, Heejong Eom, Dohyun Lee, Jin Tae Hong, Sang-Bae Han, Hye Jin Cha, Jaesuk Yu. Crystallin Alpha B Inhibits Cocaine-Induced Conditioned Place Preference via the Modulation of Dopaminergic Neurotransmission. Addiction biology. vol 30. issue 3. 2025-03-17. PMID:40095747. |
dopamine levels in the nacc and cpp development of cpp are significantly increased by cocaine in cryab knockout (ko) mice. |
2025-03-17 |
2025-03-20 |
mouse |
| Sun Mi Gu, Daejin Park, Sowoon Seo, Sanghyeon Kim, Young Eun Kim, Maree J Webster, Heejong Eom, Dohyun Lee, Jin Tae Hong, Sang-Bae Han, Hye Jin Cha, Jaesuk Yu. Crystallin Alpha B Inhibits Cocaine-Induced Conditioned Place Preference via the Modulation of Dopaminergic Neurotransmission. Addiction biology. vol 30. issue 3. 2025-03-17. PMID:40095747. |
we suggest that oligodendrocyte-derived cryab regulates dopamine neurotransmission and stress-evoked cocaine reward behaviour via the modulation of eaat2 in the nacc. |
2025-03-17 |
2025-03-20 |
mouse |
| Maxime Fouyssac, Tristan Hynes, Aude Belin-Rauscent, Dhaval D Joshi, David Beli. Incentive Cocaine-Seeking Habits and Their Compulsive Manifestation Emerge After a Downregulation of the Dopamine Transporter in Astrocytes Across Functional Domains of the Striatum. The European journal of neuroscience. vol 61. issue 5. 2025-03-14. PMID:40082733. |
this shift is paralleled by drug-induced (including cocaine) dopamine transporter (dat) alterations originating in the ventral striatum that spread eventually to encompass the adls. |
2025-03-14 |
2025-03-16 |
rat |
| Conner W Wallace, Clare Y Slinkard, Rachael Shaughnessy, Katherine M Holleran, Samuel W Centanni, Christopher C Lapish, Sara R Jone. Fiber photometry analysis of spontaneous dopamine signals: The z-scored data are not the data. bioRxiv : the preprint server for biology. 2025-03-10. PMID:40060421. |
the d1-like receptor antagonist sch23390 was used to prevent dlight sensors from interacting with dopamine in the extracellular space, while cocaine was used to inhibit uptake and raclopride to increase release of dopamine in the nucleus accumbens. |
2025-03-10 |
2025-03-12 |
mouse |
| Leah M Salinsky, Christina R Merritt, Erik J Garcia, Robert G Fox, Joshua C Zamora, Noelle C Anastasio, Kathryn A Cunningha. The psychedelic (-)-2,5-dimethoxy-4-iodoamphetamine [(-)-DOI] demonstrates efficacy in reducing cocaine reward and motivation in male rats. Psychopharmacology. 2025-03-04. PMID:40035828. |
the abuse liability of cocaine is reliant upon inhibition of dopamine (da) reuptake and consequent increase in da efflux in meso-corticolimbic circuitry that controls reward and motivation. |
2025-03-04 |
2025-03-06 |
rat |
| Riley Merkel, Nicole S Hernandez, Vanessa Weir, Yafang Zhang, Antonia Caffrey, Matthew T Rich, Richard C Crist, Benjamin C Reiner, Heath D Schmid. An endogenous GLP-1 circuit engages VTA GABA neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking. Science advances. vol 11. issue 9. 2025-02-26. PMID:40009667. |
an endogenous glp-1 circuit engages vta gaba neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking. |
2025-02-26 |
2025-03-01 |
rat |
| Riley Merkel, Nicole S Hernandez, Vanessa Weir, Yafang Zhang, Antonia Caffrey, Matthew T Rich, Richard C Crist, Benjamin C Reiner, Heath D Schmid. An endogenous GLP-1 circuit engages VTA GABA neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking. Science advances. vol 11. issue 9. 2025-02-26. PMID:40009667. |
using in vivo fiber photometry, we found that the efficacy of a systemic glp-1r agonist to attenuate cocaine seeking was associated with increased activity of vta gaba neurons and decreased activity of vta dopamine neurons. |
2025-02-26 |
2025-03-01 |
rat |
| Jocelyn A Ricard, Loïc Labache, Ashlea Segal, Elvisha Dhamala, Carrisa V Cocuzza, Grant Jones, Sarah W Yip, Sidhant Chopra, Avram J Holme. Author Correction: A shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D Communications biology. vol 8. issue 1. 2025-02-23. PMID:39988590. |
author correction: a shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine d |
2025-02-23 |
2025-02-26 |
Not clear |
| Mia I Allen, Omeed Rahimi, Bernard N Johnson, Jianjing Cao, Amy Hauck Newman, Michael A Nade. Contrasting the reinforcing effects of the novel dopamine transport inhibitors JJC8-088 and JJC8-091 in monkeys: Potential translation to medication assisted treatment. The Journal of pharmacology and experimental therapeutics. vol 392. issue 1. 2025-02-01. PMID:39892998. |
one strategy to mitigate cocaine craving and relapse is to elevate dopamine. |
2025-02-01 |
2025-02-04 |
human |
| Mia I Allen, Omeed Rahimi, Bernard N Johnson, Jianjing Cao, Amy Hauck Newman, Michael A Nade. Contrasting the reinforcing effects of the novel dopamine transport inhibitors JJC8-088 and JJC8-091 in monkeys: Potential translation to medication assisted treatment. The Journal of pharmacology and experimental therapeutics. vol 392. issue 1. 2025-02-01. PMID:39892998. |
the dopamine transport inhibitor and releaser d-amphetamine has been shown to decrease cocaine self-administration (sa), although it has abuse liability. |
2025-02-01 |
2025-02-04 |
human |
| Bailey Remmers, Amélia Nicot, Kanako Matsumura, Polina Lyuboslavsky, In Bae Choi, Yiru Ouyang, Lauren K Dobb. Mu opioid receptors expressed in striatal D2 medium spiny neurons have divergent contributions to cocaine and morphine reward. Neuroscience. 2025-01-20. PMID:39832666. |
to address this, we generated mice with a targeted deletion of mors from dopamine d2 receptor-expressing msns (d2-morko) and tested the locomotor and conditioned rewarding effects of cocaine and morphine. |
2025-01-20 |
2025-01-23 |
mouse |
| Gaoyuan Lu, Fengfei Ma, Pingli Wei, Min Ma, Vu Ngoc Huong Tran, Brian A Baldo, Lingjun L. Cocaine-Induced Remodeling of the Rat Brain Peptidome: Quantitative Mass Spectrometry Reveals Anatomically Specific Patterns of Cocaine-Regulated Peptide Changes. ACS chemical neuroscience. vol 16. issue 2. 2025-01-15. PMID:39810605. |
the neuroactive effects of cocaine and other psychostimulants have been studied extensively with respect to their modulation of monoamine systems (particularly dopamine); effects on neuropeptide systems have received less attention. |
2025-01-15 |
2025-01-17 |
rat |
| b' Daniella Agrati, Gabriella Marin, Luc\\xc3\\xada Rehermann, Natalia Uriarte, Marta C Antonelli, Gabriela Bed\\xc3\\xb. Reduced sensitivity to cocaine effects and changes in mesocorticolimbic dopamine receptors in adolescent sexually active female rats. Psychopharmacology. 2024-12-27. PMID:39729197.' |
reduced sensitivity to cocaine effects and changes in mesocorticolimbic dopamine receptors in adolescent sexually active female rats. |
2024-12-27 |
2024-12-29 |
rat |
| Philip J Clark, Volodar M Migovich, Sanjay Das, Wei Xi, Sandhya Kortagere, Rodrigo A Españ. Hypocretin Receptor 1 Blockade Early in Abstinence Prevents Incubation of Cocaine Seeking and Normalizes Dopamine Transmission. bioRxiv : the preprint server for biology. 2024-12-09. PMID:39651183. |
hypocretin receptor 1 blockade early in abstinence prevents incubation of cocaine seeking and normalizes dopamine transmission. |
2024-12-09 |
2024-12-12 |
rat |
| Philip J Clark, Volodar M Migovich, Sanjay Das, Wei Xi, Sandhya Kortagere, Rodrigo A Españ. Hypocretin Receptor 1 Blockade Early in Abstinence Prevents Incubation of Cocaine Seeking and Normalizes Dopamine Transmission. bioRxiv : the preprint server for biology. 2024-12-09. PMID:39651183. |
while the mechanisms underlying incubation of cocaine seeking remain elusive, considerable evidence suggests that abstinence from cocaine promotes mesolimbic dopamine adaptations that contribute to exaggerated cocaine seeking. |
2024-12-09 |
2024-12-12 |
rat |
| Philip J Clark, Volodar M Migovich, Sanjay Das, Wei Xi, Sandhya Kortagere, Rodrigo A Españ. Hypocretin Receptor 1 Blockade Early in Abstinence Prevents Incubation of Cocaine Seeking and Normalizes Dopamine Transmission. bioRxiv : the preprint server for biology. 2024-12-09. PMID:39651183. |
consequently, preventing these dopamine adaptations may reduce incubation of cocaine seeking and thereby reduce the likelihood of relapse. |
2024-12-09 |
2024-12-12 |
rat |
| Philip J Clark, Volodar M Migovich, Sanjay Das, Wei Xi, Sandhya Kortagere, Rodrigo A Españ. Hypocretin Receptor 1 Blockade Early in Abstinence Prevents Incubation of Cocaine Seeking and Normalizes Dopamine Transmission. bioRxiv : the preprint server for biology. 2024-12-09. PMID:39651183. |
in the present studies, we first examined if incubation of cocaine seeking was associated with aberrant dopamine transmission in the nucleus accumbens after seven days of abstinence from intermittent access to cocaine. |
2024-12-09 |
2024-12-12 |
rat |
| Philip J Clark, Volodar M Migovich, Sanjay Das, Wei Xi, Sandhya Kortagere, Rodrigo A Españ. Hypocretin Receptor 1 Blockade Early in Abstinence Prevents Incubation of Cocaine Seeking and Normalizes Dopamine Transmission. bioRxiv : the preprint server for biology. 2024-12-09. PMID:39651183. |
given the extensive evidence that hypocretins/orexins regulate motivation for cocaine, we then examined to what extent hypocretin receptor 1 antagonism on the first day of abstinence prevented incubation of cocaine seeking and dopamine adaptations later in abstinence. |
2024-12-09 |
2024-12-12 |
rat |