| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abhinav Goyal, Jason Yuen, Stephen Sinicrope, Bailey Winter, Lindsey Randall, Aaron E Rusheen, Charles D Blaha, Kevin E Bennet, Kendall H Lee, Hojin Shin, Yoonbae O. Resolution of tonic concentrations of highly similar neurotransmitters using voltammetry and deep learning. Molecular psychiatry. 2024-04-25. PMID:38664492. |
discrimnet is also shown to accurately predict the expected changes in dopamine and serotonin after cocaine and oxycodone administration in anesthetized rats in vivo. |
2024-04-25 |
2024-04-28 |
rat |
| Kevin M Honeywell, Timothy G Freels, Megan A McWain, Abigail S Chaffin, Hunter G Nolen, Helen J Sable, Deranda B Leste. Indirect and direct cannabinoid agonists differentially affect mesolimbic dopamine release and related behaviors. Behavioral neuroscience. vol 138. issue 2. 2024-04-25. PMID:38661670. |
chronic exposure to acea decreased rearing and decreased phasic dopamine release while increasing the dopaminergic response to cocaine. |
2024-04-25 |
2024-04-28 |
mouse |
| Chiara Prodani, Elaine E Irvine, Alessandro Sardini, Hannah J Gleneadie, Andrew Dimond, Mathew Van de Pette, Rosalind John, Michelle Kokkinou, Oliver Howes, Dominic J Withers, Mark A Ungless, Matthias Merkenschlager, Amanda G Fishe. Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker genes. Scientific reports. vol 14. issue 1. 2024-04-12. PMID:38609446. |
positron emission tomography (pet) imaging revealed an increase in striatal dopamine synthesis capacity in lpd-exposed offspring, where elevated levels of dopamine correlated with an enhanced sensitivity to cocaine. |
2024-04-12 |
2024-04-15 |
mouse |
| Lefika Bathobakae, Sacide S Ozgur, Rammy Bashir, Tyler Wilkinson, Phenyo Phuu, Ruhin Yuridullah, Gabriel Melki, Jessica Escobar, Sohail Qayyu. Cocaine Gut: A Rare Case of Cocaine-Induced Esophageal, Gastric, and Small Bowel Necrosis. Journal of investigative medicine high impact case reports. vol 12. 2024-03-28. PMID:38546011. |
cocaine is an indirect-acting sympathomimetic drug that inhibits norepinephrine and dopamine reuptake in the adrenergic presynaptic cleft. |
2024-03-28 |
2024-03-30 |
human |
| Alaa Khayat, Rami Yak. Activation of nucleus accumbens projections to the ventral tegmental area alters molecular signaling and neurotransmission in the reward system. Frontiers in molecular neuroscience. vol 17. 2024-03-26. PMID:38528956. |
previously, we have demonstrated that activation of nac-vta afferents during the acquisition of cocaine conditioned place preference (cpp) reduces the rewarding properties of cocaine and diminished the activity of vta dopamine neurons. |
2024-03-26 |
2024-03-28 |
Not clear |
| Paige M Estave, Steven E Albertson, Anushree N Karkhanis, Sara R Jone. Co-targeting the kappa opioid receptor and dopamine transporter reduces motivation to self-administer cocaine and partially reverses dopamine system dysregulation. Scientific reports. vol 14. issue 1. 2024-03-19. PMID:38499566. |
co-targeting the kappa opioid receptor and dopamine transporter reduces motivation to self-administer cocaine and partially reverses dopamine system dysregulation. |
2024-03-19 |
2024-03-21 |
rat |
| Paige M Estave, Steven E Albertson, Anushree N Karkhanis, Sara R Jone. Co-targeting the kappa opioid receptor and dopamine transporter reduces motivation to self-administer cocaine and partially reverses dopamine system dysregulation. Scientific reports. vol 14. issue 1. 2024-03-19. PMID:38499566. |
cocaine disrupts dopamine (da) and kappa opioid receptor (kor) system activity, with long-term exposure reducing inhibiton of da uptake by cocaine and increasing kor system function. |
2024-03-19 |
2024-03-21 |
rat |
| Paige M Estave, Steven E Albertson, Anushree N Karkhanis, Sara R Jone. Co-targeting the kappa opioid receptor and dopamine transporter reduces motivation to self-administer cocaine and partially reverses dopamine system dysregulation. Scientific reports. vol 14. issue 1. 2024-03-19. PMID:38499566. |
single treatment therapies have not been successful for cocaine use disorder; therefore, this study focuses on a combination therapy targeting the dopamine transporter (dat) and kor. |
2024-03-19 |
2024-03-21 |
rat |
| Valeria Lallai, Cristina Congiu, Giulia Craig, Letizia Manca, Yen-Chu Chen, Angeline J Dukes, Christie D Fowler, Laura Dazz. Social isolation postweaning alters reward-related dopamine dynamics in a region-specific manner in adolescent male rats. Neurobiology of stress. vol 30. 2024-03-15. PMID:38486879. |
importantly, the deficit in reward-related behavior during isolation could be reversed by microinjection of either dopamine or cocaine into the mpfc. |
2024-03-15 |
2024-03-17 |
human |
| Rong Che. Cholesterol modulation of interactions between psychostimulants and dopamine transporters. Advances in pharmacology (San Diego, Calif.). vol 99. 2024-03-11. PMID:38467486. |
the dopamine transporter (dat) is a key site of action for cocaine and amphetamines. |
2024-03-11 |
2024-03-14 |
Not clear |
| Melinda Hersey, Maddalena Mereu, Claire S Jones, Mattingly K Bartole, Andy Y Chen, Jianjing Cao, Takato Hiranita, Lauren E Chun, Jessica P Lopez, Jonathan L Katz, Amy Hauck Newman, Gianluigi Tand. Dual DAT and sigma receptor inhibitors attenuate cocaine effects on nucleus accumbens dopamine dynamics in rats. The European journal of neuroscience. 2024-03-06. PMID:38444104. |
dual dat and sigma receptor inhibitors attenuate cocaine effects on nucleus accumbens dopamine dynamics in rats. |
2024-03-06 |
2024-03-08 |
rat |
| Melinda Hersey, Maddalena Mereu, Claire S Jones, Mattingly K Bartole, Andy Y Chen, Jianjing Cao, Takato Hiranita, Lauren E Chun, Jessica P Lopez, Jonathan L Katz, Amy Hauck Newman, Gianluigi Tand. Dual DAT and sigma receptor inhibitors attenuate cocaine effects on nucleus accumbens dopamine dynamics in rats. The European journal of neuroscience. 2024-03-06. PMID:38444104. |
previous studies have shown that dual inhibitors of the dopamine transporter (dat) and sigma receptors significantly reduce the behavioral/reinforcing effects of cocaine, which have been associated with stimulation of extracellular dopamine (da) levels resulting from dat inhibition. |
2024-03-06 |
2024-03-08 |
rat |
| Jinmin Kim, Hyebin Yoo, Sungwook Woo, Seung Soo O. Aptasensor-encapsulating semi-permeable proteinosomes for direct target detection in non-treated biofluids. Biosensors & bioelectronics. vol 251. 2024-02-13. PMID:38350238. |
three different structure-switching aptamers specific for estradiol, dopamine, and cocaine, respectively, are demonstrated to fully conserve their high affinities and specificities inside the microcapsules. |
2024-02-13 |
2024-02-16 |
Not clear |
| Miguel Siqueira Campos Junior, Andréia Gomes Bezerra, Daniela Fernández Curado, Renata Pauluci Gregório, José Carlos Fernandes Galduró. Preliminary investigation of the administration of biperiden to reduce relapses in individuals with cocaine/crack user disorder: A randomized controlled clinical trial. Pharmacology, biochemistry, and behavior. 2024-02-10. PMID:38340989. |
several studies have demonstrated that ach modulates the dopaminergic circuit in the nucleus accumbens, and its blockade appears to be associated with the inhibition of the reinforced effect or the increase in dopamine caused by cocaine use. |
2024-02-10 |
2024-02-14 |
Not clear |
| David L Bernstein, Stacia I Lewandowski, Christina Besada, Delaney Place, Rodrigo A España, Ole V Mortense. Inactivation of ERK1/2 Signaling in Dopaminergic Neurons by Map Kinase Phosphatase MKP3 Regulates Dopamine Signaling and Motivation for Cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 44. issue 5. 2024-01-31. PMID:38296649. |
inactivation of erk1/2 signaling in dopaminergic neurons by map kinase phosphatase mkp3 regulates dopamine signaling and motivation for cocaine. |
2024-01-31 |
2024-02-03 |
rat |
| David L Bernstein, Stacia I Lewandowski, Christina Besada, Delaney Place, Rodrigo A España, Ole V Mortense. Inactivation of ERK1/2 Signaling in Dopaminergic Neurons by Map Kinase Phosphatase MKP3 Regulates Dopamine Signaling and Motivation for Cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 44. issue 5. 2024-01-31. PMID:38296649. |
together, these results indicate that erk1/2 signaling plays a critical role in shaping the dopamine response to cocaine and may provide additional insights into the function of dopaminergic neurons. |
2024-01-31 |
2024-02-03 |
rat |
| David L Bernstein, Stacia I Lewandowski, Christina Besada, Delaney Place, Rodrigo A España, Ole V Mortense. Inactivation of ERK1/2 Signaling in Dopaminergic Neurons by Map Kinase Phosphatase MKP3 Regulates Dopamine Signaling and Motivation for Cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 44. issue 5. 2024-01-31. PMID:38296649. |
further, these findings lay important groundwork toward the assessment of how signaling pathways and their downstream effectors influence dopamine transmission and could ultimately provide therapeutic targets for treating cocaine use disorders. |
2024-01-31 |
2024-02-03 |
rat |
| Ginna Urueña-Méndez, Chloé Arrondeau, Lidia Bellés, Nathalie Ginovar. Decoupling Dopamine Synthesis from Impulsive Action, Risk-related Decision-Making, and Propensity to Cocaine Intake: A Longitudinal [ eNeuro. 2024-01-22. PMID:38253584. |
decoupling dopamine synthesis from impulsive action, risk-related decision-making, and propensity to cocaine intake: a longitudinal [ impulsive action and risk-related decision-making (rdm) are two facets of impulsivity linked to a hyperdopaminergic release in the striatum and an increased propensity to cocaine intake. |
2024-01-22 |
2024-01-25 |
rat |
| A Khayat, R Yak. Activation of RMTg projections to the VTA reverse cocaine-induced molecular adaptation in the reward system. Translational psychiatry. vol 14. issue 1. 2024-01-19. PMID:38242878. |
recently we have shown that activation of rmtg projections to the vta during the acquisition of cocaine-conditioned place preference (cpp) reduces the rewarding properties of cocaine and decreases vta dopamine neuron activity. |
2024-01-19 |
2024-01-22 |
Not clear |
| A Khayat, R Yak. Activation of RMTg projections to the VTA reverse cocaine-induced molecular adaptation in the reward system. Translational psychiatry. vol 14. issue 1. 2024-01-19. PMID:38242878. |
by inhibiting dopamine neurons in the vta, we hypothesized that rmtg projections hold the potential to restore reward system homeostasis disrupted by repeated cocaine use, and attenuate molecular adaptations in the reward system, including alterations in signaling pathways. |
2024-01-19 |
2024-01-22 |
Not clear |