| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susana Barbosa-Méndez, Alberto Salazar-Juáre. Mirtazapine decreased cocaine-induced Frontiers in psychiatry. vol 15. 2024-08-28. PMID:39188520. |
mirtazapine decreased cocaine-induced chronic cocaine exposure induces an increase in dopamine release and an increase in the expression of the fos protein in the rat striatum. |
2024-08-28 |
2024-08-30 |
rat |
| Takato Hiranita, Su-Min Li, Jonathan L Kat. Effects of Dual Inhibition at Dopamine Transporter and σ Receptors in the Discriminative-Stimulus Effects of Cocaine in Male Rats. The Journal of pharmacology and experimental therapeutics. 2024-08-23. PMID:39179413. |
effects of dual inhibition at dopamine transporter and σ receptors in the discriminative-stimulus effects of cocaine in male rats. |
2024-08-23 |
2024-08-27 |
rat |
| Takato Hiranita, Su-Min Li, Jonathan L Kat. Effects of Dual Inhibition at Dopamine Transporter and σ Receptors in the Discriminative-Stimulus Effects of Cocaine in Male Rats. The Journal of pharmacology and experimental therapeutics. 2024-08-23. PMID:39179413. |
however, σr antagonists when combined with dopamine transporter (dat) inhibitors substantially decrease cocaine self-administration. |
2024-08-23 |
2024-08-27 |
rat |
| Reda M Chalhoub, Anze Testen, Jordan Hopkins, Camille Carthy, Peter W Kaliva. Formation of an Enduring Ensemble of Accumbens Neurons Leads to Prepotent Seeking for Cocaine Over Natural Reward Cues. bioRxiv : the preprint server for biology. 2024-08-16. PMID:39149274. |
we leveraged single-cell calcium imaging of dopamine d1- and d2-receptor-expressing medium spiny neurons (msns) in the nacore of mice to examine differences between sucrose and cocaine rewarded (self-administration) and unrewarded (abstinent and cue-induced) seeking. |
2024-08-16 |
2024-08-18 |
mouse |
| Elaine M Grafelman, Bridgitte E Côté, Lisa Vlach, Ella Geise, G Nino Padula, Daniel S Wheeler, Matthew Hearing, John Mantsch, Robert A Wheele. Aversion-induced drug taking and escape behavior involve similar nucleus accumbens core dopamine signaling signatures. bioRxiv : the preprint server for biology. 2024-08-16. PMID:39149329. |
nacc dopamine was measured using fiber photometry in male and female rats during cocaine self-administration sessions in which an acutely aversive 90 db white noise was intermittently presented. |
2024-08-16 |
2024-08-18 |
rat |
| Elaine M Grafelman, Bridgitte E Côté, Lisa Vlach, Ella Geise, G Nino Padula, Daniel S Wheeler, Matthew Hearing, John Mantsch, Robert A Wheele. Aversion-induced drug taking and escape behavior involve similar nucleus accumbens core dopamine signaling signatures. bioRxiv : the preprint server for biology. 2024-08-16. PMID:39149329. |
aversive white noise significantly reduced nacc dopamine and increased cocaine self-administration in both male and female rats. |
2024-08-16 |
2024-08-18 |
rat |
| Jeppe C Nielsen, Kristine Salomon, Iris E Kalenderoglou, Sarah Bargmeyer, Tillmann Pape, Azadeh Shahsavar, Claus J Lolan. Structure of the human dopamine transporter in complex with cocaine. Nature. 2024-08-07. PMID:39112703. |
structure of the human dopamine transporter in complex with cocaine. |
2024-08-07 |
2024-08-10 |
human |
| Jeppe C Nielsen, Kristine Salomon, Iris E Kalenderoglou, Sarah Bargmeyer, Tillmann Pape, Azadeh Shahsavar, Claus J Lolan. Structure of the human dopamine transporter in complex with cocaine. Nature. 2024-08-07. PMID:39112703. |
the dopamine transporter (dat) is crucial for regulating dopamine signalling and is the prime mediator for the rewarding and addictive effects of cocaine |
2024-08-07 |
2024-08-10 |
human |
| Colleen S Peterson, Samantha L Baglot, Nada A Sallam, Sarah Mina, Matthew N Hill, Stephanie L Borglan. Oral pre- and early postnatal cannabis exposure disinhibits ventral tegmental area dopamine neuron activity but does not influence cocaine preference in offspring in mice. Journal of neuroscience research. vol 102. issue 7. 2024-07-22. PMID:39037062. |
oral pre- and early postnatal cannabis exposure disinhibits ventral tegmental area dopamine neuron activity but does not influence cocaine preference in offspring in mice. |
2024-07-22 |
2024-07-24 |
mouse |
| Anna Maria Borruto, Claudia Calpe-López, Rainer Spanagel, Rick E Bernard. Conditional Deletion of the AMPA-GluA1 and NMDA-GluN1 Receptor Subunit Genes in Midbrain D1 Neurons does not Alter Cocaine Reward in Mice. Neuropharmacology. 2024-07-13. PMID:39002853. |
however, the specific behavioral relevance of glutamatergic excitatory drive onto dopamine d1 receptor (d1r)-expressing neurons in mediating the reinforcing effect of cocaine remains unclear. |
2024-07-13 |
2024-07-16 |
mouse |
| Sophia J Weber, Alex B Kawa, Alana L Moutier, Madelyn M Beutler, Lara M Koyshman, Cloe D Moreno, Jonathan G Westlake, Amanda M Wunsch, Marina E Wol. Dopamine transmission at D1 and D2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving. bioRxiv : the preprint server for biology. 2024-07-09. PMID:38979157. |
dopamine transmission at d1 and d2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving. |
2024-07-09 |
2024-07-12 |
rat |
| Sophia J Weber, Alex B Kawa, Alana L Moutier, Madelyn M Beutler, Lara M Koyshman, Cloe D Moreno, Jonathan G Westlake, Amanda M Wunsch, Marina E Wol. Dopamine transmission at D1 and D2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving. bioRxiv : the preprint server for biology. 2024-07-09. PMID:38979157. |
however, despite the importance of dopaminergic signaling in the nacc for motivated behavior, little is known about the role that dopamine (da) plays in the incubation of cocaine craving. |
2024-07-09 |
2024-07-12 |
rat |
| Riley Merkel, Nicole Hernandez, Vanessa Weir, Yafang Zhang, Matthew T Rich, Richard C Crist, Benjamin C Reiner, Heath D Schmid. An endogenous GLP-1 circuit engages VTA GABA neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking. bioRxiv : the preprint server for biology. 2024-07-09. PMID:38979354. |
an endogenous glp-1 circuit engages vta gaba neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking. |
2024-07-09 |
2024-07-12 |
rat |
| Brooke N Bender, Sierra J Stringfield, Mary M Torregross. Changes in dorsomedial striatum activity during expression of goal-directed vs. habit-like cue-induced cocaine seeking. Addiction neuroscience. vol 11. 2024-07-03. PMID:38957402. |
we used fiber photometry in rats trained to self-administer cocaine paired with an audiovisual cue to examine how dorsal striatal intracellular calcium and extracellular dopamine activity differs between goal-directed and habit-like cue-induced cocaine seeking and how it is impacted by cue extinction. |
2024-07-03 |
2024-07-06 |
rat |
| Jae Hun Ahn, Min Hwan Kim, Kyongkyu Lee, Keumrok Oh, Hyunwoo Lim, Hee Seup Kil, Soon Jeong Kwon, Jae Yong Choi, Dae Yoon Chi, Yong Jin Le. Preclinical evaluation of [ EJNMMI research. vol 14. issue 1. 2024-07-03. PMID:38958796. |
preclinical evaluation of [ n-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (fp-cit), the representative cocaine derivative used in dopamine transporter imaging, is a promising biomarker, as it reflects the severity of parkinson's disease (pd). |
2024-07-03 |
2024-07-06 |
Not clear |
| Gyeong Hee Pyeon, Joung-Hun Kim, June-Seek Choi, Yong Sang J. Activation of CGRP neurons in the parabrachial nucleus suppresses addictive behavior. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 24. 2024-06-06. PMID:38843183. |
furthermore, activating cgrp neurons suppresses not only addictive behavior induced by self-stimulating dopamine neurons but also behavior resulting from self-administering cocaine, without eliciting nocifensive reactions. |
2024-06-06 |
2024-06-10 |
Not clear |
| Young-Jung Kim, Su Jeong Choi, Sa-Ik Hong, Jung-Cheol Park, Youyoung Lee, Shi-Xun Ma, Kwang-Hyun Hur, Young Lee, Kyeong-Man Kim, Hyung Kyu Kim, Hee Young Kim, Seok-Yong Lee, Se-Young Choi, Choon-Gon Jan. The ion channel TRPA1 is a modulator of the cocaine reward circuit in the nucleus accumbens. Molecular psychiatry. 2024-05-31. PMID:38822069. |
in our study, we demonstrate that trpa1 inhibition in the nac reduces cocaine activity and dopamine release, and conversely, that trpa1 is critical for cocaine-induced synaptic strength in dopamine receptor 1-expressing medium spiny neurons. |
2024-05-31 |
2024-06-02 |
mouse |
| Dominik Szabó, Vedran Franke, Simona Bianco, Mykhailo Y Batiuk, Eleanor J Paul, Alexander Kukalev, Ulrich G Pfisterer, Ibai Irastorza-Azcarate, Andrea M Chiariello, Samuel Demharter, Luna Zea-Redondo, Jose P Lopez-Atalaya, Mario Nicodemi, Altuna Akalin, Konstantin Khodosevich, Mark A Ungless, Warren Winick-Ng, Ana Pomb. A single dose of cocaine rewires the 3D genome structure of midbrain dopamine neurons. bioRxiv : the preprint server for biology. 2024-05-20. PMID:38766140. |
a single dose of cocaine rewires the 3d genome structure of midbrain dopamine neurons. |
2024-05-20 |
2024-05-27 |
Not clear |
| Haylee R Hammond, Shainnel O Eans, Thomas J Cirino, Subramaniam Ananthan, Ana Catya Jimenez-Torres, Jun Zhu, Jay P McLaughli. SRI-30827, a novel allosteric modulator of the dopamine transporter, alleviates HIV-1 Tat-induced potentiation of cocaine conditioned place preference in mice. NeuroImmune pharmacology and therapeutics. vol 3. issue 1. 2024-05-08. PMID:38711842. |
sri-30827, a novel allosteric modulator of the dopamine transporter, alleviates hiv-1 tat-induced potentiation of cocaine conditioned place preference in mice. |
2024-05-08 |
2024-05-27 |
mouse |
| Bo W Sortman, Samantha Rakela, Sarah Paprotna, Berk Cerci, Brandon L Warre. Nucleus accumbens neuronal ensembles vary with cocaine reinforcement in male and female rats. Addiction biology. vol 29. issue 5. 2024-05-07. PMID:38711205. |
in the no-cocaine session, we saw reduced dopamine d1 type neuronal activation, while in the cocaine self-administration session, we found preferential dopamine d1 type neuronal activity in the naccore. |
2024-05-07 |
2024-05-27 |
rat |