| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z J Yu, D K Lim, B Hoskins, R W Rockhold, I K H. Effects of acute and subacute cocaine administration on the CNS dopaminergic system in Wistar-Kyoto and spontaneously hypertensive rats: I. Levels of dopamine and metabolites. Neurochemical research. vol 15. issue 6. 1990-11-01. PMID:2215853. |
effects of acute and subacute cocaine administration on dopamine (da) and its metabolites in striata and nucleus accumbens of nine week-old wistar-kyoto and spontaneously hypertensive rats were studied. |
1990-11-01 |
2023-08-11 |
rat |
| D K Lim, Z J Yu, B Hoskins, R W Rockhold, I K H. Effects of acute and subacute cocaine administration on the CNS dopaminergic system in Wistar-Kyoto and spontaneously hypertensive rats: III. Dopamine uptake. Neurochemical research. vol 15. issue 6. 1990-11-01. PMID:2215854. |
the characteristics of dopamine uptake after acute and subacute cocaine administration were determined in striata from wky and shr. |
1990-11-01 |
2023-08-11 |
rat |
| D K Lim, Z J Yu, B Hoskins, R W Rockhold, I K H. Effects of acute and subacute cocaine administration on the CNS dopaminergic system in Wistar-Kyoto and spontaneously hypertensive rats: III. Dopamine uptake. Neurochemical research. vol 15. issue 6. 1990-11-01. PMID:2215854. |
in acutely-treated (40 mg/kg, s.c.) rats, significant increases in the vmax of dopamine uptake were observed 30 min after the cocaine injection in both strains, without changes in km values. |
1990-11-01 |
2023-08-11 |
rat |
| D K Lim, Z J Yu, B Hoskins, R W Rockhold, I K H. Effects of acute and subacute cocaine administration on the CNS dopaminergic system in Wistar-Kyoto and spontaneously hypertensive rats: III. Dopamine uptake. Neurochemical research. vol 15. issue 6. 1990-11-01. PMID:2215854. |
the results suggest that cocaine administration alters dopamine uptake and characteristics of dopamine uptake sites in the rat brain. |
1990-11-01 |
2023-08-11 |
rat |
| M P Gallowa. Regulation of dopamine and serotonin synthesis by acute administration of cocaine. Synapse (New York, N.Y.). vol 6. issue 1. 1990-10-18. PMID:2119072. |
regulation of dopamine and serotonin synthesis by acute administration of cocaine. |
1990-10-18 |
2023-08-11 |
Not clear |
| M P Gallowa. Regulation of dopamine and serotonin synthesis by acute administration of cocaine. Synapse (New York, N.Y.). vol 6. issue 1. 1990-10-18. PMID:2119072. |
because cocaine effectively increases extracellular levels of both dopamine (da) and serotonin (5ht), it might be expected that this agent would inhibit transmitter biosynthesis in these monoamine neurons by activation of autoregulatory feedback pathways. |
1990-10-18 |
2023-08-11 |
Not clear |
| N K Mello, J H Mendelson, J Drieze, M Kell. Acute effects of cocaine on prolactin and gonadotropins in female rhesus monkey during the follicular phase of the menstrual cycle. The Journal of pharmacology and experimental therapeutics. vol 254. issue 3. 1990-10-11. PMID:2118570. |
inasmuch as cocaine blocks dopamine reuptake, prl suppression is consistent with dopaminergic inhibitory control of prl release from the pituitary. |
1990-10-11 |
2023-08-11 |
monkey |
| N E Goeders, M A McNulty, A M Guidroz, S I Dworki. Potential neurotoxic effects of self-administered cocaine on dopamine receptors. NIDA research monograph. vol 95. 1990-09-20. PMID:2561841. |
potential neurotoxic effects of self-administered cocaine on dopamine receptors. |
1990-09-20 |
2023-08-11 |
Not clear |
| H O Pettit, H T Pan, L H Parsons, J B Justic. Extracellular concentrations of cocaine and dopamine are enhanced during chronic cocaine administration. Journal of neurochemistry. vol 55. issue 3. 1990-09-17. PMID:2384752. |
extracellular concentrations of cocaine and dopamine are enhanced during chronic cocaine administration. |
1990-09-17 |
2023-08-11 |
Not clear |
| H O Pettit, H T Pan, L H Parsons, J B Justic. Extracellular concentrations of cocaine and dopamine are enhanced during chronic cocaine administration. Journal of neurochemistry. vol 55. issue 3. 1990-09-17. PMID:2384752. |
in vivo microdialysis procedures were used to monitor extracellular dopamine (da) and cocaine concentrations in the nucleus accumbens (n acc) and cocaine concentrations in plasma of animals that received chronic or acute cocaine treatments. |
1990-09-17 |
2023-08-11 |
Not clear |
| C A Dackis, M S Gol. Addictiveness of central stimulants. Advances in alcohol & substance abuse. vol 9. issue 1-2. 1990-09-05. PMID:1974121. |
with regard to cocaine, it has been hypothesized that depletion of central dopamine leads to craving. |
1990-09-05 |
2023-08-11 |
Not clear |
| L Kokkinidis, B D McCarte. Postcocaine depression and sensitization of brain-stimulation reward: analysis of reinforcement and performance effects. Pharmacology, biochemistry, and behavior. vol 36. issue 3. 1990-09-05. PMID:2377648. |
it was suggested that depressed reward-system functioning might reflect reduced dopamine synthesis following cocaine withdrawal, and the icss sensitization was related to long-term compensatory changes in dopamine neurotransmission possibly involving presynpatic mechanisms. |
1990-09-05 |
2023-08-11 |
Not clear |
| M S Kleven, E W Anthony, W L Woolverto. Pharmacological characterization of the discriminative stimulus effects of cocaine in rhesus monkeys. The Journal of pharmacology and experimental therapeutics. vol 254. issue 1. 1990-08-13. PMID:2195158. |
the indirect dopamine agonists gbr 12909 (0.2-1.6 mg/kg), mazindol (0.025-0.4 mg/kg), nomifensine (0.025-0.2 mg/kg) and bupropion (0.1-1.6 mg/kg) each produced dose-related increases in cocaine-appropriate responding, with complete substitution for cocaine achieved at the highest doses of each drug. |
1990-08-13 |
2023-08-11 |
monkey |
| M S Kleven, E W Anthony, W L Woolverto. Pharmacological characterization of the discriminative stimulus effects of cocaine in rhesus monkeys. The Journal of pharmacology and experimental therapeutics. vol 254. issue 1. 1990-08-13. PMID:2195158. |
the results indicate that blockade of dopamine re-uptake is sufficient to mimic the cocaine discriminative stimulus and suggest that stimulation of either d1 or d2 receptors is necessary but not sufficient for the expression of the discriminative stimulus effects of cocaine. |
1990-08-13 |
2023-08-11 |
monkey |
| N Uchimura, R A Nort. Actions of cocaine on rat nucleus accumbens neurones in vitro. British journal of pharmacology. vol 99. issue 4. 1990-08-08. PMID:2193689. |
both actions of dopamine as well as the effect of 5-hydroxytryptamine were potentiated by cocaine (0.3-30 microm), which had no effect of its own on membrane potential. |
1990-08-08 |
2023-08-11 |
rat |
| N Uchimura, R A Nort. Actions of cocaine on rat nucleus accumbens neurones in vitro. British journal of pharmacology. vol 99. issue 4. 1990-08-08. PMID:2193689. |
cocaine (1-30 microm) caused the same dose-ratio whether dopamine depolarizations (d2) or hyperpolarizations (d1) were measured; the dose-ratio ranged from 2 (1 microm) to 50 (30 microm). |
1990-08-08 |
2023-08-11 |
rat |
| N Uchimura, R A Nort. Actions of cocaine on rat nucleus accumbens neurones in vitro. British journal of pharmacology. vol 99. issue 4. 1990-08-08. PMID:2193689. |
responses to 5-hydroxytryptamine were increased more than responses to dopamine; cocaine 1 microm gave a dose-ratio of 13.4 and at 30 microm gave a dose-ratio of 118. |
1990-08-08 |
2023-08-11 |
rat |
| N Uchimura, R A Nort. Actions of cocaine on rat nucleus accumbens neurones in vitro. British journal of pharmacology. vol 99. issue 4. 1990-08-08. PMID:2193689. |
it is concluded that cocaine acts to inhibit the uptake of dopamine and 5-hydroxytryptamine in slices of rat nucleus accumbens; lower concentrations of cocaine (0.3 to 1 microm) are particularly effective in potentiating the action of 5-hydroxytryptamine. |
1990-08-08 |
2023-08-11 |
rat |
| M G Lacey, N B Mercuri, R A Nort. Actions of cocaine on rat dopaminergic neurones in vitro. British journal of pharmacology. vol 99. issue 4. 1990-08-08. PMID:2361170. |
these effects of dopamine were potentiated about five fold by cocaine (10 microm). |
1990-08-08 |
2023-08-11 |
rat |
| M G Lacey, N B Mercuri, R A Nort. Actions of cocaine on rat dopaminergic neurones in vitro. British journal of pharmacology. vol 99. issue 4. 1990-08-08. PMID:2361170. |
it is concluded that cocaine (1-10 microm) inhibits the firing and hyperpolarizes substantia nigra zona compacta neurones in vitro by blocking the uptake of dopamine which the cells continuously release. |
1990-08-08 |
2023-08-11 |
rat |