| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C J Cao, M M Young, J B Wong, L G Mahran, M E Eldefraw. Putative cocaine receptor in striatum is a glycoprotein with active thiol function. Membrane biochemistry. vol 8. issue 4. 1991-03-14. PMID:2562128. |
dopamine transporters of bovine and rat striata were identified by their specific [3h]cocaine binding and cocaine-sensitive [3h]dopamine [( 3h]da) uptake. |
1991-03-14 |
2023-08-11 |
rat |
| R Trouve, G G Nahas, W M Mange. Catecholamines, cocaine toxicity, and their antidotes in the rat. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 196. issue 2. 1991-03-07. PMID:1846676. |
acute lethal cocaine intoxication in the rat induces significant increases of plasma dopamine, norepinephrine, and epinephrine concentrations associated with cardiac functional and morphologic changes. |
1991-03-07 |
2023-08-11 |
rat |
| P B Silverma. Cocaine and local anesthetics: stimulant activity in rats with nigral lesions. Psychopharmacology. vol 102. issue 2. 1991-02-26. PMID:1980374. |
on the other hand, cocaine or dimethocaine treatment induced active rotation directed ipsilaterally to the lesioned side, indicating indirect dopamine agonist activity. |
1991-02-26 |
2023-08-11 |
rat |
| S Izenwasser, H M Jacocks, J G Rosenberger, B M Co. Nicotine indirectly inhibits [3H]dopamine uptake at concentrations that do not directly promote [3H]dopamine release in rat striatum. Journal of neurochemistry. vol 56. issue 2. 1991-02-26. PMID:1988558. |
in the presence of 1 nm nicotine, the residual [3h]dopamine uptake was less sensitive to inhibition by cocaine than uptake in the absence of nicotine. |
1991-02-26 |
2023-08-11 |
rat |
| W L Hearn, D D Flynn, G W Hime, S Rose, J C Cofino, E Mantero-Atienza, C V Wetli, D C Mas. Cocaethylene: a unique cocaine metabolite displays high affinity for the dopamine transporter. Journal of neurochemistry. vol 56. issue 2. 1991-02-26. PMID:1988563. |
cocaethylene: a unique cocaine metabolite displays high affinity for the dopamine transporter. |
1991-02-26 |
2023-08-11 |
human |
| W L Hearn, D D Flynn, G W Hime, S Rose, J C Cofino, E Mantero-Atienza, C V Wetli, D C Mas. Cocaethylene: a unique cocaine metabolite displays high affinity for the dopamine transporter. Journal of neurochemistry. vol 56. issue 2. 1991-02-26. PMID:1988563. |
cocaethylene was equipotent to cocaine at inhibiting [3h]mazindol binding to the dopamine transporter. |
1991-02-26 |
2023-08-11 |
human |
| W L Hearn, D D Flynn, G W Hime, S Rose, J C Cofino, E Mantero-Atienza, C V Wetli, D C Mas. Cocaethylene: a unique cocaine metabolite displays high affinity for the dopamine transporter. Journal of neurochemistry. vol 56. issue 2. 1991-02-26. PMID:1988563. |
the blockade of dopamine reuptake in the synaptic cleft by cocaethylene may account for the enhanced euphoria associated with combined alcohol and cocaine abuse. |
1991-02-26 |
2023-08-11 |
human |
| E E Brown, J M Finlay, J T Wong, G Damsma, H C Fibige. Behavioral and neurochemical interactions between cocaine and buprenorphine: implications for the pharmacotherapy of cocaine abuse. The Journal of pharmacology and experimental therapeutics. vol 256. issue 1. 1991-02-22. PMID:1988653. |
cocaine (5.0 mg/kg) rapidly increased extracellular dopamine concentrations (180% of basal values within 20 min), which returned to baseline in 2 to 3 hr. |
1991-02-22 |
2023-08-11 |
Not clear |
| E E Brown, J M Finlay, J T Wong, G Damsma, H C Fibige. Behavioral and neurochemical interactions between cocaine and buprenorphine: implications for the pharmacotherapy of cocaine abuse. The Journal of pharmacology and experimental therapeutics. vol 256. issue 1. 1991-02-22. PMID:1988653. |
this effect of cocaine was significantly potentiated by coadministering buprenorphine (0.01 mg/kg); under this condition the peak increase in extracellular dopamine reached 260% of baseline values. |
1991-02-22 |
2023-08-11 |
Not clear |
| D Sulzer, S Raypor. Amphetamine and other psychostimulants reduce pH gradients in midbrain dopaminergic neurons and chromaffin granules: a mechanism of action. Neuron. vol 5. issue 6. 1991-02-21. PMID:2268433. |
as exemplified by cocaine, many psychostimulants act by binding to the dopamine uptake transporter. |
1991-02-21 |
2023-08-11 |
Not clear |
| E Hollander, E Nunes, C M DeCaria, F M Quitkin, T Cooper, S Wager, D F Klei. Dopaminergic sensitivity and cocaine abuse: response to apomorphine. Psychiatry research. vol 33. issue 2. 1991-01-03. PMID:2243893. |
ten male patients with chronic cocaine abuse received a single dose of the dopamine agonist apomorphine. |
1991-01-03 |
2023-08-11 |
Not clear |
| E Hollander, E Nunes, C M DeCaria, F M Quitkin, T Cooper, S Wager, D F Klei. Dopaminergic sensitivity and cocaine abuse: response to apomorphine. Psychiatry research. vol 33. issue 2. 1991-01-03. PMID:2243893. |
implications for the "dopamine" hypothesis of cocaine abuse are discussed. |
1991-01-03 |
2023-08-11 |
Not clear |
| N K Mello, J H Mendelson, J Drieze, M Kell. Cocaine effects on luteinizing hormone-releasing hormone-stimulated anterior pituitary hormones in female rhesus monkey. The Journal of clinical endocrinology and metabolism. vol 71. issue 6. 1990-12-27. PMID:2121776. |
these findings are consistent with dopaminergic inhibitory control of prl and suggest that cocaine's inhibition of dopamine reuptake down-regulates pituitary lactotroph activity in rhesus monkey. |
1990-12-27 |
2023-08-11 |
monkey |
| J A Kiritsy-Roy, J B Halter, S M Gordon, M J Smith, L C Terr. Role of the central nervous system in hemodynamic and sympathoadrenal responses to cocaine in rats. The Journal of pharmacology and experimental therapeutics. vol 255. issue 1. 1990-11-21. PMID:2213551. |
antagonist drugs selective for the d-1 or d-2 dopamine receptors attenuated effects of cocaine on plasma catecholamine concentrations but not on cardiovascular parameters. |
1990-11-21 |
2023-08-11 |
rat |
| M C Ritz, J W Boja, D Grigoriadis, R Zaczek, F I Carroll, A H Lewis, M J Kuha. [3H]WIN 35,065-2: a ligand for cocaine receptors in striatum. Journal of neurochemistry. vol 55. issue 5. 1990-11-20. PMID:2120386. |
taken together, these data are consistent with the presence of multiple cocaine binding sites associated with the dopamine transporter. |
1990-11-20 |
2023-08-11 |
Not clear |
| S Izenwasser, L L Werling, B M Co. Comparison of the effects of cocaine and other inhibitors of dopamine uptake in rat striatum, nucleus accumbens, olfactory tubercle, and medial prefrontal cortex. Brain research. vol 520. issue 1-2. 1990-11-14. PMID:2145054. |
comparison of the effects of cocaine and other inhibitors of dopamine uptake in rat striatum, nucleus accumbens, olfactory tubercle, and medial prefrontal cortex. |
1990-11-14 |
2023-08-11 |
rat |
| S Izenwasser, L L Werling, B M Co. Comparison of the effects of cocaine and other inhibitors of dopamine uptake in rat striatum, nucleus accumbens, olfactory tubercle, and medial prefrontal cortex. Brain research. vol 520. issue 1-2. 1990-11-14. PMID:2145054. |
it is thought that inhibition of dopamine reuptake into neurons may play a major role in the mechanisms by which cocaine produces its reinforcing effects. |
1990-11-14 |
2023-08-11 |
rat |
| S Izenwasser, L L Werling, B M Co. Comparison of the effects of cocaine and other inhibitors of dopamine uptake in rat striatum, nucleus accumbens, olfactory tubercle, and medial prefrontal cortex. Brain research. vol 520. issue 1-2. 1990-11-14. PMID:2145054. |
the effects of cocaine, gbr 12909, amfonelic acid, and methylphenidate on dopamine uptake in the striatum, nucleus accumbens, olfactory tubercle, and medial prefrontal cortex were examined. |
1990-11-14 |
2023-08-11 |
rat |
| S Izenwasser, L L Werling, B M Co. Comparison of the effects of cocaine and other inhibitors of dopamine uptake in rat striatum, nucleus accumbens, olfactory tubercle, and medial prefrontal cortex. Brain research. vol 520. issue 1-2. 1990-11-14. PMID:2145054. |
in the medial prefrontal cortex, cocaine and gbr 12909 could inhibit only about 40% of the [3h]dopamine uptake. |
1990-11-14 |
2023-08-11 |
rat |
| D K Lim, Z J Yu, B Hoskins, R W Rockhold, I K H. Effects of acute and subacute cocaine administration on the CNS dopaminergic system in Wistar-Kyoto and spontaneously hypertensive rats: II. Dopamine receptors. Neurochemical research. vol 15. issue 6. 1990-11-01. PMID:2145522. |
the characteristics of d-1 and d-2 dopamine receptors after acute and subacute cocaine administration were determined in striata and nuclei accumbens from wky and shr. |
1990-11-01 |
2023-08-11 |
rat |