| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' V Palat\\xc3\\xb. Swelling of the small adrenergic storage vesicles and the loss of vesicular ATP induced by cocaine in the isolated rat tail artery. Naunyn-Schmiedeberg\'s archives of pharmacology. vol 343. issue 2. 1991-08-14. PMID:2067588.' |
after having been lowered by cocaine, the fractions of vesicles containing electron-dense cores in specimens processed by the chromaffin and uranaffin methods were restored during incubation of the tissue in cocaine-free medium supplemented with dopamine (7 mumol/l) and l-ascorbate (0.3 mmol/l). |
1991-08-14 |
2023-08-11 |
rat |
| B Borowsky, C M Kuh. Chronic cocaine administration sensitizes behavioral but not neuroendocrine responses. Brain research. vol 543. issue 2. 1991-08-07. PMID:1647834. |
to test this possibility the neuroendocrine actions of cocaine which are mediated, in part, by hypothalamic dopamine neurons were evaluated after chronic cocaine administration. |
1991-08-07 |
2023-08-11 |
rat |
| B Borowsky, C M Kuh. Chronic cocaine administration sensitizes behavioral but not neuroendocrine responses. Brain research. vol 543. issue 2. 1991-08-07. PMID:1647834. |
these findings suggest that the marked sensitization observed in other dopamine systems does not occur in the hypothalamic dopamine neurons thought to mediate the neuroendocrine responses to cocaine during chronic administration, despite recently described commonalities in uptake and autoreceptor functions in these dopamine cell populations. |
1991-08-07 |
2023-08-11 |
rat |
| B Borowsky, C M Kuh. Chronic cocaine administration sensitizes behavioral but not neuroendocrine responses. Brain research. vol 543. issue 2. 1991-08-07. PMID:1647834. |
this contrast suggests a role for long loop feedback systems unique to telencephalic dopamine systems or region-specific neurochemical adaptations in cocaine sensitization. |
1991-08-07 |
2023-08-11 |
rat |
| B A Faraj, Z L Olkowski, R T Jackso. Binding of [3H]-dopamine to human lymphocytes: possible relationship to neurotransmitter uptake sites. Pharmacology. vol 42. issue 3. 1991-08-01. PMID:1676177. |
dopamine binding was markedly affected by cocaine (ic50 = 150 nm) and other inhibitors of biogenic amine uptake. |
1991-08-01 |
2023-08-11 |
human |
| B A Faraj, Z L Olkowski, R T Jackso. Binding of [3H]-dopamine to human lymphocytes: possible relationship to neurotransmitter uptake sites. Pharmacology. vol 42. issue 3. 1991-08-01. PMID:1676177. |
the relatively high potency of cocaine in competing for dopamine binding suggested that human lymphocytes may serve as a readily accessible model to detect changes in the neuronal uptake of dopamine and perhaps other monoamine neurotransmitters. |
1991-08-01 |
2023-08-11 |
human |
| L Brow. Pharmacological responses to dopamine in isolated guinea-pig cardiovascular tissues: mechanisms of action. Archives internationales de pharmacodynamie et de therapie. vol 308. 1991-07-26. PMID:1983064. |
in isolated, contracting right ventricular papillary muscles, dopamine-induced positive inotropy (-log ec50, 4.77 +/- 0.06) was unaltered by incubation with dopamine antagonists (sch 23390, domperidone), alpha-adrenoceptor antagonists (prazosin, yohimbine), or an inhibitor of uptake1 (cocaine). |
1991-07-26 |
2023-08-11 |
Not clear |
| M S Brodie, T V Dunwiddi. Cocaine effects in the ventral tegmental area: evidence for an indirect dopaminergic mechanism of action. Naunyn-Schmiedeberg's archives of pharmacology. vol 342. issue 6. 1991-07-18. PMID:2096297. |
while there was a considerable variability in the response to a given concentration of cocaine among the individual units, every cell inhibited by dopamine was also inhibited by cocaine. |
1991-07-18 |
2023-08-11 |
Not clear |
| M S Brodie, T V Dunwiddi. Cocaine effects in the ventral tegmental area: evidence for an indirect dopaminergic mechanism of action. Naunyn-Schmiedeberg's archives of pharmacology. vol 342. issue 6. 1991-07-18. PMID:2096297. |
inhibitory responses to either dopamine or cocaine were blocked by the specific d2 dopamine receptor antagonist sulpiride. |
1991-07-18 |
2023-08-11 |
Not clear |
| M S Brodie, T V Dunwiddi. Cocaine effects in the ventral tegmental area: evidence for an indirect dopaminergic mechanism of action. Naunyn-Schmiedeberg's archives of pharmacology. vol 342. issue 6. 1991-07-18. PMID:2096297. |
small concentrations of cocaine (0.1-0.5 microm), which by themselves had little or no effect on spontaneous activity, potentiated the inhibitory effect of exogenously applied dopamine. |
1991-07-18 |
2023-08-11 |
Not clear |
| M S Brodie, T V Dunwiddi. Cocaine effects in the ventral tegmental area: evidence for an indirect dopaminergic mechanism of action. Naunyn-Schmiedeberg's archives of pharmacology. vol 342. issue 6. 1991-07-18. PMID:2096297. |
these observations suggest that in low concentrations, cocaine can act as a dopamine reuptake inhibitor in the vta, and that the resultant increase in extracellular dopamine acts upon dopamine autoreceptors to inhibit cellular activity. |
1991-07-18 |
2023-08-11 |
Not clear |
| N S Kula, R J Baldessarin. Lack of increase in dopamine transporter binding or function in rat brain tissue after treatment with blockers of neuronal uptake of dopamine. Neuropharmacology. vol 30. issue 1. 1991-07-17. PMID:2046881. |
rats were pretreated daily for 10 days with a dopamine (da) uptake blocker ([+]amphetamine, benztropine, cocaine, gbr-12909, mazindol, or nomifensine) or control vehicle and, after 1-4 days of no treatment, striatal tissue was fractionated to provide synaptosomes and membranes for assays of transport of 3h-da or binding of 3h-gbr-12935. |
1991-07-17 |
2023-08-11 |
rat |
| H Ujike, K Akiyama, S Otsuk. D-2 but not D-1 dopamine agonists produce augmented behavioral response in rats after subchronic treatment with methamphetamine or cocaine. Psychopharmacology. vol 102. issue 4. 1991-07-17. PMID:2151400. |
d-2 but not d-1 dopamine agonists produce augmented behavioral response in rats after subchronic treatment with methamphetamine or cocaine. |
1991-07-17 |
2023-08-11 |
rat |
| H Ujike, K Akiyama, S Otsuk. D-2 but not D-1 dopamine agonists produce augmented behavioral response in rats after subchronic treatment with methamphetamine or cocaine. Psychopharmacology. vol 102. issue 4. 1991-07-17. PMID:2151400. |
a study was performed to examine behavioral response to a challenge of selective dopamine d-1 and d-2 agonists in rats previously sensitized by subchronic administration of methamphetamine or cocaine. |
1991-07-17 |
2023-08-11 |
rat |
| H Ujike, K Akiyama, S Otsuk. D-2 but not D-1 dopamine agonists produce augmented behavioral response in rats after subchronic treatment with methamphetamine or cocaine. Psychopharmacology. vol 102. issue 4. 1991-07-17. PMID:2151400. |
these results suggest that the enduring behavioral sensitization induced by two pharmacologically distinct psychostimulant agents, methamphetamine and cocaine, occurs through a common neurobiological mechanism of lasting supersensitivity in postsynaptic d-2, but not d-1 dopamine receptors. |
1991-07-17 |
2023-08-11 |
rat |
| U Scheffel, S Pögün, M Stathis, J W Boja, M J Kuha. In vivo labeling of cocaine binding sites on dopamine transporters with [3H]WIN 35,428. The Journal of pharmacology and experimental therapeutics. vol 257. issue 3. 1991-07-12. PMID:2046028. |
in vivo labeling of cocaine binding sites on dopamine transporters with [3h]win 35,428. |
1991-07-12 |
2023-08-11 |
mouse |
| U Scheffel, S Pögün, M Stathis, J W Boja, M J Kuha. In vivo labeling of cocaine binding sites on dopamine transporters with [3H]WIN 35,428. The Journal of pharmacology and experimental therapeutics. vol 257. issue 3. 1991-07-12. PMID:2046028. |
thus, [3h]win 35,428 is a suitable ligand for labeling cocaine receptors associated with dopamine transporters in vivo. |
1991-07-12 |
2023-08-11 |
mouse |
| J M Witkin, D E Nichols, P Terry, J L Kat. Behavioral effects of selective dopaminergic compounds in rats discriminating cocaine injections. The Journal of pharmacology and experimental therapeutics. vol 257. issue 2. 1991-06-24. PMID:1674533. |
the involvement of dopamine receptor subtypes in the discriminative stimulus effects of cocaine was evaluated by the ability of a series of compounds selective for d1 or d2 dopamine receptors to produce discriminative stimulus effects comparable to cocaine. |
1991-06-24 |
2023-08-11 |
rat |
| J M Witkin, D E Nichols, P Terry, J L Kat. Behavioral effects of selective dopaminergic compounds in rats discriminating cocaine injections. The Journal of pharmacology and experimental therapeutics. vol 257. issue 2. 1991-06-24. PMID:1674533. |
inhibitors of catecholamine and serotonin reuptake (gbr 12909, win 35,428 and mazindol), d-amphetamine, and the nonselective dopamine agonist, apomorphine, produced dose-dependent increases in cocaine-appropriate responding and fully substituted for cocaine. |
1991-06-24 |
2023-08-11 |
rat |
| M Grilli, A G Wright, I Hanbaue. Characterization of [3H]dopamine uptake sites and [3H]cocaine recognition sites in primary cultures of mesencephalic neurons during in vitro development. Journal of neurochemistry. vol 56. issue 6. 1991-06-12. PMID:2027018. |
characterization of [3h]dopamine uptake sites and [3h]cocaine recognition sites in primary cultures of mesencephalic neurons during in vitro development. |
1991-06-12 |
2023-08-11 |
rat |