| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J W Boja, M A Rahman, A Philip, A H Lewin, F I Carroll, M J Kuha. Isothiocyanate derivatives of cocaine: irreversible inhibition of ligand binding at the dopamine transporter. Molecular pharmacology. vol 39. issue 3. 1991-04-22. PMID:1826041. |
the uptake of [3h]dopamine was inhibited by p-isococ with an ic50 comparable to that of cocaine. |
1991-04-22 |
2023-08-11 |
rat |
| D W Clow, R P Hamme. Cocaine abstinence following chronic treatment alters cerebral metabolism in dopaminergic reward regions. Bromocriptine enhances recovery. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 4. issue 1. 1991-04-22. PMID:2003868. |
these data suggest that cerebral metabolism is decreased during cocaine abstinence following chronic treatment in critical brain regions, and that this alteration can be prevented by treatment with direct-acting dopamine agonists such as bromocriptine. |
1991-04-22 |
2023-08-11 |
rat |
| L Pani, A Kuzmin, E Stefanini, G L Gessa, Z L Rossett. Flunarizine potentiates cocaine-induced dopamine release and motor stimulation in rats. European journal of pharmacology. vol 190. issue 1-2. 1991-04-22. PMID:2076754. |
pretreatment with flunarizine (20 mg/kg), a diphenylalkylamine calcium channel antagonist, markedly potentiated cocaine (10 mg/kg)-induced dopamine (da) output from the ventral striatum, as measured by microdialysis in freely moving rats. |
1991-04-22 |
2023-08-11 |
rat |
| F I Carroll, A H Lewin, P Abraham, K Parham, J W Boja, M J Kuha. Synthesis and ligand binding of cocaine isomers at the cocaine receptor. Journal of medicinal chemistry. vol 34. issue 3. 1991-04-17. PMID:2002468. |
the cocaine binding site at the dopamine transporter has been found to be stereoselective. |
1991-04-17 |
2023-08-11 |
Not clear |
| I M Maisonneuve, R W Keller, S D Glic. Similar effects of D-amphetamine and cocaine on extracellular dopamine levels in medial prefrontal cortex of rats. Brain research. vol 535. issue 2. 1991-04-16. PMID:1963569. |
similar effects of d-amphetamine and cocaine on extracellular dopamine levels in medial prefrontal cortex of rats. |
1991-04-16 |
2023-08-11 |
rat |
| I M Maisonneuve, R W Keller, S D Glic. Similar effects of D-amphetamine and cocaine on extracellular dopamine levels in medial prefrontal cortex of rats. Brain research. vol 535. issue 2. 1991-04-16. PMID:1963569. |
the effects of behaviorally equivalent doses of d-amphetamine and cocaine on extracellular dopamine (da) levels in the left and right medial prefrontal cortex (pfc) were investigated using microdialysis in anesthetized rats. |
1991-04-16 |
2023-08-11 |
rat |
| I M Maisonneuve, R W Keller, S D Glic. Similar effects of D-amphetamine and cocaine on extracellular dopamine levels in medial prefrontal cortex of rats. Brain research. vol 535. issue 2. 1991-04-16. PMID:1963569. |
contrary to some previous reports, the present data indicate that d-amphetamine and cocaine do not differ substantially with regard to their effects on dopamine neurotransmission in the pfc. |
1991-04-16 |
2023-08-11 |
rat |
| P Soares-da-Silva, M C Garret. Overflow of endogenous dopamine and 3,4-dihydroxyphenylacetic acid from tissues of the rat brain, elicited by electrical stimulation, depolarization by potassium and activation of carrier-mediated release. Neuropharmacology. vol 29. issue 12. 1991-04-09. PMID:2149872. |
inhibition of neuronal uptake by cocaine (10 mumol/l) or gbr 12909 (100 nmol/l) was found to increase only the spontaneous outflow of dopamine. |
1991-04-09 |
2023-08-11 |
rat |
| J W Brock, J P Ng, J B Justic. Effect of chronic cocaine on dopamine synthesis in the nucleus accumbens as determined by microdialysis perfusion with NSD-1015. Neuroscience letters. vol 117. issue 1-2. 1991-04-01. PMID:2127087. |
effect of chronic cocaine on dopamine synthesis in the nucleus accumbens as determined by microdialysis perfusion with nsd-1015. |
1991-04-01 |
2023-08-11 |
rat |
| J W Brock, J P Ng, J B Justic. Effect of chronic cocaine on dopamine synthesis in the nucleus accumbens as determined by microdialysis perfusion with NSD-1015. Neuroscience letters. vol 117. issue 1-2. 1991-04-01. PMID:2127087. |
the results indicate the rate of dopamine synthesis in the n. acc is significantly reduced by repeated cocaine administration. |
1991-04-01 |
2023-08-11 |
rat |
| S Izenwasser, B M Co. Daily cocaine treatment produces a persistent reduction of [3H]dopamine uptake in vitro in rat nucleus accumbens but not in striatum. Brain research. vol 531. issue 1-2. 1991-04-01. PMID:2289133. |
daily cocaine treatment produces a persistent reduction of [3h]dopamine uptake in vitro in rat nucleus accumbens but not in striatum. |
1991-04-01 |
2023-08-11 |
rat |
| S Izenwasser, B M Co. Daily cocaine treatment produces a persistent reduction of [3H]dopamine uptake in vitro in rat nucleus accumbens but not in striatum. Brain research. vol 531. issue 1-2. 1991-04-01. PMID:2289133. |
furthermore, cocaine was a more potent inhibitor of [3h]dopamine uptake in vitro in the nucleus accumbens of rats treated with cocaine than in those which had received saline. |
1991-04-01 |
2023-08-11 |
rat |
| J M Ackerman, F J Whit. A10 somatodendritic dopamine autoreceptor sensitivity following withdrawal from repeated cocaine treatment. Neuroscience letters. vol 117. issue 1-2. 1991-04-01. PMID:2290614. |
a10 somatodendritic dopamine autoreceptor sensitivity following withdrawal from repeated cocaine treatment. |
1991-04-01 |
2023-08-11 |
rat |
| J M Ackerman, F J Whit. A10 somatodendritic dopamine autoreceptor sensitivity following withdrawal from repeated cocaine treatment. Neuroscience letters. vol 117. issue 1-2. 1991-04-01. PMID:2290614. |
the mesoaccumbens dopamine (da) pathway is known to be involved in both the rewarding properties of cocaine and in behavioral sensitization to its locomotor-stimulating effects. |
1991-04-01 |
2023-08-11 |
rat |
| S T Young, L J Porrino, M J Iadarol. Cocaine induces striatal c-fos-immunoreactive proteins via dopaminergic D1 receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 88. issue 4. 1991-03-27. PMID:1825356. |
these data indicate that d1 dopamine receptors are linked to a cellular immediate-early gene system(s) and suggest an action of cocaine at one or more levels of gene expression via modulation of transcriptional processes in activated cells. |
1991-03-27 |
2023-08-11 |
rat |
| R H Kline, J Wright, A J Eshleman, K M Fox, M E Eldefraw. Synthesis of 3-carbamoylecgonine methyl ester analogues as inhibitors of cocaine binding and dopamine uptake. Journal of medicinal chemistry. vol 34. issue 2. 1991-03-27. PMID:1995895. |
synthesis of 3-carbamoylecgonine methyl ester analogues as inhibitors of cocaine binding and dopamine uptake. |
1991-03-27 |
2023-08-11 |
rat |
| R H Kline, J Wright, A J Eshleman, K M Fox, M E Eldefraw. Synthesis of 3-carbamoylecgonine methyl ester analogues as inhibitors of cocaine binding and dopamine uptake. Journal of medicinal chemistry. vol 34. issue 2. 1991-03-27. PMID:1995895. |
these cocaine derivatives were assessed for their ability to inhibit [3h]cocaine binding to rat striatal tissue and to inhibit [3h]dopamine uptake into synaptosomes prepared from the same tissue. |
1991-03-27 |
2023-08-11 |
rat |
| R H Kline, J Wright, A J Eshleman, K M Fox, M E Eldefraw. Synthesis of 3-carbamoylecgonine methyl ester analogues as inhibitors of cocaine binding and dopamine uptake. Journal of medicinal chemistry. vol 34. issue 2. 1991-03-27. PMID:1995895. |
ic50 values for inhibition of cocaine binding and dopamine uptake were 37 and 178 nm, respectively. |
1991-03-27 |
2023-08-11 |
rat |
| M S Kleven, B D Perry, W L Woolverton, L S Seide. Effects of repeated injections of cocaine on D1 and D2 dopamine receptors in rat brain. Brain research. vol 532. issue 1-2. 1991-03-21. PMID:2149299. |
effects of repeated injections of cocaine on d1 and d2 dopamine receptors in rat brain. |
1991-03-21 |
2023-08-11 |
rat |
| F Karoum, R L Suddath, R J Wyat. Chronic cocaine and rat brain catecholamines: long-term reduction in hypothalamic and frontal cortex dopamine metabolism. European journal of pharmacology. vol 186. issue 1. 1991-03-15. PMID:2282931. |
chronic cocaine and rat brain catecholamines: long-term reduction in hypothalamic and frontal cortex dopamine metabolism. |
1991-03-15 |
2023-08-11 |
rat |