| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R H Kline, J Wright, K M Fox, M E Eldefraw. Synthesis of 3-arylecgonine analogues as inhibitors of cocaine binding and dopamine uptake. Journal of medicinal chemistry. vol 33. issue 7. 1990-08-06. PMID:2362282. |
synthesis of 3-arylecgonine analogues as inhibitors of cocaine binding and dopamine uptake. |
1990-08-06 |
2023-08-11 |
cattle |
| R H Kline, J Wright, K M Fox, M E Eldefraw. Synthesis of 3-arylecgonine analogues as inhibitors of cocaine binding and dopamine uptake. Journal of medicinal chemistry. vol 33. issue 7. 1990-08-06. PMID:2362282. |
these analogues were tested for their ability to inhibit [3h]cocaine binding to bovine striatal tissue and to inhibit [3h]dopamine uptake into striatal synaptosomes. |
1990-08-06 |
2023-08-11 |
cattle |
| R H Kline, J Wright, K M Fox, M E Eldefraw. Synthesis of 3-arylecgonine analogues as inhibitors of cocaine binding and dopamine uptake. Journal of medicinal chemistry. vol 33. issue 7. 1990-08-06. PMID:2362282. |
ic50 values for inhibition of cocaine binding and dopamine uptake were 20 and 100 nm, respectively. |
1990-08-06 |
2023-08-11 |
cattle |
| N Goeders, V Bell, A Guidroz, M McNult. Dopaminergic involvement in the cocaine-induced up-regulation of benzodiazepine receptors in the rat caudate nucleus. Brain research. vol 515. issue 1-2. 1990-08-01. PMID:2162715. |
chronic cocaine administration resulted in significant increases in benzodiazepine receptors in the caudate nucleus, and these effects were attenuated following dopamine depletion. |
1990-08-01 |
2023-08-11 |
rat |
| P L Smiley, M Johnson, L Bush, J W Gibb, G R Hanso. Effects of cocaine on extrapyramidal and limbic dynorphin systems. The Journal of pharmacology and experimental therapeutics. vol 253. issue 3. 1990-07-31. PMID:1972755. |
this change appeared to be due primarily to the ability of cocaine to block dopamine re-uptake; consequently, the increase in dli levels was either totally or partially blocked by coadministration of selective d1 (sch 23390) and d2 (sulpiride) receptor blockers and multiple doses of the selective dopamine uptake blockers, amfonelic acid and gbr 12909, caused cocaine-like enhancement of extrapyramidal dli content. |
1990-07-31 |
2023-08-11 |
Not clear |
| S J Yi, K M Johnso. Effects of acute and chronic administration of cocaine on striatal uptake, compartmentalization and release of [3H]dopamine. Neuropharmacology. vol 29. issue 5. 1990-07-25. PMID:2356003. |
effects of acute and chronic administration of cocaine on striatal uptake, compartmentalization and release of [3h]dopamine. |
1990-07-25 |
2023-08-11 |
rat |
| S J Yi, K M Johnso. Effects of acute and chronic administration of cocaine on striatal uptake, compartmentalization and release of [3H]dopamine. Neuropharmacology. vol 29. issue 5. 1990-07-25. PMID:2356003. |
the effects of acute and repetitive administration of cocaine were studied on several parameters associated with the uptake and release of [3h]dopamine ([3h]da) in the striatum. |
1990-07-25 |
2023-08-11 |
rat |
| S J Yi, K M Johnso. Effects of acute and chronic administration of cocaine on striatal uptake, compartmentalization and release of [3H]dopamine. Neuropharmacology. vol 29. issue 5. 1990-07-25. PMID:2356003. |
it was found that repetitive administration of cocaine followed 7 days later by acute challenge with cocaine, produced an increase in the vmax with no change in the affinity of the uptake carrier for either dopamine (da) or cocaine. |
1990-07-25 |
2023-08-11 |
rat |
| R B Rothma. High affinity dopamine reuptake inhibitors as potential cocaine antagonists: a strategy for drug development. Life sciences. vol 46. issue 20. 1990-07-03. PMID:2111866. |
high affinity dopamine reuptake inhibitors as potential cocaine antagonists: a strategy for drug development. |
1990-07-03 |
2023-08-11 |
Not clear |
| R B Rothma. High affinity dopamine reuptake inhibitors as potential cocaine antagonists: a strategy for drug development. Life sciences. vol 46. issue 20. 1990-07-03. PMID:2111866. |
the addictive and euphorogenic effects of cocaine are thought to result primarily from inhibition of dopamine reuptake. |
1990-07-03 |
2023-08-11 |
Not clear |
| P Berger, J D Elsworth, J Arroyo, R H Rot. Interaction of [3H]GBR 12935 and GBR 12909 with the dopamine uptake complex in nucleus accumbens. European journal of pharmacology. vol 177. issue 1-2. 1990-06-28. PMID:1967129. |
although some behavioral effects of cocaine are hypothesized to be due to blockade of dopamine uptake in nucleus accumbens, it has been reported that in nucleus accumbens there are no specific cocaine binding sites and that cocaine is a weak inhibitor of dopamine uptake. |
1990-06-28 |
2023-08-11 |
Not clear |
| R D Spealma. Antagonism of behavioral effects of cocaine by selective dopamine receptor blockers. Psychopharmacology. vol 101. issue 1. 1990-06-27. PMID:1971446. |
the results suggest a prominent role for d1 as well as d2 dopamine receptors in mediating the effects of cocaine on schedule-controlled behavior. |
1990-06-27 |
2023-08-11 |
monkey |
| G L Kovàcs, Z Sarnyai, E Barbarczi, G Szabó, G Telegd. The role of oxytocin-dopamine interactions in cocaine-induced locomotor hyperactivity. Neuropharmacology. vol 29. issue 4. 1990-06-27. PMID:2160623. |
moreover, oxytocin antagonized the increased utilization of dopamine, elicited by cocaine in the nucleus accumbens. |
1990-06-27 |
2023-08-11 |
mouse |
| N D Volkow, J S Fowler, A P Wolf, D Schlyer, C Y Shiue, R Alpert, S L Dewey, J Logan, B Bendriem, D Christma. Effects of chronic cocaine abuse on postsynaptic dopamine receptors. The American journal of psychiatry. vol 147. issue 6. 1990-06-25. PMID:2343913. |
effects of chronic cocaine abuse on postsynaptic dopamine receptors. |
1990-06-25 |
2023-08-11 |
human |
| N D Volkow, J S Fowler, A P Wolf, D Schlyer, C Y Shiue, R Alpert, S L Dewey, J Logan, B Bendriem, D Christma. Effects of chronic cocaine abuse on postsynaptic dopamine receptors. The American journal of psychiatry. vol 147. issue 6. 1990-06-25. PMID:2343913. |
to assess the effects of chronic cocaine intoxication on dopamine receptors in human subjects, the authors evaluated [18f]n-methylspiroperidol binding using positron emission tomography in 10 cocaine abusers and 10 normal control subjects. |
1990-06-25 |
2023-08-11 |
human |
| N S Pilotte, L G Sharpe, E M Da. Multiple, but not acute, infusions of cocaine alter the release of prolactin in male rats. Brain research. vol 512. issue 1. 1990-06-21. PMID:2159825. |
repeated administration of cocaine may produce long-term changes in either the tuberoinfundibular dopaminergic neurons or the adenohypophysial dopamine d2-receptors, or both. |
1990-06-21 |
2023-08-11 |
rat |
| K Akimoto, T Hamamura, Y Kazahaya, K Akiyama, S Otsuk. Enhanced extracellular dopamine level may be the fundamental neuropharmacological basis of cross-behavioral sensitization between methamphetamine and cocaine--an in vivo dialysis study in freely moving rats. Brain research. vol 507. issue 2. 1990-06-20. PMID:2337776. |
enhanced extracellular dopamine level may be the fundamental neuropharmacological basis of cross-behavioral sensitization between methamphetamine and cocaine--an in vivo dialysis study in freely moving rats. |
1990-06-20 |
2023-08-11 |
rat |
| K Akimoto, T Hamamura, Y Kazahaya, K Akiyama, S Otsuk. Enhanced extracellular dopamine level may be the fundamental neuropharmacological basis of cross-behavioral sensitization between methamphetamine and cocaine--an in vivo dialysis study in freely moving rats. Brain research. vol 507. issue 2. 1990-06-20. PMID:2337776. |
the challenge injection of cocaine caused a significantly greater increase in striatal perfusate dopamine (da) levels in map-pretreated rats than in saline-pretreated rats. |
1990-06-20 |
2023-08-11 |
rat |
| C A Moody, R A Fran. Cocaine facilitates prefrontal cortex self-stimulation. Pharmacology, biochemistry, and behavior. vol 35. issue 3. 1990-06-18. PMID:2339164. |
however, the role of dopamine in cocaine's effects at both sites remains speculative. |
1990-06-18 |
2023-08-11 |
Not clear |
| J Peris, S J Boyson, W A Cass, P Curella, L P Dwoskin, G Larson, L H Lin, R P Yasuda, N R Zahnise. Persistence of neurochemical changes in dopamine systems after repeated cocaine administration. The Journal of pharmacology and experimental therapeutics. vol 253. issue 1. 1990-05-30. PMID:2329520. |
persistence of neurochemical changes in dopamine systems after repeated cocaine administration. |
1990-05-30 |
2023-08-11 |
rat |