| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Z Bosy, J A Rut. Differential inhibition of synaptosomal accumulation of [3H]-monoamines by cocaine, tropacocaine and amphetamine in four inbred strains of mice. Pharmacology, biochemistry, and behavior. vol 34. issue 1. 1990-04-03. PMID:2626447. |
the relative ability of cocaine, tropacocaine and amphetamine to inhibit the uptake of [3h]norepinephrine (ne), [3h]dopamine (da) and [3h]5-hydroxytryptamine (5ht) was examined in whole brain synaptosomes from balb, c3h, c57bl and dba inbred mouse strains. |
1990-04-03 |
2023-08-11 |
mouse |
| H O Pettit, J B Justic. Dopamine in the nucleus accumbens during cocaine self-administration as studied by in vivo microdialysis. Pharmacology, biochemistry, and behavior. vol 34. issue 4. 1990-03-27. PMID:2623043. |
dopamine in the nucleus accumbens during cocaine self-administration as studied by in vivo microdialysis. |
1990-03-27 |
2023-08-11 |
Not clear |
| H O Pettit, J B Justic. Dopamine in the nucleus accumbens during cocaine self-administration as studied by in vivo microdialysis. Pharmacology, biochemistry, and behavior. vol 34. issue 4. 1990-03-27. PMID:2623043. |
the extracellular dopamine (da) concentration in the nucleus accumbens was measured following intravenous cocaine administration. |
1990-03-27 |
2023-08-11 |
Not clear |
| P W Kalivas, P Duff. Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens. Synapse (New York, N.Y.). vol 5. issue 1. 1990-03-01. PMID:2300906. |
effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens. |
1990-03-01 |
2023-08-11 |
rat |
| P W Kalivas, P Duff. Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens. Synapse (New York, N.Y.). vol 5. issue 1. 1990-03-01. PMID:2300906. |
in vivo dialysis in the nucleus accumbens of conscious rats was used to determine if the increased behavioral response following daily cocaine administration is associated with an increase in extracellular dopamine concentration. |
1990-03-01 |
2023-08-11 |
rat |
| P W Kalivas, P Duff. Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens. Synapse (New York, N.Y.). vol 5. issue 1. 1990-03-01. PMID:2300906. |
acute injection of cocaine (15 mg/kg, ip) produced an elevation in extracellular dopamine concentration in the nucleus accumbens. |
1990-03-01 |
2023-08-11 |
rat |
| P W Kalivas, P Duff. Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens. Synapse (New York, N.Y.). vol 5. issue 1. 1990-03-01. PMID:2300906. |
following daily pretreatment with cocaine (15 mg/kg, ip x 4 days), a subsequent acute injection of cocaine (15 mg/kg, ip) significantly elevated the extracellular dopamine levels compared to that produced by a single acute injection. |
1990-03-01 |
2023-08-11 |
rat |
| P W Kalivas, P Duff. Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens. Synapse (New York, N.Y.). vol 5. issue 1. 1990-03-01. PMID:2300906. |
although the levels of extracellular dopamine metabolites was significantly lowered by both acute cocaine and daily cocaine, no difference between these two groups of animals was measured. |
1990-03-01 |
2023-08-11 |
rat |
| P W Kalivas, P Duff. Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens. Synapse (New York, N.Y.). vol 5. issue 1. 1990-03-01. PMID:2300906. |
the increase in extracellular dopamine following a single acute injection of cocaine was not correlated to the motor stimulant response. |
1990-03-01 |
2023-08-11 |
rat |
| P W Kalivas, P Duff. Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens. Synapse (New York, N.Y.). vol 5. issue 1. 1990-03-01. PMID:2300906. |
however, after daily pretreatment with cocaine the motor stimulant response to acute cocaine was positively correlated with the increased extracellular concentration of dopamine in the nucleus accumbens. |
1990-03-01 |
2023-08-11 |
rat |
| P W Kalivas, P Duff. Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens. Synapse (New York, N.Y.). vol 5. issue 1. 1990-03-01. PMID:2300906. |
these data demonstrate that enhanced dopamine release into the nucleus accumbens may mediate the behavioral sensitization produced by daily injections of cocaine, but that other neural systems are influential in mediating the acute motor stimulant effect of cocaine. |
1990-03-01 |
2023-08-11 |
rat |
| A E Calogero, W T Gallucci, M A Kling, G P Chrousos, P W Gol. Cocaine stimulates rat hypothalamic corticotropin-releasing hormone secretion in vitro. Brain research. vol 505. issue 1. 1990-03-01. PMID:2611679. |
the psychomotor stimulant properties of cocaine are thought to be related to its ability to modify the metabolism and the activity of many neurotransmitter systems, such as acetylcholine (ach), serotonin (5-ht), norepinephrine (ne), and dopamine (da). |
1990-03-01 |
2023-08-11 |
rat |
| M J Bannon, C H Xue, K Shibata, L J Dragovic, G Kapato. Expression of a human cocaine-sensitive dopamine transporter in Xenopus laevis oocytes. Journal of neurochemistry. vol 54. issue 2. 1990-02-27. PMID:2137162. |
furthermore, [3h]dopamine accumulation was prevented by coincubation of oocytes with dopamine (100 microm) or with the dopamine uptake inhibitors gbr 12909 (1 microm) or cocaine (3 microm). |
1990-02-27 |
2023-08-11 |
human |
| Y K Fung, J A Reed, Y S La. Prenatal cocaine exposure fails to modify neurobehavioral responses and the striatal dopaminergic system in newborn rats. General pharmacology. vol 20. issue 5. 1990-02-21. PMID:2606336. |
the effects of cocaine on locomotor activity and striatal dopaminergic receptors and dopamine turnover were studied in rat pups exposed to cocaine (30 mg/kg/day) throughout the entire gestational period. |
1990-02-21 |
2023-08-11 |
rat |
| T Di Paolo, C Rouillard, M Morissette, D Lévesque, P J Bédar. Endocrine and neurochemical actions of cocaine. Canadian journal of physiology and pharmacology. vol 67. issue 9. 1990-02-08. PMID:2688866. |
a review of the neurochemical actions of cocaine indicates the important role of dopamine systems in the euphoric effects of the drug, as well as its withdrawal symptoms. |
1990-02-08 |
2023-08-11 |
human |
| T Di Paolo, C Rouillard, M Morissette, D Lévesque, P J Bédar. Endocrine and neurochemical actions of cocaine. Canadian journal of physiology and pharmacology. vol 67. issue 9. 1990-02-08. PMID:2688866. |
cocaine is a potent dopamine uptake inhibitor, as shown by its competition with [3h]gbr-12935 (a specific ligand for the dopamine uptake sites) for striatum binding sites. |
1990-02-08 |
2023-08-11 |
human |
| T Di Paolo, C Rouillard, M Morissette, D Lévesque, P J Bédar. Endocrine and neurochemical actions of cocaine. Canadian journal of physiology and pharmacology. vol 67. issue 9. 1990-02-08. PMID:2688866. |
using microdialysis techniques, cocaine is shown to rapidly cause a large increase of rat striatal dopamine levels, while its metabolites dihydroxyphenylacetic acid and homovanillic acid are slightly decreased and increased, respectively. |
1990-02-08 |
2023-08-11 |
human |
| J S Fowler, N D Volkow, A P Wolf, S L Dewey, D J Schlyer, R R Macgregor, R Hitzemann, J Logan, B Bendriem, S J Gatle. Mapping cocaine binding sites in human and baboon brain in vivo. Synapse (New York, N.Y.). vol 4. issue 4. 1990-01-31. PMID:2557686. |
blockade of the dopamine reuptake sites with nomifensine reduced the striatal but not the cerebellar uptake of [11c]cocaine in baboons indicating that cocaine binding is associated with the dopamine reuptake site in the corpus striatum. |
1990-01-31 |
2023-08-11 |
human |
| D J Henry, M A Greene, F J Whit. Electrophysiological effects of cocaine in the mesoaccumbens dopamine system: repeated administration. The Journal of pharmacology and experimental therapeutics. vol 251. issue 3. 1990-01-30. PMID:2557418. |
behavioral evidence indicates that the potent rewarding effects of cocaine are mediated, in part, by the mesoaccumbens dopamine (da) system projecting from a10 da cells in the ventral tegmental area (vta) to the nucleus accumbens (nac). |
1990-01-30 |
2023-08-11 |
rat |
| T Farooqui, R A Wallace, D D Miller, N J Uretsk. Effect of the inhibition of dopamine uptake on the dopamine- and dimethyldopamine-induced-inhibition of the potassium-evoked release of [3H]acetylcholine from striatal slices. General pharmacology. vol 20. issue 6. 1990-01-25. PMID:2591702. |
cocaine and mazindol produced an eight-fold shift in the concentration-response curve for dopamine, but not for dimethyldopamine. |
1990-01-25 |
2023-08-11 |
Not clear |