| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B A Faraj, V M Camp, D C Davis, M Kutner, G A Cotsonis, T Hollowa. Elevated concentrations of dopamine sulfate in plasma of cocaine abusers. Biochemical pharmacology. vol 46. issue 8. 1993-11-29. PMID:8240395. |
specifically, we measured the concentration of free dopamine, dopamine sulfate, free norepinephrine, norepinephrine sulfate, free epinephrine and epinephrine sulfate in plasma samples obtained from the blood of a group of patients with cocaine addiction (n = 15). |
1993-11-29 |
2023-08-12 |
human |
| B A Faraj, V M Camp, D C Davis, M Kutner, G A Cotsonis, T Hollowa. Elevated concentrations of dopamine sulfate in plasma of cocaine abusers. Biochemical pharmacology. vol 46. issue 8. 1993-11-29. PMID:8240395. |
the results of this study revealed significant (p < 0.0001) elevation in plasma dopamine sulfate (8926 +/- 1204 pg/ml) of cocaine addicts upon admission to an in-patient treatment facility when compared with the level of this dopamine metabolite in plasma of control subjects (2356 +/- 121 pg/ml). |
1993-11-29 |
2023-08-12 |
human |
| B A Faraj, V M Camp, D C Davis, M Kutner, G A Cotsonis, T Hollowa. Elevated concentrations of dopamine sulfate in plasma of cocaine abusers. Biochemical pharmacology. vol 46. issue 8. 1993-11-29. PMID:8240395. |
furthermore, there was a significant (p < 0.0001) relationship between elevation in plasma dopamine sulfate levels and severity of cocaine use among these patients, and in the majority of cases the plasma levels of dopamine sulfate declined appreciably in time with abstinence from cocaine. |
1993-11-29 |
2023-08-12 |
human |
| B A Faraj, V M Camp, D C Davis, M Kutner, G A Cotsonis, T Hollowa. Elevated concentrations of dopamine sulfate in plasma of cocaine abusers. Biochemical pharmacology. vol 46. issue 8. 1993-11-29. PMID:8240395. |
differences in plasma dopamine sulfate among these patients versus controls may be interpreted as a reflection of activation of extracellular dopamine metabolism associated with chronic cocaine exposure in humans. |
1993-11-29 |
2023-08-12 |
human |
| J A Nathanson, E J Hunnicutt, L Kantham, C Scavon. Cocaine as a naturally occurring insecticide. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 20. 1993-11-19. PMID:8415755. |
unlike its known action on dopamine reuptake in mammals, cocaine's pesticidal effects are shown to result from a potentiation of insect octopaminergic neurotransmission. |
1993-11-19 |
2023-08-12 |
Not clear |
| M J Morgan, N G Cascella, J M Stapleton, R L Phillips, B C Yung, D F Wong, E K Shaya, E D Londo. Sensitivity to subjective effects of cocaine in drug abusers: relationship to cerebral ventricle size. The American journal of psychiatry. vol 150. issue 11. 1993-11-16. PMID:8214181. |
the purpose of this study was to assess the functional significance of ventricle-brain ratio (vbr) in terms of how it might affect sensitivity to cocaine, an indirect dopamine agonist. |
1993-11-16 |
2023-08-12 |
Not clear |
| R B Rothman, K M Becketts, L R Radesca, B R de Costa, K C Rice, F I Carroll, C M Dersc. Studies of the biogenic amine transporters. II. A brief study on the use of [3H]DA-uptake-inhibition to transporter-binding-inhibition ratios for the in vitro evaluation of putative cocaine antagonists. Life sciences. vol 53. issue 17. 1993-11-12. PMID:8412496. |
the cocaine receptor on the dopamine transporter is a logical target binding site for the design and synthesis of novel agents for evaluation as possible cocaine antagonists. |
1993-11-12 |
2023-08-12 |
Not clear |
| R B Rothman, K M Becketts, L R Radesca, B R de Costa, K C Rice, F I Carroll, C M Dersc. Studies of the biogenic amine transporters. II. A brief study on the use of [3H]DA-uptake-inhibition to transporter-binding-inhibition ratios for the in vitro evaluation of putative cocaine antagonists. Life sciences. vol 53. issue 17. 1993-11-12. PMID:8412496. |
although there is no widely accepted and validated assay for detecting a cocaine antagonist, one commonly accepted strategy is to compare the ic50 value of a test agent for inhibition of [3h]dopamine uptake and its ic50 value for inhibition of the binding of a transporter ligand such as [125i]rti-55. |
1993-11-12 |
2023-08-12 |
Not clear |
| F I Carroll, J L Gray, P Abraham, M A Kuzemko, A H Lewin, J W Boja, M J Kuha. 3-Aryl-2-(3'-substituted-1',2',4'-oxadiazol-5'-yl)tropane analogues of cocaine: affinities at the cocaine binding site at the dopamine, serotonin, and norepinephrine transporters. Journal of medicinal chemistry. vol 36. issue 20. 1993-11-09. PMID:8411004. |
3-aryl-2-(3'-substituted-1',2',4'-oxadiazol-5'-yl)tropane analogues of cocaine: affinities at the cocaine binding site at the dopamine, serotonin, and norepinephrine transporters. |
1993-11-09 |
2023-08-12 |
Not clear |
| F I Carroll, J L Gray, P Abraham, M A Kuzemko, A H Lewin, J W Boja, M J Kuha. 3-Aryl-2-(3'-substituted-1',2',4'-oxadiazol-5'-yl)tropane analogues of cocaine: affinities at the cocaine binding site at the dopamine, serotonin, and norepinephrine transporters. Journal of medicinal chemistry. vol 36. issue 20. 1993-11-09. PMID:8411004. |
previous studies have shown that 3 beta-(substituted phenyl)tropan-2 beta-carboxylic acid esters possess high affinity for the cocaine binding site on the dopamine transporter both in vitro and in vivo and inhibit dopamine uptake in vitro. |
1993-11-09 |
2023-08-12 |
Not clear |
| M Tateyama, S Ohta, T Nagao, M Hirobe, H On. Inhibitory effect of 4-phenyltetrahydroisoquinoline on locomotion and dopamine release induced by micro-injection of methamphetamine into the nucleus accumbens of the rat. Neuropharmacology. vol 32. issue 8. 1993-11-09. PMID:8413840. |
thus 4-ptiq but not cocaine inhibited the dopamine-releasing effect of methamphetamine, and 4-ptiq is suggested to block methamphetamine-induced locomotion by inhibition of dopamine release. |
1993-11-09 |
2023-08-12 |
rat |
| K D Nantwi, E P Schoene. Cocaine and dopaminergic actions in rat neostriatum. Neuropharmacology. vol 32. issue 8. 1993-11-09. PMID:8413844. |
electrophysiological experiments were conducted in vivo to characterize the involvement of dopamine in effects of cocaine at the cellular level. |
1993-11-09 |
2023-08-12 |
rat |
| M Tateyama, T Nagao, S Ohta, M Hirobe, H On. 4-Phenyltetrahydroisoquinoline, but not nomifensine or cocaine, inhibits methamphetamine-induced dopamine release. European journal of pharmacology. vol 240. issue 1. 1993-11-02. PMID:8405121. |
4-phenyltetrahydroisoquinoline, but not nomifensine or cocaine, inhibits methamphetamine-induced dopamine release. |
1993-11-02 |
2023-08-12 |
rat |
| M Tateyama, T Nagao, S Ohta, M Hirobe, H On. 4-Phenyltetrahydroisoquinoline, but not nomifensine or cocaine, inhibits methamphetamine-induced dopamine release. European journal of pharmacology. vol 240. issue 1. 1993-11-02. PMID:8405121. |
although the uptake inhibitors, cocaine (3 x 10(-6) m) and nomifensine (10(-6) m), failed to block dopamine release, 4-ptiq (10(-6 m) inhibited the dopamine-releasing effect of methamphetamine. |
1993-11-02 |
2023-08-12 |
rat |
| M Tateyama, T Nagao, S Ohta, M Hirobe, H On. 4-Phenyltetrahydroisoquinoline, but not nomifensine or cocaine, inhibits methamphetamine-induced dopamine release. European journal of pharmacology. vol 240. issue 1. 1993-11-02. PMID:8405121. |
4-ptiq did not affect the elevation of the extracellular dopamine level induced by high concentrations of nomifensine (10(-5) m) and cocaine (3 x 10(-5) m). |
1993-11-02 |
2023-08-12 |
rat |
| F Karoum, S J Chrapusta, M F Egan, R J Wyat. Absence of 6-hydroxydopamine in the rat brain after treatment with stimulants and other dopaminergic agents: a mass fragmentographic study. Journal of neurochemistry. vol 61. issue 4. 1993-10-21. PMID:8104232. |
we used mass fragmentography to search for 6-ohda in the rat frontal cortex and striatum after the administration of a number of drugs including 3,4-dihydroxyphenyl-l-alanine, methamphetamine, amphetamine, and cocaine, all of which increase synaptic dopamine. |
1993-10-21 |
2023-08-12 |
rat |
| N R Richardson, M F Piercey, K Svensson, R J Collins, J E Myers, D C Robert. Antagonism of cocaine self-administration by the preferential dopamine autoreceptor antagonist, (+)-AJ 76. Brain research. vol 619. issue 1-2. 1993-10-20. PMID:8374772. |
antagonism of cocaine self-administration by the preferential dopamine autoreceptor antagonist, (+)-aj 76. |
1993-10-20 |
2023-08-12 |
Not clear |
| J R Wamsley, M E Alburge. Cocaine causes a time dependent and dose dependent increase in D1 receptors and dopamine transporters. Proceedings of the Western Pharmacology Society. vol 36. 1993-10-15. PMID:8378389. |
cocaine causes a time dependent and dose dependent increase in d1 receptors and dopamine transporters. |
1993-10-15 |
2023-08-12 |
Not clear |
| P Skjoldager, G Winger, J H Wood. Effects of GBR 12909 and cocaine on cocaine-maintained behavior in rhesus monkeys. Drug and alcohol dependence. vol 33. issue 1. 1993-10-14. PMID:8370338. |
the reinforcing effect of the high affinity dopamine reuptake inhibitor gbr 12909 (1-[2-[bis(4-fluorophenyl)methoxy]ethyl)-4(3- phenylpropyl)piperazine) was compared with that of cocaine, and the effects of both gbr 12909 and cocaine pretreatments were evaluated on behaviour maintained by cocaine in rhesus monkeys. |
1993-10-14 |
2023-08-12 |
monkey |
| J D Elsworth, J R Taylor, P Berger, R H Rot. Cocaine-sensitive and -insensitive dopamine uptake in prefrontal cortex, nucleus accumbens and striatum. Neurochemistry international. vol 23. issue 1. 1993-10-08. PMID:8369733. |
behavioral studies have indicated that the reinforcing effects of cocaine are dependent on inhibition of dopamine uptake in nucleus accumbens and prefrontal cortex. |
1993-10-08 |
2023-08-12 |
Not clear |