| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P A Broderick, E P Kornak, F Eng, R Wechsle. Real time detection of acute (IP) cocaine-enhanced dopamine and serotonin release in ventrolateral nucleus accumbens of the behaving Norway rat. Pharmacology, biochemistry, and behavior. vol 46. issue 3. 1994-02-09. PMID:8278450. |
cocaine (10 mg/kg), administered intraperitoneal (ip), was studied for its effects on dopamine (da) and serotonin (5-ht) release in ventrolateral nucleus accumbens (vlnacc) of conscious and behaving male, virus-free, sprague-dawley rats with in vivo electrochemistry (voltammetry). |
1994-02-09 |
2023-08-12 |
rat |
| S Izenwasser, A H Newman, J L Kat. Cocaine and several sigma receptor ligands inhibit dopamine uptake in rat caudate-putamen. European journal of pharmacology. vol 243. issue 2. 1994-02-04. PMID:8276070. |
cocaine and several sigma receptor ligands inhibit dopamine uptake in rat caudate-putamen. |
1994-02-04 |
2023-08-12 |
rat |
| S Izenwasser, A H Newman, J L Kat. Cocaine and several sigma receptor ligands inhibit dopamine uptake in rat caudate-putamen. European journal of pharmacology. vol 243. issue 2. 1994-02-04. PMID:8276070. |
cocaine and several sigma receptor ligands inhibit dopamine uptake via a common site. |
1994-02-04 |
2023-08-12 |
rat |
| S Izenwasser, A H Newman, J L Kat. Cocaine and several sigma receptor ligands inhibit dopamine uptake in rat caudate-putamen. European journal of pharmacology. vol 243. issue 2. 1994-02-04. PMID:8276070. |
this is evidenced by a concentration-dependent inhibition of dopamine uptake and displacement of the binding of [3h]win 35,428 (also called cft), a cocaine analog with high affinity for the dopamine transporter. |
1994-02-04 |
2023-08-12 |
rat |
| E A Kiyatki. Cocaine enhances the changes in extracellular dopamine in nucleus accumbens associated with reinforcing stimuli: a high-speed chronoamperometric study in freely moving rats. The European journal of neuroscience. vol 5. issue 3. 1994-01-27. PMID:8261108. |
cocaine enhances the changes in extracellular dopamine in nucleus accumbens associated with reinforcing stimuli: a high-speed chronoamperometric study in freely moving rats. |
1994-01-27 |
2023-08-12 |
rat |
| E A Kiyatki. Cocaine enhances the changes in extracellular dopamine in nucleus accumbens associated with reinforcing stimuli: a high-speed chronoamperometric study in freely moving rats. The European journal of neuroscience. vol 5. issue 3. 1994-01-27. PMID:8261108. |
numerous data suggest that the mesocorticolimbic dopamine (da) system is critically involved in the organization and regulation of goal-directed behaviours of various types as well as in the mediation of the psychogenic effects of cocaine. |
1994-01-27 |
2023-08-12 |
rat |
| N H Chen, M E Reit. Dopamine and serotonin release-regulating autoreceptor sensitivity in A9/A10 cell body and terminal areas after withdrawal of rats from continuous infusion of cocaine. The Journal of pharmacology and experimental therapeutics. vol 267. issue 3. 1994-01-27. PMID:8263807. |
dopamine and serotonin release-regulating autoreceptor sensitivity in a9/a10 cell body and terminal areas after withdrawal of rats from continuous infusion of cocaine. |
1994-01-27 |
2023-08-12 |
rat |
| N H Chen, M E Reit. Dopamine and serotonin release-regulating autoreceptor sensitivity in A9/A10 cell body and terminal areas after withdrawal of rats from continuous infusion of cocaine. The Journal of pharmacology and experimental therapeutics. vol 267. issue 3. 1994-01-27. PMID:8263807. |
the effects of dopamine (da) and 5-hydroxytryptamine (5-ht) autoreceptor agents on electrically induced [3h]da and [3h]5-ht release from superfused slices of striatum, nucleus accumbens and ventral mesencephalon (vm) containing a9 and a10 neurons were investigated in rats made tolerant to the stimulatory effect of cocaine on locomotor behavior by a 14-day continuous infusion of cocaine (29 mg/kg/day) by s.c. implanted osmotic minipumps followed by a 7-day drug-free period. |
1994-01-27 |
2023-08-12 |
rat |
| I L Extein, M S Gol. Hypothesized neurochemical models for psychiatric syndromes in alcohol and drug dependence. Journal of addictive diseases. vol 12. issue 3. 1994-01-13. PMID:7504527. |
for example, hypothesized serotonergic deficits in alcoholism, endorphin deficits in opioid dependence, and dopamine depletion in cocaine dependence all might predispose to depression. |
1994-01-13 |
2023-08-12 |
Not clear |
| A McGregor, D C Robert. Dopaminergic antagonism within the nucleus accumbens or the amygdala produces differential effects on intravenous cocaine self-administration under fixed and progressive ratio schedules of reinforcement. Brain research. vol 624. issue 1-2. 1994-01-13. PMID:8252397. |
these results demonstrate that a significant contribution is made by amy dopamine to cocaine reinforcement mechanisms, which appears to be different to that of the nacc. |
1994-01-13 |
2023-08-12 |
Not clear |
| Z J Yu, C Jin, R W Rockhold, B Hoskins, I K H. Site and mechanism of behavioral tolerance to cocaine: a study of dopamine release in Wistar-Kyoto and spontaneously hypertensive rats. Neurochemical research. vol 18. issue 11. 1994-01-13. PMID:8255373. |
site and mechanism of behavioral tolerance to cocaine: a study of dopamine release in wistar-kyoto and spontaneously hypertensive rats. |
1994-01-13 |
2023-08-12 |
rat |
| Z J Yu, C Jin, R W Rockhold, B Hoskins, I K H. Site and mechanism of behavioral tolerance to cocaine: a study of dopamine release in Wistar-Kyoto and spontaneously hypertensive rats. Neurochemical research. vol 18. issue 11. 1994-01-13. PMID:8255373. |
release of [3h]dopamine was maximal in both brain regions 2 hr after acute cocaine challenge. |
1994-01-13 |
2023-08-12 |
rat |
| Z J Yu, C Jin, R W Rockhold, B Hoskins, I K H. Site and mechanism of behavioral tolerance to cocaine: a study of dopamine release in Wistar-Kyoto and spontaneously hypertensive rats. Neurochemical research. vol 18. issue 11. 1994-01-13. PMID:8255373. |
after 14 days of cocaine infusion, cocaine challenge in both strains reduced [3h]dopamine release in the nucleus accumbens, but not in the striatum; the reduction being greater in wistar-kyoto rats. |
1994-01-13 |
2023-08-12 |
rat |
| Z J Yu, C Jin, R W Rockhold, B Hoskins, I K H. Site and mechanism of behavioral tolerance to cocaine: a study of dopamine release in Wistar-Kyoto and spontaneously hypertensive rats. Neurochemical research. vol 18. issue 11. 1994-01-13. PMID:8255373. |
the behavioral tolerance which accompanies similar cocaine infusion regimens may be related to striatal "tolerance" to cocaine-induced dopamine release. |
1994-01-13 |
2023-08-12 |
rat |
| D Simoni, J Stoelwinder, A P Kozikowski, K M Johnson, J S Bergmann, R G Bal. Methoxylation of cocaine reduces binding affinity and produces compounds of differential binding and dopamine uptake inhibitory activity: discovery of a weak cocaine "antagonist". Journal of medicinal chemistry. vol 36. issue 24. 1994-01-11. PMID:8254627. |
methoxylation of cocaine reduces binding affinity and produces compounds of differential binding and dopamine uptake inhibitory activity: discovery of a weak cocaine "antagonist". |
1994-01-11 |
2023-08-12 |
Not clear |
| S Rosenzweig-Lipson, J Bergma. Dopamine D1 receptor involvement in the discriminative-stimulus effects of SKF 81297 in squirrel monkeys. The Journal of pharmacology and experimental therapeutics. vol 267. issue 2. 1994-01-06. PMID:7902432. |
other dopaminergic drugs, including the d1 partial agonists skf 75670 and r(+)-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-[1h]-3- benzazepine (r-skf 38393), and the indirect dopamine agonists, cocaine, d-amphetamine and 1-(2-[bis(4-fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl)piperazine (gbr 12909), did not substitute fully for skf 81297 in any monkey studied. |
1994-01-06 |
2023-08-12 |
monkey |
| M E Alburges, N Narang, J K Wamsle. Alterations in the dopaminergic receptor system after chronic administration of cocaine. Synapse (New York, N.Y.). vol 14. issue 4. 1994-01-03. PMID:8161369. |
several studies suggest that one of the most important factors contributing to cocaine dependence is an alteration in the actions of the neurotransmitter dopamine in the central nervous system. |
1994-01-03 |
2023-08-12 |
rat |
| M E Alburges, N Narang, J K Wamsle. Alterations in the dopaminergic receptor system after chronic administration of cocaine. Synapse (New York, N.Y.). vol 14. issue 4. 1994-01-03. PMID:8161369. |
the binding of [3h]sch23390 to d1 dopamine receptors was significantly increased at day 3 of cocaine exposure. |
1994-01-03 |
2023-08-12 |
rat |
| S L Vrana, K E Vrana, T R Koves, J E Smith, S I Dworki. Chronic cocaine administration increases CNS tyrosine hydroxylase enzyme activity and mRNA levels and tryptophan hydroxylase enzyme activity levels. Journal of neurochemistry. vol 61. issue 6. 1993-12-23. PMID:7902421. |
cocaine is an inhibitor of dopamine and serotonin reuptake by synaptic terminals and has potent reinforcing effects that lead to its abuse. |
1993-12-23 |
2023-08-12 |
human |
| S L Vrana, K E Vrana, T R Koves, J E Smith, S I Dworki. Chronic cocaine administration increases CNS tyrosine hydroxylase enzyme activity and mRNA levels and tryptophan hydroxylase enzyme activity levels. Journal of neurochemistry. vol 61. issue 6. 1993-12-23. PMID:7902421. |
tyrosine hydroxylase (th) and tryptophan hydroxylase (tph) catalyze the rate-limiting steps in dopamine and serotonin biosynthesis, respectively, and are the subject of dynamic regulatory mechanisms that could be sensitive to the actions of cocaine. |
1993-12-23 |
2023-08-12 |
human |