| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J M Koff, L Shuster, L G Mille. Chronic cocaine administration is associated with behavioral sensitization and time-dependent changes in striatal dopamine transporter binding. The Journal of pharmacology and experimental therapeutics. vol 268. issue 1. 1994-03-10. PMID:8301568. |
chronic cocaine administration is associated with behavioral sensitization and time-dependent changes in striatal dopamine transporter binding. |
1994-03-10 |
2023-08-12 |
mouse |
| J M Koff, L Shuster, L G Mille. Chronic cocaine administration is associated with behavioral sensitization and time-dependent changes in striatal dopamine transporter binding. The Journal of pharmacology and experimental therapeutics. vol 268. issue 1. 1994-03-10. PMID:8301568. |
because cocaine acts at the presynaptic dopamine transporter, we evaluated sensitization and striatal dopamine transporter binding in vivo in several mouse strains. |
1994-03-10 |
2023-08-12 |
mouse |
| J M Koff, L Shuster, L G Mille. Chronic cocaine administration is associated with behavioral sensitization and time-dependent changes in striatal dopamine transporter binding. The Journal of pharmacology and experimental therapeutics. vol 268. issue 1. 1994-03-10. PMID:8301568. |
striatal dopamine transporter binding in vivo was increased in dba/2j and b6af1/j mice when determined 72 hr after five injections of 40 mg/kg/day cocaine. |
1994-03-10 |
2023-08-12 |
mouse |
| J M Koff, L Shuster, L G Mille. Chronic cocaine administration is associated with behavioral sensitization and time-dependent changes in striatal dopamine transporter binding. The Journal of pharmacology and experimental therapeutics. vol 268. issue 1. 1994-03-10. PMID:8301568. |
these data indicate that both sensitization and alterations in dopamine transporter binding occur after chronic cocaine injection but that these changes are unlikely to be directly related. |
1994-03-10 |
2023-08-12 |
mouse |
| B E Scanley, R M Baldwin, M Laruelle, M S al-Tikriti, Y Zea-Ponce, S Zoghbi, S S Giddings, D S Charney, P B Hoffer, S Wan. Active and inactive enantiomers of 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane: comparison using homogenate binding and single photon emission computed tomographic imaging. Molecular pharmacology. vol 45. issue 1. 1994-03-10. PMID:8302272. |
2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane (beta-cit; also designated rti-55) is an analog of cocaine that has been developed as a single photon emission computed tomography radiotracer that labels dopamine and serotonin transporters. |
1994-03-10 |
2023-08-12 |
Not clear |
| M G Henderson, B A McMille. Changes in dopamine, serotonin and their metabolites in discrete brain areas of rat offspring after in utero exposure to cocaine or related drugs. Teratology. vol 48. issue 5. 1994-03-09. PMID:7508151. |
changes in dopamine, serotonin and their metabolites in discrete brain areas of rat offspring after in utero exposure to cocaine or related drugs. |
1994-03-09 |
2023-08-12 |
rat |
| M G Henderson, B A McMille. Changes in dopamine, serotonin and their metabolites in discrete brain areas of rat offspring after in utero exposure to cocaine or related drugs. Teratology. vol 48. issue 5. 1994-03-09. PMID:7508151. |
the concentrations of dopamine (da), serotonin (5ht) and their metabolites were quantified in 5 brain areas of rats exposed to saline, cocaine (15 mg/kg b.i.d. |
1994-03-09 |
2023-08-12 |
rat |
| M G Henderson, B A McMille. Changes in dopamine, serotonin and their metabolites in discrete brain areas of rat offspring after in utero exposure to cocaine or related drugs. Teratology. vol 48. issue 5. 1994-03-09. PMID:7508151. |
afa was used to mimic the dopamine (da) uptake blockade and stimulant properties of cocaine and amitriptyline was used to mimic the other pharmacological effects of cocaine. |
1994-03-09 |
2023-08-12 |
rat |
| J K Staley, M Basile, D D Flynn, D C Mas. Visualizing dopamine and serotonin transporters in the human brain with the potent cocaine analogue [125I]RTI-55: in vitro binding and autoradiographic characterization. Journal of neurochemistry. vol 62. issue 2. 1994-03-02. PMID:8294917. |
visualizing dopamine and serotonin transporters in the human brain with the potent cocaine analogue [125i]rti-55: in vitro binding and autoradiographic characterization. |
1994-03-02 |
2023-08-12 |
human |
| J K Staley, M Basile, D D Flynn, D C Mas. Visualizing dopamine and serotonin transporters in the human brain with the potent cocaine analogue [125I]RTI-55: in vitro binding and autoradiographic characterization. Journal of neurochemistry. vol 62. issue 2. 1994-03-02. PMID:8294917. |
the cocaine analogue rti-55 was evaluated as a probe for in vitro labeling and localization of dopamine and serotonin transporters after death in the human brain. |
1994-03-02 |
2023-08-12 |
human |
| J K Staley, M Basile, D D Flynn, D C Mas. Visualizing dopamine and serotonin transporters in the human brain with the potent cocaine analogue [125I]RTI-55: in vitro binding and autoradiographic characterization. Journal of neurochemistry. vol 62. issue 2. 1994-03-02. PMID:8294917. |
the rank order of potency demonstrated in competition assays with human putamen membranes indicates that the radioligand labels cocaine recognition sites on the dopamine transporter (mazindol > gbr 12909 > gbr 12935 > paroxetine > nisoxetine > desipramine > or = fluoxetine > citalopram). |
1994-03-02 |
2023-08-12 |
human |
| M L Albuquerque, C D Kurt. Cocaine constricts immature cerebral arterioles by a local anesthetic mechanism. European journal of pharmacology. vol 249. issue 2. 1994-02-24. PMID:8287903. |
topically applied lidocaine (10(-7) m to 10(-3) m), a local anesthetic without sympathomimetic properties, caused a dose-dependent constriction similar to cocaine, whereas topically applied nomifensine and desipramine (each 10(-7) m to 10(-3) m), inhibitors of dopamine and norepinephrine re-uptake, respectively, did not constrict cerebral arterioles. |
1994-02-24 |
2023-08-12 |
Not clear |
| D J Fontana, R M Post, A Per. Conditioned increases in mesolimbic dopamine overflow by stimuli associated with cocaine. Brain research. vol 629. issue 1. 1994-02-23. PMID:8287278. |
conditioned increases in mesolimbic dopamine overflow by stimuli associated with cocaine. |
1994-02-23 |
2023-08-12 |
rat |
| D J Fontana, R M Post, A Per. Conditioned increases in mesolimbic dopamine overflow by stimuli associated with cocaine. Brain research. vol 629. issue 1. 1994-02-23. PMID:8287278. |
environmental stimuli paired with a large dose of cocaine for one training session elicited significant increases in locomotor activity and in extracellular dopamine in the nucleus accumbens of rats during a second test session with a low dose of cocaine. |
1994-02-23 |
2023-08-12 |
rat |
| D J Fontana, R M Post, A Per. Conditioned increases in mesolimbic dopamine overflow by stimuli associated with cocaine. Brain research. vol 629. issue 1. 1994-02-23. PMID:8287278. |
the increases in extracellular dopamine are not likely a secondary consequence of this increase in locomotor output of rats conditioned to cocaine, since doses of mk-801 which produced similar increases in locomotor behavior had no effect on mesolimbic dopamine. |
1994-02-23 |
2023-08-12 |
rat |
| K C Leskawa, G H Jackson, C A Moody, L P Spea. Cocaine exposure during pregnancy affects rat neonate and maternal brain glycosphingolipids. Brain research bulletin. vol 33. issue 2. 1994-02-10. PMID:8275339. |
behavioral dysfunctions in offspring exposed in utero to cocaine have been observed, along with alterations in dopamine systems, but few studies of the underlying biochemistry have been conducted. |
1994-02-10 |
2023-08-12 |
rat |
| J M Koff, L G Mille. Prenatal cocaine exposure: increased striatal dopamine transporter binding in offspring at 3 and 6 months of age. Brain research bulletin. vol 33. issue 2. 1994-02-10. PMID:8275343. |
prenatal cocaine exposure: increased striatal dopamine transporter binding in offspring at 3 and 6 months of age. |
1994-02-10 |
2023-08-12 |
mouse |
| J M Koff, L G Mille. Prenatal cocaine exposure: increased striatal dopamine transporter binding in offspring at 3 and 6 months of age. Brain research bulletin. vol 33. issue 2. 1994-02-10. PMID:8275343. |
prior studies indicate that prenatal cocaine exposure can alter dopamine transporter binding in mature mice. |
1994-02-10 |
2023-08-12 |
mouse |
| J M Koff, L G Mille. Prenatal cocaine exposure: increased striatal dopamine transporter binding in offspring at 3 and 6 months of age. Brain research bulletin. vol 33. issue 2. 1994-02-10. PMID:8275343. |
to determine the persistence of these effects, pregnant mice were treated with cocaine, 10 mg/kg/d, during days 13 to 20 of gestation and dopamine transporter binding was evaluated in offspring at 3 and 6 months of age. |
1994-02-10 |
2023-08-12 |
mouse |
| F G Kaddis, L J Wallace, N J Uretsk. AMPA/kainate antagonists in the nucleus accumbens inhibit locomotor stimulatory response to cocaine and dopamine agonists. Pharmacology, biochemistry, and behavior. vol 46. issue 3. 1994-02-09. PMID:7506423. |
ampa/kainate antagonists in the nucleus accumbens inhibit locomotor stimulatory response to cocaine and dopamine agonists. |
1994-02-09 |
2023-08-12 |
Not clear |