| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Y Burger, M T Martin-Iverso. Increased occupation of D1 and D2 dopamine receptors accompanies cocaine-induced behavioral sensitization. Brain research. vol 639. issue 2. 1994-07-13. PMID:8205476. |
these findings strongly support the hypothesis that enhanced dopamine release and subsequent interaction with dopamine receptors is a substrate for behavioural sensitization to cocaine and have implications for the pharmacotherapy of cocaine abuse. |
1994-07-13 |
2023-08-12 |
rat |
| F Karoum, M F Egan, R J Wyat. Selective reduction in dopamine turnover in the rat frontal cortex and hypothalamus during withdrawal from repeated cocaine exposure. European journal of pharmacology. vol 254. issue 1-2. 1994-07-13. PMID:8206108. |
selective reduction in dopamine turnover in the rat frontal cortex and hypothalamus during withdrawal from repeated cocaine exposure. |
1994-07-13 |
2023-08-12 |
rat |
| F Karoum, M F Egan, R J Wyat. Selective reduction in dopamine turnover in the rat frontal cortex and hypothalamus during withdrawal from repeated cocaine exposure. European journal of pharmacology. vol 254. issue 1-2. 1994-07-13. PMID:8206108. |
the effects of 7 days repeated cocaine administration on the dynamics of dopamine release and metabolism in four rat brain regions (frontal cortex, hypothalamus, nucleus accumbens and striatum) were evaluated 1 week (long-term effects) after the final cocaine injection. |
1994-07-13 |
2023-08-12 |
rat |
| F Karoum, M F Egan, R J Wyat. Selective reduction in dopamine turnover in the rat frontal cortex and hypothalamus during withdrawal from repeated cocaine exposure. European journal of pharmacology. vol 254. issue 1-2. 1994-07-13. PMID:8206108. |
dopamine release as indicated by 3-methoxytyramine steady-state concentration and its rate of formation was normal in all four brain regions 1 week after repeated cocaine exposure. |
1994-07-13 |
2023-08-12 |
rat |
| F Karoum, M F Egan, R J Wyat. Selective reduction in dopamine turnover in the rat frontal cortex and hypothalamus during withdrawal from repeated cocaine exposure. European journal of pharmacology. vol 254. issue 1-2. 1994-07-13. PMID:8206108. |
the ratios of 3-methoxytyramine rate of formation to that of dopac were calculated and found to be increased in the frontal cortex and hypothalamus suggesting dopamine reuptake inhibition, at least 1 week after cocaine withdrawal, continued to be depressed in these regions. |
1994-07-13 |
2023-08-12 |
rat |
| F Karoum, M F Egan, R J Wyat. Selective reduction in dopamine turnover in the rat frontal cortex and hypothalamus during withdrawal from repeated cocaine exposure. European journal of pharmacology. vol 254. issue 1-2. 1994-07-13. PMID:8206108. |
it is concluded that repeated cocaine has no long-term effect on dopamine release but produces selective long-term reductions in dopamine turnover in frontal cortex and hypothalamus. |
1994-07-13 |
2023-08-12 |
rat |
| F Karoum, M F Egan, R J Wyat. Selective reduction in dopamine turnover in the rat frontal cortex and hypothalamus during withdrawal from repeated cocaine exposure. European journal of pharmacology. vol 254. issue 1-2. 1994-07-13. PMID:8206108. |
cocaine withdrawal is therefore better associated with changes in dopamine turnover than with its release. |
1994-07-13 |
2023-08-12 |
rat |
| L J Porrino, K Migliarese, H M Davies, E Saikali, S R Childer. Behavioral effects of the novel tropane analog, 2 beta-propanoyl-3 beta-(4-toluyl)-tropane (PTT). Life sciences. vol 54. issue 26. 1994-07-11. PMID:8208059. |
in vitro studies have demonstrated that a novel tropane analog, ptt, in which both of the esters of cocaine have been removed is 20 times more potent than cocaine and more selective than cocaine in binding to dopamine transporters. |
1994-07-11 |
2023-08-12 |
rat |
| L J Porrino, K Migliarese, H M Davies, E Saikali, S R Childer. Behavioral effects of the novel tropane analog, 2 beta-propanoyl-3 beta-(4-toluyl)-tropane (PTT). Life sciences. vol 54. issue 26. 1994-07-11. PMID:8208059. |
ptt was 10-20 times more potent than cocaine in this behavioral assay, closely paralleling its potency relative to cocaine in dopamine transporter binding and uptake assays in vitro. |
1994-07-11 |
2023-08-12 |
rat |
| M Yonetani, C C Huang, N Lajevardi, A Pastuszko, M Delivoria-Papadopoulous, E Anda. Effect of acute cocaine injection on the extracellular level of dopamine, blood flow, and oxygen pressure in brain of newborn piglets. Biochemical medicine and metabolic biology. vol 51. issue 1. 1994-06-28. PMID:8192923. |
effect of acute cocaine injection on the extracellular level of dopamine, blood flow, and oxygen pressure in brain of newborn piglets. |
1994-06-28 |
2023-08-12 |
Not clear |
| M Yonetani, C C Huang, N Lajevardi, A Pastuszko, M Delivoria-Papadopoulous, E Anda. Effect of acute cocaine injection on the extracellular level of dopamine, blood flow, and oxygen pressure in brain of newborn piglets. Biochemical medicine and metabolic biology. vol 51. issue 1. 1994-06-28. PMID:8192923. |
the present study examined the effects of acute cocaine administration on oxygen pressure in the vasculature of the cortex as well as on blood flow and extracellular levels of dopamine in the striatum of newborn piglets. |
1994-06-28 |
2023-08-12 |
Not clear |
| M Yonetani, C C Huang, N Lajevardi, A Pastuszko, M Delivoria-Papadopoulous, E Anda. Effect of acute cocaine injection on the extracellular level of dopamine, blood flow, and oxygen pressure in brain of newborn piglets. Biochemical medicine and metabolic biology. vol 51. issue 1. 1994-06-28. PMID:8192923. |
extracellular dopamine, measured using in vivo microdialysis, showed a large increase after cocaine injection. |
1994-06-28 |
2023-08-12 |
Not clear |
| M Yonetani, C C Huang, N Lajevardi, A Pastuszko, M Delivoria-Papadopoulous, E Anda. Effect of acute cocaine injection on the extracellular level of dopamine, blood flow, and oxygen pressure in brain of newborn piglets. Biochemical medicine and metabolic biology. vol 51. issue 1. 1994-06-28. PMID:8192923. |
the mechanism(s) by which the increase in the extracellular level of dopamine occurred may include a direct effect of cocaine on the dopamine transporter and/or an indirect effect due to the decrease in cerebral oxygenation and blood flow. |
1994-06-28 |
2023-08-12 |
Not clear |
| W H Pan, N H Chen, Y J Lai, H F Luo. Differential effects of chloral hydrate and pentobarbital sodium on cocaine-induced electroencephalographic desynchronization at the medial prefrontal cortex in rats. Life sciences. vol 54. issue 23. 1994-06-28. PMID:8196486. |
therefore, in vivo microdialysis coupled with high performance liquid chromatography was used to quantify the changes of extracellular dopamine (da) concentrations at the mpfc for 90 minutes at 10 minute intervals after 1.5 mg/kg cocaine i.v. |
1994-06-28 |
2023-08-12 |
rat |
| L L Demchyshyn, Z B Pristupa, K S Sugamori, E L Barker, R D Blakely, W J Wolfgang, M A Forte, H B Nizni. Cloning, expression, and localization of a chloride-facilitated, cocaine-sensitive serotonin transporter from Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 11. 1994-06-27. PMID:8197200. |
both cocaine and rti-55 inhibited 5ht uptake by dsert with estimated inhibition constants of approximately 500 nm, while high concentrations (> 10 microm) of dopamine, norepinephrine, octopamine, tyramine, and histamine failed to inhibit transport. |
1994-06-27 |
2023-08-12 |
human |
| L Farde, C Halldin, L Müller, T Suhara, P Karlsson, H Hal. PET study of [11C]beta-CIT binding to monoamine transporters in the monkey and human brain. Synapse (New York, N.Y.). vol 16. issue 2. 1994-06-27. PMID:8197578. |
the cocaine congener beta-cit has been labeled with 11c for positron emission tomographic (pet) studies of the dopamine transporter. |
1994-06-27 |
2023-08-12 |
human |
| L Farde, C Halldin, L Müller, T Suhara, P Karlsson, H Hal. PET study of [11C]beta-CIT binding to monoamine transporters in the monkey and human brain. Synapse (New York, N.Y.). vol 16. issue 2. 1994-06-27. PMID:8197578. |
a high dose of cocaine intravenously (7 mg/kg) induced a 50% occupancy of specific [11c]beta-cit binding to the dopamine transporter in the striatum. |
1994-06-27 |
2023-08-12 |
human |
| L Farde, C Halldin, L Müller, T Suhara, P Karlsson, H Hal. PET study of [11C]beta-CIT binding to monoamine transporters in the monkey and human brain. Synapse (New York, N.Y.). vol 16. issue 2. 1994-06-27. PMID:8197578. |
the finding indicates that cocaine arousal may be induced at a low dopamine transporter occupancy of a few percent. |
1994-06-27 |
2023-08-12 |
human |
| M C Ritz, M J Kuha. Psychostimulant drugs and a dopamine hypothesis regarding addiction: update on recent research. Biochemical Society symposium. vol 59. 1994-06-23. PMID:7910741. |
cocaine, the best characterized psychostimulant, is seen to fulfil this hypothesis by blocking dopamine transporters, thereby preventing re-uptake of the neurotransmitter and enhancing its synaptic concentration (fig. |
1994-06-23 |
2023-08-12 |
human |
| G Di Chiara, E Acquas, G Tanda, C Cadon. Drugs of abuse: biochemical surrogates of specific aspects of natural reward? Biochemical Society symposium. vol 59. 1994-06-23. PMID:7910742. |
both natural rewards and drugs of abuse, including amphetamine, cocaine and other psychostimulants, preferentially stimulate dopamine transmission in the mesolimbic nucleus accumbens compared with the dorsal caudate, an area related to the extrapyramidal motor system. |
1994-06-23 |
2023-08-12 |
Not clear |