| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S B Caine, G F Koo. Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat. The Journal of pharmacology and experimental therapeutics. vol 270. issue 1. 1994-08-15. PMID:8035317. |
the effects of three dopamine d-1 receptor antagonists (sch23390, sch39166 and a69024) and three dopamine d-2 antagonists (raclopride, eticlopride and spiperone) on cocaine self-administration maintained under different schedules of reinforcement were examined in the rat. |
1994-08-15 |
2023-08-12 |
rat |
| S B Caine, G F Koo. Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat. The Journal of pharmacology and experimental therapeutics. vol 270. issue 1. 1994-08-15. PMID:8035317. |
moreover, a low dose of either of the benzazepine dopamine d-1 antagonists sch23390 or sch39166, but not the other compounds, selectively reduced cocaine self-administration without altering responding for food under the multiple schedule. |
1994-08-15 |
2023-08-12 |
rat |
| S B Caine, G F Koo. Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat. The Journal of pharmacology and experimental therapeutics. vol 270. issue 1. 1994-08-15. PMID:8035317. |
these results suggest that benzazepine dopamine d-1 antagonists, at low doses, may attenuate the reinforcing properties of cocaine more selectively than other dopamine receptor antagonists. |
1994-08-15 |
2023-08-12 |
rat |
| S B Caine, G F Koo. Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat. The Journal of pharmacology and experimental therapeutics. vol 270. issue 1. 1994-08-15. PMID:8035317. |
the results also demonstrate the advantages of using different schedules to investigate the effects of dopamine d-1 and d-2 antagonists on cocaine self-administration. |
1994-08-15 |
2023-08-12 |
rat |
| R B Rothman, J L Cadet, H C Akunne, M L Silverthorn, M H Baumann, F I Carroll, K C Rice, B R de Costa, J S Partilla, J B Wan. Studies of the biogenic amine transporters. IV. Demonstration of a multiplicity of binding sites in rat caudate membranes for the cocaine analog [125I]RTI-55. The Journal of pharmacology and experimental therapeutics. vol 270. issue 1. 1994-08-15. PMID:8035327. |
the drug 3 beta-[4'-iodophenyl]tropan-2 beta-carboxylic acid methyl ester (rti-55) is a cocaine congener with high affinity for the dopamine transporter (kd < 1 nm). |
1994-08-15 |
2023-08-12 |
human |
| R P Hammer, E S Cook. Gradual tolerance of metabolic activity is produced in mesolimbic regions by chronic cocaine treatment, while subsequent cocaine challenge activates extrapyramidal regions of rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 7. 1994-08-11. PMID:8027779. |
acute administration of cocaine is known to enhance extracellular dopamine levels in the striatum and to activate immediate-early gene expression in striatal neurons. |
1994-08-11 |
2023-08-12 |
rat |
| G A van der Hoek, S J Coope. The selective dopamine uptake inhibitor GBR 12909: its effects on the microstructure of feeding in rats. Pharmacology, biochemistry, and behavior. vol 48. issue 1. 1994-08-10. PMID:8029284. |
previous experiments have investigated the anorectic effects of mazindol and cocaine, both of which can inhibit dopamine (da) uptake into presynaptic terminals but do not do so selectively. |
1994-08-10 |
2023-08-12 |
rat |
| L Pulvirenti, G F Koo. Lisuride reduces intravenous cocaine self-administration in rats. Pharmacology, biochemistry, and behavior. vol 47. issue 4. 1994-08-08. PMID:8029249. |
cocaine self-administration appears to depend upon activation of dopamine terminals within mesocorticolimbic areas. |
1994-08-08 |
2023-08-12 |
rat |
| S E Hemby, G H Jones, G W Hubert, D B Neill, J B Justic. Assessment of the relative contribution of peripheral and central components in cocaine place conditioning. Pharmacology, biochemistry, and behavior. vol 47. issue 4. 1994-08-08. PMID:8029272. |
the first experiment was conducted to examine changes in locomotor activity and extracellular dopamine (da) concentrations in the nucleus accumbens (nacc) following intraperitoneal (ip) injections of cocaine hcl (15 mg/kg) or cocaine methiodide (19.6 mg/kg). |
1994-08-08 |
2023-08-12 |
Not clear |
| A P Newton, J B Justic. Temporal response of microdialysis probes to local perfusion of dopamine and cocaine followed with one-minute sampling. Analytical chemistry. vol 66. issue 9. 1994-07-28. PMID:8017633. |
temporal response of microdialysis probes to local perfusion of dopamine and cocaine followed with one-minute sampling. |
1994-07-28 |
2023-08-12 |
rat |
| A P Newton, J B Justic. Temporal response of microdialysis probes to local perfusion of dopamine and cocaine followed with one-minute sampling. Analytical chemistry. vol 66. issue 9. 1994-07-28. PMID:8017633. |
the response under four conditions was examined: in vitro sampling of dopamine (da), in vitro perfusion of da, in vivo perfusion of da, and in vivo perfusion of cocaine. |
1994-07-28 |
2023-08-12 |
rat |
| R C Saunders, B S Kolachana, D R Weinberge. Local pharmacological manipulation of extracellular dopamine levels in the dorsolateral prefrontal cortex and caudate nucleus in the rhesus monkey: an in vivo microdialysis study. Experimental brain research. vol 98. issue 1. 1994-07-27. PMID:8013591. |
administration of indirect dopamine agonists d-amphetamine and cocaine into the prefrontal cortex and the caudate nucleus increased extracellular dopamine levels 250% and 5000%, respectively. |
1994-07-27 |
2023-08-12 |
monkey |
| R C Saunders, B S Kolachana, D R Weinberge. Local pharmacological manipulation of extracellular dopamine levels in the dorsolateral prefrontal cortex and caudate nucleus in the rhesus monkey: an in vivo microdialysis study. Experimental brain research. vol 98. issue 1. 1994-07-27. PMID:8013591. |
amphetamine and cocaine had greater effects on dopamine levels in the caudate than in the prefrontal cortex. |
1994-07-27 |
2023-08-12 |
monkey |
| N S Pilotte, L G Sharpe, M J Kuha. Withdrawal of repeated intravenous infusions of cocaine persistently reduces binding to dopamine transporters in the nucleus accumbens of Lewis rats. The Journal of pharmacology and experimental therapeutics. vol 269. issue 3. 1994-07-26. PMID:7912283. |
withdrawal of repeated intravenous infusions of cocaine persistently reduces binding to dopamine transporters in the nucleus accumbens of lewis rats. |
1994-07-26 |
2023-08-12 |
rat |
| T A Kosten, E J Nestle. Clozapine attenuates cocaine conditioned place preference. Life sciences. vol 55. issue 1. 1994-07-25. PMID:8015343. |
clozapine, an atypical neuroleptic, has dopamine and serotonin antagonist actions that suggest its potential as a cocaine abuse pharmacotherapy. |
1994-07-25 |
2023-08-12 |
Not clear |
| C Cerruti, N S Pilotte, G Uhl, M J Kuha. Reduction in dopamine transporter mRNA after cessation of repeated cocaine administration. Brain research. Molecular brain research. vol 22. issue 1-4. 1994-07-25. PMID:8015373. |
reduction in dopamine transporter mrna after cessation of repeated cocaine administration. |
1994-07-25 |
2023-08-12 |
rat |
| A Hitri, M F Casanova, J E Kleinman, R J Wyat. Fewer dopamine transporter receptors in the prefrontal cortex of cocaine users. The American journal of psychiatry. vol 151. issue 7. 1994-07-15. PMID:8010366. |
fewer dopamine transporter receptors in the prefrontal cortex of cocaine users. |
1994-07-15 |
2023-08-12 |
human |
| A Hitri, M F Casanova, J E Kleinman, R J Wyat. Fewer dopamine transporter receptors in the prefrontal cortex of cocaine users. The American journal of psychiatry. vol 151. issue 7. 1994-07-15. PMID:8010366. |
the authors investigated dopamine transporter receptor binding in the post-mortem prefrontal cortex of 13 subjects with histories of cocaine use who had positive blood screens for cocaine at autopsy and 13 comparison subjects with no history of cocaine use and negative blood screens for cocaine at autopsy. |
1994-07-15 |
2023-08-12 |
human |
| L Y Burger, M T Martin-Iverso. Increased occupation of D1 and D2 dopamine receptors accompanies cocaine-induced behavioral sensitization. Brain research. vol 639. issue 2. 1994-07-13. PMID:8205476. |
injections, the occupation of d1 and d2 dopamine receptors by dopamine, measured as protection from n-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (eedq) receptor denaturation, was increased by about 100% compared to animals receiving cocaine in a treatment regimen that produced behavioural tolerance. |
1994-07-13 |
2023-08-12 |
rat |
| L Y Burger, M T Martin-Iverso. Increased occupation of D1 and D2 dopamine receptors accompanies cocaine-induced behavioral sensitization. Brain research. vol 639. issue 2. 1994-07-13. PMID:8205476. |
co-administration with nimodipine, an agent that blocks the impulse-dependent increase in synaptic concentrations of dopamine caused by cocaine, not only blocked sensitization but also blocked the increase in occupation of receptors. |
1994-07-13 |
2023-08-12 |
rat |