| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C P Silvia, G R King, T H Lee, Z Y Xue, M G Caron, E H Ellinwoo. Intranigral administration of D2 dopamine receptor antisense oligodeoxynucleotides establishes a role for nigrostriatal D2 autoreceptors in the motor actions of cocaine. Molecular pharmacology. vol 46. issue 1. 1994-09-09. PMID:8058056. |
the robustness of cocaine-induced rotation and the impaired ability of sulpiride to enhance dopamine release from slices suggest that nigrostriatal d2 autoreceptors play a direct role in reducing the motor response to cocaine administration. |
1994-09-09 |
2023-08-12 |
rat |
| D E Weese-Mayer, J M Silvestri, D Lin, C M Buhrfiend, L R Ptak, E S Lo, P M Carve. Hypoxia after prenatal cocaine attenuates striatal dopamine and neurotrophic activity. Neurotoxicology and teratology. vol 16. issue 2. 1994-09-06. PMID:8052192. |
hypoxia after prenatal cocaine attenuates striatal dopamine and neurotrophic activity. |
1994-09-06 |
2023-08-12 |
rabbit |
| J S Meyer, P Robinson, M S Todtenkop. Prenatal cocaine treatment reduces haloperidol-induced catalepsy on postnatal day 10. Neurotoxicology and teratology. vol 16. issue 2. 1994-09-06. PMID:8052194. |
this study examined the influence of prenatal cocaine on subsequent cataleptic responses to the dopamine (da) receptor antagonist haloperidol. |
1994-09-06 |
2023-08-12 |
human |
| N D Volkow, J S Fowler, G J Wang, J Logan, D Schlyer, R MacGregor, R Hitzemann, A P Wol. Decreased dopamine transporters with age in health human subjects. Annals of neurology. vol 36. issue 2. 1994-09-06. PMID:8053661. |
the effects of aging on brain dopamine transporters was evaluated in 26 healthy male volunteers (age range, 21-63 years) using positron emission tomography and [11c]cocaine. |
1994-09-06 |
2023-08-12 |
human |
| N D Volkow, J S Fowler, G J Wang, J Logan, D Schlyer, R MacGregor, R Hitzemann, A P Wol. Decreased dopamine transporters with age in health human subjects. Annals of neurology. vol 36. issue 2. 1994-09-06. PMID:8053661. |
the ratio of the distribution volume for [11c]cocaine in basal ganglia to that in cerebellum was used as a model parameter for dopamine transporter availability and showed a significant negative correlation with age (r = 0.65, p < 0.0005). |
1994-09-06 |
2023-08-12 |
human |
| N Minematsu, I Ushijima, N Obara, Y Mizuki, M Yamad. [Effects of dopamine receptor agonists and antagonists on cocaine-induced behaviors in rats]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 14. issue 1. 1994-08-26. PMID:8048279. |
in this study, cocaine (5-20 mg/kg), an indirect dopamine agonist, increased locomotor activity and rearing accompanied with head circling and body shaking in a dose-dependent manner. |
1994-08-26 |
2023-08-12 |
rat |
| N Minematsu, I Ushijima, N Obara, Y Mizuki, M Yamad. [Effects of dopamine receptor agonists and antagonists on cocaine-induced behaviors in rats]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 14. issue 1. 1994-08-26. PMID:8048279. |
the actions of cocaine on dopamine d-1 receptors seem to be more potent than that on d-2 receptors. |
1994-08-26 |
2023-08-12 |
rat |
| R H Kline, A J Eshleman, J Wright, M E Eldefraw. Synthesis of substituted 3-carbamoylecgonine methyl ester analogues: irreversible and photoaffinity ligands for the cocaine receptor/dopamine transporter. Journal of medicinal chemistry. vol 37. issue 14. 1994-08-18. PMID:8035432. |
as a step toward the goal of producing a photoaffinity probe for the dopamine transporter, isocyanato and azido derivatives of 3-[(phenylcarbamoyl)oxy]ecgonine methyl ester were synthesized and tested for their ability to interact with the cocaine receptor of mammalian brain via two different assays. |
1994-08-18 |
2023-08-12 |
Not clear |
| R H Kline, A J Eshleman, J Wright, M E Eldefraw. Synthesis of substituted 3-carbamoylecgonine methyl ester analogues: irreversible and photoaffinity ligands for the cocaine receptor/dopamine transporter. Journal of medicinal chemistry. vol 37. issue 14. 1994-08-18. PMID:8035432. |
the ability of two isothiocyanato (n=c=s) (para and meta) and two azido (n3) (para and meta) derivatives, as well as (-)-cocaine, to inhibit [3h]cocaine binding and [3h]dopamine uptake and to covalently interact with the cocaine-binding site was tested. |
1994-08-18 |
2023-08-12 |
Not clear |
| R H Kline, A J Eshleman, J Wright, M E Eldefraw. Synthesis of substituted 3-carbamoylecgonine methyl ester analogues: irreversible and photoaffinity ligands for the cocaine receptor/dopamine transporter. Journal of medicinal chemistry. vol 37. issue 14. 1994-08-18. PMID:8035432. |
the p-n=c=s was the most potent, with ic50 values of 0.23 and 0.49 microm for [3h]cocaine binding and [3h]dopamine uptake. |
1994-08-18 |
2023-08-12 |
Not clear |
| R H Kline, A J Eshleman, J Wright, M E Eldefraw. Synthesis of substituted 3-carbamoylecgonine methyl ester analogues: irreversible and photoaffinity ligands for the cocaine receptor/dopamine transporter. Journal of medicinal chemistry. vol 37. issue 14. 1994-08-18. PMID:8035432. |
the m-n3 and p-n3 inhibited [3h]cocaine binding with ic50 values of 0.63 and 1.00 microm and inhibited [3h]dopamine uptake with ic50 values of 5.08 and 1.32 microm, respectively. |
1994-08-18 |
2023-08-12 |
Not clear |
| P Simon, R Dupuis, J Costenti. Thigmotaxis as an index of anxiety in mice. Influence of dopaminergic transmissions. Behavioural brain research. vol 61. issue 1. 1994-08-16. PMID:7913324. |
on this test the selective or non-selective indirect dopamine agonists gbr 12783, dexamphetamine and cocaine induced an increase of thigmotaxis. |
1994-08-16 |
2023-08-12 |
mouse |
| E A Kiyatki. Changes in dopamine-dependent electrochemical signal in the nucleus accumbens associated with repeated cocaine injections in rats. Brain research. vol 642. issue 1-2. 1994-08-16. PMID:8032884. |
high-speed chronoamperometry with nafion-coated monoamine-sensitive electrodes was used to evaluate changes in the extracellular dopamine (da) concentrations in the nucleus accumbens following each of a series of daily cocaine injections (15 mg/kg, i.p. |
1994-08-16 |
2023-08-12 |
rat |
| S P Gygi, J W Gibb, G R Hanso. Differential effects of antipsychotic and psychotomimetic drugs on neurotensin systems of discrete extrapyramidal and limbic regions. The Journal of pharmacology and experimental therapeutics. vol 270. issue 1. 1994-08-15. PMID:7913495. |
the effects of two antipsychotic (dopamine antagonist) drugs, haloperidol and clozapine, and of two psychotomimetic (dopamine-releasing) drugs, methamphetamine and cocaine, on neurotensin (nt) concentrations in discrete regions of the caudate nucleus, nucleus accumbens and globus pallidus were examined. |
1994-08-15 |
2023-08-12 |
Not clear |
| J M Masserano, D Venable, R J Wyat. Effects of chronic cocaine administration on [3H]dopamine uptake in the nucleus accumbens, striatum and frontal cortex of rats. The Journal of pharmacology and experimental therapeutics. vol 270. issue 1. 1994-08-15. PMID:8035309. |
effects of chronic cocaine administration on [3h]dopamine uptake in the nucleus accumbens, striatum and frontal cortex of rats. |
1994-08-15 |
2023-08-12 |
rat |
| J M Masserano, D Venable, R J Wyat. Effects of chronic cocaine administration on [3H]dopamine uptake in the nucleus accumbens, striatum and frontal cortex of rats. The Journal of pharmacology and experimental therapeutics. vol 270. issue 1. 1994-08-15. PMID:8035309. |
the uptake of [3h]dopamine into synaptosomes obtained from the nucleus accumbens, striatum and frontal cortex was evaluated after chronic treatment with cocaine. |
1994-08-15 |
2023-08-12 |
rat |
| J M Masserano, D Venable, R J Wyat. Effects of chronic cocaine administration on [3H]dopamine uptake in the nucleus accumbens, striatum and frontal cortex of rats. The Journal of pharmacology and experimental therapeutics. vol 270. issue 1. 1994-08-15. PMID:8035309. |
chronic cocaine administration produced a significant decrease in the uptake of [3h]dopamine into the frontal cortex (49%) with no significant differences in the nucleus accumbens or striatum. |
1994-08-15 |
2023-08-12 |
rat |
| J M Masserano, D Venable, R J Wyat. Effects of chronic cocaine administration on [3H]dopamine uptake in the nucleus accumbens, striatum and frontal cortex of rats. The Journal of pharmacology and experimental therapeutics. vol 270. issue 1. 1994-08-15. PMID:8035309. |
no differences were produced in the ic50 values of gbr 12909 or cocaine for [3h] dopamine uptake after chronic cocaine treatment. |
1994-08-15 |
2023-08-12 |
rat |
| J M Masserano, D Venable, R J Wyat. Effects of chronic cocaine administration on [3H]dopamine uptake in the nucleus accumbens, striatum and frontal cortex of rats. The Journal of pharmacology and experimental therapeutics. vol 270. issue 1. 1994-08-15. PMID:8035309. |
these data indicate an inhibition effect of repeated cocaine administration on [3h]dopamine uptake in the frontal cortex of rats. |
1994-08-15 |
2023-08-12 |
rat |
| S B Caine, G F Koo. Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat. The Journal of pharmacology and experimental therapeutics. vol 270. issue 1. 1994-08-15. PMID:8035317. |
effects of dopamine d-1 and d-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat. |
1994-08-15 |
2023-08-12 |
rat |