| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J K Staley, W L Hearn, A J Ruttenber, C V Wetli, D C Mas. High affinity cocaine recognition sites on the dopamine transporter are elevated in fatal cocaine overdose victims. The Journal of pharmacology and experimental therapeutics. vol 271. issue 3. 1995-01-17. PMID:7996484. |
cocaine mediates its powerful reinforcement by binding to recognition sites on the dopamine (da) transporter. |
1995-01-17 |
2023-08-12 |
human |
| J K Staley, W L Hearn, A J Ruttenber, C V Wetli, D C Mas. High affinity cocaine recognition sites on the dopamine transporter are elevated in fatal cocaine overdose victims. The Journal of pharmacology and experimental therapeutics. vol 271. issue 3. 1995-01-17. PMID:7996484. |
the pharmacological identity of cocaine recognition sites and their relevance to dopamine transport function has remained unclear. |
1995-01-17 |
2023-08-12 |
human |
| L Wang, D K Pitt. Perinatal cocaine exposure decreases the number of spontaneously active midbrain dopamine neurons in neonatal rats. Synapse (New York, N.Y.). vol 17. issue 4. 1995-01-09. PMID:7992202. |
perinatal cocaine exposure decreases the number of spontaneously active midbrain dopamine neurons in neonatal rats. |
1995-01-09 |
2023-08-12 |
rat |
| S D Glick, J Raucci, S Wang, R W Keller, J N Carlso. Neurochemical predisposition to self-administer cocaine in rats: individual differences in dopamine and its metabolites. Brain research. vol 653. issue 1-2. 1995-01-03. PMID:7526957. |
neurochemical predisposition to self-administer cocaine in rats: individual differences in dopamine and its metabolites. |
1995-01-03 |
2023-08-12 |
rat |
| S D Glick, J Raucci, S Wang, R W Keller, J N Carlso. Neurochemical predisposition to self-administer cocaine in rats: individual differences in dopamine and its metabolites. Brain research. vol 653. issue 1-2. 1995-01-03. PMID:7526957. |
estimated extracellular levels of dopamine and its metabolites were measured bilaterally in the mesocorticolimbic and nigrostriatal systems of naive rats that were subsequently trained to self-administer cocaine intravenously. |
1995-01-03 |
2023-08-12 |
rat |
| S D Glick, J Raucci, S Wang, R W Keller, J N Carlso. Neurochemical predisposition to self-administer cocaine in rats: individual differences in dopamine and its metabolites. Brain research. vol 653. issue 1-2. 1995-01-03. PMID:7526957. |
there were several significant relationships between dopamine and dopamine metabolite (3,4-dihydroxyphenylacetic acid and homovanillic acid) levels and rates of cocaine self-administration during both acquisition and asymptotic phases of testing. |
1995-01-03 |
2023-08-12 |
rat |
| S V Kelkar, S Izenwasser, J L Katz, C L Klein, N Zhu, M L Trudel. Synthesis, cocaine receptor affinity, and dopamine uptake inhibition of several new 2 beta-substituted 3 beta-phenyltropanes. Journal of medicinal chemistry. vol 37. issue 23. 1994-12-29. PMID:7966147. |
synthesis, cocaine receptor affinity, and dopamine uptake inhibition of several new 2 beta-substituted 3 beta-phenyltropanes. |
1994-12-29 |
2023-08-12 |
Not clear |
| C S Maldonado-Irizarry, J R Stellar, A E Kelle. Effects of cocaine and GBR-12909 on brain stimulation reward. Pharmacology, biochemistry, and behavior. vol 48. issue 4. 1994-12-29. PMID:7972296. |
cocaine and gbr-12909, two dopamine reuptake blockers, were administered in a multiple current rate-frequency curve-shift test of intracranial self-stimulation (icss) reward in rats with medial forebrain bundle (mfb) electrodes. |
1994-12-29 |
2023-08-12 |
rat |
| S Saadouni, F Refahi-Lyamani, J Costentin, J J Bonne. Cocaine and GBR 12783 recognize nonidentical, overlapping binding domains on the dopamine neuronal carrier. European journal of pharmacology. vol 268. issue 2. 1994-12-21. PMID:7957640. |
cocaine and gbr 12783 recognize nonidentical, overlapping binding domains on the dopamine neuronal carrier. |
1994-12-21 |
2023-08-12 |
rat |
| S Saadouni, F Refahi-Lyamani, J Costentin, J J Bonne. Cocaine and GBR 12783 recognize nonidentical, overlapping binding domains on the dopamine neuronal carrier. European journal of pharmacology. vol 268. issue 2. 1994-12-21. PMID:7957640. |
treatment of the striatal membranes with n-ethylmaleimide resulted in a concentration-dependent reduction of the specific binding of [3h]gbr 12783 (1-[2-(diphenylmethoxy)ethyl]4-(3-phenyl-2-[1-3h]propenyl)-piperaz ine) which was significantly more marked than that of the specific binding of [3h]cocaine, the nonspecific binding of [3h]cocaine being measured with either cocaine or dopamine. |
1994-12-21 |
2023-08-12 |
rat |
| J R Nation, R T Burke. Attenuation of cocaine-induced elevation of nucleus accumbens dopamine in lead-exposed rats. Brain research bulletin. vol 35. issue 1. 1994-12-20. PMID:7953752. |
the results of this experiment showed that cocaine caused a significantly greater increase in extracellular nucleus accumbens dopamine in control animals relative to lead-treated animals. |
1994-12-20 |
2023-08-12 |
rat |
| R J Carey, E N Damianopoulos, G DePalm. Differential temporal dynamics of serum and brain cocaine: relationship to behavioral, neuroendocrine and neurochemical cocaine induced responses. Life sciences. vol 55. issue 22. 1994-12-15. PMID:7968250. |
neurochemical effects of cocaine upon limbic dopamine turnover and plasma corticosterone had a time course similar to serum cocaine. |
1994-12-15 |
2023-08-12 |
rat |
| D L Cameron, J T William. Cocaine inhibits GABA release in the VTA through endogenous 5-HT. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 11 Pt 1. 1994-12-06. PMID:7965077. |
it has been hypothesized that cocaine exerts its actions in the vta by blocking the reuptake of dopamine released from the dendrites of the a10 dopamine neurons, thus prolonging the actions of dopamine at d2 autoreceptors. |
1994-12-06 |
2023-08-12 |
Not clear |
| D L Cameron, J T William. Cocaine inhibits GABA release in the VTA through endogenous 5-HT. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 11 Pt 1. 1994-12-06. PMID:7965077. |
using intracellular recordings from midbrain dopamine neurons in a brain slice preparation, we have found that cocaine (0.1-10 microm) inhibited the gabab ipsp in a dose-dependent manner. |
1994-12-06 |
2023-08-12 |
Not clear |
| D L Cameron, J T William. Cocaine inhibits GABA release in the VTA through endogenous 5-HT. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 11 Pt 1. 1994-12-06. PMID:7965077. |
we conclude that cocaine acts to modulate the gaba input to a10 dopamine neurons via inhibition of the 5-ht transporter, increasing the concentration of 5-ht at presynaptic 5-ht1d receptors. |
1994-12-06 |
2023-08-12 |
Not clear |
| D L Cameron, J T William. Cocaine inhibits GABA release in the VTA through endogenous 5-HT. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 11 Pt 1. 1994-12-06. PMID:7965077. |
these actions of cocaine were apparent at lower concentrations than those required to act via inhibition of the dopamine transporter. |
1994-12-06 |
2023-08-12 |
Not clear |
| P Couceyro, K M Pollock, K Drews, J Douglas. Cocaine differentially regulates activator protein-1 mRNA levels and DNA-binding complexes in the rat striatum and cerebellum. Molecular pharmacology. vol 46. issue 4. 1994-12-06. PMID:7969045. |
pharmacological studies further reveal that the dopamine d1, dopamine d2, gamma-aminobutyric acid type b, and n-methyl-d-aspartate receptor systems mediate the effects of cocaine on cerebellar neurons, whereas striatal effects are modulated through d1 and n-methyl-d-aspartate receptors. |
1994-12-06 |
2023-08-12 |
rat |
| S P Berger, K Farrell, D Conant, E S Kempner, S M Pau. Radiation inactivation studies of the dopamine reuptake transporter protein. Molecular pharmacology. vol 46. issue 4. 1994-12-06. PMID:7969052. |
we conclude that the dopamine transporter protein is a homo- or hetero-oligomer when occupied in situ by uptake-blocking drugs like cocaine. |
1994-12-06 |
2023-08-12 |
Not clear |
| B A Faraj, D C Davis, V M Camp, A J Mooney, T Hollowa. The effect of cocaine abuse on plasma levels of sulfated dopamine and salsolinol in alcoholics. Alcohol (Fayetteville, N.Y.). vol 11. issue 4. 1994-12-01. PMID:7945989. |
the effect of cocaine abuse on plasma levels of sulfated dopamine and salsolinol in alcoholics. |
1994-12-01 |
2023-08-12 |
Not clear |
| B A Faraj, D C Davis, V M Camp, A J Mooney, T Hollowa. The effect of cocaine abuse on plasma levels of sulfated dopamine and salsolinol in alcoholics. Alcohol (Fayetteville, N.Y.). vol 11. issue 4. 1994-12-01. PMID:7945989. |
this study investigated the effect of cocaine abuse on peripheral dopamine and its tetrahydroisoquinoline metabolite salsolinol in chronic alcoholics. |
1994-12-01 |
2023-08-12 |
Not clear |