| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P M Callahan, R De La Garza, K A Cunningha. Discriminative stimulus properties of cocaine: modulation by dopamine D1 receptors in the nucleus accumbens. Psychopharmacology. vol 115. issue 1-2. 1995-03-20. PMID:7862881. |
dopamine (da) d1 and d2 receptors are involved in mediating the behavioral effects of cocaine, including its discriminative stimulus properties. |
1995-03-20 |
2023-08-12 |
rat |
| S Puglisi-Allegra, V Cestari, S Cabib, C Castellan. Strain-dependent effects of post-training cocaine or nomifensine on memory storage involve both D1 and D2 dopamine receptors. Psychopharmacology. vol 115. issue 1-2. 1995-03-20. PMID:7862889. |
strain-dependent effects of post-training cocaine or nomifensine on memory storage involve both d1 and d2 dopamine receptors. |
1995-03-20 |
2023-08-12 |
mouse |
| M S Hooks, P Duffy, C Striplin, P W Kaliva. Behavioral and neurochemical sensitization following cocaine self-administration. Psychopharmacology. vol 115. issue 1-2. 1995-03-20. PMID:7862906. |
neither the motor stimulant response nor the increase in extracellular dopamine following an acute cocaine challenge given after 24 h of withdrawal was different between rats which self-administered cocaine and yoked saline controls. |
1995-03-20 |
2023-08-12 |
rat |
| M S Hooks, P Duffy, C Striplin, P W Kaliva. Behavioral and neurochemical sensitization following cocaine self-administration. Psychopharmacology. vol 115. issue 1-2. 1995-03-20. PMID:7862906. |
however, when the cocaine challenge was given 21 days after discontinuing cocaine self-administration both the motor response and extracellular dopamine content in the ventral straitum were significantly augmented in rats that self-administered cocaine. |
1995-03-20 |
2023-08-12 |
rat |
| M S Hooks, P Duffy, C Striplin, P W Kaliva. Behavioral and neurochemical sensitization following cocaine self-administration. Psychopharmacology. vol 115. issue 1-2. 1995-03-20. PMID:7862906. |
while no correlation was observed between the average amount of cocaine self-administered each day and the cocaine-induced alterations in extracellular dopamine at either 24 h or 21 days of withdrawl, a significant positive correlation was measured between the increase in photocell counts and the average daily cocaine administration at 21 days of withdrawl. |
1995-03-20 |
2023-08-12 |
rat |
| J B Wang, A Moriwaki, G R Uh. Dopamine transporter cysteine mutants: second extracellular loop cysteines are required for transporter expression. Journal of neurochemistry. vol 64. issue 3. 1995-03-17. PMID:7861176. |
substitutions at positions 90, 242, 305, and 345 had no significant effect in decreasing dopamine uptake, mpp+ uptake, or cocaine analogue binding. |
1995-03-17 |
2023-08-12 |
Not clear |
| D J Ennulat, S m Babb, B M Cohe. Persistent reduction of immediate early gene mRNA in rat forebrain following single or multiple doses of cocaine. Brain research. Molecular brain research. vol 26. issue 1-2. 1995-03-16. PMID:7854036. |
previous studies have demonstrated that the iegs ngfi-a (zif268) and c-fos are each rapidly induced in the caudate putamen (cp) by treatment with the indirect dopamine agonist cocaine. |
1995-03-16 |
2023-08-12 |
rat |
| M P Paulus, C W Callaway, M A Geye. Quantitative assessment of the microstructure of rat behavior: II. Distinctive effects of dopamine releasers and uptake inhibitors. Psychopharmacology. vol 113. issue 2. 1995-03-16. PMID:7855180. |
the effects of four indirect dopamine agonists, d-amphetamine (0.25-4.0 mg/kg), cocaine (2.5-40.0 mg/kg), gbr 12909 (10.0-30.0 mg/kg), and nomifensine (5.0-20.0 mg/kg), on the behavioral organization of movements in an unconditioned motor paradigm were investigated in rats. |
1995-03-16 |
2023-08-12 |
rat |
| I M Maisonneuve, A Ho, M J Kree. Chronic administration of a cocaine "binge" alters basal extracellular levels in male rats: an in vivo microdialysis study. The Journal of pharmacology and experimental therapeutics. vol 272. issue 2. 1995-03-15. PMID:7853178. |
after 13 days of daily cocaine "binges," estimated basal dopamine levels were lowered in the ventromedial striatum: 10 mg/kg x 3: 3.32 +/- 0.52 nm (n = 9) vs. 5.50 +/- 1.28 nm (n = 7) (t test, p < .1), and 15 mg/kg x 3: 3.50 +/- 0.37 nm (n = 6) vs. 5.66 +/- 0.58 nm (n = 7) (p < .01); and in the dorsolateral striatum 10 mg/kg x 3: 7.17 +/- 0.55 nm (n = 9) vs. 9.54 +/- 1.08 nm (n = 7) (t test, p < .05), and 15 mg/kg x 3: 6.88 +/- 0.22 nm (n = 5) vs. 10.00 +/- 1.04 nm (n = 7) (t test, p < .03). |
1995-03-15 |
2023-08-12 |
rat |
| L J Porrino, H M Davies, S R Childer. Behavioral and local cerebral metabolic effects of the novel tropane analog, 2 beta-propanoyl-3 beta-(4-tolyl)-tropane. The Journal of pharmacology and experimental therapeutics. vol 272. issue 2. 1995-03-15. PMID:7853208. |
a novel cocaine analog, 2 beta-propanoyl-3 beta-(4-tolyl)-tropane (ptt), in which both esters have been removed, has been shown to be more potent at and more selective for dopamine transporters than cocaine. |
1995-03-15 |
2023-08-12 |
rat |
| B K Madras, M J Kaufma. Cocaine accumulates in dopamine-rich regions of primate brain after i.v. administration: comparison with mazindol distribution. Synapse (New York, N.Y.). vol 18. issue 3. 1995-03-14. PMID:7855738. |
pharmacological and neurochemical evidence suggest that brain dopamine systems, and the dopamine transporter in particular, contribute significantly to the behavioral effects and reinforcing properties of cocaine. |
1995-03-14 |
2023-08-12 |
monkey |
| J A Lago, T R Koste. Stimulant withdrawal. Addiction (Abingdon, England). vol 89. issue 11. 1995-03-08. PMID:7841859. |
another study using pet and f18-methylspiroperidol found decreased dopamine d2 receptor binding during cocaine withdrawal and also a separate study using pet and f-18-dopa discovered low dopaminergic brain activity. |
1995-03-08 |
2023-08-12 |
Not clear |
| M C Ritz, C R Mantione, E D Londo. Spermine interacts with cocaine binding sites on dopamine transporters. Psychopharmacology. vol 114. issue 1. 1995-03-08. PMID:7846207. |
spermine interacts with cocaine binding sites on dopamine transporters. |
1995-03-08 |
2023-08-12 |
Not clear |
| M C Ritz, C R Mantione, E D Londo. Spermine interacts with cocaine binding sites on dopamine transporters. Psychopharmacology. vol 114. issue 1. 1995-03-08. PMID:7846207. |
these studies were designed to assess the potential interaction of the polyamine spermine with cocaine binding to dopamine and serotonin transporters. |
1995-03-08 |
2023-08-12 |
Not clear |
| M C Ritz, C R Mantione, E D Londo. Spermine interacts with cocaine binding sites on dopamine transporters. Psychopharmacology. vol 114. issue 1. 1995-03-08. PMID:7846207. |
finally, saturation experiments show that the inhibition of ligand binding to the cocaine binding site on dopamine transporters appears not to be due to a modification of ligand affinity for the transporter, but to a decrease in the apparent density of ligand binding sites. |
1995-03-08 |
2023-08-12 |
Not clear |
| M C Ritz, C R Mantione, E D Londo. Spermine interacts with cocaine binding sites on dopamine transporters. Psychopharmacology. vol 114. issue 1. 1995-03-08. PMID:7846207. |
the results of these experiments indicate that endogenously produced polyamines can alter cocaine binding to the dopamine transporter. |
1995-03-08 |
2023-08-12 |
Not clear |
| S Izenwasser, P Terry, B Heller, J M Witkin, J L Kat. Differential relationships among dopamine transporter affinities and stimulant potencies of various uptake inhibitors. European journal of pharmacology. vol 263. issue 3. 1995-03-03. PMID:7843265. |
binding to the dopamine transporter and inhibiting dopamine reuptake are considered important factors in regulating behavioral effects of cocaine. |
1995-03-03 |
2023-08-12 |
mouse |
| S Izenwasser, P Terry, B Heller, J M Witkin, J L Kat. Differential relationships among dopamine transporter affinities and stimulant potencies of various uptake inhibitors. European journal of pharmacology. vol 263. issue 3. 1995-03-03. PMID:7843265. |
one prominent behavioral effect of cocaine and other dopamine uptake inhibitors is the stimulation of locomotor activity. |
1995-03-03 |
2023-08-12 |
mouse |
| S Izenwasser, P Terry, B Heller, J M Witkin, J L Kat. Differential relationships among dopamine transporter affinities and stimulant potencies of various uptake inhibitors. European journal of pharmacology. vol 263. issue 3. 1995-03-03. PMID:7843265. |
to examine the relationship between action at the dopamine transporter and behavior, the displacement of [3h]win 35,428 (cft naphthalene sulfate; 2-beta-carbomethoxy-3-beta-(4-fluorophenyl)tropane-1,5-naphthalene disulfonate) binding in rat caudate putamen by cocaine and other uptake inhibitors was compared with stimulation of mouse locomotor activity. |
1995-03-03 |
2023-08-12 |
mouse |
| S Izenwasser, P Terry, B Heller, J M Witkin, J L Kat. Differential relationships among dopamine transporter affinities and stimulant potencies of various uptake inhibitors. European journal of pharmacology. vol 263. issue 3. 1995-03-03. PMID:7843265. |
these findings provide evidence that cocaine analogs may bind to the dopamine transporter in a manner that is fundamentally different from that for structurally dissimilar uptake inhibitors. |
1995-03-03 |
2023-08-12 |
mouse |