| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N D Volkow, S J Gatley, J S Fowler, R Chen, J Logan, S L Dewey, Y S Ding, N Pappas, P King, R R MacGrego. Long-lasting inhibition of in vivo cocaine binding to dopamine transporters by 3 beta-(4-iodophenyl)tropane-2-carboxylic acid methyl ester: RTI-55 or beta CIT. Synapse (New York, N.Y.). vol 19. issue 3. 1995-07-18. PMID:7784960. |
cocaine analogs such as 3 beta-(4-iodophenyl)tropane-2 beta-carboxylic acid methyl ester (rti-55 or beta cit) with a higher affinity for the dopamine transporter (dat) may be potentially useful in interfering with cocaine's actions in brain. |
1995-07-18 |
2023-08-12 |
mouse |
| F J Seidler, S W Temple, E C McCook, T A Slotki. Cocaine inhibits central noradrenergic and dopaminergic activity during the critical developmental period in which catecholamines influence cell development. Brain research. Developmental brain research. vol 85. issue 1. 1995-07-14. PMID:7781166. |
neonatal rats (1, 7, 14 and 21 days old) were given cocaine (30 mg/kg) acutely and the turnover of norepinephrine and dopamine, a measure of synaptic activity, was evaluated in vivo in three different brain regions known to be adversely affected by cocaine. |
1995-07-14 |
2023-08-12 |
rat |
| D Clark, M Exner, L J Furmidge, K Svensson, C Sonesso. Effects of the dopamine autoreceptor antagonist (-)-DS121 on the discriminative stimulus properties of d-amphetamine and cocaine. European journal of pharmacology. vol 275. issue 1. 1995-07-10. PMID:7774664. |
effects of the dopamine autoreceptor antagonist (-)-ds121 on the discriminative stimulus properties of d-amphetamine and cocaine. |
1995-07-10 |
2023-08-12 |
rat |
| C A Schad, J B Justice, S G Holtzma. Naloxone reduces the neurochemical and behavioral effects of amphetamine but not those of cocaine. European journal of pharmacology. vol 275. issue 1. 1995-07-10. PMID:7774666. |
amphetamine and cocaine dose-dependently increased extracellular dopamine in both the nucleus accumbens and striatum. |
1995-07-10 |
2023-08-12 |
rat |
| F Refahi-Lyamani, S Saadouni, J Costentin, J J Bonne. Interaction of two sulfhydryl reagents with a cation recognition site on the neuronal dopamine carrier evidences small differences between [3H]GBR 12783 and [3H]cocaine binding sites. Naunyn-Schmiedeberg's archives of pharmacology. vol 351. issue 2. 1995-07-06. PMID:7770096. |
interaction of two sulfhydryl reagents with a cation recognition site on the neuronal dopamine carrier evidences small differences between [3h]gbr 12783 and [3h]cocaine binding sites. |
1995-07-06 |
2023-08-12 |
rat |
| F Refahi-Lyamani, S Saadouni, J Costentin, J J Bonne. Interaction of two sulfhydryl reagents with a cation recognition site on the neuronal dopamine carrier evidences small differences between [3H]GBR 12783 and [3H]cocaine binding sites. Naunyn-Schmiedeberg's archives of pharmacology. vol 351. issue 2. 1995-07-06. PMID:7770096. |
we have compared the effect of treating rat striatal cell membranes with ionic hydrophilic sulfhydryl reagents on the specific bindings of [3h]cocaine and of [3h]gbr 12783 (1-[2-(diphenylmethoxy)ethyl]4-(3-phenyl-2-[1-3h]propenyl)-piperaz ine) to the neuronal transporter of dopamine. |
1995-07-06 |
2023-08-12 |
rat |
| F Refahi-Lyamani, S Saadouni, J Costentin, J J Bonne. Interaction of two sulfhydryl reagents with a cation recognition site on the neuronal dopamine carrier evidences small differences between [3H]GBR 12783 and [3H]cocaine binding sites. Naunyn-Schmiedeberg's archives of pharmacology. vol 351. issue 2. 1995-07-06. PMID:7770096. |
some of these drugs (100 mumol/l dopamine, 1 mumol/l mazindol or 100 mumol/l cocaine) protected the specific binding of [3h]cocaine against the effects of phmbs, whereas 1 mmol/l p-tyramine, 10 mumol/l nomifensine and 10 nmol/l gbr 12783 were ineffective. |
1995-07-06 |
2023-08-12 |
rat |
| R S Mansbach, S A Jortani, R L Balste. Discriminative stimulus effects of esteratic local anesthetics in squirrel monkeys. European journal of pharmacology. vol 274. issue 1-3. 1995-07-05. PMID:7768269. |
doses of dimethocaine (1.7 mg/kg) and cocaine (0.3 mg/kg) which produced full (> 80%) substitution for cocaine were administered in combination with the dopamine d1 receptor antagonist sch 39166 ((-)-trans-6,7,7a,8,9,13b-hexahydro-3-chloro-2-hydroxy-n-methyl-5h -benzo [d]naphtho-(2,1-b)azepine) and the dopamine d2 receptor antagonist raclopride (both at 0.003-0.03 mg/kg). |
1995-07-05 |
2023-08-12 |
monkey |
| H Sershen, A Hashim, A Lajth. The effect of ibogaine on kappa-opioid- and 5-HT3-induced changes in stimulation-evoked dopamine release in vitro from striatum of C57BL/6By mice. Brain research bulletin. vol 36. issue 6. 1995-06-29. PMID:7757494. |
cocaine (10(-6) m), a dopamine uptake blocker, increased the electrically-evoked release of dopamine; ibogaine pretreatment did not affect the enhanced electrically-induced release of [3h]dopamine by in vitro cocaine. |
1995-06-29 |
2023-08-12 |
mouse |
| S R Jones, P A Garris, C D Kilts, R M Wightma. Comparison of dopamine uptake in the basolateral amygdaloid nucleus, caudate-putamen, and nucleus accumbens of the rat. Journal of neurochemistry. vol 64. issue 6. 1995-06-28. PMID:7760038. |
addition of a dopamine uptake inhibitor, cocaine or nomifensine (10 microm), to the perfusion buffer increased the apparent km value > 25-fold in slices of both the caudate-putamen and nucleus accumbens. |
1995-06-28 |
2023-08-12 |
rat |
| B Ferger, K Kuschinsk. Effects of morphine on EEG in rats and their possible relations to hypo- and hyperkinesia. Psychopharmacology. vol 117. issue 2. 1995-06-22. PMID:7753968. |
it was previously shown in rats that administration of cocaine or d-amphetamine in moderate doses produced alterations in eeg characteristic for activation of d1 dopamine receptors, whereas large doses induced alterations resembling activation of d2 dopamine receptors. |
1995-06-22 |
2023-08-12 |
rat |
| G S Robertson, M Jia. D1 and D2 dopamine receptors differentially increase Fos-like immunoreactivity in accumbal projections to the ventral pallidum and midbrain. Neuroscience. vol 64. issue 4. 1995-06-21. PMID:7753373. |
stimulants such as d-amphetamine and cocaine increase fos-like immunoreactivity by enhancing the activation of d1 dopamine receptors. |
1995-06-21 |
2023-08-12 |
Not clear |
| S E Hemby, T J Martin, C Co, S I Dworkin, J E Smit. The effects of intravenous heroin administration on extracellular nucleus accumbens dopamine concentrations as determined by in vivo microdialysis. The Journal of pharmacology and experimental therapeutics. vol 273. issue 2. 1995-06-19. PMID:7752060. |
in addition to the evidence from selective lesions and receptor antagonists, recent determinations of increased extracellular dopamine concentrations ([da]e) in this structure during cocaine and ethanol self-administration have extended this notion. |
1995-06-19 |
2023-08-12 |
rat |
| S E Hemby, C Co, D Reboussin, H M Davies, S I Dworkin, J E Smit. Comparison of a novel tropane analog of cocaine, 2 beta-propanoyl-3 beta-(4-tolyl) tropane with cocaine HCl in rats: nucleus accumbens extracellular dopamine concentration and motor activity. The Journal of pharmacology and experimental therapeutics. vol 273. issue 2. 1995-06-19. PMID:7752068. |
comparison of a novel tropane analog of cocaine, 2 beta-propanoyl-3 beta-(4-tolyl) tropane with cocaine hcl in rats: nucleus accumbens extracellular dopamine concentration and motor activity. |
1995-06-19 |
2023-08-12 |
rat |
| S E Hemby, C Co, D Reboussin, H M Davies, S I Dworkin, J E Smit. Comparison of a novel tropane analog of cocaine, 2 beta-propanoyl-3 beta-(4-tolyl) tropane with cocaine HCl in rats: nucleus accumbens extracellular dopamine concentration and motor activity. The Journal of pharmacology and experimental therapeutics. vol 273. issue 2. 1995-06-19. PMID:7752068. |
2 beta-propanoyl-3 beta-(4-tolyl) tropane (ptt) is a novel tropane that has been shown to be approximately 20 times more potent than cocaine in binding to the 3 beta-[4'-iodophenyl] tropane-2 beta-carboxylic acid methyl ester (rti-55) site on the dopamine transporter, an effect partially attributable to the methyl constituent at the para position on the phenyl ring. |
1995-06-19 |
2023-08-12 |
rat |
| H Steiner, C R Gerfe. Dynorphin opioid inhibition of cocaine-induced, D1 dopamine receptor-mediated immediate-early gene expression in the striatum. The Journal of comparative neurology. vol 353. issue 2. 1995-06-15. PMID:7745131. |
in the present experiments, we examined such a potential role for dynorphin by analyzing the influence of the dynorphin (kappa opioid receptor) agonist spiradoline on immediate-early gene induction by cocaine, and we determined that this immediate-early gene response is mediated by d1 dopamine receptors located in the striatum. |
1995-06-15 |
2023-08-12 |
rat |
| H Steiner, C R Gerfe. Dynorphin opioid inhibition of cocaine-induced, D1 dopamine receptor-mediated immediate-early gene expression in the striatum. The Journal of comparative neurology. vol 353. issue 2. 1995-06-15. PMID:7745131. |
these results demonstrate that, in striatum, immediate-early gene induction by cocaine is a d1 dopamine receptor-mediated process that is inhibited by activation of kappa opioid receptors. |
1995-06-15 |
2023-08-12 |
rat |
| R A Vaugha. Photoaffinity-labeled ligand binding domains on dopamine transporters identified by peptide mapping. Molecular pharmacology. vol 47. issue 5. 1995-06-12. PMID:7746282. |
binding domains on rat dopamine transporters for cocaine and 1-(2-diphenylmethoxy)ethyl-4-(3-phenylpropyl)piperazine compounds were identified using controlled proteolysis of photoaffinity-labeled protein and epitope-specific immunoprecipitation of the labeled fragments. |
1995-06-12 |
2023-08-12 |
rat |
| R A Vaugha. Photoaffinity-labeled ligand binding domains on dopamine transporters identified by peptide mapping. Molecular pharmacology. vol 47. issue 5. 1995-06-12. PMID:7746282. |
rat dopamine transporters were photoaffinity labeled with 1-[2-(diphenylmethoxy)ethyl]-4-[2-(4-azido- 3-[125i]iodophenyl)ethyl]piperazine ([125i]deep) [a 1-(2-di- phenylmethoxy)ethyl-4-(3-phenylpropyl)piperazine analog] or 3 beta-(p-chlorophenyl)tropane-2 beta-carboxylic acid, 4'-azido-3'- [125i]iodophenylethyl ester ([125i]rti 82) (a cocaine analog) and were gel purified to remove contaminating radioactivity. |
1995-06-12 |
2023-08-12 |
rat |
| D J Friedman, S P Duckle. Prejunctional interaction of alpha 2-adrenoceptors and D2 dopamine receptors on perivascular sympathetic nerves. Journal of autonomic pharmacology. vol 15. issue 1. 1995-06-09. PMID:7744888. |
in the presence of cocaine (10(-5)m), which enhanced stimulation-evoked tritium overflow, the d2 dopamine agonist n-0923 [(s)-(-) 2-(n-propyl-n-2-thienylethylamino)-5-hydroxytetralin] (10(-8)m) was less effective at inhibiting stimulation-evoked tritium overflow compared to inhibition in the absence of cocaine. |
1995-06-09 |
2023-08-12 |
rat |