| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E J Cline, C E Adams, G A Larson, G A Gerhardt, N R Zahnise. Medial dorsal striatum is more sensitive than lateral dorsal striatum to cocaine inhibition of exogenous dopamine clearance: relation to [3H]mazindol binding, but not striosome/matrix. Experimental neurology. vol 134. issue 1. 1995-10-18. PMID:7672034. |
medial dorsal striatum is more sensitive than lateral dorsal striatum to cocaine inhibition of exogenous dopamine clearance: relation to [3h]mazindol binding, but not striosome/matrix. |
1995-10-18 |
2023-08-12 |
Not clear |
| E J Cline, C E Adams, G A Larson, G A Gerhardt, N R Zahnise. Medial dorsal striatum is more sensitive than lateral dorsal striatum to cocaine inhibition of exogenous dopamine clearance: relation to [3H]mazindol binding, but not striosome/matrix. Experimental neurology. vol 134. issue 1. 1995-10-18. PMID:7672034. |
previous studies have shown that acute systemic cocaine inhibits dopamine (da) transport and thereby produces dose-dependent changes in exogenous da clearance in the brain. |
1995-10-18 |
2023-08-12 |
Not clear |
| D J Henry, F J Whit. The persistence of behavioral sensitization to cocaine parallels enhanced inhibition of nucleus accumbens neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 9. 1995-10-12. PMID:7666211. |
these findings suggest that cocaine sensitization is relatively persistent, but not necessarily permanent, and support the hypothesis that expression of behavioral sensitization to cocaine involves actions within the nac, particularly those mediated by dopamine d1 receptors. |
1995-10-12 |
2023-08-12 |
Not clear |
| J Broadbent, T M Gaspard, S I Dworki. Assessment of the discriminative stimulus effects of cocaine in the rat: lack of interaction with opioids. Pharmacology, biochemistry, and behavior. vol 51. issue 2-3. 1995-10-11. PMID:7667357. |
these results suggest that fentanyl and u50,488h, at doses that purportedly influence mesolimbic dopamine levels, do not alter the discriminative stimulus effects of cocaine. |
1995-10-11 |
2023-08-12 |
rat |
| M D Schechter, S M Meeha. Role of dopamine D1 receptors in cocaine lethality. Pharmacology, biochemistry, and behavior. vol 51. issue 2-3. 1995-10-11. PMID:7667379. |
role of dopamine d1 receptors in cocaine lethality. |
1995-10-11 |
2023-08-12 |
mouse |
| E N Damianopoulos, R J Care. Evidence for N-methyl-D-aspartate receptor mediation of cocaine induced corticosterone release and cocaine conditioned stimulant effects. Behavioural brain research. vol 68. issue 2. 1995-10-05. PMID:7654307. |
mk-801 did not alter serum or brain cocaine concentration or the cocaine effects on dopamine metabolism in limbic brain tissue. |
1995-10-05 |
2023-08-12 |
rat |
| J J Woodward, D M Compton, R L Balster, B R Marti. In vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter. European journal of pharmacology. vol 277. issue 1. 1995-09-14. PMID:7635175. |
in vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter. |
1995-09-14 |
2023-08-12 |
rat |
| J J Woodward, D M Compton, R L Balster, B R Marti. In vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter. European journal of pharmacology. vol 277. issue 1. 1995-09-14. PMID:7635175. |
the effects of selected local anesthetics on in vitro and in vivo measurements of dopamine transporter activity were determined to investigate the role of local anesthetic activity in the neuronal actions of cocaine. |
1995-09-14 |
2023-08-12 |
rat |
| J J Woodward, D M Compton, R L Balster, B R Marti. In vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter. European journal of pharmacology. vol 277. issue 1. 1995-09-14. PMID:7635175. |
cocaine inhibited [3h]2-beta-carbomethoxy-3-beta-(4-fluorophenyl)tropane 1.5-naphthalenedisulfonate (cft) binding and [3h]dopamine uptake with estimated ki and ic50 values of 0.6 microm and 0.7 micorm, respectively. |
1995-09-14 |
2023-08-12 |
rat |
| J J Woodward, D M Compton, R L Balster, B R Marti. In vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter. European journal of pharmacology. vol 277. issue 1. 1995-09-14. PMID:7635175. |
dimethocaine was only slightly less potent than cocaine with an estimated ki of 1.4 micorm and an ic50 value of 1.2 microm for [3h]cft binding and dopamine uptake. |
1995-09-14 |
2023-08-12 |
rat |
| J J Woodward, D M Compton, R L Balster, B R Marti. In vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter. European journal of pharmacology. vol 277. issue 1. 1995-09-14. PMID:7635175. |
a 10 min administration of cocaine, dimethocaine, or procaine in the dialysis solution produced dose-dependent, reversible increases in endogenous dopamine efflux from the striata of awake rats. |
1995-09-14 |
2023-08-12 |
rat |
| J J Woodward, D M Compton, R L Balster, B R Marti. In vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter. European journal of pharmacology. vol 277. issue 1. 1995-09-14. PMID:7635175. |
cocaine and dimethocaine produced similar 12-fold increases in dialysate dopamine at concentrations of 0.1 mm and 1 mm respectively. |
1995-09-14 |
2023-08-12 |
rat |
| A P Kozikowski, M K Eddine Saiah, K M Johnson, J S Bergman. Chemistry and biology of the 2 beta-alkyl-3 beta-phenyl analogues of cocaine: subnanomolar affinity ligands that suggest a new pharmacophore model at the C-2 position. Journal of medicinal chemistry. vol 38. issue 16. 1995-09-14. PMID:7636872. |
a series of 2 beta-alkyl-3 beta-phenyltropanes (i.e., the 2 beta-alkyl analogues of the win series) were prepared as analogues of cocaine and tested for their ability to displace [3h]mazindol binding and to inhibit high-affinity dopamine uptake into striatal nerve endings (synaptosomes). |
1995-09-14 |
2023-08-12 |
rat |
| K M Kantak, M A Edwards, R D Spealma. Effects of N-methyl-D-aspartate antagonists in rats discriminating different doses of cocaine: comparison with direct and indirect dopamine agonists. The Journal of pharmacology and experimental therapeutics. vol 274. issue 2. 1995-09-08. PMID:7636725. |
effects of n-methyl-d-aspartate antagonists in rats discriminating different doses of cocaine: comparison with direct and indirect dopamine agonists. |
1995-09-08 |
2023-08-12 |
human |
| K M Kantak, M A Edwards, R D Spealma. Effects of N-methyl-D-aspartate antagonists in rats discriminating different doses of cocaine: comparison with direct and indirect dopamine agonists. The Journal of pharmacology and experimental therapeutics. vol 274. issue 2. 1995-09-08. PMID:7636725. |
dose-response functions for selected n-methyl-d-aspartate (nmda) antagonists and direct and indirect dopamine agonists were compared in rats trained to discriminate either a low (2 mg/kg) or a high (10 mg/kg) dose of cocaine from vehicle. |
1995-09-08 |
2023-08-12 |
human |
| K M Kantak, M A Edwards, R D Spealma. Effects of N-methyl-D-aspartate antagonists in rats discriminating different doses of cocaine: comparison with direct and indirect dopamine agonists. The Journal of pharmacology and experimental therapeutics. vol 274. issue 2. 1995-09-08. PMID:7636725. |
the results show that change in the training dose of cocaine can affect both the shape and position of the dose-response functions for representative nmda-associated ion channel blockers and direct and indirect dopamine agonists. |
1995-09-08 |
2023-08-12 |
human |
| R C Pierce, P Duffy, P W Kaliva. Sensitization to cocaine and dopamine autoreceptor subsensitivity in the nucleus accumbens. Synapse (New York, N.Y.). vol 20. issue 1. 1995-08-31. PMID:7624827. |
sensitization to cocaine and dopamine autoreceptor subsensitivity in the nucleus accumbens. |
1995-08-31 |
2023-08-12 |
rat |
| R C Pierce, P Duffy, P W Kaliva. Sensitization to cocaine and dopamine autoreceptor subsensitivity in the nucleus accumbens. Synapse (New York, N.Y.). vol 20. issue 1. 1995-08-31. PMID:7624827. |
in order to evaluate this hypothesis, we administered cocaine to rats daily (15 mg/kg ip x 2 days, 30 mg/kg ip x 5 days) and then monitored nucleus accumbens dopamine during the local administration (through the dialysis probe) of the d2/d3 agonist, quinpirole (0, 0.1, 1, and 10 microm). |
1995-08-31 |
2023-08-12 |
rat |
| R C Pierce, P Duffy, P W Kaliva. Sensitization to cocaine and dopamine autoreceptor subsensitivity in the nucleus accumbens. Synapse (New York, N.Y.). vol 20. issue 1. 1995-08-31. PMID:7624827. |
our results indicate that, relative to saline-pretreated control animals, repeated cocaine administration impaired the ability of quinpirole to decrease extracellular dopamine 1-2 days after the last drug injection. |
1995-08-31 |
2023-08-12 |
rat |
| R C Pierce, P Duffy, P W Kaliva. Sensitization to cocaine and dopamine autoreceptor subsensitivity in the nucleus accumbens. Synapse (New York, N.Y.). vol 20. issue 1. 1995-08-31. PMID:7624827. |
these results demonstrate that repeated cocaine produces a short duration functional tolerance in the capacity of autoreceptor stimulation to inhibit accumbal dopamine release. |
1995-08-31 |
2023-08-12 |
rat |