| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S E Hyman, R L Cole, C Konradi, B E Kosofsk. Dopamine regulation of transcription factor-target interactions in rat striatum. Chemical senses. vol 20. issue 2. 1995-11-30. PMID:7583020. |
the indirect dopamine agonists, amphetamine and cocaine have been shown to induce expression of immediate early genes, such as c-fos, and neuropeptide genes, such as prodynorphin in the rat striatum. |
1995-11-30 |
2023-08-12 |
rat |
| J H Shah, S Izenwasser, B Geter-Douglass, J M Witkin, A H Newma. (+/-)-(N-alkylamino)benzazepine analogs: novel dopamine D1 receptor antagonists. Journal of medicinal chemistry. vol 38. issue 21. 1995-11-28. PMID:7473556. |
(+/-)-(n-alkylamino)benzazepine analogs were prepared as novel dopamine d1 receptor antagonists to further elucidate the role of these receptor subtypes in the pharmacology and toxicology of cocaine. |
1995-11-28 |
2023-08-12 |
rat |
| M Stathis, U Scheffel, S Z Lever, J W Boja, F I Carroll, M J Kuha. Rate of binding of various inhibitors at the dopamine transporter in vivo. Psychopharmacology. vol 119. issue 4. 1995-11-24. PMID:7480516. |
eleven cocaine analogs (rti-31, rti-32, rti-51, rti-55, rti-113, rti-114, rti-117, rti-120, rti-121, win 35,065-2, and win 35,428) as well as other dopamine uptake site blockers (bupropion, nomifensine, and methylphenidate) were compared with (-) cocaine for their rates of displacement of 3h-win 35,428 binding in vivo. |
1995-11-24 |
2023-08-12 |
mouse |
| G A Goodwin, L Rajachandran, C A Moody, R Francis, C M Kuhn, L P Spea. Effects of prenatal cocaine exposure on haloperidol-induced increases in prolactin release and dopamine turnover in weanling, periadolescent, and adult offspring. Neurotoxicology and teratology. vol 17. issue 4. 1995-11-22. PMID:7565497. |
effects of prenatal cocaine exposure on haloperidol-induced increases in prolactin release and dopamine turnover in weanling, periadolescent, and adult offspring. |
1995-11-22 |
2023-08-12 |
Not clear |
| R D Spealma. Noradrenergic involvement in the discriminative stimulus effects of cocaine in squirrel monkeys. The Journal of pharmacology and experimental therapeutics. vol 275. issue 1. 1995-11-21. PMID:7562595. |
the selective norepinephrine[fnc] uptake inhibitors talsupram, tomoxetine, nisoxetine and desipramine substituted for cocaine in the majority of subjects under the low-dose training condition, whereas the selective dopamine uptake inhibitor gbr 12909 [1-(2-[bis(4-fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl) piperazine] substituted for cocaine under both training conditions and the selective serotonin uptake inhibitor citalopram failed to substitute for cocaine under either condition. |
1995-11-21 |
2023-08-12 |
human |
| R D Spealma. Noradrenergic involvement in the discriminative stimulus effects of cocaine in squirrel monkeys. The Journal of pharmacology and experimental therapeutics. vol 275. issue 1. 1995-11-21. PMID:7562595. |
the results support a role for norepinephrine uptake and alpha-1 adrenoceptor mechanisms in the ds effects of cocaine, possibly reflecting a facilitory noradrenergic influence on mesocorticolimbic dopamine activity. |
1995-11-21 |
2023-08-12 |
human |
| B A Faraj, Z L Olkowski, R T Jackso. A cocaine-sensitive active dopamine transport in human lymphocytes. Biochemical pharmacology. vol 50. issue 7. 1995-11-21. PMID:7575655. |
the uptake of dopamine was blocked significantly in a concentration-dependent manner by cocaine and its congeners. |
1995-11-21 |
2023-08-12 |
human |
| B A Faraj, Z L Olkowski, R T Jackso. A cocaine-sensitive active dopamine transport in human lymphocytes. Biochemical pharmacology. vol 50. issue 7. 1995-11-21. PMID:7575655. |
furthermore, preliminary evidence is presented linking the possible relationship between decreased lymphocyte [3h]dopamine uptake and chronic cocaine abuse in humans. |
1995-11-21 |
2023-08-12 |
human |
| A H Newman, R H Kline, A C Allen, S Izenwasser, C George, J L Kat. Novel 4'-substituted and 4',4"-disubstituted 3 alpha-(diphenylmethoxy)tropane analogs as potent and selective dopamine uptake inhibitors. Journal of medicinal chemistry. vol 38. issue 20. 1995-11-08. PMID:7562926. |
the present data coupled with the observed differences from cocaine in structure-activity relationships suggested that the 3 alpha-(diphenylmethoxy)tropane analogs may be interacting at a different active site than cocaine on the dopamine transporter and that an additional binding domain might be exploited for the identification of potential therapeutics for the treatment of cocaine abuse. |
1995-11-08 |
2023-08-12 |
rat |
| S R White, G C Harris, K M Imel, M J Wheato. Inhibitory effects of dopamine and methylenedioxymethamphetamine (MDMA) on glutamate-evoked firing of nucleus accumbens and caudate/putamen cells are enhanced following cocaine self-administration. Brain research. vol 681. issue 1-2. 1995-11-06. PMID:7552276. |
inhibitory effects of dopamine and methylenedioxymethamphetamine (mdma) on glutamate-evoked firing of nucleus accumbens and caudate/putamen cells are enhanced following cocaine self-administration. |
1995-11-06 |
2023-08-12 |
rat |
| S R White, G C Harris, K M Imel, M J Wheato. Inhibitory effects of dopamine and methylenedioxymethamphetamine (MDMA) on glutamate-evoked firing of nucleus accumbens and caudate/putamen cells are enhanced following cocaine self-administration. Brain research. vol 681. issue 1-2. 1995-11-06. PMID:7552276. |
one to 11 days after the last cocaine exposure, rats were anesthetized with urethane and effects of microiontophoretically-applied dopamine on glutamate-evoked firing of neurons in the nucleus accumbens and in the caudate/putamen were tested. |
1995-11-06 |
2023-08-12 |
rat |
| S R White, G C Harris, K M Imel, M J Wheato. Inhibitory effects of dopamine and methylenedioxymethamphetamine (MDMA) on glutamate-evoked firing of nucleus accumbens and caudate/putamen cells are enhanced following cocaine self-administration. Brain research. vol 681. issue 1-2. 1995-11-06. PMID:7552276. |
dopamine produced a dose-dependent inhibition of glutamate-evoked firing in both the nucleus accumbens and the caudate/putamen of rats that had been repeatedly exposed to self-administered cocaine and in control rats. |
1995-11-06 |
2023-08-12 |
rat |
| S R White, G C Harris, K M Imel, M J Wheato. Inhibitory effects of dopamine and methylenedioxymethamphetamine (MDMA) on glutamate-evoked firing of nucleus accumbens and caudate/putamen cells are enhanced following cocaine self-administration. Brain research. vol 681. issue 1-2. 1995-11-06. PMID:7552276. |
the cocaine self-administration group was significantly sensitized to the inhibitory effects of dopamine in both early (1-3 day) and later (9-11 days) periods of cocaine abstinence. |
1995-11-06 |
2023-08-12 |
rat |
| M R Serper, M Alpert, N A Richardson, S Dickson, M H Allen, A Werne. Clinical effects of recent cocaine use on patients with acute schizophrenia. The American journal of psychiatry. vol 152. issue 10. 1995-10-31. PMID:7573585. |
dopamine function has been hypothesized to be involved in both producing schizophrenic symptoms and mediating cocaine's reinforcing properties. |
1995-10-31 |
2023-08-12 |
Not clear |
| S J Gatley, N D Volkow, J S Fowler, S L Dewey, J Loga. Sensitivity of striatal [11C]cocaine binding to decreases in synaptic dopamine. Synapse (New York, N.Y.). vol 20. issue 2. 1995-10-26. PMID:7570343. |
sensitivity of striatal [11c]cocaine binding to decreases in synaptic dopamine. |
1995-10-26 |
2023-08-12 |
human |
| S J Gatley, N D Volkow, J S Fowler, S L Dewey, J Loga. Sensitivity of striatal [11C]cocaine binding to decreases in synaptic dopamine. Synapse (New York, N.Y.). vol 20. issue 2. 1995-10-26. PMID:7570343. |
we have previously shown that tracer concentrations of [11c]cocaine binding to the dopamine transporter (dat) in human and baboon striatum can be visualized using positron emission tomography (pet). |
1995-10-26 |
2023-08-12 |
human |
| S J Gatley, N D Volkow, J S Fowler, S L Dewey, J Loga. Sensitivity of striatal [11C]cocaine binding to decreases in synaptic dopamine. Synapse (New York, N.Y.). vol 20. issue 2. 1995-10-26. PMID:7570343. |
to determine whether the concentration of dopamine normally present in the synaptic cleft can compete with [11c]cocaine for transporter binding sites, we conducted baboon pet studies with drugs (sodium 4-hydroxybutyrate, four studies, 200 mg/kg; gamma-vinylgaba, three studies, 300 mg/kg; and citalopram, three studies, 2 mg/kg) expected to decrease synaptic dopamine. |
1995-10-26 |
2023-08-12 |
human |
| A N Schoffelmeer, T J De Vries, L J Vanderschuren, G H Tjon, P Nestby, G Wardeh, A H Mulde. Glucocorticoid receptor activation potentiates the morphine-induced adaptive increase in dopamine D-1 receptor efficacy in gamma-aminobutyric acid neurons of rat striatum/nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 274. issue 3. 1995-10-25. PMID:7562482. |
these data show that the morphine-induced adaptive increase of postsynaptic dopamine d-1 receptor efficacy (also observed in striatal slices of rats weeks after repeated treatment with morphine or cocaine) is strongly enhanced after previous or simultaneous glucocorticoid receptor activation. |
1995-10-25 |
2023-08-12 |
rat |
| N K Mello, S S Negus, S E Lukas, J H Mendelson, J W Sholar, J Driez. A primate model of polydrug abuse: cocaine and heroin combinations. The Journal of pharmacology and experimental therapeutics. vol 274. issue 3. 1995-10-25. PMID:7562505. |
pretreatment with a dopamine antagonist, flupenthixol (0.018 mg/kg), antagonized the discriminative stimulus effects of cocaine but did not affect the cocaine-like effects of heroin. |
1995-10-25 |
2023-08-12 |
monkey |
| P A Garris, R M Wightma. Distinct pharmacological regulation of evoked dopamine efflux in the amygdala and striatum of the rat in vivo. Synapse (New York, N.Y.). vol 20. issue 3. 1995-10-25. PMID:7570359. |
dopamine uptake inhibitors, nomifensine (25 mg/kg) and cocaine (20 mg/kg), and the dopamine receptor antagonist, haloperidol (0.5 mg/kg), robustly increased evoked extracellular dopamine in the cp. |
1995-10-25 |
2023-08-12 |
rat |