| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R C Pierce, P W Kaliva. Amphetamine produces sensitized increases in locomotion and extracellular dopamine preferentially in the nucleus accumbens shell of rats administered repeated cocaine. The Journal of pharmacology and experimental therapeutics. vol 275. issue 2. 1995-12-19. PMID:7473128. |
in the core at early withdrawal there was tolerance to the amphetamine-induced increase in extracellular dopamine in the cocaine group, whereas there was no difference between the repeated saline and cocaine groups at late withdrawal. |
1995-12-19 |
2023-08-12 |
rat |
| M F Suaud-Chagny, C Dugast, K Chergui, M Msghina, F Gono. Uptake of dopamine released by impulse flow in the rat mesolimbic and striatal systems in vivo. Journal of neurochemistry. vol 65. issue 6. 1995-12-15. PMID:7595557. |
inhibition of dopamine uptake by nomifensine (2-20 mg/kg), gbr 12909 (20 mg/kg), cocaine (20 mg/kg), mazindol (10 mg/kg), or bupropion (25 mg/kg) enhanced this decay time by up to +602%. |
1995-12-15 |
2023-08-12 |
rat |
| M P Kung, W D Essman, D Frederick, S Meegalla, M Goodman, M Mu, I Lucki, H F Kun. IPT: a novel iodinated ligand for the CNS dopamine transporter. Synapse (New York, N.Y.). vol 20. issue 4. 1995-12-14. PMID:7482291. |
an iodinated cocaine derivative, n-(3'-iodopropen-2'-yl)-2 beta-carbomethoxy-3 beta-(4-chlorophenyl) tropane (ipt), was evaluated as a probe for in vitro and in vivo labeling of dopamine (da) and serotonin (5-ht) transporters in sprague-dawley rat brain. |
1995-12-14 |
2023-08-12 |
rat |
| M Daras, L Kakkouras, A J Tuchman, B S Koppe. Rhabdomyolysis and hyperthermia after cocaine abuse: a variant of the neuroleptic malignant syndrome? Acta neurologica Scandinavica. vol 92. issue 2. 1995-12-12. PMID:7484066. |
since chronic cocaine use may alter the availability of dopamine either through transmitter depletion or decrease in the number of dopamine receptors, a common pathogenetic mechanism is possible. |
1995-12-12 |
2023-08-12 |
Not clear |
| M L Paul, R W Currie, H A Robertso. Priming of a D1 dopamine receptor behavioural response is dissociated from striatal immediate-early gene activity. Neuroscience. vol 66. issue 2. 1995-12-07. PMID:7477877. |
repeated administration of direct-acting (apomorphine, skf-38393, quinpirole) or indirect-acting (amphetamine, cocaine) dopaminergic agonists can produce enhancement of locomotor and sterotypic behaviours in response to subsequent dopamine agonist challenge. |
1995-12-07 |
2023-08-12 |
rat |
| R A Wise, P Newton, K Leeb, B Burnette, D Pocock, J B Justic. Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats. Psychopharmacology. vol 120. issue 1. 1995-12-07. PMID:7480530. |
fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats. |
1995-12-07 |
2023-08-12 |
rat |
| R A Wise, P Newton, K Leeb, B Burnette, D Pocock, J B Justic. Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats. Psychopharmacology. vol 120. issue 1. 1995-12-07. PMID:7480530. |
fluctuations in extracellular dopamine and dopac levels in nucleus accumbens septi (nas) were monitored in 1-min microdialysis samples taken from rats engaged in intravenous cocaine self-administration. |
1995-12-07 |
2023-08-12 |
rat |
| R A Wise, P Newton, K Leeb, B Burnette, D Pocock, J B Justic. Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats. Psychopharmacology. vol 120. issue 1. 1995-12-07. PMID:7480530. |
regardless of the dosing regimen, extracellular dopamine levels were tonically elevated by 200-800% within the cocaine self-administration periods, fluctuating phasically within this range between responses. |
1995-12-07 |
2023-08-12 |
rat |
| R A Wise, P Newton, K Leeb, B Burnette, D Pocock, J B Justic. Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats. Psychopharmacology. vol 120. issue 1. 1995-12-07. PMID:7480530. |
in the variable dose condition greater increases in dopamine and longer inter-response times followed injections of the higher doses; dopamine fluctuations were consistent with the multiple-infusion pharmacokinetics of cocaine. |
1995-12-07 |
2023-08-12 |
rat |
| R A Wise, P Newton, K Leeb, B Burnette, D Pocock, J B Justic. Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats. Psychopharmacology. vol 120. issue 1. 1995-12-07. PMID:7480530. |
these data are consistent with the hypothesis that falling dopamine levels trigger successive responses in the intravenous cocaine self-administration paradigm, but inconsistent with the notion that extracellular dopamine levels are depleted at the times within sessions when the animal initiates drug-seeking responses. |
1995-12-07 |
2023-08-12 |
rat |
| A Smith, M Piercey, D C Robert. Effect of (-)-DS 121 and (+)-UH 232 on cocaine self-administration in rats. Psychopharmacology. vol 120. issue 1. 1995-12-07. PMID:7480540. |
the novel dopamine autoreceptor antagonists (-)-ds 121 and (+)-uh 232 were tested for their ability to alter cocaine self-administration behavior in rats reinforced on a progressive ratio (pr) schedule. |
1995-12-07 |
2023-08-12 |
rat |
| R N Iyer, J B Nobiletti, P I Jatlow, C W Bradberr. Cocaine and cocaethylene: effects on extracellular dopamine in the primate. Psychopharmacology. vol 120. issue 2. 1995-12-07. PMID:7480546. |
cocaine and cocaethylene: effects on extracellular dopamine in the primate. |
1995-12-07 |
2023-08-12 |
monkey |
| J B Acri, S R Carter, K Alling, B Geter-Douglass, D Dijkstra, H Wikström, J L Katz, J M Witki. Assessment of cocaine-like discriminative stimulus effects of dopamine D3 receptor ligands. European journal of pharmacology. vol 281. issue 2. 1995-12-07. PMID:7589197. |
the highly selective dopamine d3 receptor ligand, (+)-pd 128907 4ar10br-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2h5h[4,3- b]-1,4- oxazin-9-ol), and other dopamine d3 receptor ligands, (+/-)-7-hydroxy-2-(n,n-di-n-propylamino)tetralin and (+)-7-hydroxy-2-(n,n-di-n-propylamino)tetralin, substituted for the discriminative stimulus effects of cocaine in rats, an animal model of subjective effects in humans. |
1995-12-07 |
2023-08-12 |
rat |
| J B Acri, S R Carter, K Alling, B Geter-Douglass, D Dijkstra, H Wikström, J L Katz, J M Witki. Assessment of cocaine-like discriminative stimulus effects of dopamine D3 receptor ligands. European journal of pharmacology. vol 281. issue 2. 1995-12-07. PMID:7589197. |
these results suggest that dopamine d3 receptors may be involved in the subjective effects of cocaine, and therefore may be a target for the discovery of treatments for cocaine dependence. |
1995-12-07 |
2023-08-12 |
rat |
| S E Hyman, R L Cole, C Konradi, B E Kosofsk. Dopamine regulation of transcription factor-target interactions in rat striatum. Chemical senses. vol 20. issue 2. 1995-11-30. PMID:7583020. |
the indirect dopamine agonists, amphetamine and cocaine have been shown to induce expression of immediate early genes, such as c-fos, and neuropeptide genes, such as prodynorphin in the rat striatum. |
1995-11-30 |
2023-08-12 |
rat |
| J H Shah, S Izenwasser, B Geter-Douglass, J M Witkin, A H Newma. (+/-)-(N-alkylamino)benzazepine analogs: novel dopamine D1 receptor antagonists. Journal of medicinal chemistry. vol 38. issue 21. 1995-11-28. PMID:7473556. |
(+/-)-(n-alkylamino)benzazepine analogs were prepared as novel dopamine d1 receptor antagonists to further elucidate the role of these receptor subtypes in the pharmacology and toxicology of cocaine. |
1995-11-28 |
2023-08-12 |
rat |
| M Stathis, U Scheffel, S Z Lever, J W Boja, F I Carroll, M J Kuha. Rate of binding of various inhibitors at the dopamine transporter in vivo. Psychopharmacology. vol 119. issue 4. 1995-11-24. PMID:7480516. |
eleven cocaine analogs (rti-31, rti-32, rti-51, rti-55, rti-113, rti-114, rti-117, rti-120, rti-121, win 35,065-2, and win 35,428) as well as other dopamine uptake site blockers (bupropion, nomifensine, and methylphenidate) were compared with (-) cocaine for their rates of displacement of 3h-win 35,428 binding in vivo. |
1995-11-24 |
2023-08-12 |
mouse |
| G A Goodwin, L Rajachandran, C A Moody, R Francis, C M Kuhn, L P Spea. Effects of prenatal cocaine exposure on haloperidol-induced increases in prolactin release and dopamine turnover in weanling, periadolescent, and adult offspring. Neurotoxicology and teratology. vol 17. issue 4. 1995-11-22. PMID:7565497. |
effects of prenatal cocaine exposure on haloperidol-induced increases in prolactin release and dopamine turnover in weanling, periadolescent, and adult offspring. |
1995-11-22 |
2023-08-12 |
Not clear |
| R D Spealma. Noradrenergic involvement in the discriminative stimulus effects of cocaine in squirrel monkeys. The Journal of pharmacology and experimental therapeutics. vol 275. issue 1. 1995-11-21. PMID:7562595. |
the selective norepinephrine[fnc] uptake inhibitors talsupram, tomoxetine, nisoxetine and desipramine substituted for cocaine in the majority of subjects under the low-dose training condition, whereas the selective dopamine uptake inhibitor gbr 12909 [1-(2-[bis(4-fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl) piperazine] substituted for cocaine under both training conditions and the selective serotonin uptake inhibitor citalopram failed to substitute for cocaine under either condition. |
1995-11-21 |
2023-08-12 |
human |
| R D Spealma. Noradrenergic involvement in the discriminative stimulus effects of cocaine in squirrel monkeys. The Journal of pharmacology and experimental therapeutics. vol 275. issue 1. 1995-11-21. PMID:7562595. |
the results support a role for norepinephrine uptake and alpha-1 adrenoceptor mechanisms in the ds effects of cocaine, possibly reflecting a facilitory noradrenergic influence on mesocorticolimbic dopamine activity. |
1995-11-21 |
2023-08-12 |
human |