| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B A Faraj, Z L Olkowski, R T Jackso. A cocaine-sensitive active dopamine transport in human lymphocytes. Biochemical pharmacology. vol 50. issue 7. 1995-11-21. PMID:7575655. |
the uptake of dopamine was blocked significantly in a concentration-dependent manner by cocaine and its congeners. |
1995-11-21 |
2023-08-12 |
human |
| B A Faraj, Z L Olkowski, R T Jackso. A cocaine-sensitive active dopamine transport in human lymphocytes. Biochemical pharmacology. vol 50. issue 7. 1995-11-21. PMID:7575655. |
furthermore, preliminary evidence is presented linking the possible relationship between decreased lymphocyte [3h]dopamine uptake and chronic cocaine abuse in humans. |
1995-11-21 |
2023-08-12 |
human |
| A H Newman, R H Kline, A C Allen, S Izenwasser, C George, J L Kat. Novel 4'-substituted and 4',4"-disubstituted 3 alpha-(diphenylmethoxy)tropane analogs as potent and selective dopamine uptake inhibitors. Journal of medicinal chemistry. vol 38. issue 20. 1995-11-08. PMID:7562926. |
the present data coupled with the observed differences from cocaine in structure-activity relationships suggested that the 3 alpha-(diphenylmethoxy)tropane analogs may be interacting at a different active site than cocaine on the dopamine transporter and that an additional binding domain might be exploited for the identification of potential therapeutics for the treatment of cocaine abuse. |
1995-11-08 |
2023-08-12 |
rat |
| S R White, G C Harris, K M Imel, M J Wheato. Inhibitory effects of dopamine and methylenedioxymethamphetamine (MDMA) on glutamate-evoked firing of nucleus accumbens and caudate/putamen cells are enhanced following cocaine self-administration. Brain research. vol 681. issue 1-2. 1995-11-06. PMID:7552276. |
inhibitory effects of dopamine and methylenedioxymethamphetamine (mdma) on glutamate-evoked firing of nucleus accumbens and caudate/putamen cells are enhanced following cocaine self-administration. |
1995-11-06 |
2023-08-12 |
rat |
| S R White, G C Harris, K M Imel, M J Wheato. Inhibitory effects of dopamine and methylenedioxymethamphetamine (MDMA) on glutamate-evoked firing of nucleus accumbens and caudate/putamen cells are enhanced following cocaine self-administration. Brain research. vol 681. issue 1-2. 1995-11-06. PMID:7552276. |
one to 11 days after the last cocaine exposure, rats were anesthetized with urethane and effects of microiontophoretically-applied dopamine on glutamate-evoked firing of neurons in the nucleus accumbens and in the caudate/putamen were tested. |
1995-11-06 |
2023-08-12 |
rat |
| S R White, G C Harris, K M Imel, M J Wheato. Inhibitory effects of dopamine and methylenedioxymethamphetamine (MDMA) on glutamate-evoked firing of nucleus accumbens and caudate/putamen cells are enhanced following cocaine self-administration. Brain research. vol 681. issue 1-2. 1995-11-06. PMID:7552276. |
dopamine produced a dose-dependent inhibition of glutamate-evoked firing in both the nucleus accumbens and the caudate/putamen of rats that had been repeatedly exposed to self-administered cocaine and in control rats. |
1995-11-06 |
2023-08-12 |
rat |
| S R White, G C Harris, K M Imel, M J Wheato. Inhibitory effects of dopamine and methylenedioxymethamphetamine (MDMA) on glutamate-evoked firing of nucleus accumbens and caudate/putamen cells are enhanced following cocaine self-administration. Brain research. vol 681. issue 1-2. 1995-11-06. PMID:7552276. |
the cocaine self-administration group was significantly sensitized to the inhibitory effects of dopamine in both early (1-3 day) and later (9-11 days) periods of cocaine abstinence. |
1995-11-06 |
2023-08-12 |
rat |
| M R Serper, M Alpert, N A Richardson, S Dickson, M H Allen, A Werne. Clinical effects of recent cocaine use on patients with acute schizophrenia. The American journal of psychiatry. vol 152. issue 10. 1995-10-31. PMID:7573585. |
dopamine function has been hypothesized to be involved in both producing schizophrenic symptoms and mediating cocaine's reinforcing properties. |
1995-10-31 |
2023-08-12 |
Not clear |
| S J Gatley, N D Volkow, J S Fowler, S L Dewey, J Loga. Sensitivity of striatal [11C]cocaine binding to decreases in synaptic dopamine. Synapse (New York, N.Y.). vol 20. issue 2. 1995-10-26. PMID:7570343. |
sensitivity of striatal [11c]cocaine binding to decreases in synaptic dopamine. |
1995-10-26 |
2023-08-12 |
human |
| S J Gatley, N D Volkow, J S Fowler, S L Dewey, J Loga. Sensitivity of striatal [11C]cocaine binding to decreases in synaptic dopamine. Synapse (New York, N.Y.). vol 20. issue 2. 1995-10-26. PMID:7570343. |
we have previously shown that tracer concentrations of [11c]cocaine binding to the dopamine transporter (dat) in human and baboon striatum can be visualized using positron emission tomography (pet). |
1995-10-26 |
2023-08-12 |
human |
| S J Gatley, N D Volkow, J S Fowler, S L Dewey, J Loga. Sensitivity of striatal [11C]cocaine binding to decreases in synaptic dopamine. Synapse (New York, N.Y.). vol 20. issue 2. 1995-10-26. PMID:7570343. |
to determine whether the concentration of dopamine normally present in the synaptic cleft can compete with [11c]cocaine for transporter binding sites, we conducted baboon pet studies with drugs (sodium 4-hydroxybutyrate, four studies, 200 mg/kg; gamma-vinylgaba, three studies, 300 mg/kg; and citalopram, three studies, 2 mg/kg) expected to decrease synaptic dopamine. |
1995-10-26 |
2023-08-12 |
human |
| A N Schoffelmeer, T J De Vries, L J Vanderschuren, G H Tjon, P Nestby, G Wardeh, A H Mulde. Glucocorticoid receptor activation potentiates the morphine-induced adaptive increase in dopamine D-1 receptor efficacy in gamma-aminobutyric acid neurons of rat striatum/nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 274. issue 3. 1995-10-25. PMID:7562482. |
these data show that the morphine-induced adaptive increase of postsynaptic dopamine d-1 receptor efficacy (also observed in striatal slices of rats weeks after repeated treatment with morphine or cocaine) is strongly enhanced after previous or simultaneous glucocorticoid receptor activation. |
1995-10-25 |
2023-08-12 |
rat |
| N K Mello, S S Negus, S E Lukas, J H Mendelson, J W Sholar, J Driez. A primate model of polydrug abuse: cocaine and heroin combinations. The Journal of pharmacology and experimental therapeutics. vol 274. issue 3. 1995-10-25. PMID:7562505. |
pretreatment with a dopamine antagonist, flupenthixol (0.018 mg/kg), antagonized the discriminative stimulus effects of cocaine but did not affect the cocaine-like effects of heroin. |
1995-10-25 |
2023-08-12 |
monkey |
| P A Garris, R M Wightma. Distinct pharmacological regulation of evoked dopamine efflux in the amygdala and striatum of the rat in vivo. Synapse (New York, N.Y.). vol 20. issue 3. 1995-10-25. PMID:7570359. |
dopamine uptake inhibitors, nomifensine (25 mg/kg) and cocaine (20 mg/kg), and the dopamine receptor antagonist, haloperidol (0.5 mg/kg), robustly increased evoked extracellular dopamine in the cp. |
1995-10-25 |
2023-08-12 |
rat |
| G J Wang, N D Volkow, J S Fowler, Y S Ding, J Logan, S J Gatley, R R MacGregor, A P Wol. Comparison of two pet radioligands for imaging extrastriatal dopamine transporters in human brain. Life sciences. vol 57. issue 14. 1995-10-23. PMID:7564877. |
we compared the sensitivity of two dopamine transporter (dat) ligands ([c-11]cocaine and [c-11]d-threo-methylphenidate) for measurement of extrastriatal dat availability using positron emission tomography (pet) on separated groups of 10 age matched male volunteers (age range, 21-49 years). |
1995-10-23 |
2023-08-12 |
human |
| R D Spealma. Discriminative stimulus effects of cocaine in squirrel monkeys: lack of antagonism by the dopamine D2 partial agonists terguride, SDZ 208-911, and SDZ 208-912. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675840. |
discriminative stimulus effects of cocaine in squirrel monkeys: lack of antagonism by the dopamine d2 partial agonists terguride, sdz 208-911, and sdz 208-912. |
1995-10-19 |
2023-08-12 |
monkey |
| R D Spealma. Discriminative stimulus effects of cocaine in squirrel monkeys: lack of antagonism by the dopamine D2 partial agonists terguride, SDZ 208-911, and SDZ 208-912. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675840. |
the effects of cocaine alone and after pretreatment with the dopamine d2 partial agonists terguride, sdz 208-911, and sdz 208-912 were determined in squirrel monkeys trained to discriminate cocaine from saline using a two-lever drug discrimination procedure. |
1995-10-19 |
2023-08-12 |
monkey |
| S R Tell. Effects of monoamine reuptake inhibitors on cocaine self-administration in rats. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675844. |
these data indicate that the acute enhancement of endogenous dopaminergic activity by pretreatment with dopamine reuptake inhibitor reduces the total intake of cocaine, thus supporting the hypothesis that the dopamine is critically involved in the reinforcing properties of cocaine. |
1995-10-19 |
2023-08-12 |
rat |
| P M Callahan, S K Bryan, K A Cunningha. Discriminative stimulus effects of cocaine: antagonism by dopamine D1 receptor blockade in the amygdala. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675856. |
discriminative stimulus effects of cocaine: antagonism by dopamine d1 receptor blockade in the amygdala. |
1995-10-19 |
2023-08-12 |
rat |
| P M Callahan, S K Bryan, K A Cunningha. Discriminative stimulus effects of cocaine: antagonism by dopamine D1 receptor blockade in the amygdala. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675856. |
mesolimbic dopamine (da) d1 and d2 receptors appear to be involved in mediating the discriminative stimulus effects of cocaine. |
1995-10-19 |
2023-08-12 |
rat |