| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G J Wang, N D Volkow, J S Fowler, Y S Ding, J Logan, S J Gatley, R R MacGregor, A P Wol. Comparison of two pet radioligands for imaging extrastriatal dopamine transporters in human brain. Life sciences. vol 57. issue 14. 1995-10-23. PMID:7564877. |
we compared the sensitivity of two dopamine transporter (dat) ligands ([c-11]cocaine and [c-11]d-threo-methylphenidate) for measurement of extrastriatal dat availability using positron emission tomography (pet) on separated groups of 10 age matched male volunteers (age range, 21-49 years). |
1995-10-23 |
2023-08-12 |
human |
| R D Spealma. Discriminative stimulus effects of cocaine in squirrel monkeys: lack of antagonism by the dopamine D2 partial agonists terguride, SDZ 208-911, and SDZ 208-912. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675840. |
discriminative stimulus effects of cocaine in squirrel monkeys: lack of antagonism by the dopamine d2 partial agonists terguride, sdz 208-911, and sdz 208-912. |
1995-10-19 |
2023-08-12 |
monkey |
| R D Spealma. Discriminative stimulus effects of cocaine in squirrel monkeys: lack of antagonism by the dopamine D2 partial agonists terguride, SDZ 208-911, and SDZ 208-912. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675840. |
the effects of cocaine alone and after pretreatment with the dopamine d2 partial agonists terguride, sdz 208-911, and sdz 208-912 were determined in squirrel monkeys trained to discriminate cocaine from saline using a two-lever drug discrimination procedure. |
1995-10-19 |
2023-08-12 |
monkey |
| S R Tell. Effects of monoamine reuptake inhibitors on cocaine self-administration in rats. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675844. |
these data indicate that the acute enhancement of endogenous dopaminergic activity by pretreatment with dopamine reuptake inhibitor reduces the total intake of cocaine, thus supporting the hypothesis that the dopamine is critically involved in the reinforcing properties of cocaine. |
1995-10-19 |
2023-08-12 |
rat |
| P M Callahan, S K Bryan, K A Cunningha. Discriminative stimulus effects of cocaine: antagonism by dopamine D1 receptor blockade in the amygdala. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675856. |
discriminative stimulus effects of cocaine: antagonism by dopamine d1 receptor blockade in the amygdala. |
1995-10-19 |
2023-08-12 |
rat |
| P M Callahan, S K Bryan, K A Cunningha. Discriminative stimulus effects of cocaine: antagonism by dopamine D1 receptor blockade in the amygdala. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675856. |
mesolimbic dopamine (da) d1 and d2 receptors appear to be involved in mediating the discriminative stimulus effects of cocaine. |
1995-10-19 |
2023-08-12 |
rat |
| K Shimosato, R J Marley, T Sait. Differential effects of NMDA receptor and dopamine receptor antagonists on cocaine toxicities. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675859. |
the present study examined the involvement of the n-methyl-d-aspartate (nmda) subtype of the glutamate receptors and the dopamine d1 and d2 receptors in seizure activity and lethality observed following single and repeated injections of cocaine in ddy mice. |
1995-10-19 |
2023-08-12 |
mouse |
| K Shimosato, R J Marley, T Sait. Differential effects of NMDA receptor and dopamine receptor antagonists on cocaine toxicities. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675859. |
on the other hand, treatment with 0.1-0.5 mg/kg of the dopamine d1 receptor antagonist, sch 23390, not only prolonged the latency to 90 mg/kg cocaine-induced seizures but also delayed the development of sensitization to the convulsant effects of cocaine. |
1995-10-19 |
2023-08-12 |
mouse |
| H Kuribar. Modification of cocaine sensitization by dopamine D1 and D2 receptor antagonists in terms of ambulation in mice. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675862. |
modification of cocaine sensitization by dopamine d1 and d2 receptor antagonists in terms of ambulation in mice. |
1995-10-19 |
2023-08-12 |
mouse |
| H Kuribar. Modification of cocaine sensitization by dopamine D1 and D2 receptor antagonists in terms of ambulation in mice. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675862. |
the progressive enhancement in the ambulation increase caused by the repeated five-time dosings of cocaine (10 mg/kg sc) at 3- to 4-day intervals was dose dependently reduced by simultaneous administration with the selective dopamine d1 and d2 receptor antagonists, sch 23390; r(+)-7-chloro-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine (0.01, 0.03, and 0.1 mg/kg sc) and ym-09151-2 (nemonapride); cis-n-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4- methylaminobenzamide (0.01, 0.03, and 0.1 mg/kg sc), respectively. |
1995-10-19 |
2023-08-12 |
mouse |
| H Kuribar. Modification of cocaine sensitization by dopamine D1 and D2 receptor antagonists in terms of ambulation in mice. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675862. |
the present results suggest that the blockade of dopamine d1 receptors is responsible for a significant enhancement in the cocaine sensitization, independent of the timings of its administration, whereas the blockade of dopamine d2 receptors elicits time-dependent alterations in the cocaine sensitization, a strong enhancement in the simultaneous administration schedule, but a slight retardation in the early posttreatment schedule. |
1995-10-19 |
2023-08-12 |
mouse |
| M R Weed, A S Mackevicius, J Kebabian, W L Woolverto. Reinforcing and discriminative stimulus effects of beta-CIT in rhesus monkeys. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675883. |
beta-cit (also designated rti-55) is one of a series of 2 beta-carbomethoxy-3 beta-phenyltropane cocaine analogues that have recently been synthesized for characterizing the dopamine transporter and its function. |
1995-10-19 |
2023-08-12 |
monkey |
| E J Cline, C E Adams, G A Larson, G A Gerhardt, N R Zahnise. Medial dorsal striatum is more sensitive than lateral dorsal striatum to cocaine inhibition of exogenous dopamine clearance: relation to [3H]mazindol binding, but not striosome/matrix. Experimental neurology. vol 134. issue 1. 1995-10-18. PMID:7672034. |
medial dorsal striatum is more sensitive than lateral dorsal striatum to cocaine inhibition of exogenous dopamine clearance: relation to [3h]mazindol binding, but not striosome/matrix. |
1995-10-18 |
2023-08-12 |
Not clear |
| E J Cline, C E Adams, G A Larson, G A Gerhardt, N R Zahnise. Medial dorsal striatum is more sensitive than lateral dorsal striatum to cocaine inhibition of exogenous dopamine clearance: relation to [3H]mazindol binding, but not striosome/matrix. Experimental neurology. vol 134. issue 1. 1995-10-18. PMID:7672034. |
previous studies have shown that acute systemic cocaine inhibits dopamine (da) transport and thereby produces dose-dependent changes in exogenous da clearance in the brain. |
1995-10-18 |
2023-08-12 |
Not clear |
| D J Henry, F J Whit. The persistence of behavioral sensitization to cocaine parallels enhanced inhibition of nucleus accumbens neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 9. 1995-10-12. PMID:7666211. |
these findings suggest that cocaine sensitization is relatively persistent, but not necessarily permanent, and support the hypothesis that expression of behavioral sensitization to cocaine involves actions within the nac, particularly those mediated by dopamine d1 receptors. |
1995-10-12 |
2023-08-12 |
Not clear |
| J Broadbent, T M Gaspard, S I Dworki. Assessment of the discriminative stimulus effects of cocaine in the rat: lack of interaction with opioids. Pharmacology, biochemistry, and behavior. vol 51. issue 2-3. 1995-10-11. PMID:7667357. |
these results suggest that fentanyl and u50,488h, at doses that purportedly influence mesolimbic dopamine levels, do not alter the discriminative stimulus effects of cocaine. |
1995-10-11 |
2023-08-12 |
rat |
| M D Schechter, S M Meeha. Role of dopamine D1 receptors in cocaine lethality. Pharmacology, biochemistry, and behavior. vol 51. issue 2-3. 1995-10-11. PMID:7667379. |
role of dopamine d1 receptors in cocaine lethality. |
1995-10-11 |
2023-08-12 |
mouse |
| E N Damianopoulos, R J Care. Evidence for N-methyl-D-aspartate receptor mediation of cocaine induced corticosterone release and cocaine conditioned stimulant effects. Behavioural brain research. vol 68. issue 2. 1995-10-05. PMID:7654307. |
mk-801 did not alter serum or brain cocaine concentration or the cocaine effects on dopamine metabolism in limbic brain tissue. |
1995-10-05 |
2023-08-12 |
rat |
| J J Woodward, D M Compton, R L Balster, B R Marti. In vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter. European journal of pharmacology. vol 277. issue 1. 1995-09-14. PMID:7635175. |
in vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter. |
1995-09-14 |
2023-08-12 |
rat |
| J J Woodward, D M Compton, R L Balster, B R Marti. In vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter. European journal of pharmacology. vol 277. issue 1. 1995-09-14. PMID:7635175. |
the effects of selected local anesthetics on in vitro and in vivo measurements of dopamine transporter activity were determined to investigate the role of local anesthetic activity in the neuronal actions of cocaine. |
1995-09-14 |
2023-08-12 |
rat |