| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S B Caine, S C Heinrichs, V L Coffin, G F Koo. Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat. Brain research. vol 692. issue 1-2. 1996-02-20. PMID:8548319. |
effects of the dopamine d-1 antagonist sch 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat. |
1996-02-20 |
2023-08-12 |
rat |
| S B Caine, S C Heinrichs, V L Coffin, G F Koo. Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat. Brain research. vol 692. issue 1-2. 1996-02-20. PMID:8548319. |
this study tested the hypothesis that blockade of d-1 dopamine receptors in the nucleus accumbens shell, central nucleus of the amygdala or dorsal striatum by intracerebral microinjection of the dopamine antagonist sch 23390 produces an attenuation of the effects of self-administered cocaine. |
1996-02-20 |
2023-08-12 |
rat |
| S B Caine, S C Heinrichs, V L Coffin, G F Koo. Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat. Brain research. vol 692. issue 1-2. 1996-02-20. PMID:8548319. |
these results support a role for d-1 dopamine receptors in the nucleus accumbens and amygdala in the effects of self-administered cocaine, and suggest that d-1 receptors in certain portions of the 'extended amygdala' may be an important substrate for the reinforcing actions of cocaine. |
1996-02-20 |
2023-08-12 |
rat |
| P D Mozley, J B Stubbs, H J Kim, W McElgin, M P Kung, S Meegalla, H F Kun. Dosimetry of an iodine-123-labeled tropane to image dopamine transporters. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 37. issue 1. 1996-02-13. PMID:8543985. |
n-(3-iodopropen-2-yl)-2 beta-carbomethoxy-3 beta-(4-chlorophenyl)tropane (ipt) is an analog of cocaine that selectively binds the presynaptic dopamine transporter. |
1996-02-13 |
2023-08-12 |
human |
| C L Coulter, H K Happe, D A Bergman, L C Murri. Localization and quantification of the dopamine transporter: comparison of [3H]WIN 35,428 and [125I]RTI-55. Brain research. vol 690. issue 2. 1996-02-07. PMID:8535839. |
this transporter is a specific marker for dopamine terminals and is a primary site for cns actions of cocaine. |
1996-02-07 |
2023-08-12 |
rat |
| C A Crawford, S A McDougall, C A Bolanos, S Hall, S P Berge. The effects of the kappa agonist U-50,488 on cocaine-induced conditioned and unconditioned behaviors and Fos immunoreactivity. Psychopharmacology. vol 120. issue 4. 1996-02-07. PMID:8539319. |
it was predicted that kappa agonist treatment would block the unconditioned and conditioned behaviors produced by cocaine (an indirect dopamine agonist). |
1996-02-07 |
2023-08-12 |
rat |
| X H Wang, P Levitt, D R Grayson, E H Murph. Intrauterine cocaine exposure of rabbits: persistent elevation of GABA-immunoreactive neurons in anterior cingulate cortex but not visual cortex. Brain research. vol 689. issue 1. 1996-01-30. PMID:8528704. |
in addition, acc receives dense dopaminergic innervation and cocaine's action in inhibiting the re-uptake of dopamine is believed to underly the rewarding properties of cocaine. |
1996-01-30 |
2023-08-12 |
rabbit |
| J E Sasaki, T A Tatham, J E Barret. The discriminative stimulus effects of methamphetamine in pigeons. Psychopharmacology. vol 120. issue 3. 1996-01-19. PMID:8524978. |
substitution tests revealed drug-appropriate responding following administration of the psychomotor stimulants methamphetamine, amphetamine and cocaine, the dopamine (da) reuptake inhibitor bupropion, norepinephrine (ne) reuptake inhibitors imipramine and tomoxetine, and the serotonin (5-ht) releaser fenfluramine. |
1996-01-19 |
2023-08-12 |
Not clear |
| D L Pruitt, C A Bolanos, S A McDougal. Effects of dopamine D1 and D2 receptor antagonists on cocaine-induced place preference conditioning in preweanling rats. European journal of pharmacology. vol 283. issue 1-3. 1996-01-18. PMID:7498301. |
during six experiments, 10- and 17-day-old rats (age at initial conditioning) were injected intraperitoneally with either saline, the dopamine d1 receptor antagonist r(+/-)-sch 23390 hydrochloride (0.01-1.0 mg/kg), or the dopamine d2 receptor antagonists (+/-)-sulpiride (1-100 mg/kg) or s(-)-eticlopride hydrochloride (0.1-0.5 mg/kg) 30 min prior to being injected with cocaine hydrochloride (20 mg/kg) or saline. |
1996-01-18 |
2023-08-12 |
rat |
| C Freed, R Revay, R A Vaughan, E Kriek, S Grant, G R Uhl, M J Kuha. Dopamine transporter immunoreactivity in rat brain. The Journal of comparative neurology. vol 359. issue 2. 1996-01-18. PMID:7499533. |
the dopamine transporter (dat) is a primary site for the action of cocaine in inducing euphoria. |
1996-01-18 |
2023-08-12 |
rat |
| W L Thomas, E S Cooke, R P Hamme. Pretreatment with a dopamine D1-receptor antagonist prevents metabolic activation by cocaine. Neuroscience letters. vol 196. issue 3. 1996-01-18. PMID:7501273. |
pretreatment with a dopamine d1-receptor antagonist prevents metabolic activation by cocaine. |
1996-01-18 |
2023-08-12 |
rat |
| W L Thomas, E S Cooke, R P Hamme. Pretreatment with a dopamine D1-receptor antagonist prevents metabolic activation by cocaine. Neuroscience letters. vol 196. issue 3. 1996-01-18. PMID:7501273. |
these results suggest that activity in striatonigral circuits is induced by stimulation of d1-like receptors by dopamine in the presence of acute cocaine. |
1996-01-18 |
2023-08-12 |
rat |
| J T Kuikka, K Akerman, K A Bergström, J Karhu, J Hiltunen, J Haukka, J Heikkinen, J Tiihonen, S Wang, J L Neumeye. Iodine-123 labelled N-(2-fluoroethyl)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)nortropane for dopamine transporter imaging in the living human brain. European journal of nuclear medicine. vol 22. issue 7. 1996-01-17. PMID:7498231. |
there are several cocaine analogs which have potential for imaging the dopamine transporters (dat). |
1996-01-17 |
2023-08-12 |
human |
| F Rougé-Pont, M Marinelli, M Le Moal, H Simon, P V Piazz. Stress-induced sensitization and glucocorticoids. II. Sensitization of the increase in extracellular dopamine induced by cocaine depends on stress-induced corticosterone secretion. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 11. 1995-12-26. PMID:7472473. |
sensitization of the increase in extracellular dopamine induced by cocaine depends on stress-induced corticosterone secretion. |
1995-12-26 |
2023-08-12 |
rat |
| F Rougé-Pont, M Marinelli, M Le Moal, H Simon, P V Piazz. Stress-induced sensitization and glucocorticoids. II. Sensitization of the increase in extracellular dopamine induced by cocaine depends on stress-induced corticosterone secretion. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 11. 1995-12-26. PMID:7472473. |
in order to investigate the mechanisms of this interaction between glucocorticoids and dopamine, we studied the sensitization of the increase in extracellular concentration of dopamine induced by cocaine in male rats in which corticosterone secretion was either intact or blocked. |
1995-12-26 |
2023-08-12 |
rat |
| F Rougé-Pont, M Marinelli, M Le Moal, H Simon, P V Piazz. Stress-induced sensitization and glucocorticoids. II. Sensitization of the increase in extracellular dopamine induced by cocaine depends on stress-induced corticosterone secretion. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 11. 1995-12-26. PMID:7472473. |
it was found that metyrapone (100 mg/kg s.c. twice a day for 8 d) suppressed stress-induced sensitization of the increase in accumbens dopamine induced by cocaine (10 mg/kg, i.p.) |
1995-12-26 |
2023-08-12 |
rat |
| F Rougé-Pont, M Marinelli, M Le Moal, H Simon, P V Piazz. Stress-induced sensitization and glucocorticoids. II. Sensitization of the increase in extracellular dopamine induced by cocaine depends on stress-induced corticosterone secretion. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 11. 1995-12-26. PMID:7472473. |
in conclusion, our results suggest that glucocorticoids modify sensitization of the behavioral effects of cocaine by acting on extracellular concentrations of dopamine. |
1995-12-26 |
2023-08-12 |
rat |
| O K Ronnekleiv, B R Naylo. Chronic cocaine exposure in the fetal rhesus monkey: consequences for early development of dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 11. 1995-12-26. PMID:7472487. |
chronic cocaine exposure in the fetal rhesus monkey: consequences for early development of dopamine neurons. |
1995-12-26 |
2023-08-12 |
monkey |
| S M Antelman, A R Caggiula, S Kiss, D J Edwards, D Kocan, R Stille. Neurochemical and physiological effects of cocaine oscillate with sequential drug treatment: possibly a major factor in drug variability. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 12. issue 4. 1995-12-22. PMID:7576006. |
we report that for a wide array of endpoints-amphetamine-evoked, in vitro striatal dopamine efflux, amphetamine and k(+)-evoked efflux of heart norepinephrine and nonevoked plasma levels of corticosterone and glucose-repeated, in vivo cocaine (15 mg/kg ip) administration to male rats precipitated successive oscillations in the magnitude or direction of the organism's responsiveness to subsequent cocaine administration. |
1995-12-22 |
2023-08-12 |
rat |
| R C Pierce, P W Kaliva. Amphetamine produces sensitized increases in locomotion and extracellular dopamine preferentially in the nucleus accumbens shell of rats administered repeated cocaine. The Journal of pharmacology and experimental therapeutics. vol 275. issue 2. 1995-12-19. PMID:7473128. |
amphetamine produces sensitized increases in locomotion and extracellular dopamine preferentially in the nucleus accumbens shell of rats administered repeated cocaine. |
1995-12-19 |
2023-08-12 |
rat |