| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F E Pontieri, G Tanda, G Di Chiar. Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 26. 1996-06-07. PMID:8618890. |
the present study investigated the effect in freely moving rats of intravenous cocaine, amphetamine, and morphine on extracellular dopamine concentrations in the nucleus accumbens shell and core by means of microdialysis with vertically implanted concentric probes. |
1996-06-07 |
2023-08-12 |
rat |
| F E Pontieri, G Tanda, G Di Chiar. Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 26. 1996-06-07. PMID:8618890. |
morphine, at 0.2 and 0.4 mg/kg, and cocaine, at 0.5 mg/kg, increased extracellular dopamine selectivity in the shell. |
1996-06-07 |
2023-08-12 |
rat |
| F E Pontieri, G Tanda, G Di Chiar. Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 26. 1996-06-07. PMID:8618890. |
higher doses of cocaine (1.0 mg/kg) and the lowest dose of amphetamine tested (0.125 mg/kg) increased extracellular dopamine both in the shell and in the core, but the effect was significantly more pronounced in the shell compared with the core. |
1996-06-07 |
2023-08-12 |
rat |
| J B Acri, B K Siedleck, J M Witki. Effects of benztropine on behavioral and toxic effects of cocaine: comparison with atropine and the selective dopamine uptake inhibitor 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-propyl)-piperazine. The Journal of pharmacology and experimental therapeutics. vol 277. issue 1. 1996-06-06. PMID:8613919. |
effects of benztropine on behavioral and toxic effects of cocaine: comparison with atropine and the selective dopamine uptake inhibitor 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-propyl)-piperazine. |
1996-06-06 |
2023-08-12 |
mouse |
| J B Acri, B K Siedleck, J M Witki. Effects of benztropine on behavioral and toxic effects of cocaine: comparison with atropine and the selective dopamine uptake inhibitor 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-propyl)-piperazine. The Journal of pharmacology and experimental therapeutics. vol 277. issue 1. 1996-06-06. PMID:8613919. |
behavioral effects of cocaine that are relevant to its abuse have been associated with pharmacological actions at the dopamine uptake carrier. |
1996-06-06 |
2023-08-12 |
mouse |
| J B Acri, B K Siedleck, J M Witki. Effects of benztropine on behavioral and toxic effects of cocaine: comparison with atropine and the selective dopamine uptake inhibitor 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-propyl)-piperazine. The Journal of pharmacology and experimental therapeutics. vol 277. issue 1. 1996-06-06. PMID:8613919. |
benztropine (cogentin) is an antiparkinson agent that has limited abuse despite its ability to block dopamine uptake, and has been suggested as a candidate for the treatment of cocaine dependence. |
1996-06-06 |
2023-08-12 |
mouse |
| R M Carelli, S A Deadwyle. Dose-dependent transitions in nucleus accumbens cell firing and behavioral responding during cocaine self-administration sessions in rats. The Journal of pharmacology and experimental therapeutics. vol 277. issue 1. 1996-06-06. PMID:8613945. |
pretreatment with the dopamine d1 receptor antagonist sch23390 (5 or 10 microgram/kg) prolonged the onset of na patterned discharges, similar to responding for low doses of cocaine (0.08 and 0.16 mg/inf. |
1996-06-06 |
2023-08-12 |
rat |
| L W Fitzgerald, J Ortiz, A G Hamedani, E J Nestle. Drugs of abuse and stress increase the expression of GluR1 and NMDAR1 glutamate receptor subunits in the rat ventral tegmental area: common adaptations among cross-sensitizing agents. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 1. 1996-06-03. PMID:8613793. |
we therefore examined the effect of repeated cocaine treatment on glutamate receptor subunit expression in central dopamine (da) pathways implicated in many of cocaine's behavioral actions. |
1996-06-03 |
2023-08-12 |
rat |
| Z de Saint Hilaire, A Python, G Blanc, Y Charnay, J M Gaillar. Effects of WIN 35,428 a potent antagonist of dopamine transporter on sleep and locomotor activity in rats. Neuroreport. vol 6. issue 16. 1996-04-18. PMID:8595198. |
the new cocaine derivative cft naphthalene sulphonate (win 35,428), has been shown to have a considerably longer duration of action and greater potency than cocaine as a central stimulant and it appears to have a similar mode of action on dopamine (da) systems. |
1996-04-18 |
2023-08-12 |
rat |
| T Kano, Y Suzuki, M Shibuya, K Kiuchi, M Hagiwar. Cocaine-induced CREB phosphorylation and c-Fos expression are suppressed in Parkinsonism model mice. Neuroreport. vol 6. issue 16. 1996-04-18. PMID:8595201. |
cocaine exerts multiple neurochemical effects in the central nervous system through inhibition of the dopamine transporter at the synapse. |
1996-04-18 |
2023-08-12 |
mouse |
| B S Kolachana, R C Saunders, D R Weinberge. Augmentation of prefrontal cortical monoaminergic activity inhibits dopamine release in the caudate nucleus: an in vivo neurochemical assessment in the rhesus monkey. Neuroscience. vol 69. issue 3. 1996-04-18. PMID:8596654. |
increase of monoaminergic activity by infusion of either d-amphetamine (100 microm) or cocaine hydrochloride (100 microm) resulted in a gradual and prolonged decrease in caudate nucleus dopamine levels. |
1996-04-18 |
2023-08-12 |
monkey |
| B M Prasad, B A Sorg, C Ulibarri, P W Kaliva. Sensitization to stress and psychostimulants. Involvement of dopamine transmission versus the HPA axis. Annals of the New York Academy of Sciences. vol 771. 1996-04-17. PMID:8597435. |
this behavioral cross-sensitization between stress (repeated mild footshock) and cocaine (15 mg/kg, ip) is associated with an increase in extracellular dopamine in the nucleus accumbens, but a decrease in the prefrontal cortex. |
1996-04-17 |
2023-08-12 |
rat |
| J Chen, R Marmur, W Paredes, A Pulles, E L Gardne. Systemic cocaine challenge after chronic cocaine treatment reveals sensitization of extracellular dopamine levels in nucleus accumbens but direct cocaine perfusion into nucleus accumbens does not: implications for the neural locus of cocaine sensitization. Life sciences. vol 58. issue 8. 1996-04-10. PMID:8594313. |
systemic cocaine challenge after chronic cocaine treatment reveals sensitization of extracellular dopamine levels in nucleus accumbens but direct cocaine perfusion into nucleus accumbens does not: implications for the neural locus of cocaine sensitization. |
1996-04-10 |
2023-08-12 |
rat |
| J Chen, R Marmur, W Paredes, A Pulles, E L Gardne. Systemic cocaine challenge after chronic cocaine treatment reveals sensitization of extracellular dopamine levels in nucleus accumbens but direct cocaine perfusion into nucleus accumbens does not: implications for the neural locus of cocaine sensitization. Life sciences. vol 58. issue 8. 1996-04-10. PMID:8594313. |
on the next day, rats were challenged with an acute dose of cocaine administered by one of two routes (systemic or intracranial), and extra-cellular dopamine (da) in the nucleus accumbens (acb) was measured by in vivo microdialysis. |
1996-04-10 |
2023-08-12 |
rat |
| M Y Li, Q S Yan, L L Coffey, M E Reit. Extracellular dopamine, norepinephrine, and serotonin in the nucleus accumbens of freely moving rats during intracerebral dialysis with cocaine and other monoamine uptake blockers. Journal of neurochemistry. vol 66. issue 2. 1996-04-03. PMID:8592125. |
extracellular dopamine, norepinephrine, and serotonin in the nucleus accumbens of freely moving rats during intracerebral dialysis with cocaine and other monoamine uptake blockers. |
1996-04-03 |
2023-08-12 |
rat |
| M Y Li, Q S Yan, L L Coffey, M E Reit. Extracellular dopamine, norepinephrine, and serotonin in the nucleus accumbens of freely moving rats during intracerebral dialysis with cocaine and other monoamine uptake blockers. Journal of neurochemistry. vol 66. issue 2. 1996-04-03. PMID:8592125. |
cocaine increased all three amines with the greatest effects on dopamine and serotonin. |
1996-04-03 |
2023-08-12 |
rat |
| M Y Li, Q S Yan, L L Coffey, M E Reit. Extracellular dopamine, norepinephrine, and serotonin in the nucleus accumbens of freely moving rats during intracerebral dialysis with cocaine and other monoamine uptake blockers. Journal of neurochemistry. vol 66. issue 2. 1996-04-03. PMID:8592125. |
the present results suggest a contribution of the increase in norepinephrine, but not serotonin, to the enhancement of dopamine after cocaine applied focally in the nucleus accumbens. |
1996-04-03 |
2023-08-12 |
rat |
| I Ushijima, M A Carino, A Horit. Involvement of D1 and D2 dopamine systems in the behavioral effects of cocaine in rats. Pharmacology, biochemistry, and behavior. vol 52. issue 4. 1996-03-27. PMID:8587913. |
involvement of d1 and d2 dopamine systems in the behavioral effects of cocaine in rats. |
1996-03-27 |
2023-08-12 |
rat |
| I Ushijima, M A Carino, A Horit. Involvement of D1 and D2 dopamine systems in the behavioral effects of cocaine in rats. Pharmacology, biochemistry, and behavior. vol 52. issue 4. 1996-03-27. PMID:8587913. |
the increases of locomotion and rearing, head circling, and body shaking induced by cocaine may involve the indirect activation of postsynaptic d1 and d2 receptors, presumably via dopamine release, resulting from inhibition of the presynaptic d2 receptors. |
1996-03-27 |
2023-08-12 |
rat |
| I Ushijima, M A Carino, A Horit. Involvement of D1 and D2 dopamine systems in the behavioral effects of cocaine in rats. Pharmacology, biochemistry, and behavior. vol 52. issue 4. 1996-03-27. PMID:8587913. |
these results also provide evidence that the indirect stimulation of postsynaptic d2 receptors by cocaine (20 mg/kg) is insufficient to induce stereotyped behaviors, and that the role of dopamine d1 receptors in mediating the behavioral actions of acute cocaine appears to be more important than that of d2 receptors. |
1996-03-27 |
2023-08-12 |
rat |