| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z de Saint Hilaire, A Python, G Blanc, Y Charnay, J M Gaillar. Effects of WIN 35,428 a potent antagonist of dopamine transporter on sleep and locomotor activity in rats. Neuroreport. vol 6. issue 16. 1996-04-18. PMID:8595198. |
the new cocaine derivative cft naphthalene sulphonate (win 35,428), has been shown to have a considerably longer duration of action and greater potency than cocaine as a central stimulant and it appears to have a similar mode of action on dopamine (da) systems. |
1996-04-18 |
2023-08-12 |
rat |
| T Kano, Y Suzuki, M Shibuya, K Kiuchi, M Hagiwar. Cocaine-induced CREB phosphorylation and c-Fos expression are suppressed in Parkinsonism model mice. Neuroreport. vol 6. issue 16. 1996-04-18. PMID:8595201. |
cocaine exerts multiple neurochemical effects in the central nervous system through inhibition of the dopamine transporter at the synapse. |
1996-04-18 |
2023-08-12 |
mouse |
| B S Kolachana, R C Saunders, D R Weinberge. Augmentation of prefrontal cortical monoaminergic activity inhibits dopamine release in the caudate nucleus: an in vivo neurochemical assessment in the rhesus monkey. Neuroscience. vol 69. issue 3. 1996-04-18. PMID:8596654. |
increase of monoaminergic activity by infusion of either d-amphetamine (100 microm) or cocaine hydrochloride (100 microm) resulted in a gradual and prolonged decrease in caudate nucleus dopamine levels. |
1996-04-18 |
2023-08-12 |
monkey |
| B M Prasad, B A Sorg, C Ulibarri, P W Kaliva. Sensitization to stress and psychostimulants. Involvement of dopamine transmission versus the HPA axis. Annals of the New York Academy of Sciences. vol 771. 1996-04-17. PMID:8597435. |
this behavioral cross-sensitization between stress (repeated mild footshock) and cocaine (15 mg/kg, ip) is associated with an increase in extracellular dopamine in the nucleus accumbens, but a decrease in the prefrontal cortex. |
1996-04-17 |
2023-08-12 |
rat |
| J Chen, R Marmur, W Paredes, A Pulles, E L Gardne. Systemic cocaine challenge after chronic cocaine treatment reveals sensitization of extracellular dopamine levels in nucleus accumbens but direct cocaine perfusion into nucleus accumbens does not: implications for the neural locus of cocaine sensitization. Life sciences. vol 58. issue 8. 1996-04-10. PMID:8594313. |
systemic cocaine challenge after chronic cocaine treatment reveals sensitization of extracellular dopamine levels in nucleus accumbens but direct cocaine perfusion into nucleus accumbens does not: implications for the neural locus of cocaine sensitization. |
1996-04-10 |
2023-08-12 |
rat |
| J Chen, R Marmur, W Paredes, A Pulles, E L Gardne. Systemic cocaine challenge after chronic cocaine treatment reveals sensitization of extracellular dopamine levels in nucleus accumbens but direct cocaine perfusion into nucleus accumbens does not: implications for the neural locus of cocaine sensitization. Life sciences. vol 58. issue 8. 1996-04-10. PMID:8594313. |
on the next day, rats were challenged with an acute dose of cocaine administered by one of two routes (systemic or intracranial), and extra-cellular dopamine (da) in the nucleus accumbens (acb) was measured by in vivo microdialysis. |
1996-04-10 |
2023-08-12 |
rat |
| M Y Li, Q S Yan, L L Coffey, M E Reit. Extracellular dopamine, norepinephrine, and serotonin in the nucleus accumbens of freely moving rats during intracerebral dialysis with cocaine and other monoamine uptake blockers. Journal of neurochemistry. vol 66. issue 2. 1996-04-03. PMID:8592125. |
extracellular dopamine, norepinephrine, and serotonin in the nucleus accumbens of freely moving rats during intracerebral dialysis with cocaine and other monoamine uptake blockers. |
1996-04-03 |
2023-08-12 |
rat |
| M Y Li, Q S Yan, L L Coffey, M E Reit. Extracellular dopamine, norepinephrine, and serotonin in the nucleus accumbens of freely moving rats during intracerebral dialysis with cocaine and other monoamine uptake blockers. Journal of neurochemistry. vol 66. issue 2. 1996-04-03. PMID:8592125. |
cocaine increased all three amines with the greatest effects on dopamine and serotonin. |
1996-04-03 |
2023-08-12 |
rat |
| M Y Li, Q S Yan, L L Coffey, M E Reit. Extracellular dopamine, norepinephrine, and serotonin in the nucleus accumbens of freely moving rats during intracerebral dialysis with cocaine and other monoamine uptake blockers. Journal of neurochemistry. vol 66. issue 2. 1996-04-03. PMID:8592125. |
the present results suggest a contribution of the increase in norepinephrine, but not serotonin, to the enhancement of dopamine after cocaine applied focally in the nucleus accumbens. |
1996-04-03 |
2023-08-12 |
rat |
| I Ushijima, M A Carino, A Horit. Involvement of D1 and D2 dopamine systems in the behavioral effects of cocaine in rats. Pharmacology, biochemistry, and behavior. vol 52. issue 4. 1996-03-27. PMID:8587913. |
involvement of d1 and d2 dopamine systems in the behavioral effects of cocaine in rats. |
1996-03-27 |
2023-08-12 |
rat |
| I Ushijima, M A Carino, A Horit. Involvement of D1 and D2 dopamine systems in the behavioral effects of cocaine in rats. Pharmacology, biochemistry, and behavior. vol 52. issue 4. 1996-03-27. PMID:8587913. |
the increases of locomotion and rearing, head circling, and body shaking induced by cocaine may involve the indirect activation of postsynaptic d1 and d2 receptors, presumably via dopamine release, resulting from inhibition of the presynaptic d2 receptors. |
1996-03-27 |
2023-08-12 |
rat |
| I Ushijima, M A Carino, A Horit. Involvement of D1 and D2 dopamine systems in the behavioral effects of cocaine in rats. Pharmacology, biochemistry, and behavior. vol 52. issue 4. 1996-03-27. PMID:8587913. |
these results also provide evidence that the indirect stimulation of postsynaptic d2 receptors by cocaine (20 mg/kg) is insufficient to induce stereotyped behaviors, and that the role of dopamine d1 receptors in mediating the behavioral actions of acute cocaine appears to be more important than that of d2 receptors. |
1996-03-27 |
2023-08-12 |
rat |
| M H Baumann, T M Gendron, K M Becketts, J E Henningfield, D A Gorelick, R B Rothma. Effects of intravenous cocaine on plasma cortisol and prolactin in human cocaine abusers. Biological psychiatry. vol 38. issue 11. 1996-03-21. PMID:8580229. |
however, based on the well-known importance of dopamine as a prolactin-inhibiting factor, the failure of cocaine to suppress prolactin in the present study raises questions concerning the role of dopamine in the mechanism of acute cocaine action in humans. |
1996-03-21 |
2023-08-12 |
human |
| M Balte. New clues to brain dopamine control, cocaine addiction. Science (New York, N.Y.). vol 271. issue 5251. 1996-03-21. PMID:8584927. |
new clues to brain dopamine control, cocaine addiction. |
1996-03-21 |
2023-08-12 |
Not clear |
| V J Aloyo, P S Pazdalski, A L Kirifides, J A Harve. Behavioral sensitization, behavioral tolerance, and increased [3H]WIN 35,428 binding in rabbit caudate nucleus after repeated injections of cocaine. Pharmacology, biochemistry, and behavior. vol 52. issue 2. 1996-03-11. PMID:8577799. |
this study examined whether changes in the behavioral response to repeated intravenous injections of cocaine hydrochloride (4 mg/kg, twice daily for 22 days) might be related to alterations in the dopamine (da) transporter as measured by the binding of the potent cocaine analog [3h]win 35,428 to membranes derived from fresh caudate tissue. |
1996-03-11 |
2023-08-12 |
rabbit |
| R B Rothman, J R Glow. A review of the effects of dopaminergic agents on humans, animals, and drug-seeking behavior, and its implications for medication development. Focus on GBR 12909. Molecular neurobiology. vol 11. issue 1-3. 1996-03-07. PMID:8561954. |
the hypothesis that mesolimbic dopamine (da) is the key neurochemical mediator of cocaine's addictive and reinforcing effects is well supported by a wide variety of data from animal studies. |
1996-03-07 |
2023-08-12 |
human |
| T Macedo, C A Ribeiro, D Cotrim, P Tavares, M T Morgadinho, M Caramona, M T Vicente, L Rodrigues, M G Cardoso, M L Keatin. Catecholamine and MHPG plasma levels, platelet MAO activity, and 3H-imipramine binding in heroin and cocaine addicts. Molecular neurobiology. vol 11. issue 1-3. 1996-03-07. PMID:8561963. |
conversely, dopamine and mhpg plasma levels increased with the duration of heroin use, and even more with cocaine abuse. |
1996-03-07 |
2023-08-12 |
human |
| M T Martin-Iverson, L Y Burge. Behavioral sensitization and tolerance to cocaine and the occupation of dopamine receptors by dopamine. Molecular neurobiology. vol 11. issue 1-3. 1996-03-07. PMID:8561966. |
behavioral sensitization and tolerance to cocaine and the occupation of dopamine receptors by dopamine. |
1996-03-07 |
2023-08-12 |
rat |
| M T Martin-Iverson, L Y Burge. Behavioral sensitization and tolerance to cocaine and the occupation of dopamine receptors by dopamine. Molecular neurobiology. vol 11. issue 1-3. 1996-03-07. PMID:8561966. |
the increase in locomotion produced by cocaine was associated with an increase in the occupation of striatal dopamine d1 and d2 receptors, measured as the density of receptors protected from denaturation by n-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (eedq). |
1996-03-07 |
2023-08-12 |
rat |
| M T Martin-Iverson, L Y Burge. Behavioral sensitization and tolerance to cocaine and the occupation of dopamine receptors by dopamine. Molecular neurobiology. vol 11. issue 1-3. 1996-03-07. PMID:8561966. |
this suggests that the differences in occupancy of striatal dopamine receptors by dopamine observed in the prewithdrawal condition are likely the results of differences in brain levels of cocaine achieved by the two treatment regimens. |
1996-03-07 |
2023-08-12 |
rat |