| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W L Thomas, E S Cooke, R P Hamme. Cocaine-induced sensitization of metabolic activity in extrapyramidal circuits involves prior dopamine D1-like receptor stimulation. The Journal of pharmacology and experimental therapeutics. vol 278. issue 1. 1996-09-23. PMID:8764369. |
the pharmacology underlying this sensitized metabolic response to cocaine was investigated by administering either dopamine d1- or d2-like receptor agonists on the first treatment day, followed by cocaine on the final day. |
1996-09-23 |
2023-08-12 |
Not clear |
| R C Pierce, B Born, M Adams, P W Kaliva. Repeated intra-ventral tegmental area administration of SKF-38393 induces behavioral and neurochemical sensitization to a subsequent cocaine challenge. The Journal of pharmacology and experimental therapeutics. vol 278. issue 1. 1996-09-23. PMID:8764374. |
the increase in dopamine levels in the nucleus accumbens shell induced by cocaine was significantly greater among rats pretreated with repeated skf-38393 administration. |
1996-09-23 |
2023-08-12 |
rat |
| A Bonci, J T William. A common mechanism mediates long-term changes in synaptic transmission after chronic cocaine and morphine. Neuron. vol 16. issue 3. 1996-09-20. PMID:8785060. |
although morphine and cocaine act by separate cellular mechanisms initially, the present study describes a common change in synaptic regulation of dopamine cells in the ventral tegmental area 1 week after termination of chronic treatment with either drug. |
1996-09-20 |
2023-08-12 |
Not clear |
| J Peri. Repeated cocaine injections decrease the function of striatal gamma-aminobutyric acid(A) receptors. The Journal of pharmacology and experimental therapeutics. vol 276. issue 3. 1996-09-20. PMID:8786528. |
although behavioral sensitization to cocaine is commonly thought to involve increased dopamine (da) neurotransmission in nigrostriatal and mesolimbic pathways, it is possible that alterations in the characteristics of other neurotransmitters, such as gamma-aminobutyric acid (gaba), contribute to cocaine-induced behavioral changes. |
1996-09-20 |
2023-08-12 |
rat |
| M S Reid, K Hsu, B K Tolliver, C A Crawford, S P Berge. Evidence for the involvement of phospholipase A2 mechanisms in the development of stimulant sensitization. The Journal of pharmacology and experimental therapeutics. vol 276. issue 3. 1996-09-20. PMID:8786557. |
local injections of melittin (0.1 microgram/0.4 microliter) into the ventral tegmental area sensitized the subsequent stimulation of locomotor activity, stereotypy and nucleus accumbens dopamine release by cocaine, when tested 72 hr later. |
1996-09-20 |
2023-08-12 |
rat |
| E P Prinssen, M S Kleven, J Vignon, J M Kamenka, W Koe. Effects of repeated administration of N-[1-(2-benzo(b)-thiophenyl)cyclohexy]piperidine and cocaine on locomotor activity in C57BL/6 mice. The Journal of pharmacology and experimental therapeutics. vol 276. issue 3. 1996-09-20. PMID:8786568. |
the present study investigated the effects of repeated administration of the dopamine reuptake inhibitors n-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine (btcp) and cocaine on locomotor activity, as well as their ability to induce or express cross-sensitization. |
1996-09-20 |
2023-08-12 |
mouse |
| K L Li, J N Suojane. Cocaine-induced changes in time course of regional cerebral blood volume and transit time as determined by dynamic MR imaging. Journal of magnetic resonance imaging : JMRI. vol 5. issue 6. 1996-09-19. PMID:8748491. |
changes in mtt and rcbv in animals who had previously been given cocaine depended on the length of time between the last pretreatment injection and the acute injection and seemed to parallel cocaine-mediated changes in extracellular dopamine concentrations. |
1996-09-19 |
2023-08-12 |
rat |
| G F Koob, B Caine, A Markou, L Pulvirenti, F Weis. Role for the mesocortical dopamine system in the motivating effects of cocaine. NIDA research monograph. vol 145. 1996-09-18. PMID:8742805. |
the search for a neurobiological substrate for the stimulant and reinforcing properties of cocaine has focused for some time on a particular part of the forebrain, the mesocorticolimbic dopamine (da) system. |
1996-09-18 |
2023-08-12 |
rat |
| C Kornetsky, C Duvauchell. Dopamine, a common substrate for the rewarding effects of brain stimulation reward, cocaine, and morphine. NIDA research monograph. vol 145. 1996-09-18. PMID:8742806. |
dopamine, a common substrate for the rewarding effects of brain stimulation reward, cocaine, and morphine. |
1996-09-18 |
2023-08-12 |
Not clear |
| R A Wis. Cocaine reward and cocaine craving: the role of dopamine in perspective. NIDA research monograph. vol 145. 1996-09-18. PMID:8742814. |
cocaine reward and cocaine craving: the role of dopamine in perspective. |
1996-09-18 |
2023-08-12 |
Not clear |
| C A Heidbreder, A C Thompson, T S Shippenber. Role of extracellular dopamine in the initiation and long-term expression of behavioral sensitization to cocaine. The Journal of pharmacology and experimental therapeutics. vol 278. issue 2. 1996-09-18. PMID:8768696. |
role of extracellular dopamine in the initiation and long-term expression of behavioral sensitization to cocaine. |
1996-09-18 |
2023-08-12 |
Not clear |
| C A Heidbreder, A C Thompson, T S Shippenber. Role of extracellular dopamine in the initiation and long-term expression of behavioral sensitization to cocaine. The Journal of pharmacology and experimental therapeutics. vol 278. issue 2. 1996-09-18. PMID:8768696. |
the present study sought to characterize basal dialysate dopamine (da) concentrations within the nucleus accumbens (nac), 2, 12 or 22 days after the cessation of either repeated cocaine (20 mg/kg/day x 5 days) or saline (1.0 ml/kg/day x 5 days) treatment. |
1996-09-18 |
2023-08-12 |
Not clear |
| A I Elmallah, F Sharabi, A G Omar, M M El-Ma. Prazosin-induced blockade of extraneuronal uptake facilitates dopaminergic modulation of muscle twitches in rat vas deferens. The Journal of pharmacy and pharmacology. vol 47. issue 11. 1996-09-11. PMID:8708988. |
pretreatment with cocaine (10 microm), prazosin (50 nm) or oestradiol (10 microm) produced comparable potentiation of the inhibitory responses of dopamine; the pd2 values to dopamine amounted to 4.47 +/- 0.20, 4.72 +/- 0.21 and 4.56 +/- 0.19, respectively. |
1996-09-11 |
2023-08-12 |
rat |
| A I Elmallah, F Sharabi, A G Omar, M M El-Ma. Prazosin-induced blockade of extraneuronal uptake facilitates dopaminergic modulation of muscle twitches in rat vas deferens. The Journal of pharmacy and pharmacology. vol 47. issue 11. 1996-09-11. PMID:8708988. |
further potentiation of dopamine responses was demonstrated in tissues preincubated with a combination of cocaine plus prazosin (50 nm), or cocaine plus oestradiol (pd2, 5.40 +/- 0.11 and 5.42 +/- 0.05, respectively). |
1996-09-11 |
2023-08-12 |
rat |
| G S Frick, D L Dow-Edward. The effects of cocaine on cerebral metabolic function in periweanling rats: the roles of serotonergic and dopaminergic uptake blockade. Brain research. Developmental brain research. vol 88. issue 2. 1996-08-05. PMID:8665662. |
by comparing the effects of fluoxetine, a serotonin uptake inhibitor, and gbr12909, a dopamine uptake inhibitor, to the effects of cocaine, the contributions of these pharmacologic actions to the neurochemical effects of cocaine were determined. |
1996-08-05 |
2023-08-12 |
rat |
| G S Frick, D L Dow-Edward. The effects of cocaine on cerebral metabolic function in periweanling rats: the roles of serotonergic and dopaminergic uptake blockade. Brain research. Developmental brain research. vol 88. issue 2. 1996-08-05. PMID:8665662. |
the present study therefore suggests at 21 days of age, that inhibition of dopamine uptake makes a more significant contribution to the metabolic effects of cocaine than inhibition of serotonin uptake and that females are more sensitive to the effects of cocaine than males. |
1996-08-05 |
2023-08-12 |
rat |
| R T Malison, S E Best, E A Wallace, E McCance, M Laruelle, S S Zoghbi, R M Baldwin, J S Seibyl, P B Hoffer, L H Pric. Euphorigenic doses of cocaine reduce [123I]beta-CIT SPECT measures of dopamine transporter availability in human cocaine addicts. Psychopharmacology. vol 122. issue 4. 1996-07-30. PMID:8657833. |
euphorigenic doses of cocaine reduce [123i]beta-cit spect measures of dopamine transporter availability in human cocaine addicts. |
1996-07-30 |
2023-08-12 |
human |
| R T Malison, S E Best, E A Wallace, E McCance, M Laruelle, S S Zoghbi, R M Baldwin, J S Seibyl, P B Hoffer, L H Pric. Euphorigenic doses of cocaine reduce [123I]beta-CIT SPECT measures of dopamine transporter availability in human cocaine addicts. Psychopharmacology. vol 122. issue 4. 1996-07-30. PMID:8657833. |
the in vivo potency of euphorigenic doses of intravenous cocaine for displacing [123i]beta-cit ([123i]2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane) binding to striatal dopamine transporters (dat) was assessed in human cocaine addicts using single photon emission computed tomography (spect). |
1996-07-30 |
2023-08-12 |
human |
| S J Gatley, S M Meehan, R Chen, D F Pan, M D Schechter, S L Dewe. Place preference and microdialysis studies with two derivatives of methylphenidate. Life sciences. vol 58. issue 24. 1996-07-22. PMID:8649202. |
administration of p-methoxymethylphenidate failed to abolish increases in extracellular dopamine and locomotor activity induced by subsequent administration of cocaine (20 mg/kg). |
1996-07-22 |
2023-08-12 |
rat |
| B A Morrow, J R Taylor, R H Rot. Prior exposure to cocaine diminishes behavioral and biochemical responses to aversive conditioning: reversal by glycine/N-methyl-D-aspartate antagonist co-treatment. Neuroscience. vol 69. issue 1. 1996-07-08. PMID:8637621. |
additionally, the elevated metabolic activity of dopamine in the medial prefrontal cortex, nucleus accumbens and ventral tegmental area associated with aversive conditioning was diminished in rats pre-exposed to cocaine. |
1996-07-08 |
2023-08-12 |
rat |