| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N D Volkow, G J Wang, J S Fowler, J Logan, R Hitzemannn, S J Gatley, R R MacGregor, A P Wol. Cocaine uptake is decreased in the brain of detoxified cocaine abusers. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 3. 1996-12-03. PMID:8866699. |
values for da d2 receptor availability were decreased in cocaine abusers and did not correlate with estimates of dopamine transporter availability. |
1996-12-03 |
2023-08-12 |
Not clear |
| G C Harris, M A Hedaya, W J Pan, P Kaliva. beta-adrenergic antagonism alters the behavioral and neurochemical responses to cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 3. 1996-12-03. PMID:8866703. |
in experiment 2, propranolol was shown to augment significantly the increase in extracellular dopamine content in the nucleus accumbens that accompanies a cocaine challenge. |
1996-12-03 |
2023-08-12 |
rat |
| G C Harris, M A Hedaya, W J Pan, P Kaliva. beta-adrenergic antagonism alters the behavioral and neurochemical responses to cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 3. 1996-12-03. PMID:8866703. |
these data suggest that the blockade of beta-adrenergic receptors potentiates cocaine-induced elevation of dopamine transmission in the nucleus accumbens, which is associated with an increase in cocaine-induced motor activity and a decrease in cocaine self-administration. |
1996-12-03 |
2023-08-12 |
rat |
| A Hitri, K Y Little, E H Ellinwoo. Effect of cocaine on dopamine transporter receptors depends on routes of chronic cocaine administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 3. 1996-12-03. PMID:8866704. |
effect of cocaine on dopamine transporter receptors depends on routes of chronic cocaine administration. |
1996-12-03 |
2023-08-12 |
rat |
| A Hitri, K Y Little, E H Ellinwoo. Effect of cocaine on dopamine transporter receptors depends on routes of chronic cocaine administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 3. 1996-12-03. PMID:8866704. |
we studied the effect of routes of cocaine administration on the dopamine transporter receptors (datr), the presumed neuronal mediator of cocaine reward, using the diphenyl substituted piperazine derivative, [3h]gbr 12935 and the cocaine analogue [3h]win 35,428. |
1996-12-03 |
2023-08-12 |
rat |
| A Hitri, K Y Little, E H Ellinwoo. Effect of cocaine on dopamine transporter receptors depends on routes of chronic cocaine administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 3. 1996-12-03. PMID:8866704. |
continuous infusion of cocaine did not alter the [3h]gbr 12935 dopamine transporter (dat) binding either in the caudate nucleus or in the prefrontal cortex, but it enhanced the density of [3h]win 35,428-labeled dat receptor sites in the caudate putamen. |
1996-12-03 |
2023-08-12 |
rat |
| C Halldin, L Farde, C Lundkvist, N Ginovart, Y Nakashima, P Karlsson, C G Swah. [11C]beta-CIT-FE, a radioligand for quantitation of the dopamine transporter in the living brain using positron emission tomography. Synapse (New York, N.Y.). vol 22. issue 4. 1996-12-03. PMID:8867033. |
the cocaine analogue beta-cit-fe (n-(2-fluoroethyl)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)nortropane) was labeled with 11c for positron emission tomography (pet) studies of the dopamine transporter. |
1996-12-03 |
2023-08-12 |
monkey |
| J R BAIRD, J J LEWI. THE EFFECTS OF COCAINE, AMPHETAMINE AND SOME AMPHETAMINE-LIKE COMPOUNDS ON THE IN VIVO LEVELS OF NORADRENALINE AND DOPAMINE IN THE RAT BRAIN. Biochemical pharmacology. vol 13. 1996-12-01. PMID:14239622. |
the effects of cocaine, amphetamine and some amphetamine-like compounds on the in vivo levels of noradrenaline and dopamine in the rat brain. |
1996-12-01 |
2023-08-12 |
rat |
| M A Nader, R H Mac. Self-administration of the dopamine D3 agonist 7-OH-DPAT in rhesus monkeys is modified by prior cocaine exposure. Psychopharmacology. vol 125. issue 1. 1996-11-27. PMID:8724444. |
self-administration of the dopamine d3 agonist 7-oh-dpat in rhesus monkeys is modified by prior cocaine exposure. |
1996-11-27 |
2023-08-12 |
monkey |
| M A Nader, R H Mac. Self-administration of the dopamine D3 agonist 7-OH-DPAT in rhesus monkeys is modified by prior cocaine exposure. Psychopharmacology. vol 125. issue 1. 1996-11-27. PMID:8724444. |
cocaine self-administration was compared with responding maintained by the dopamine d3 agonist 7-hydroxy-n,n-di-n-propyl-2-aminotetralin (7-oh-dpat) in rhesus monkeys. |
1996-11-27 |
2023-08-12 |
monkey |
| B A Mattingly, S E Fields, M S Langfels, J K Rowlett, P M Robinet, M T Bard. Repeated 7-OH-DPAT treatments: behavioral sensitization, dopamine synthesis and subsequent sensitivity to apomorphine and cocaine. Psychopharmacology. vol 125. issue 1. 1996-11-27. PMID:8724446. |
repeated 7-oh-dpat treatments: behavioral sensitization, dopamine synthesis and subsequent sensitivity to apomorphine and cocaine. |
1996-11-27 |
2023-08-12 |
rat |
| B A Mattingly, S E Fields, M S Langfels, J K Rowlett, P M Robinet, M T Bard. Repeated 7-OH-DPAT treatments: behavioral sensitization, dopamine synthesis and subsequent sensitivity to apomorphine and cocaine. Psychopharmacology. vol 125. issue 1. 1996-11-27. PMID:8724446. |
major findings were as follows: a) acute 7-oh-dpat treatment produced a dose-dependent decrease in locomotor activity; b) when tested for 2 h, the 1.0 mg/kg dose of 7-oh-dpat produced a progressively greater increase in activity across the 10 test days (i.e., behavioral sensitization); c) subchronic treatment with 7-oh-dpat did not result in cross-sensitization to either apomorphine or cocaine; d) acute treatment with the 1.0 mg/kg dose of 7-oh-dpat significantly decreased dopamine synthesis in both striatal and mesolimbic regions; and e) chronic 7-oh-dpat treatments did not affect basal dopamine synthesis in either brain region. |
1996-11-27 |
2023-08-12 |
rat |
| T W Seale, I Niekrasz, F Chang, S Singh, G P Basmadjia. Selective behavioral alterations on addition of a 4'-phenyl group to cocaine. Neuroreport. vol 7. issue 2. 1996-11-25. PMID:8730843. |
this substitution caused a modest reduction (four-fold compared with cocaine) in binding potency for the primate (papio) dopamine transporter as judged by displacement of [3h]win 35,428 binding from caudate/putamen membranes. |
1996-11-25 |
2023-08-12 |
mouse |
| E P Prinssen, M S Kleven, W Koe. Repeated administration of cocaethylene induces context-dependent sensitization to its locomotor effects. Psychopharmacology. vol 124. issue 4. 1996-11-25. PMID:8739544. |
since this compound exhibits affinity for the dopamine transporter that is more selective than that of cocaine, it is conceivable that its behavioral properties may be distinguishable from those of cocaine (cf. |
1996-11-25 |
2023-08-12 |
mouse |
| X Lamas, S S Negus, M A Nader, N K Mell. Effects of the putative dopamine D3 receptor agonist 7-OH-DPAT in rhesus monkeys trained to discriminate cocaine from saline. Psychopharmacology. vol 124. issue 4. 1996-11-25. PMID:8739545. |
effects of the putative dopamine d3 receptor agonist 7-oh-dpat in rhesus monkeys trained to discriminate cocaine from saline. |
1996-11-25 |
2023-08-12 |
monkey |
| X Lamas, S S Negus, M A Nader, N K Mell. Effects of the putative dopamine D3 receptor agonist 7-OH-DPAT in rhesus monkeys trained to discriminate cocaine from saline. Psychopharmacology. vol 124. issue 4. 1996-11-25. PMID:8739545. |
these studies were designed to evaluate the effects of the putative dopamine d3 receptor agonist 7-hydroxy-n,n-di-n-propyl-2-aminotetraline (7-oh-dpat), alone and in combination with cocaine, in four rhesus monkeys trained to discriminate cocaine (0.4 mg/kg, im) from saline under a fixed-ratio 30 schedule of food presentation. |
1996-11-25 |
2023-08-12 |
monkey |
| X Lamas, S S Negus, M A Nader, N K Mell. Effects of the putative dopamine D3 receptor agonist 7-OH-DPAT in rhesus monkeys trained to discriminate cocaine from saline. Psychopharmacology. vol 124. issue 4. 1996-11-25. PMID:8739545. |
finally, the d3/d2 dopamine agonist quinpirole completely generalized to cocaine in three monkeys, and partially in the fourth monkey. |
1996-11-25 |
2023-08-12 |
monkey |
| C Ollo, T N Alim, R B Rosse, T Lindquist, T Green, T Gillis, J Ricci, M Khan, S I Deutsc. Lack of neurotoxic effect of diethylpropion in crack-cocaine abusers. Clinical neuropharmacology. vol 19. issue 1. 1996-11-15. PMID:8867517. |
dopamine agonists have been used with some success in treating cocaine addiction. |
1996-11-15 |
2023-08-12 |
Not clear |
| N D Volkow, G J Wang, J S Fowler, S J Gatley, Y S Ding, J Logan, S L Dewey, R Hitzemann, J Lieberma. Relationship between psychostimulant-induced "high" and dopamine transporter occupancy. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 19. 1996-11-13. PMID:8816810. |
the ability of cocaine to inhibit the dopamine transporter (dat) appears to be crucial for its reinforcing properties. |
1996-11-13 |
2023-08-12 |
human |
| J M Wilson, A I Levey, C Bergeron, K Kalasinsky, L Ang, F Peretti, V I Adams, J Smialek, W R Anderson, K Shannak, J Deck, H B Niznik, S J Kis. Striatal dopamine, dopamine transporter, and vesicular monoamine transporter in chronic cocaine users. Annals of neurology. vol 40. issue 3. 1996-11-12. PMID:8797532. |
striatal dopamine, dopamine transporter, and vesicular monoamine transporter in chronic cocaine users. |
1996-11-12 |
2023-08-12 |
human |