| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S L Vrana, K E Vrana, T R Koves, J E Smith, S I Dworki. Chronic cocaine administration increases CNS tyrosine hydroxylase enzyme activity and mRNA levels and tryptophan hydroxylase enzyme activity levels. Journal of neurochemistry. vol 61. issue 6. 1993-12-23. PMID:7902421. |
in summary, the chronic response-independent administration of cocaine produces increases in the expression of th mrna and activity in both the cell bodies of motor (nigrostriatal) and reinforcement (mesolimbic) dopamine pathways. |
1993-12-23 |
2023-08-12 |
human |
| W A Cass, N R Zahniser, K A Flach, G A Gerhard. Clearance of exogenous dopamine in rat dorsal striatum and nucleus accumbens: role of metabolism and effects of locally applied uptake inhibitors. Journal of neurochemistry. vol 61. issue 6. 1993-12-23. PMID:8245977. |
in contrast, lesioning the dopamine terminals with 6-hydroxydopamine, or locally applying the dopamine uptake inhibitors cocaine or nomifensine before pressure ejection of dopamine, significantly increased the amplitude and time course of the dopamine signals in both regions. |
1993-12-23 |
2023-08-12 |
rat |
| J T Kuikka, K A Bergström, E Vanninen, V Laulumaa, P Hartikainen, E Länsimie. Initial experience with single-photon emission tomography using iodine-123-labelled 2 beta-carbomethoxy-3 beta-(4-iodophenyl) tropane in human brain. European journal of nuclear medicine. vol 20. issue 9. 1993-12-16. PMID:8223773. |
the iodinated cocaine analogue 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane ([123i]beta-cit), a new dopamine transporter, was preliminary tested in human brain. |
1993-12-16 |
2023-08-12 |
human |
| A J Eshleman, D O Calligaro, M E Eldefraw. Allosteric regulation by sodium of the binding of [3H]cocaine and [3H]GBR 12935 to rat and bovine striata. Membrane biochemistry. vol 10. issue 3. 1993-12-16. PMID:8231896. |
it is suggested that the cation form of tris binds to the dopamine transporter and that the tris-receptor complex does not bind [3h]cocaine or [3h]gbr 12935. |
1993-12-16 |
2023-08-12 |
rat |
| A J Eshleman, D O Calligaro, M E Eldefraw. Allosteric regulation by sodium of the binding of [3H]cocaine and [3H]GBR 12935 to rat and bovine striata. Membrane biochemistry. vol 10. issue 3. 1993-12-16. PMID:8231896. |
thus, it is suggested that the na(+)-dependent binding of cocaine to the dopamine transporter is observed only in tris. |
1993-12-16 |
2023-08-12 |
rat |
| A Brouard, D Pelaprat, J W Boja, F I Carroll, M Vial, M J Kuhar, W Rosten. Potent cocaine analogs inhibit [3H]dopamine uptake in rat mesencephalic cells in primary cultures: pharmacological selectivity of embryonic cocaine sites. Brain research. Developmental brain research. vol 75. issue 1. 1993-12-10. PMID:8222207. |
potent cocaine analogs inhibit [3h]dopamine uptake in rat mesencephalic cells in primary cultures: pharmacological selectivity of embryonic cocaine sites. |
1993-12-10 |
2023-08-12 |
rat |
| A Brouard, D Pelaprat, J W Boja, F I Carroll, M Vial, M J Kuhar, W Rosten. Potent cocaine analogs inhibit [3H]dopamine uptake in rat mesencephalic cells in primary cultures: pharmacological selectivity of embryonic cocaine sites. Brain research. Developmental brain research. vol 75. issue 1. 1993-12-10. PMID:8222207. |
in order to know whether this different localization was associated with a different pharmacological selectivity, we tested the effect of new cocaine analogs on tritiated dopamine ([3h]da) uptake in primary cultures of rat embryonic mesencephalic cells. |
1993-12-10 |
2023-08-12 |
rat |
| J H Meador-Woodruff, K Y Little, S P Damask, A Mansour, S J Watso. Effects of cocaine on dopamine receptor gene expression: a study in the postmortem human brain. Biological psychiatry. vol 34. issue 6. 1993-12-09. PMID:8218601. |
the effects of chronic cocaine exposure on dopamine d1 and d2 receptor gene expression in the human brain were studied in postmortem samples from chronic cocaine abusing and matched control subjects. |
1993-12-09 |
2023-08-12 |
human |
| V G Erwin, D E Womer, A D Campbell, B C Jone. Pharmacogenetics of cocaine: II. Mesocorticolimbic and striatal dopamine and cocaine receptors in C57BL and DBA mice. Pharmacogenetics. vol 3. issue 4. 1993-12-09. PMID:8220438. |
mesocorticolimbic and striatal dopamine and cocaine receptors in c57bl and dba mice. |
1993-12-09 |
2023-08-12 |
mouse |
| V G Erwin, D E Womer, A D Campbell, B C Jone. Pharmacogenetics of cocaine: II. Mesocorticolimbic and striatal dopamine and cocaine receptors in C57BL and DBA mice. Pharmacogenetics. vol 3. issue 4. 1993-12-09. PMID:8220438. |
studies were conducted to determine whether genetic differences in behavioural effects of cocaine in c57bl/6 and dba/2 mice might be mediated by strain differences in dopamine and serotonin transporters and dopamine d1 and d2 receptors in specific brain regions. |
1993-12-09 |
2023-08-12 |
mouse |
| V G Erwin, D E Womer, A D Campbell, B C Jone. Pharmacogenetics of cocaine: II. Mesocorticolimbic and striatal dopamine and cocaine receptors in C57BL and DBA mice. Pharmacogenetics. vol 3. issue 4. 1993-12-09. PMID:8220438. |
binding characteristics of [3h]cft, a cocaine analogue, in the presence of either gbr12909, a dopamine uptake blocker or fluoxetine, a serotonin uptake blocker and binding of [3h]-paroxetine, a specific serotonin uptake receptor antagonist, were evaluated. |
1993-12-09 |
2023-08-12 |
mouse |
| C Spyraki, S C Sealfo. Regulation of dopamine D2 receptor mRNA expression in the olfactory tubercle by cocaine. Brain research. Molecular brain research. vol 19. issue 4. 1993-12-01. PMID:8231734. |
regulation of dopamine d2 receptor mrna expression in the olfactory tubercle by cocaine. |
1993-12-01 |
2023-08-12 |
rat |
| C Spyraki, S C Sealfo. Regulation of dopamine D2 receptor mRNA expression in the olfactory tubercle by cocaine. Brain research. Molecular brain research. vol 19. issue 4. 1993-12-01. PMID:8231734. |
the influence of acute and chronic cocaine treatment on the expression of dopamine d2 receptor (d2r) mrna was examined in the rat basal ganglia by in situ hybridization histochemistry. |
1993-12-01 |
2023-08-12 |
rat |
| L H Parsons, J B Justic. Serotonin and dopamine sensitization in the nucleus accumbens, ventral tegmental area, and dorsal raphe nucleus following repeated cocaine administration. Journal of neurochemistry. vol 61. issue 5. 1993-11-29. PMID:7693863. |
serotonin and dopamine sensitization in the nucleus accumbens, ventral tegmental area, and dorsal raphe nucleus following repeated cocaine administration. |
1993-11-29 |
2023-08-12 |
rat |
| L H Parsons, J B Justic. Serotonin and dopamine sensitization in the nucleus accumbens, ventral tegmental area, and dorsal raphe nucleus following repeated cocaine administration. Journal of neurochemistry. vol 61. issue 5. 1993-11-29. PMID:7693863. |
the present study was designed to examine the effects of chronic cocaine administration on the extracellular response of serotonin (5-ht) and dopamine (da) to a peripheral cocaine injection using in vivo brain microdialysis in awake rats. |
1993-11-29 |
2023-08-12 |
rat |
| J M Witkin, A H Newman, G Nowak, J L Kat. Role of dopamine D1 receptors in the lethal effects of cocaine and a quaternary methiodide analog. The Journal of pharmacology and experimental therapeutics. vol 267. issue 1. 1993-11-29. PMID:7901394. |
role of dopamine d1 receptors in the lethal effects of cocaine and a quaternary methiodide analog. |
1993-11-29 |
2023-08-12 |
mouse |
| K L Preston, J T Sullivan, P Berger, G E Bigelo. Effects of cocaine alone and in combination with mazindol in human cocaine abusers. The Journal of pharmacology and experimental therapeutics. vol 267. issue 1. 1993-11-29. PMID:8229755. |
mazindol is a catecholamine reuptake inhibitor that blocks binding of cocaine at the dopamine reuptake site. |
1993-11-29 |
2023-08-12 |
human |
| N H Chen, M E Reit. [3H]dopamine and [3H]serotonin release in vitro induced by electrical stimulation in A9 and A10 dopamine regions of rat brain: characterization and responsiveness to cocaine. The Journal of pharmacology and experimental therapeutics. vol 267. issue 1. 1993-11-29. PMID:8229765. |
[3h]dopamine and [3h]serotonin release in vitro induced by electrical stimulation in a9 and a10 dopamine regions of rat brain: characterization and responsiveness to cocaine. |
1993-11-29 |
2023-08-12 |
rat |
| R V Bhat, J M Baraba. Activation of transcription factor genes in striatum by cocaine: role of both serotonin and dopamine systems. The Journal of pharmacology and experimental therapeutics. vol 267. issue 1. 1993-11-29. PMID:8229780. |
activation of transcription factor genes in striatum by cocaine: role of both serotonin and dopamine systems. |
1993-11-29 |
2023-08-12 |
Not clear |
| B A Faraj, V M Camp, D C Davis, M Kutner, G A Cotsonis, T Hollowa. Elevated concentrations of dopamine sulfate in plasma of cocaine abusers. Biochemical pharmacology. vol 46. issue 8. 1993-11-29. PMID:8240395. |
elevated concentrations of dopamine sulfate in plasma of cocaine abusers. |
1993-11-29 |
2023-08-12 |
human |