| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J D Elsworth, J R Taylor, P Berger, R H Rot. Cocaine-sensitive and -insensitive dopamine uptake in prefrontal cortex, nucleus accumbens and striatum. Neurochemistry international. vol 23. issue 1. 1993-10-08. PMID:8369733. |
dopamine uptake was resolved into two processes, which accounts for some of the apparent reported regional differences in sensitivity of dopamine to inhibition by cocaine. |
1993-10-08 |
2023-08-12 |
Not clear |
| J D Elsworth, J R Taylor, P Berger, R H Rot. Cocaine-sensitive and -insensitive dopamine uptake in prefrontal cortex, nucleus accumbens and striatum. Neurochemistry international. vol 23. issue 1. 1993-10-08. PMID:8369733. |
there appeared to be no regional difference in susceptibility of this mode of dopamine uptake to either cocaine or gbr 12909. |
1993-10-08 |
2023-08-12 |
Not clear |
| J D Elsworth, J R Taylor, P Berger, R H Rot. Cocaine-sensitive and -insensitive dopamine uptake in prefrontal cortex, nucleus accumbens and striatum. Neurochemistry international. vol 23. issue 1. 1993-10-08. PMID:8369733. |
the other type of dopamine uptake, which represented a significant proportion of the total in prefrontal cortex, but not in striatum or nucleus accumbens, was relatively insensitive to cocaine, gbr 12909 and ouabain and was dependent on temperature, but not sodium ion concentration. |
1993-10-08 |
2023-08-12 |
Not clear |
| J D Elsworth, J R Taylor, P Berger, R H Rot. Cocaine-sensitive and -insensitive dopamine uptake in prefrontal cortex, nucleus accumbens and striatum. Neurochemistry international. vol 23. issue 1. 1993-10-08. PMID:8369733. |
the occurrence of cocaine-sensitive dopamine uptake in all examined regions and its equal sensitivity to cocaine and gbr 12909 is consistent with the involvement of nucleus accumbens and/or prefrontal cortex in the reinforcing effects of cocaine. |
1993-10-08 |
2023-08-12 |
Not clear |
| J J Frost, A J Rosier, S G Reich, J S Smith, M D Ehlers, S H Snyder, H T Ravert, R F Dannal. Positron emission tomographic imaging of the dopamine transporter with 11C-WIN 35,428 reveals marked declines in mild Parkinson's disease. Annals of neurology. vol 34. issue 3. 1993-09-30. PMID:8363363. |
recently, 11c-win 35,428, a cocaine analogue that specifically labels the dopamine transporter, was developed and can be used to label dopaminergic nerve terminals in vivo by positron emission tomography. |
1993-09-30 |
2023-08-12 |
human |
| J J Byrnes, G A Pritchard, J M Koff, L G Mille. Prenatal cocaine exposure: decreased sensitization to cocaine and decreased striatal dopamine transporter binding in offspring. Neuropharmacology. vol 32. issue 7. 1993-09-24. PMID:8361584. |
prenatal cocaine exposure: decreased sensitization to cocaine and decreased striatal dopamine transporter binding in offspring. |
1993-09-24 |
2023-08-12 |
mouse |
| J J Byrnes, G A Pritchard, J M Koff, L G Mille. Prenatal cocaine exposure: decreased sensitization to cocaine and decreased striatal dopamine transporter binding in offspring. Neuropharmacology. vol 32. issue 7. 1993-09-24. PMID:8361584. |
cocaine sensitization and dopamine transporter binding were evaluated in offspring at 6 weeks of age. |
1993-09-24 |
2023-08-12 |
mouse |
| D D Wheeler, B M Chapman, J G Ond. Effects of veratridine and cocaine on the kinetics of synaptosomal dopamine release. Pharmacology. vol 47. issue 2. 1993-09-21. PMID:8356101. |
effects of veratridine and cocaine on the kinetics of synaptosomal dopamine release. |
1993-09-21 |
2023-08-12 |
Not clear |
| F J White, X T Hu, D J Henr. Electrophysiological effects of cocaine in the rat nucleus accumbens: microiontophoretic studies. The Journal of pharmacology and experimental therapeutics. vol 266. issue 2. 1993-09-17. PMID:8355182. |
cocaine inhibits the firing of most nac cells due to its ability to prevent the reuptake of dopamine (da) and 5-hydroxytryptamine (5-ht), both of which predominantly inhibit nac cell discharge in vivo. |
1993-09-17 |
2023-08-12 |
rat |
| P M Callahan, K A Cunningha. Discriminative stimulus properties of cocaine in relation to dopamine D2 receptor function in rats. The Journal of pharmacology and experimental therapeutics. vol 266. issue 2. 1993-09-17. PMID:8355192. |
discriminative stimulus properties of cocaine in relation to dopamine d2 receptor function in rats. |
1993-09-17 |
2023-08-12 |
rat |
| P M Callahan, K A Cunningha. Discriminative stimulus properties of cocaine in relation to dopamine D2 receptor function in rats. The Journal of pharmacology and experimental therapeutics. vol 266. issue 2. 1993-09-17. PMID:8355192. |
previous studies indicate that the discriminative stimulus effects of cocaine are mediated predominantly by indirect activation of dopamine (da) d2 postsynaptic receptors, although da d1 receptors may also be involved. |
1993-09-17 |
2023-08-12 |
rat |
| K E Vanover, M F Piercey, W L Woolverto. Evaluation of the reinforcing and discriminative stimulus effects of cocaine in combination with (+)-AJ76 or clozapine. The Journal of pharmacology and experimental therapeutics. vol 266. issue 2. 1993-09-17. PMID:8355207. |
the present study was designed to evaluate the effects of the putative dopamine autoreceptor antagonist (+)-aj76 (aj) or the atypical antipsychotic clozapine (clz) on the reinforcing and discriminative stimulus effects of cocaine in monkeys. |
1993-09-17 |
2023-08-12 |
rat |
| M J Kaufman, B K Madra. [3H]CFT ([3H]WIN 35,428) accumulation in dopamine regions of monkey brain: comparison of a mature and an aged monkey. Brain research. vol 611. issue 2. 1993-08-26. PMID:8334525. |
the present findings support the use of the cocaine congener cft for monitoring the dopamine transporter on dopamine nerve terminals by pet (positron emission tomography) imaging. |
1993-08-26 |
2023-08-12 |
monkey |
| N D Volkow, J S Fowler, G J Wang, R Hitzemann, J Logan, D J Schlyer, S L Dewey, A P Wol. Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers. Synapse (New York, N.Y.). vol 14. issue 2. 1993-08-18. PMID:8101394. |
decreased dopamine d2 receptor availability is associated with reduced frontal metabolism in cocaine abusers. |
1993-08-18 |
2023-08-12 |
Not clear |
| N D Volkow, J S Fowler, G J Wang, R Hitzemann, J Logan, D J Schlyer, S L Dewey, A P Wol. Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers. Synapse (New York, N.Y.). vol 14. issue 2. 1993-08-18. PMID:8101394. |
to examine the possibility that dysfunction of brain regions subserved by the dopamine system could promote cocaine self-administration, positron emission tomography and a dual-tracer approach was used to examine dopamine d2 receptor availability and regional brain glucose metabolism in cocaine abusers. |
1993-08-18 |
2023-08-12 |
Not clear |
| N D Volkow, J S Fowler, G J Wang, R Hitzemann, J Logan, D J Schlyer, S L Dewey, A P Wol. Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers. Synapse (New York, N.Y.). vol 14. issue 2. 1993-08-18. PMID:8101394. |
when compared to normal controls, cocaine abusers showed significant decreases in dopamine d2 receptor availability which persisted 3-4 months after detoxification. |
1993-08-18 |
2023-08-12 |
Not clear |
| B A Bennett, C E Hyde, J R Pecora, J E Clodfelte. Long-term cocaine administration is not neurotoxic to cultured fetal mesencephalic dopamine neurons. Neuroscience letters. vol 153. issue 2. 1993-08-12. PMID:8327196. |
long-term cocaine administration is not neurotoxic to cultured fetal mesencephalic dopamine neurons. |
1993-08-12 |
2023-08-12 |
Not clear |
| B A Bennett, C E Hyde, J R Pecora, J E Clodfelte. Long-term cocaine administration is not neurotoxic to cultured fetal mesencephalic dopamine neurons. Neuroscience letters. vol 153. issue 2. 1993-08-12. PMID:8327196. |
over the same exposure period, cocaine neither impaired neuronal function nor altered dopamine cell survival. |
1993-08-12 |
2023-08-12 |
Not clear |
| B A Bennett, C E Hyde, J R Pecora, J E Clodfelte. Long-term cocaine administration is not neurotoxic to cultured fetal mesencephalic dopamine neurons. Neuroscience letters. vol 153. issue 2. 1993-08-12. PMID:8327196. |
to test whether a longer exposure period to cocaine would alter dopamine function, we added cocaine (100 microm) to the cultures once daily for either 8 or 11 days and examined changes in dopamine uptake, cell survival and morphology 24 h after the last administration. |
1993-08-12 |
2023-08-12 |
Not clear |
| K Yoshida, D K Gjerde, M A Carino, L M Halpern, A Horit. The effects of SCH 23390 and raclopride on cocaine-induced analepsis and EEG arousal in rabbits. Neuropharmacology. vol 32. issue 5. 1993-08-03. PMID:8100623. |
these results suggest that in the rabbit, cocaine exerts a cholinergically-mediated behavioral and eeg arousal through a d1 dopamine mechanism. |
1993-08-03 |
2023-08-12 |
rabbit |