| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J S Meyer, S A Dupon. Prenatal cocaine administration stimulates fetal brain tyrosine hydroxylase activity. Brain research. vol 608. issue 1. 1993-06-21. PMID:8098647. |
finally, the presence of cocaine implants from gd18 to gd21 had no influence on fetal brain neurotransmitter and metabolite concentrations, however, the treated dams exhibited significant reductions in dopamine (da) and the serotonin metabolite, 5-hydroxyindoleacetic acid. |
1993-06-21 |
2023-08-12 |
rat |
| M H Baumann, R B Rothma. Effects of acute and chronic cocaine on the activity of tuberoinfundibular dopamine neurons in the rat. Brain research. vol 608. issue 1. 1993-06-21. PMID:8495344. |
effects of acute and chronic cocaine on the activity of tuberoinfundibular dopamine neurons in the rat. |
1993-06-21 |
2023-08-12 |
rat |
| M H Baumann, R B Rothma. Effects of acute and chronic cocaine on the activity of tuberoinfundibular dopamine neurons in the rat. Brain research. vol 608. issue 1. 1993-06-21. PMID:8495344. |
we investigated the effects of acute and chronic cocaine on dopamine (da) synthesis in tuberoinfundibular dopamine (tida) neurons by measuring the accumulation of 3,4-dihydroxyphenylalanine (dopa) in the median eminence (me). |
1993-06-21 |
2023-08-12 |
rat |
| A C McCreary, C A Marsde. Cocaine-induced behaviour: dopamine D1 receptor antagonism by SCH 23390 prevents expression of conditioned sensitisation following repeated administration of cocaine. Neuropharmacology. vol 32. issue 4. 1993-06-21. PMID:8497339. |
cocaine-induced behaviour: dopamine d1 receptor antagonism by sch 23390 prevents expression of conditioned sensitisation following repeated administration of cocaine. |
1993-06-21 |
2023-08-12 |
Not clear |
| A C McCreary, C A Marsde. Cocaine-induced behaviour: dopamine D1 receptor antagonism by SCH 23390 prevents expression of conditioned sensitisation following repeated administration of cocaine. Neuropharmacology. vol 32. issue 4. 1993-06-21. PMID:8497339. |
the potentiation of the effects of cocaine by a small dose of haloperidol may indicate increased release of dopamine due to blockade of pre-synaptic d2 autoreceptors. |
1993-06-21 |
2023-08-12 |
Not clear |
| L Müller, C Halldin, L Farde, P Karlsson, H Hall, C G Swahn, J Neumeyer, Y Gao, R Miliu. [11C] beta-CIT, a cocaine analogue. Preparation, autoradiography and preliminary PET investigations. Nuclear medicine and biology. vol 20. issue 3. 1993-06-10. PMID:8485483. |
beta-cit (2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane) is a cocaine analogue with a high affinity for the dopamine transporter. |
1993-06-10 |
2023-08-12 |
human |
| A N Gifford, J S Bergmann, K M Johnso. GBR 12909 fails to antagonize cocaine-induced elevation of dopamine in striatal slices. Drug and alcohol dependence. vol 32. issue 1. 1993-06-10. PMID:8486086. |
the effects of cocaine and 1-(2-bis (4-fluorophenyl)methoxy)-ethyl)-4-(3-phenyl-propyl) piperazine (gbr 12909), alone and together, on [3h] dopamine efflux from superfused rat striatal slices was studied. |
1993-06-10 |
2023-08-12 |
rat |
| A N Gifford, J S Bergmann, K M Johnso. GBR 12909 fails to antagonize cocaine-induced elevation of dopamine in striatal slices. Drug and alcohol dependence. vol 32. issue 1. 1993-06-10. PMID:8486086. |
gbr 12909 when added together with cocaine, had no effect on cocaine-induced [3h] dopamine efflux. |
1993-06-10 |
2023-08-12 |
rat |
| A N Gifford, J S Bergmann, K M Johnso. GBR 12909 fails to antagonize cocaine-induced elevation of dopamine in striatal slices. Drug and alcohol dependence. vol 32. issue 1. 1993-06-10. PMID:8486086. |
administration of gbr 12909 antagonized the effect of cocaine on extracellular striatal dopamine levels when infused directly through the dialysis probe, perhaps by acting as a 'partial agonist' at the inhibitory site on the dopamine transporter (rothman et al., 1991 pharmacol. |
1993-06-10 |
2023-08-12 |
rat |
| B A Sorg, P W Kaliva. Effects of cocaine and footshock stress on extracellular dopamine levels in the medial prefrontal cortex. Neuroscience. vol 53. issue 3. 1993-06-08. PMID:7683777. |
effects of cocaine and footshock stress on extracellular dopamine levels in the medial prefrontal cortex. |
1993-06-08 |
2023-08-12 |
rat |
| B A Sorg, P W Kaliva. Effects of cocaine and footshock stress on extracellular dopamine levels in the medial prefrontal cortex. Neuroscience. vol 53. issue 3. 1993-06-08. PMID:7683777. |
the interaction between cocaine and footshock stress was evaluated by determining changes in extracellular dopamine and metabolite levels by in vivo microdialysis in the medial prefrontal cortex. |
1993-06-08 |
2023-08-12 |
rat |
| B A Sorg, P W Kaliva. Effects of cocaine and footshock stress on extracellular dopamine levels in the medial prefrontal cortex. Neuroscience. vol 53. issue 3. 1993-06-08. PMID:7683777. |
in rats pretreated with daily cocaine, this stress-induced response was completely abolished and extracellular dopamine was reduced 38% below baseline levels by 100 min post-shock. |
1993-06-08 |
2023-08-12 |
rat |
| B A Sorg, P W Kaliva. Effects of cocaine and footshock stress on extracellular dopamine levels in the medial prefrontal cortex. Neuroscience. vol 53. issue 3. 1993-06-08. PMID:7683777. |
in daily sham-pretreated rats, extracellular dopamine levels were increased to 500% of baseline in response to acute cocaine. |
1993-06-08 |
2023-08-12 |
rat |
| T Maurice, G Barbanel, J Vigno. Endogenous dopamine differently affects N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine and cocaine binding to the dopamine uptake complex. General pharmacology. vol 24. issue 1. 1993-05-28. PMID:8482495. |
endogenous dopamine differently affects n-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine and cocaine binding to the dopamine uptake complex. |
1993-05-28 |
2023-08-12 |
mouse |
| T Maurice, G Barbanel, J Vigno. Endogenous dopamine differently affects N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine and cocaine binding to the dopamine uptake complex. General pharmacology. vol 24. issue 1. 1993-05-28. PMID:8482495. |
thus in vivo, endogenous dopamine and cocaine are competitive and non-competitive inhibitors, respectively, of the binding of [3h]btcp. |
1993-05-28 |
2023-08-12 |
mouse |
| Y L Hurd, M Herkenha. Molecular alterations in the neostriatum of human cocaine addicts. Synapse (New York, N.Y.). vol 13. issue 4. 1993-05-25. PMID:7683144. |
dopamine uptake site binding was reduced in the caudate and putamen of cocaine subjects. |
1993-05-25 |
2023-08-12 |
human |
| M Ukai, E Mori, T Kameyam. Discriminative stimulus properties of cocaine in the rat using a two-choice discrete-trial avoidance paradigm. Pharmacology, biochemistry, and behavior. vol 44. issue 4. 1993-05-11. PMID:8097045. |
cocaine (10.0 mg/kg) generalized to the dopamine reuptake inhibitor 1-[2-[bis(4-fluorophenyl)methyoxy]ethyl]-4-(3-phenylpropyl)piperaz ine 2hcl (gbr 12909) (30.0 mg/kg), methamphetamine (0.3 mg/kg), apomorphine (0.3 mg/kg), and the d2 dopamine agonist quinpirole (0.1 mg/kg), but not to the d1 dopamine agonist sk&f38393 (3.0-30.0 mg/kg). |
1993-05-11 |
2023-08-12 |
rat |
| M Ukai, E Mori, T Kameyam. Discriminative stimulus properties of cocaine in the rat using a two-choice discrete-trial avoidance paradigm. Pharmacology, biochemistry, and behavior. vol 44. issue 4. 1993-05-11. PMID:8097045. |
haloperidol (0.1 and 0.3 mg/kg), the d1 dopamine antagonist 7-chloro-2,3,4,5-tetrahydro-3-methyl-phenyl-1-h-benzazepine-7-ol maleate (sch23390) (0.01-0.3 mg/kg), and the d2 dopamine antagonist s(-)-sulpiride (20.0 and 40.0 mg/kg) only partially blocked the stimulus effects of cocaine. |
1993-05-11 |
2023-08-12 |
rat |
| M Ukai, E Mori, T Kameyam. Discriminative stimulus properties of cocaine in the rat using a two-choice discrete-trial avoidance paradigm. Pharmacology, biochemistry, and behavior. vol 44. issue 4. 1993-05-11. PMID:8097045. |
these data suggest that both d1 and d2 dopamine receptors contribute to the discriminative stimulus effects of cocaine. |
1993-05-11 |
2023-08-12 |
rat |
| B A Bennett, C E Hyde, J R Pecora, J E Clodfelte. Differing neurotoxic potencies of methamphetamine, mazindol, and cocaine in mesencephalic cultures. Journal of neurochemistry. vol 60. issue 4. 1993-04-19. PMID:8095976. |
the potent reinforcing effects of methamphetamine and cocaine are thought to be mediated by their interactions with cns dopamine neurons. |
1993-04-19 |
2023-08-12 |
Not clear |