| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D D Wheeler, A M Edwards, J G Ond. Dopamine uptake in five structures of the brain: comparison of rate, sodium dependence and sensitivity to cocaine. Neuropharmacology. vol 32. issue 5. 1993-08-03. PMID:8321431. |
dopamine uptake in five structures of the brain: comparison of rate, sodium dependence and sensitivity to cocaine. |
1993-08-03 |
2023-08-12 |
rat |
| D D Wheeler, A M Edwards, J G Ond. Dopamine uptake in five structures of the brain: comparison of rate, sodium dependence and sensitivity to cocaine. Neuropharmacology. vol 32. issue 5. 1993-08-03. PMID:8321431. |
the rate of uptake of dopamine (da) per microgram protein and the sensitivity of uptake to sodium ([na]o) and cocaine, have been measured in synaptosomes from five structures in the brain of the rat: striatum, nucleus accumbens, neocortex, limbic cortex and thalamus. |
1993-08-03 |
2023-08-12 |
rat |
| T Baptista, S R Weiss, R M Pos. Carbamazepine attenuates cocaine-induced increases in dopamine in the nucleus accumbens: an in vivo dialysis study. European journal of pharmacology. vol 236. issue 1. 1993-07-30. PMID:8319744. |
the basal levels of dopamine in the nucleus accumbens did not differ between groups; however, the increases in dopamine following cocaine administration (4 mg/kg i.v.) |
1993-07-30 |
2023-08-12 |
rat |
| W A Cass, G A Gerhardt, K Gillespie, P Curella, R D Mayfield, N R Zahnise. Reduced clearance of exogenous dopamine in rat nucleus accumbens, but not in dorsal striatum, following cocaine challenge in rats withdrawn from repeated cocaine administration. Journal of neurochemistry. vol 61. issue 1. 1993-07-22. PMID:8515274. |
reduced clearance of exogenous dopamine in rat nucleus accumbens, but not in dorsal striatum, following cocaine challenge in rats withdrawn from repeated cocaine administration. |
1993-07-22 |
2023-08-12 |
rat |
| W A Cass, G A Gerhardt, K Gillespie, P Curella, R D Mayfield, N R Zahnise. Reduced clearance of exogenous dopamine in rat nucleus accumbens, but not in dorsal striatum, following cocaine challenge in rats withdrawn from repeated cocaine administration. Journal of neurochemistry. vol 61. issue 1. 1993-07-22. PMID:8515274. |
quantitative autoradiography with [3h]mazindol revealed that the affinity of the dopamine transporter for cocaine and the density of binding sites were similar in cocaine- and saline-treated rats. |
1993-07-22 |
2023-08-12 |
rat |
| W A Cass, G A Gerhardt, K Gillespie, P Curella, R D Mayfield, N R Zahnise. Reduced clearance of exogenous dopamine in rat nucleus accumbens, but not in dorsal striatum, following cocaine challenge in rats withdrawn from repeated cocaine administration. Journal of neurochemistry. vol 61. issue 1. 1993-07-22. PMID:8515274. |
the decrease in dopamine clearance rate observed in the nucleus accumbens of the cocaine-treated rats after a challenge injection of cocaine is consistent with increased dopaminergic transmission, but does not appear to be sufficient in itself for producing behavioral sensitization. |
1993-07-22 |
2023-08-12 |
rat |
| I Vathy, L Katay, K N Min. Sexually dimorphic effects of prenatal cocaine on adult sexual behavior and brain catecholamines in rats. Brain research. Developmental brain research. vol 73. issue 1. 1993-07-21. PMID:8513550. |
cocaine-exposed male rats had significantly higher norepinephrine and dopamine levels in the preoptic area than saline-exposed controls, whereas cocaine did not affect catecholamine content in male hypothalamus, striatum, cortex or cerebellum. |
1993-07-21 |
2023-08-12 |
rat |
| R Needlman, B Zuckerman, G M Anderson, M Mirochnick, D J Cohe. Cerebrospinal fluid monoamine precursors and metabolites in human neonates following in utero cocaine exposure: a preliminary study. Pediatrics. vol 92. issue 1. 1993-07-21. PMID:8516085. |
cocaine acts in the central nervous system by increasing dopamine release and inhibiting the reuptake of dopamine and other monoaminergic neurotransmitters. |
1993-07-21 |
2023-08-12 |
human |
| R Maldonado, P Robledo, A J Chover, S B Caine, G F Koo. D1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat. Pharmacology, biochemistry, and behavior. vol 45. issue 1. 1993-07-19. PMID:8516365. |
d1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat. |
1993-07-19 |
2023-08-12 |
rat |
| R Maldonado, P Robledo, A J Chover, S B Caine, G F Koo. D1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat. Pharmacology, biochemistry, and behavior. vol 45. issue 1. 1993-07-19. PMID:8516365. |
previous work using systemic injections of dopamine receptor antagonists has established that dopamine d1 receptors may have a role in cocaine self-administration. |
1993-07-19 |
2023-08-12 |
rat |
| R Maldonado, P Robledo, A J Chover, S B Caine, G F Koo. D1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat. Pharmacology, biochemistry, and behavior. vol 45. issue 1. 1993-07-19. PMID:8516365. |
sch23390, a selective d1 dopamine antagonist, significantly increased the self-administration of cocaine when injected into the nucleus accumbens. |
1993-07-19 |
2023-08-12 |
rat |
| M H Baumann, T J Raley, J S Partilla, R B Rothma. Biosynthesis of dopamine and serotonin in the rat brain after repeated cocaine injections: a microdissection mapping study. Synapse (New York, N.Y.). vol 14. issue 1. 1993-07-15. PMID:8511717. |
biosynthesis of dopamine and serotonin in the rat brain after repeated cocaine injections: a microdissection mapping study. |
1993-07-15 |
2023-08-12 |
rat |
| M H Baumann, T J Raley, J S Partilla, R B Rothma. Biosynthesis of dopamine and serotonin in the rat brain after repeated cocaine injections: a microdissection mapping study. Synapse (New York, N.Y.). vol 14. issue 1. 1993-07-15. PMID:8511717. |
the purpose of the present study was to examine the effects of chronic cocaine on dopamine (da) and serotonin (5-ht) synthesis in several rat brain regions implicated in drug reinforcement. |
1993-07-15 |
2023-08-12 |
rat |
| R P Hammer, W S Pires, A Markou, G F Koo. Withdrawal following cocaine self-administration decreases regional cerebral metabolic rate in critical brain reward regions. Synapse (New York, N.Y.). vol 14. issue 1. 1993-07-15. PMID:8511720. |
the pattern of regional effects suggests that mesolimbic and rostral extrapyramidal dopamine terminal regions and certain of their efferent pathways are preferentially affected during cocaine withdrawal. |
1993-07-15 |
2023-08-12 |
rat |
| C Giroud, T Colassis, L Rivier, E Ottinge. [Cocaine and alcohol: an explosive cocktail!]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis. vol 82. issue 15. 1993-07-13. PMID:8511449. |
cocaine inhibits the reuptake of dopamine into presynaptic terminals, resulting in an overstimulation of the dopaminergic system. |
1993-07-13 |
2023-08-12 |
Not clear |
| S B Caine, G F Koo. Modulation of cocaine self-administration in the rat through D-3 dopamine receptors. Science (New York, N.Y.). vol 260. issue 5115. 1993-07-09. PMID:8099761. |
modulation of cocaine self-administration in the rat through d-3 dopamine receptors. |
1993-07-09 |
2023-08-12 |
rat |
| S B Caine, G F Koo. Modulation of cocaine self-administration in the rat through D-3 dopamine receptors. Science (New York, N.Y.). vol 260. issue 5115. 1993-07-09. PMID:8099761. |
the reinforcing properties of cocaine are probably mediated by the mesocorticolimbic dopamine pathways in the central nervous system, but not all of the dopamine receptor subtypes involved in cocaine's reinforcing actions have been clearly identified. |
1993-07-09 |
2023-08-12 |
rat |
| N A Sharif, J L Nunes, V Kalfayan, D L McClelland, R P Rosenkranz, R M Eglen, R L Whitin. A pharmacological comparison of [3H]GBR12935 binding to rodent striatal and kidney homogenates: binding to dopamine transporters? Neurochemistry international. vol 21. issue 1. 1993-06-24. PMID:1303143. |
although two dopamine uptake inhibitors, namely gbr12909 and benztropine, displaced [3h]gbr12935 binding from striatal and kidney homogenates with a similar affinity in both tissues of these species, unlabelled mazindol, (+/-)cocaine, nomifensine and amfonelic acid were significantly (p < 0.001-0.02) more potent inhibitors of [3h]gbr12935 binding in the striatum than in the kidney. |
1993-06-24 |
2023-08-11 |
mouse |
| N E Goeders, J E Smit. Intracranial cocaine self-administration into the medial prefrontal cortex increases dopamine turnover in the nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 265. issue 2. 1993-06-22. PMID:8496810. |
intracranial cocaine self-administration into the medial prefrontal cortex increases dopamine turnover in the nucleus accumbens. |
1993-06-22 |
2023-08-12 |
rat |
| N E Goeders, J E Smit. Intracranial cocaine self-administration into the medial prefrontal cortex increases dopamine turnover in the nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 265. issue 2. 1993-06-22. PMID:8496810. |
discrete response-contingent infusions of cocaine into the medial prefrontal cortex resulted in decreases in the turnover of dopamine and serotonin and increases in norepinephrine utilization at the site of self-injection compared to vehicle-infused controls. |
1993-06-22 |
2023-08-12 |
rat |