| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S B Caine, S S Negus, N K Mell. Effects of dopamine D(1-like) and D(2-like) agonists on cocaine self-administration in rhesus monkeys: rapid assessment of cocaine dose-effect functions. Psychopharmacology. vol 148. issue 1. 2000-02-25. PMID:10663416. |
effects of dopamine d(1-like) and d(2-like) agonists on cocaine self-administration in rhesus monkeys: rapid assessment of cocaine dose-effect functions. |
2000-02-25 |
2023-08-12 |
monkey |
| S B Caine, S S Negus, N K Mell. Effects of dopamine D(1-like) and D(2-like) agonists on cocaine self-administration in rhesus monkeys: rapid assessment of cocaine dose-effect functions. Psychopharmacology. vol 148. issue 1. 2000-02-25. PMID:10663416. |
the reinforcing effects of cocaine have been most compellingly related to its action as an indirect dopamine agonist. |
2000-02-25 |
2023-08-12 |
monkey |
| J L Katz, S Izenwasser, P Terr. Relationships among dopamine transporter affinities and cocaine-like discriminative-stimulus effects. Psychopharmacology. vol 148. issue 1. 2000-02-25. PMID:10663422. |
the discriminative-stimulus effects of cocaine have been reported to be mediated by indirect agonist actions initiated by the blockade of dopamine uptake, and the potencies of drugs that have discriminative-stimulus effects like cocaine are directly related to their dopamine transporter binding affinities. |
2000-02-25 |
2023-08-12 |
Not clear |
| J L Katz, S Izenwasser, P Terr. Relationships among dopamine transporter affinities and cocaine-like discriminative-stimulus effects. Psychopharmacology. vol 148. issue 1. 2000-02-25. PMID:10663422. |
the binding to the dopamine transporter by cocaine and many of its analogs has been reported to fit better using a two-site model than a one-site model. |
2000-02-25 |
2023-08-12 |
Not clear |
| N Chen, J V Ferrer, J A Javitch, J B Justic. Transport-dependent accessibility of a cytoplasmic loop cysteine in the human dopamine transporter. The Journal of biological chemistry. vol 275. issue 3. 2000-02-24. PMID:10636852. |
reaction of cys-90 or cys-306 with impermeant methanethiosulfonate derivatives enhanced dopamine uptake to a similar extent as the previously observed enhancement of [(3)h]cft binding caused by the same reaction, suggesting that cocaine may bind preferentially to a conformation in the transport cycle. |
2000-02-24 |
2023-08-12 |
human |
| L L Howell, P W Czoty, M J Kuhar, F I Carro. Comparative behavioral pharmacology of cocaine and the selective dopamine uptake inhibitor RTI-113 in the squirrel monkey. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640288. |
comparative behavioral pharmacology of cocaine and the selective dopamine uptake inhibitor rti-113 in the squirrel monkey. |
2000-02-22 |
2023-08-12 |
human |
| L L Howell, P W Czoty, M J Kuhar, F I Carro. Comparative behavioral pharmacology of cocaine and the selective dopamine uptake inhibitor RTI-113 in the squirrel monkey. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640288. |
the behavioral effects of 3beta-(4-chlorophenyl)tropane-2beta-carboxylic acid phenyl ester hydrochloride (rti-113; 0.03-1.0 mg/kg), a selective dopamine uptake inhibitor, were compared with those of cocaine (0.03-3.0 mg/kg) and 1-(2-[bis(4-fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride (gbr 12909; 0.03-3.0 mg/kg) in squirrel monkeys. |
2000-02-22 |
2023-08-12 |
human |
| L L Howell, P W Czoty, M J Kuhar, F I Carro. Comparative behavioral pharmacology of cocaine and the selective dopamine uptake inhibitor RTI-113 in the squirrel monkey. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640288. |
the results indicate that the behavioral pharmacology of rti-113 is similar to that of cocaine, further implicating a prominent role for dopamine uptake inhibition in the behavioral effects of cocaine. |
2000-02-22 |
2023-08-12 |
human |
| R De La Garza, K A Cunningha. The effects of the 5-hydroxytryptamine(1A) agonist 8-hydroxy-2-(di-n-propylamino)tetralin on spontaneous activity, cocaine-induced hyperactivity and behavioral sensitization: a microanalysis of locomotor activity. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640298. |
the present study implies that the stimulation of 5-hydroxytryptamine(1a) receptors is capable of modulating the hyperactivity evoked by cocaine, possibly via modulation of the mesoaccumbens dopamine circuit thought to mediate the behavioral effects of cocaine. |
2000-02-22 |
2023-08-12 |
rat |
| M Xu, Y Guo, C V Vorhees, J Zhan. Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptor. Brain research. vol 852. issue 1. 2000-02-22. PMID:10661513. |
behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine d1 receptor. |
2000-02-22 |
2023-08-12 |
mouse |
| M Xu, Y Guo, C V Vorhees, J Zhan. Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptor. Brain research. vol 852. issue 1. 2000-02-22. PMID:10661513. |
to determine whether the dopamine d1 receptor plays a crucial role in the behavioral effects of psychostimulants, we tested both the locomotor and stereotyped behaviors in d1 receptor mutant and wild-type control mice after cocaine and amphetamine treatments. |
2000-02-22 |
2023-08-12 |
mouse |
| C Davidson, E H Ellinwood, T H Le. Altered sensitivity of dopamine autoreceptors in rat accumbens 1 and 7 days after intermittent or continuous cocaine withdrawal. Brain research bulletin. vol 51. issue 1. 2000-02-18. PMID:10654586. |
altered sensitivity of dopamine autoreceptors in rat accumbens 1 and 7 days after intermittent or continuous cocaine withdrawal. |
2000-02-18 |
2023-08-12 |
rat |
| C Davidson, E H Ellinwood, T H Le. Altered sensitivity of dopamine autoreceptors in rat accumbens 1 and 7 days after intermittent or continuous cocaine withdrawal. Brain research bulletin. vol 51. issue 1. 2000-02-18. PMID:10654586. |
using slice preparations, we investigated the effects of chronic cocaine treatment on dopamine autoreceptor sensitivity in the nucleus accumbens core. |
2000-02-18 |
2023-08-12 |
rat |
| C Davidson, E H Ellinwood, T H Le. Altered sensitivity of dopamine autoreceptors in rat accumbens 1 and 7 days after intermittent or continuous cocaine withdrawal. Brain research bulletin. vol 51. issue 1. 2000-02-18. PMID:10654586. |
one or 7 days after cocaine withdrawal, we used fast scan cyclic voltammetry (10 hz sampling rate) to measure inhibition of electrically evoked dopamine release by quinpirole (3-300 nm). |
2000-02-18 |
2023-08-12 |
rat |
| C Davidson, E H Ellinwood, T H Le. Altered sensitivity of dopamine autoreceptors in rat accumbens 1 and 7 days after intermittent or continuous cocaine withdrawal. Brain research bulletin. vol 51. issue 1. 2000-02-18. PMID:10654586. |
it is suggested that these cocaine dosing regimes cause differential and dynamic changes in dopamine autoreceptor sensitivity during the early withdrawal phase. |
2000-02-18 |
2023-08-12 |
rat |
| N D Volkow, J S Fowler, G J Wan. Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. Journal of psychopharmacology (Oxford, England). vol 13. issue 4. 2000-02-18. PMID:10667609. |
imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. |
2000-02-18 |
2023-08-12 |
Not clear |
| N D Volkow, J S Fowler, G J Wan. Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. Journal of psychopharmacology (Oxford, England). vol 13. issue 4. 2000-02-18. PMID:10667609. |
we summarize our studies with positron emission tomography investigating the role of dopamine (da) in the reinforcing effects of cocaine and methylphenidate in humans and its involvement in cocaine addiction. |
2000-02-18 |
2023-08-12 |
Not clear |
| N D Volkow, J S Fowler, G J Wan. Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. Journal of psychopharmacology (Oxford, England). vol 13. issue 4. 2000-02-18. PMID:10667609. |
these studies have shown that the rate at which cocaine and methylphenidate enter the brain and block the dopamine transporters (dat) is the variable associated with the 'high', rather than the presence per se of the drug in the brain. |
2000-02-18 |
2023-08-12 |
Not clear |
| D M Donovan, L L Miner, M P Perry, R S Revay, L G Sharpe, S Przedborski, V Kostic, R M Philpot, C L Kirstein, R B Rothman, C W Schindler, G R Uh. Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581396. |
cocaine reward and mptp toxicity: alteration by regional variant dopamine transporter overexpression. |
2000-02-14 |
2023-08-12 |
mouse |
| D M Donovan, L L Miner, M P Perry, R S Revay, L G Sharpe, S Przedborski, V Kostic, R M Philpot, C L Kirstein, R B Rothman, C W Schindler, G R Uh. Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581396. |
the dopamine transporter (dat; slc6a3) is densely expressed by the dopaminergic midbrain neurons that play central roles in drug reward and is believed to be a primary site of action for cocaine reward. |
2000-02-14 |
2023-08-12 |
mouse |