| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C N Haile, G Carey, G B Varty, V L Coffi. The dopamine D(1) receptor agonist SKF-82958 serves as a discriminative stimulus in the rat. European journal of pharmacology. vol 388. issue 2. 2000-03-16. PMID:10666503. |
the dopamine d(2) receptor agonist trans-(+/-)-4,4a,5,6,7,8,8a, 9-octahydro-5-propyl-1h-propyl-1h-pyrazolo[3,4-g]quinoline dihydrochloride (quinpirole) and the indirect dopamine agonist cocaine did not substitute fully for the skf-82958 discriminative stimulus cue. |
2000-03-16 |
2023-08-12 |
rat |
| S J Li, B Biswal, Z Li, R Risinger, C Rainey, J K Cho, B J Salmeron, E A Stei. Cocaine administration decreases functional connectivity in human primary visual and motor cortex as detected by functional MRI. Magnetic resonance in medicine. vol 43. issue 1. 2000-03-14. PMID:10642730. |
it is suggested that the observed changes in low frequency components after acute cocaine administration during a resting, no-task situation may be used as a baseline reference source when assessing the effects of cocaine on task-driven activation or on mesolimbic dopamine pathways. |
2000-03-14 |
2023-08-12 |
human |
| W P Melega, G Lacan, A A Desalles, M E Phelp. Long-term methamphetamine-induced decreases of [(11)C]WIN 35,428 binding in striatum are reduced by GDNF: PET studies in the vervet monkey. Synapse (New York, N.Y.). vol 35. issue 4. 2000-03-13. PMID:10657033. |
win, a cocaine analog that binds to the dopamine transporter (dat), was used to provide an index of striatal dopamine terminal integrity. |
2000-03-13 |
2023-08-12 |
human |
| S Wang, S Sakamuri, I J Enyedy, A P Kozikowski, O Deschaux, B C Bandyopadhyay, S R Tella, W A Zaman, K M Johnso. Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationships, and behavioral pharmacological studies. Journal of medicinal chemistry. vol 43. issue 3. 2000-03-13. PMID:10669562. |
discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3d-database pharmacophore searching. |
2000-03-13 |
2023-08-12 |
mouse |
| S Wang, S Sakamuri, I J Enyedy, A P Kozikowski, O Deschaux, B C Bandyopadhyay, S R Tella, W A Zaman, K M Johnso. Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationships, and behavioral pharmacological studies. Journal of medicinal chemistry. vol 43. issue 3. 2000-03-13. PMID:10669562. |
a novel, fairly potent dopamine transporter (dat) inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone (3, k(i) values of 492 and 360 nm in binding affinity and inhibition of dopamine reuptake, respectively), with significant functional antagonism against cocaine and a different in vitro pharmacological profile from cocaine at the three transporter sites (dopamine, serotonin, and norepinephrine) was discovered through 3d-database pharmacophore searching. |
2000-03-13 |
2023-08-12 |
mouse |
| T Sato, S Kitayama, C Mitsuhata, T Ikeda, K Morita, T Doh. Selective inhibition of monoamine neurotransmitter transporters by synthetic local anesthetics. Naunyn-Schmiedeberg's archives of pharmacology. vol 361. issue 2. 2000-03-08. PMID:10685879. |
among the las tested, procaine and other ester-type las inhibited [3h]da uptake and binding of [3h]2-beta-carbomethoxy-3-beta-(4-fluorophenyl)tropane (cft), a cocaine analogue, in cos cells expressing rat dopamine transporter (dat). |
2000-03-08 |
2023-08-12 |
mouse |
| J G Chen, G Rudnic. Permeation and gating residues in serotonin transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 3. 2000-03-02. PMID:10655481. |
in net i155c, cocaine enhanced this inactivation, and the substrate, dopamine, apparently protected against inactivation. |
2000-03-02 |
2023-08-12 |
Not clear |
| S W Choi, D R Elmaleh, R N Hanson, A J Fischma. Novel 3-aminomethyl- and 4-aminopiperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazines: synthesis and evaluation as dopamine transporter ligands. Journal of medicinal chemistry. vol 43. issue 2. 2000-02-28. PMID:10649976. |
we have undertaken a program to develop cocaine antagonists based on the premise that such compounds should block cocaine binding but permit reuptake of dopamine at the dopamine transporter (dat). |
2000-02-28 |
2023-08-12 |
Not clear |
| S B Caine, S S Negus, N K Mell. Effects of dopamine D(1-like) and D(2-like) agonists on cocaine self-administration in rhesus monkeys: rapid assessment of cocaine dose-effect functions. Psychopharmacology. vol 148. issue 1. 2000-02-25. PMID:10663416. |
effects of dopamine d(1-like) and d(2-like) agonists on cocaine self-administration in rhesus monkeys: rapid assessment of cocaine dose-effect functions. |
2000-02-25 |
2023-08-12 |
monkey |
| S B Caine, S S Negus, N K Mell. Effects of dopamine D(1-like) and D(2-like) agonists on cocaine self-administration in rhesus monkeys: rapid assessment of cocaine dose-effect functions. Psychopharmacology. vol 148. issue 1. 2000-02-25. PMID:10663416. |
the reinforcing effects of cocaine have been most compellingly related to its action as an indirect dopamine agonist. |
2000-02-25 |
2023-08-12 |
monkey |
| J L Katz, S Izenwasser, P Terr. Relationships among dopamine transporter affinities and cocaine-like discriminative-stimulus effects. Psychopharmacology. vol 148. issue 1. 2000-02-25. PMID:10663422. |
the discriminative-stimulus effects of cocaine have been reported to be mediated by indirect agonist actions initiated by the blockade of dopamine uptake, and the potencies of drugs that have discriminative-stimulus effects like cocaine are directly related to their dopamine transporter binding affinities. |
2000-02-25 |
2023-08-12 |
Not clear |
| J L Katz, S Izenwasser, P Terr. Relationships among dopamine transporter affinities and cocaine-like discriminative-stimulus effects. Psychopharmacology. vol 148. issue 1. 2000-02-25. PMID:10663422. |
the binding to the dopamine transporter by cocaine and many of its analogs has been reported to fit better using a two-site model than a one-site model. |
2000-02-25 |
2023-08-12 |
Not clear |
| N Chen, J V Ferrer, J A Javitch, J B Justic. Transport-dependent accessibility of a cytoplasmic loop cysteine in the human dopamine transporter. The Journal of biological chemistry. vol 275. issue 3. 2000-02-24. PMID:10636852. |
reaction of cys-90 or cys-306 with impermeant methanethiosulfonate derivatives enhanced dopamine uptake to a similar extent as the previously observed enhancement of [(3)h]cft binding caused by the same reaction, suggesting that cocaine may bind preferentially to a conformation in the transport cycle. |
2000-02-24 |
2023-08-12 |
human |
| L L Howell, P W Czoty, M J Kuhar, F I Carro. Comparative behavioral pharmacology of cocaine and the selective dopamine uptake inhibitor RTI-113 in the squirrel monkey. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640288. |
comparative behavioral pharmacology of cocaine and the selective dopamine uptake inhibitor rti-113 in the squirrel monkey. |
2000-02-22 |
2023-08-12 |
human |
| L L Howell, P W Czoty, M J Kuhar, F I Carro. Comparative behavioral pharmacology of cocaine and the selective dopamine uptake inhibitor RTI-113 in the squirrel monkey. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640288. |
the behavioral effects of 3beta-(4-chlorophenyl)tropane-2beta-carboxylic acid phenyl ester hydrochloride (rti-113; 0.03-1.0 mg/kg), a selective dopamine uptake inhibitor, were compared with those of cocaine (0.03-3.0 mg/kg) and 1-(2-[bis(4-fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride (gbr 12909; 0.03-3.0 mg/kg) in squirrel monkeys. |
2000-02-22 |
2023-08-12 |
human |
| L L Howell, P W Czoty, M J Kuhar, F I Carro. Comparative behavioral pharmacology of cocaine and the selective dopamine uptake inhibitor RTI-113 in the squirrel monkey. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640288. |
the results indicate that the behavioral pharmacology of rti-113 is similar to that of cocaine, further implicating a prominent role for dopamine uptake inhibition in the behavioral effects of cocaine. |
2000-02-22 |
2023-08-12 |
human |
| R De La Garza, K A Cunningha. The effects of the 5-hydroxytryptamine(1A) agonist 8-hydroxy-2-(di-n-propylamino)tetralin on spontaneous activity, cocaine-induced hyperactivity and behavioral sensitization: a microanalysis of locomotor activity. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640298. |
the present study implies that the stimulation of 5-hydroxytryptamine(1a) receptors is capable of modulating the hyperactivity evoked by cocaine, possibly via modulation of the mesoaccumbens dopamine circuit thought to mediate the behavioral effects of cocaine. |
2000-02-22 |
2023-08-12 |
rat |
| M Xu, Y Guo, C V Vorhees, J Zhan. Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptor. Brain research. vol 852. issue 1. 2000-02-22. PMID:10661513. |
behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine d1 receptor. |
2000-02-22 |
2023-08-12 |
mouse |
| M Xu, Y Guo, C V Vorhees, J Zhan. Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptor. Brain research. vol 852. issue 1. 2000-02-22. PMID:10661513. |
to determine whether the dopamine d1 receptor plays a crucial role in the behavioral effects of psychostimulants, we tested both the locomotor and stereotyped behaviors in d1 receptor mutant and wild-type control mice after cocaine and amphetamine treatments. |
2000-02-22 |
2023-08-12 |
mouse |
| C Davidson, E H Ellinwood, T H Le. Altered sensitivity of dopamine autoreceptors in rat accumbens 1 and 7 days after intermittent or continuous cocaine withdrawal. Brain research bulletin. vol 51. issue 1. 2000-02-18. PMID:10654586. |
altered sensitivity of dopamine autoreceptors in rat accumbens 1 and 7 days after intermittent or continuous cocaine withdrawal. |
2000-02-18 |
2023-08-12 |
rat |