| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Izenwasser, D French, F I Carroll, P M Kunk. Continuous infusion of selective dopamine uptake inhibitors or cocaine produces time-dependent changes in rat locomotor activity. Behavioural brain research. vol 99. issue 2. 1999-10-27. PMID:10512586. |
the selective dopamine uptake inhibitors produced some of the effects of cocaine. |
1999-10-27 |
2023-08-12 |
rat |
| S Izenwasser, D French, F I Carroll, P M Kunk. Continuous infusion of selective dopamine uptake inhibitors or cocaine produces time-dependent changes in rat locomotor activity. Behavioural brain research. vol 99. issue 2. 1999-10-27. PMID:10512586. |
the possibilities that cocaine interacts with the dopamine transporter in a qualitatively different manner from that of these selective dopamine uptake inhibitors, or that other monoamine systems are involved, are discussed. |
1999-10-27 |
2023-08-12 |
rat |
| A M Kang, M A Palmatier, K K Kid. Global variation of a 40-bp VNTR in the 3'-untranslated region of the dopamine transporter gene (SLC6A3). Biological psychiatry. vol 46. issue 2. 1999-10-25. PMID:10418689. |
the dopamine transporter (dat) is the primary mechanism for dopamine clearance from the synapse in midbrain dopaminergic neurons, and the target of psychostimulant and neurotoxic drugs such as cocaine, amphetamine, and mptp. |
1999-10-25 |
2023-08-12 |
Not clear |
| M S Kleven, J M Kamenka, J Vignon, W Koe. Pharmacological characterization of the discriminative stimulus properties of the phencyclidine analog, N-[1-(2-benzo(b)thiophenyl)-cyclohexyl]piperidine. Psychopharmacology. vol 145. issue 4. 1999-10-19. PMID:10460313. |
although both cocaine and the phencyclidine analog, btcp, have dopamine (da) re-uptake blocking properties, under some conditions their behavioral effects can be differentiated. |
1999-10-19 |
2023-08-12 |
Not clear |
| M F O'Neill, G Sha. Comparison of dopamine receptor antagonists on hyperlocomotion induced by cocaine, amphetamine, MK-801 and the dopamine D1 agonist C-APB in mice. Psychopharmacology. vol 145. issue 3. 1999-10-18. PMID:10494572. |
comparison of dopamine receptor antagonists on hyperlocomotion induced by cocaine, amphetamine, mk-801 and the dopamine d1 agonist c-apb in mice. |
1999-10-18 |
2023-08-12 |
mouse |
| W Du, V J Aloyo, P S Pazdelski, J A Harve. Effects of prenatal cocaine exposure on amphetamine-induced dopamine release in the caudate nucleus of the adult rabbit. Brain research. vol 836. issue 1-2. 1999-10-15. PMID:10415418. |
effects of prenatal cocaine exposure on amphetamine-induced dopamine release in the caudate nucleus of the adult rabbit. |
1999-10-15 |
2023-08-12 |
rabbit |
| W Du, V J Aloyo, P S Pazdelski, J A Harve. Effects of prenatal cocaine exposure on amphetamine-induced dopamine release in the caudate nucleus of the adult rabbit. Brain research. vol 836. issue 1-2. 1999-10-15. PMID:10415418. |
in this study, we employed in vivo microdialysis to examine the effects of prenatal cocaine exposure on amph-induced dopamine (da) release in the caudate nucleus of the awake adult rabbit. |
1999-10-15 |
2023-08-12 |
rabbit |
| A P Kozikowski, D Simoni, M Roberti, R Rondanin, S Wang, P Du, K M Johnso. Synthesis of 8-Oxa analogues of norcocaine endowed with interesting cocaine-like activity. Bioorganic & medicinal chemistry letters. vol 9. issue 13. 1999-10-14. PMID:10406650. |
in order to further explore the importance of cocaine's bridge nitrogen atom in binding to the dopamine transporter (dat), we have synthesized the previously known racemic 8-oxa-norcocaines 3-6 in which the nitrogen atom has been replaced by oxygen. |
1999-10-14 |
2023-08-12 |
Not clear |
| A P Kozikowski, D Simoni, M Roberti, R Rondanin, S Wang, P Du, K M Johnso. Synthesis of 8-Oxa analogues of norcocaine endowed with interesting cocaine-like activity. Bioorganic & medicinal chemistry letters. vol 9. issue 13. 1999-10-14. PMID:10406650. |
(-)-8-oxa-norcocaine (3) was found to bind to the cocaine recognition site and to inhibit the dopamine transporter with potencies only about 8-fold and 4-fold, respectively, less than those of norcocaine (2). |
1999-10-14 |
2023-08-12 |
Not clear |
| J S Meyer, R Kunkl. Behavioral responses to a D1 dopamine agonist in weanling rats treated neonatally with cocaine and delta9-tetrahydrocannabinol. Neurotoxicology and teratology. vol 21. issue 4. 1999-10-14. PMID:10440481. |
behavioral responses to a d1 dopamine agonist in weanling rats treated neonatally with cocaine and delta9-tetrahydrocannabinol. |
1999-10-14 |
2023-08-12 |
rat |
| J S Meyer, R Kunkl. Behavioral responses to a D1 dopamine agonist in weanling rats treated neonatally with cocaine and delta9-tetrahydrocannabinol. Neurotoxicology and teratology. vol 21. issue 4. 1999-10-14. PMID:10440481. |
we determined whether neonatal exposure to cocaine with or without delta9-tetrahydrocannabinol (thc) altered the behavioral responses of weanling rats to the full d1 dopamine (da) agonist skf 81297. |
1999-10-14 |
2023-08-12 |
rat |
| S J Gatley, N D Volkow, A N Gifford, J S Fowler, S L Dewey, Y S Ding, J Loga. Dopamine-transporter occupancy after intravenous doses of cocaine and methylphenidate in mice and humans. Psychopharmacology. vol 146. issue 1. 1999-10-13. PMID:10485970. |
recent studies using positron emission tomography (pet) have established the relationship between an intravenous dose of cocaine and the percentage occupancy of the dopamine transporter in humans, and have documented the requirement of more than 50% occupancy for perception of the "high". |
1999-10-13 |
2023-08-12 |
mouse |
| S J Gatley, N D Volkow, A N Gifford, J S Fowler, S L Dewey, Y S Ding, J Loga. Dopamine-transporter occupancy after intravenous doses of cocaine and methylphenidate in mice and humans. Psychopharmacology. vol 146. issue 1. 1999-10-13. PMID:10485970. |
the present experiments were conducted to examine dose-occupancy and dose-effect relationships in mice for cocaine and also for methylphenidate, a dopamine uptake blocker used in pediatric psychiatry. |
1999-10-13 |
2023-08-12 |
mouse |
| J L Katz, T A Kopajtic, K A Myers, R J Mitkus, M Chide. Behavioral effects of cocaine: interactions with D1 dopaminergic antagonists and agonists in mice and squirrel monkeys. The Journal of pharmacology and experimental therapeutics. vol 291. issue 1. 1999-10-12. PMID:10490913. |
the present study compared interactions among dopamine d1-like agonists and partial agonists with cocaine on the locomotor stimulant effects of cocaine, as well as the discriminative-stimulus effects of cocaine, and effects of cocaine on rates of responding. |
1999-10-12 |
2023-08-12 |
mouse |
| J L Katz, T A Kopajtic, K A Myers, R J Mitkus, M Chide. Behavioral effects of cocaine: interactions with D1 dopaminergic antagonists and agonists in mice and squirrel monkeys. The Journal of pharmacology and experimental therapeutics. vol 291. issue 1. 1999-10-12. PMID:10490913. |
the d1 dopamine antagonists sch 23390, sch 39166, and a-69024 dose-dependently shifted the cocaine dose-effect curve for locomotor activity to the right and decreased the efficacy of cocaine. |
1999-10-12 |
2023-08-12 |
mouse |
| J L Katz, T A Kopajtic, K A Myers, R J Mitkus, M Chide. Behavioral effects of cocaine: interactions with D1 dopaminergic antagonists and agonists in mice and squirrel monkeys. The Journal of pharmacology and experimental therapeutics. vol 291. issue 1. 1999-10-12. PMID:10490913. |
this differential involvement of d1 dopamine receptors in these various behavioral effects of cocaine suggests problems in predicting clinical efficacy of at least d1 receptor antagonists as potential treatments for cocaine abuse. |
1999-10-12 |
2023-08-12 |
mouse |
| S B Caine, S S Negus, N K Mello, J Bergma. Effects of dopamine D(1-like) and D(2-like) agonists in rats that self-administer cocaine. The Journal of pharmacology and experimental therapeutics. vol 291. issue 1. 1999-10-12. PMID:10490924. |
effects of dopamine d(1-like) and d(2-like) agonists in rats that self-administer cocaine. |
1999-10-12 |
2023-08-12 |
rat |
| U C Campbell, J S Rodefer, M E Carrol. Effects of dopamine receptor antagonists (D1 and D2) on the demand for smoked cocaine base in rhesus monkeys. Psychopharmacology. vol 144. issue 4. 1999-09-28. PMID:10435411. |
previous studies suggest that dopamine antagonists may reduce the reinforcing effects of cocaine. |
1999-09-28 |
2023-08-12 |
monkey |
| P W Kalivas, P Duffy, S A Mackle. Interrupted expression of NAC-1 augments the behavioral responses to cocaine. Synapse (New York, N.Y.). vol 33. issue 2. 1999-09-27. PMID:10400893. |
the augmentation in cocaine motor behavior produced by nac-1 antisense pretreatment in the nucleus accumbens was not associated with increased dopamine release as estimated by microdialysis. |
1999-09-27 |
2023-08-12 |
rat |
| P W Kalivas, P Duffy, S A Mackle. Interrupted expression of NAC-1 augments the behavioral responses to cocaine. Synapse (New York, N.Y.). vol 33. issue 2. 1999-09-27. PMID:10400893. |
these data suggest that the induction of nac-1 by cocaine may be a compensatory mechanism that minimizes the behavioral impact of cocaine administration by regulating postsynaptic dopamine transmission within the nucleus accumbens. |
1999-09-27 |
2023-08-12 |
rat |