| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D C Mash, J K Stale. D3 dopamine and kappa opioid receptor alterations in human brain of cocaine-overdose victims. Annals of the New York Academy of Sciences. vol 877. 1999-08-10. PMID:10415668. |
cocaine is thought to be addictive because chronic use leads to molecular adaptations within the mesolimbic dopamine (da) circuitry, which affects motivated behavior and emotion. |
1999-08-10 |
2023-08-12 |
human |
| D Simoni, M Roberti, V Andrisano, M Manferdini, R Rondanin, F P Invidiat. Two-carbon bridge substituted cocaines: enantioselective synthesis, attribution of the absolute configuration and biological activity of novel 6- and 7-methoxylated cocaines. Farmaco (Societa chimica italiana : 1989). vol 54. issue 5. 1999-08-09. PMID:10418122. |
it appeared evident that methoxylation of the cocaine two-carbon bridge provides compounds of particular interest: the ki for the binding of the methoxypseudococaines is about two to four times smaller than the ki for inhibition of dopamine uptake, thus enabling these compounds capable of countering the effects of cocaine to some extent. |
1999-08-09 |
2023-08-12 |
Not clear |
| X Wu, H H G. Molecular cloning of the mouse dopamine transporter and pharmacological comparison with the human homologue. Gene. vol 233. issue 1-2. 1999-08-05. PMID:10375632. |
cocaine and amphetamines, widely used drugs of abuse, bind to dopamine (da), serotonin, and norepinephrine transporters with high affinity and block their functions. |
1999-08-05 |
2023-08-12 |
mouse |
| X Wu, H H G. Molecular cloning of the mouse dopamine transporter and pharmacological comparison with the human homologue. Gene. vol 233. issue 1-2. 1999-08-05. PMID:10375632. |
it is believed that the dopamine transporter plays a key role in the mechanism of cocaine addiction. |
1999-08-05 |
2023-08-12 |
mouse |
| B M Prasad, T Hochstatter, B A Sor. Expression of cocaine sensitization: regulation by the medial prefrontal cortex. Neuroscience. vol 88. issue 3. 1999-08-02. PMID:10363816. |
extracellular levels of dopamine are increased in response to systemic administration of cocaine in several brain areas including the nucleus accumbens and medial prefrontal cortex. |
1999-08-02 |
2023-08-12 |
rat |
| B M Prasad, T Hochstatter, B A Sor. Expression of cocaine sensitization: regulation by the medial prefrontal cortex. Neuroscience. vol 88. issue 3. 1999-08-02. PMID:10363816. |
while the cocaine-induced increase in extracellular dopamine levels in the nucleus accumbens is augmented after repeated daily cocaine, the response of extracellular dopamine levels in the medial prefrontal cortex is attenuated. |
1999-08-02 |
2023-08-12 |
rat |
| B M Prasad, T Hochstatter, B A Sor. Expression of cocaine sensitization: regulation by the medial prefrontal cortex. Neuroscience. vol 88. issue 3. 1999-08-02. PMID:10363816. |
since dopamine in the medial prefrontal cortex has an inhibitory effect on nucleus accumbens dopamine levels and locomotor activity, the role of medial prefrontal cortex dopamine tolerance in the expression of sensitized locomotor behavior was further examined by injection of d-amphetamine sulfate into the prelimbic portion of the medial prefrontal cortex just prior to cocaine challenge in cocaine-sensitized rats. |
1999-08-02 |
2023-08-12 |
rat |
| B M Prasad, T Hochstatter, B A Sor. Expression of cocaine sensitization: regulation by the medial prefrontal cortex. Neuroscience. vol 88. issue 3. 1999-08-02. PMID:10363816. |
the results suggest that in rats sensitized to cocaine, decreased medial prefrontal cortex dopamine levels in response to cocaine challenge may contribute to behavioral sensitization. |
1999-08-02 |
2023-08-12 |
rat |
| F Rougé-Pont, D N Abrous, M Le Moal, P V Piazz. Release of endogenous dopamine in cultured mesencephalic neurons: influence of dopaminergic agonists and glucocorticoid antagonists. The European journal of neuroscience. vol 11. issue 7. 1999-07-30. PMID:10383623. |
k+ (20 mm), or by the indirect dopamine agonists amphetamine and cocaine; (iv) decreased by a hyperpolarizing stimulus, e.g. |
1999-07-30 |
2023-08-12 |
Not clear |
| J R Nation, D K Mille. The effects of cadmium contamination on the discriminative stimulus properties of cocaine and related drugs. Experimental and clinical psychopharmacology. vol 7. issue 2. 1999-07-29. PMID:10340150. |
after acquisition training, successive substitution tests were conducted using cocaine, the indirect dopamine agonist d-amphetamine, the mixed d1-d2 agonist apomorphine, skf 38393 and skf 82958 (both preferential d1 agonists), quinpirole (a preferential d2 agonist), gbr 12909 (a dopamine reuptake inhibitor), procaine (a local anesthetic), and morphine (an opiate). |
1999-07-29 |
2023-08-12 |
rat |
| Y Itzhak, J L Martin, M D Black, S F Al. Effect of the dopaminergic neurotoxin MPTP on cocaine-induced locomotor sensitization. Pharmacology, biochemistry, and behavior. vol 63. issue 1. 1999-07-28. PMID:10340529. |
the blockade of dopamine (da) uptake via the dopamine transporter (dat) in the nucleus accumbens (nac) and striatum by cocaine has a major role in the reinforcing and psychomotor stimulating effects of the drug. |
1999-07-28 |
2023-08-12 |
mouse |
| N D Volkow, G J Wang, J S Fowler, M Fischman, R Foltin, N N Abumrad, S J Gatley, J Logan, C Wong, A Gifford, Y S Ding, R Hitzemann, N Pappa. Methylphenidate and cocaine have a similar in vivo potency to block dopamine transporters in the human brain. Life sciences. vol 65. issue 1. 1999-07-23. PMID:10403500. |
methylphenidate and cocaine have a similar in vivo potency to block dopamine transporters in the human brain. |
1999-07-23 |
2023-08-12 |
human |
| N D Volkow, G J Wang, J S Fowler, M Fischman, R Foltin, N N Abumrad, S J Gatley, J Logan, C Wong, A Gifford, Y S Ding, R Hitzemann, N Pappa. Methylphenidate and cocaine have a similar in vivo potency to block dopamine transporters in the human brain. Life sciences. vol 65. issue 1. 1999-07-23. PMID:10403500. |
the reinforcing effects of cocaine and methylphenidate have been linked to their ability to block dopamine transporters (dat). |
1999-07-23 |
2023-08-12 |
human |
| S Consolo, C Caltavuturo, E Colli, M Recchia, G Di Chiar. Different sensitivity of in vivo acetylcholine transmission to D1 receptor stimulation in shell and core of nucleus accumbens. Neuroscience. vol 89. issue 4. 1999-07-22. PMID:10362308. |
the dopamine release inducer d-amphetamine (1 and 2mg/kg, s.c.) and the dopamine uptake inhibitor cocaine (10 and 20 mg/kg, i.p.) |
1999-07-22 |
2023-08-12 |
rat |
| X Shi, R Yin, D Dow-Edward. Chronic haloperidol alters dopamine receptors: effects of cocaine exposure during the preweaning period. European journal of pharmacology. vol 370. issue 3. 1999-07-16. PMID:10334498. |
chronic haloperidol alters dopamine receptors: effects of cocaine exposure during the preweaning period. |
1999-07-16 |
2023-08-12 |
rat |
| X Shi, R Yin, D Dow-Edward. Chronic haloperidol alters dopamine receptors: effects of cocaine exposure during the preweaning period. European journal of pharmacology. vol 370. issue 3. 1999-07-16. PMID:10334498. |
the present study investigated the alterations in dopamine receptors in 93-day-old male and female rats treated with cocaine (50 mg kg(-1) day(-1)), 1-[2-[bis(4-fluorophenyl)methoxyl]-4-[3-phenylpropyl]piperazine (gbr 12909) (50 mg kg(-1) every other day) or water during postnatal days 11-20. |
1999-07-16 |
2023-08-12 |
rat |
| X Shi, R Yin, D Dow-Edward. Chronic haloperidol alters dopamine receptors: effects of cocaine exposure during the preweaning period. European journal of pharmacology. vol 370. issue 3. 1999-07-16. PMID:10334498. |
these data suggest that inhibition of the dopamine transporter during ontogeny produces long-term alterations in dopamine receptor regulation but that selective inhibitors of the dopamine transporter produced greater effects than cocaine on both raclopride and sch 23390 binding following chronic haloperidol injection. |
1999-07-16 |
2023-08-12 |
rat |
| L J Vanderschuren, A N Schoffelmeer, A H Mulder, T J De Vrie. Dopaminergic mechanisms mediating the long-term expression of locomotor sensitization following pre-exposure to morphine or amphetamine. Psychopharmacology. vol 143. issue 3. 1999-07-13. PMID:10353426. |
both morphine- and amphetamine-pretreated rats displayed sensitization of the locomotor effects of amphetamine, cocaine, and the selective dopamine reuptake inhibitor gbr-12909. |
1999-07-13 |
2023-08-12 |
rat |
| C A Heidbreder, T Oertle, J Feldo. Dopamine and serotonin imbalances in the left anterior cingulate and pyriform cortices following the repeated intermittent administration of cocaine. Neuroscience. vol 89. issue 3. 1999-07-07. PMID:10199606. |
dopamine and serotonin imbalances in the left anterior cingulate and pyriform cortices following the repeated intermittent administration of cocaine. |
1999-07-07 |
2023-08-12 |
Not clear |
| C A Heidbreder, T Oertle, J Feldo. Dopamine and serotonin imbalances in the left anterior cingulate and pyriform cortices following the repeated intermittent administration of cocaine. Neuroscience. vol 89. issue 3. 1999-07-07. PMID:10199606. |
studies on the neurobiology of cocaine abuse suggest that cocaine directly modifies the activity of dopamine neurons projecting from the dopamine-synthesizing cells of the ventral tegmental area to the nucleus accumbens. |
1999-07-07 |
2023-08-12 |
Not clear |