| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C E Beyer, J D Stekete. Dopamine depletion in the medial prefrontal cortex induces sensitized-like behavioral and neurochemical responses to cocaine. Brain research. vol 833. issue 2. 1999-08-13. PMID:10375688. |
dopamine depletion in the medial prefrontal cortex induces sensitized-like behavioral and neurochemical responses to cocaine. |
1999-08-13 |
2023-08-12 |
Not clear |
| C E Beyer, J D Stekete. Dopamine depletion in the medial prefrontal cortex induces sensitized-like behavioral and neurochemical responses to cocaine. Brain research. vol 833. issue 2. 1999-08-13. PMID:10375688. |
it has been postulated that behavioral sensitization to cocaine is associated with an attenuation of cocaine-induced dopamine (da) transmission in the medial prefrontal cortex (mpfc). |
1999-08-13 |
2023-08-12 |
Not clear |
| C E Beyer, J D Stekete. Dopamine depletion in the medial prefrontal cortex induces sensitized-like behavioral and neurochemical responses to cocaine. Brain research. vol 833. issue 2. 1999-08-13. PMID:10375688. |
cocaine produced a dose-dependent increase in motor activity which was significantly enhanced in animals depleted (mean of 76%) of dopamine in the mpfc. |
1999-08-13 |
2023-08-12 |
Not clear |
| Y L Hurd, P Svensson, M Ponté. The role of dopamine, dynorphin, and CART systems in the ventral striatum and amygdala in cocaine abuse. Annals of the New York Academy of Sciences. vol 877. 1999-08-10. PMID:10415667. |
the role of dopamine, dynorphin, and cart systems in the ventral striatum and amygdala in cocaine abuse. |
1999-08-10 |
2023-08-12 |
rat |
| Y L Hurd, P Svensson, M Ponté. The role of dopamine, dynorphin, and CART systems in the ventral striatum and amygdala in cocaine abuse. Annals of the New York Academy of Sciences. vol 877. 1999-08-10. PMID:10415667. |
recently, increased attention has been directed towards the opioid neuropeptide system, in particular dynorphin; inasmuch as opioid peptide-containing neurons are regulated by dopamine, these peptides have potent effects on mood and reward, and cocaine consistently modulates dynorphin activity. |
1999-08-10 |
2023-08-12 |
rat |
| Y L Hurd, P Svensson, M Ponté. The role of dopamine, dynorphin, and CART systems in the ventral striatum and amygdala in cocaine abuse. Annals of the New York Academy of Sciences. vol 877. 1999-08-10. PMID:10415667. |
our experiments have been directed towards characterizing the specific alterations of dopamine and dynorphin systems during different stages following cocaine administration, as well as assessing the contribution of nucleus accumbens and amygdala dopamine levels to cocaine-intake behavior. |
1999-08-10 |
2023-08-12 |
rat |
| Y L Hurd, P Svensson, M Ponté. The role of dopamine, dynorphin, and CART systems in the ventral striatum and amygdala in cocaine abuse. Annals of the New York Academy of Sciences. vol 877. 1999-08-10. PMID:10415667. |
we have used the techniques of in vivo microdialysis to measure and manipulate extracellular concentrations of dopamine in animals that self-administer cocaine, and in situ hybridization to study mrna expression levels of prodynorphin and dopamine receptors. |
1999-08-10 |
2023-08-12 |
rat |
| Y L Hurd, P Svensson, M Ponté. The role of dopamine, dynorphin, and CART systems in the ventral striatum and amygdala in cocaine abuse. Annals of the New York Academy of Sciences. vol 877. 1999-08-10. PMID:10415667. |
it is clear from these studies that different stages of the cocaine use cycle are characterized by distinct patterns of prodynorphin and dopamine d1 mrna expression levels. |
1999-08-10 |
2023-08-12 |
rat |
| D C Mash, J K Stale. D3 dopamine and kappa opioid receptor alterations in human brain of cocaine-overdose victims. Annals of the New York Academy of Sciences. vol 877. 1999-08-10. PMID:10415668. |
cocaine is thought to be addictive because chronic use leads to molecular adaptations within the mesolimbic dopamine (da) circuitry, which affects motivated behavior and emotion. |
1999-08-10 |
2023-08-12 |
human |
| D Simoni, M Roberti, V Andrisano, M Manferdini, R Rondanin, F P Invidiat. Two-carbon bridge substituted cocaines: enantioselective synthesis, attribution of the absolute configuration and biological activity of novel 6- and 7-methoxylated cocaines. Farmaco (Societa chimica italiana : 1989). vol 54. issue 5. 1999-08-09. PMID:10418122. |
it appeared evident that methoxylation of the cocaine two-carbon bridge provides compounds of particular interest: the ki for the binding of the methoxypseudococaines is about two to four times smaller than the ki for inhibition of dopamine uptake, thus enabling these compounds capable of countering the effects of cocaine to some extent. |
1999-08-09 |
2023-08-12 |
Not clear |
| X Wu, H H G. Molecular cloning of the mouse dopamine transporter and pharmacological comparison with the human homologue. Gene. vol 233. issue 1-2. 1999-08-05. PMID:10375632. |
cocaine and amphetamines, widely used drugs of abuse, bind to dopamine (da), serotonin, and norepinephrine transporters with high affinity and block their functions. |
1999-08-05 |
2023-08-12 |
mouse |
| X Wu, H H G. Molecular cloning of the mouse dopamine transporter and pharmacological comparison with the human homologue. Gene. vol 233. issue 1-2. 1999-08-05. PMID:10375632. |
it is believed that the dopamine transporter plays a key role in the mechanism of cocaine addiction. |
1999-08-05 |
2023-08-12 |
mouse |
| B M Prasad, T Hochstatter, B A Sor. Expression of cocaine sensitization: regulation by the medial prefrontal cortex. Neuroscience. vol 88. issue 3. 1999-08-02. PMID:10363816. |
extracellular levels of dopamine are increased in response to systemic administration of cocaine in several brain areas including the nucleus accumbens and medial prefrontal cortex. |
1999-08-02 |
2023-08-12 |
rat |
| B M Prasad, T Hochstatter, B A Sor. Expression of cocaine sensitization: regulation by the medial prefrontal cortex. Neuroscience. vol 88. issue 3. 1999-08-02. PMID:10363816. |
while the cocaine-induced increase in extracellular dopamine levels in the nucleus accumbens is augmented after repeated daily cocaine, the response of extracellular dopamine levels in the medial prefrontal cortex is attenuated. |
1999-08-02 |
2023-08-12 |
rat |
| B M Prasad, T Hochstatter, B A Sor. Expression of cocaine sensitization: regulation by the medial prefrontal cortex. Neuroscience. vol 88. issue 3. 1999-08-02. PMID:10363816. |
since dopamine in the medial prefrontal cortex has an inhibitory effect on nucleus accumbens dopamine levels and locomotor activity, the role of medial prefrontal cortex dopamine tolerance in the expression of sensitized locomotor behavior was further examined by injection of d-amphetamine sulfate into the prelimbic portion of the medial prefrontal cortex just prior to cocaine challenge in cocaine-sensitized rats. |
1999-08-02 |
2023-08-12 |
rat |
| B M Prasad, T Hochstatter, B A Sor. Expression of cocaine sensitization: regulation by the medial prefrontal cortex. Neuroscience. vol 88. issue 3. 1999-08-02. PMID:10363816. |
the results suggest that in rats sensitized to cocaine, decreased medial prefrontal cortex dopamine levels in response to cocaine challenge may contribute to behavioral sensitization. |
1999-08-02 |
2023-08-12 |
rat |
| F Rougé-Pont, D N Abrous, M Le Moal, P V Piazz. Release of endogenous dopamine in cultured mesencephalic neurons: influence of dopaminergic agonists and glucocorticoid antagonists. The European journal of neuroscience. vol 11. issue 7. 1999-07-30. PMID:10383623. |
k+ (20 mm), or by the indirect dopamine agonists amphetamine and cocaine; (iv) decreased by a hyperpolarizing stimulus, e.g. |
1999-07-30 |
2023-08-12 |
Not clear |
| J R Nation, D K Mille. The effects of cadmium contamination on the discriminative stimulus properties of cocaine and related drugs. Experimental and clinical psychopharmacology. vol 7. issue 2. 1999-07-29. PMID:10340150. |
after acquisition training, successive substitution tests were conducted using cocaine, the indirect dopamine agonist d-amphetamine, the mixed d1-d2 agonist apomorphine, skf 38393 and skf 82958 (both preferential d1 agonists), quinpirole (a preferential d2 agonist), gbr 12909 (a dopamine reuptake inhibitor), procaine (a local anesthetic), and morphine (an opiate). |
1999-07-29 |
2023-08-12 |
rat |
| Y Itzhak, J L Martin, M D Black, S F Al. Effect of the dopaminergic neurotoxin MPTP on cocaine-induced locomotor sensitization. Pharmacology, biochemistry, and behavior. vol 63. issue 1. 1999-07-28. PMID:10340529. |
the blockade of dopamine (da) uptake via the dopamine transporter (dat) in the nucleus accumbens (nac) and striatum by cocaine has a major role in the reinforcing and psychomotor stimulating effects of the drug. |
1999-07-28 |
2023-08-12 |
mouse |
| N D Volkow, G J Wang, J S Fowler, M Fischman, R Foltin, N N Abumrad, S J Gatley, J Logan, C Wong, A Gifford, Y S Ding, R Hitzemann, N Pappa. Methylphenidate and cocaine have a similar in vivo potency to block dopamine transporters in the human brain. Life sciences. vol 65. issue 1. 1999-07-23. PMID:10403500. |
methylphenidate and cocaine have a similar in vivo potency to block dopamine transporters in the human brain. |
1999-07-23 |
2023-08-12 |
human |