| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F W Telang, N D Volkow, A Levy, J Logan, J S Fowler, C Felder, C Wong, G J Wan. Distribution of tracer levels of cocaine in the human brain as assessed with averaged [11C]cocaine images. Synapse (New York, N.Y.). vol 31. issue 4. 1999-05-07. PMID:10051110. |
the ability of cocaine to block the dopamine transporter (dat) in the nucleus accumbens, as well as its non-striatal and non-dat actions, appears to be crucial for its reinforcing/rewardig effects. |
1999-05-07 |
2023-08-12 |
human |
| W J Pan, M A Heday. Cocaine and alcohol interactions in the rat: effect on cocaine pharmacokinetics and pharmacodynamics. Journal of pharmaceutical sciences. vol 88. issue 4. 1999-05-07. PMID:10187758. |
the neurochemical response to cocaine administration, measured as the change in dopamine concentration in the nucleus accumbens (n acc) and the change in the mean arterial blood pressure were monitored simultaneously. |
1999-05-07 |
2023-08-12 |
rat |
| Y Itzhak, J L Marti. Effects of cocaine, nicotine, dizocipline and alcohol on mice locomotor activity: cocaine-alcohol cross-sensitization involves upregulation of striatal dopamine transporter binding sites. Brain research. vol 818. issue 2. 1999-05-06. PMID:10082805. |
effects of cocaine, nicotine, dizocipline and alcohol on mice locomotor activity: cocaine-alcohol cross-sensitization involves upregulation of striatal dopamine transporter binding sites. |
1999-05-06 |
2023-08-12 |
mouse |
| Y Itzhak, J L Marti. Effects of cocaine, nicotine, dizocipline and alcohol on mice locomotor activity: cocaine-alcohol cross-sensitization involves upregulation of striatal dopamine transporter binding sites. Brain research. vol 818. issue 2. 1999-05-06. PMID:10082805. |
assessment of the densities of striatal dopamine transporter (dat) sites (by [3h]mazindol binding) 11 days after the extinction of repeated treatment with either cocaine or ethanol revealed a significant increase (71-108%) in the number of dat binding sites. |
1999-05-06 |
2023-08-12 |
mouse |
| C Gambarana, F Masi, A Tagliamonte, S Scheggi, O Ghiglieri, M G De Monti. A chronic stress that impairs reactivity in rats also decreases dopaminergic transmission in the nucleus accumbens: a microdialysis study. Journal of neurochemistry. vol 72. issue 5. 1999-05-06. PMID:10217282. |
to assess whether this finding was the result of a decreased release or of an enhanced removal of dopamine, we acutely administered cocaine, and 2 h later d-amphetamine, to stressed and control rats. |
1999-05-06 |
2023-08-12 |
rat |
| C Gambarana, F Masi, A Tagliamonte, S Scheggi, O Ghiglieri, M G De Monti. A chronic stress that impairs reactivity in rats also decreases dopaminergic transmission in the nucleus accumbens: a microdialysis study. Journal of neurochemistry. vol 72. issue 5. 1999-05-06. PMID:10217282. |
the increases in dopamine output observed in stressed animals after cocaine administration were significantly lower than those observed in control rats; whereas the total amount of dopamine released after d-amphetamine administration was similar in both groups of rats. |
1999-05-06 |
2023-08-12 |
rat |
| C Gambarana, F Masi, A Tagliamonte, S Scheggi, O Ghiglieri, M G De Monti. A chronic stress that impairs reactivity in rats also decreases dopaminergic transmission in the nucleus accumbens: a microdialysis study. Journal of neurochemistry. vol 72. issue 5. 1999-05-06. PMID:10217282. |
moreover, stressed rats treated with imipramine showed basal and cocaine stimulated levels of extraneuronal dopamine similar to those observed in control animals. |
1999-05-06 |
2023-08-12 |
rat |
| N D Volkow, J S Fowler, S J Gatley, S L Dewey, G J Wang, J Logan, Y S Ding, D Franceschi, A Gifford, A Morgan, N Pappas, P Kin. Comparable changes in synaptic dopamine induced by methylphenidate and by cocaine in the baboon brain. Synapse (New York, N.Y.). vol 31. issue 1. 1999-05-04. PMID:10025684. |
comparable changes in synaptic dopamine induced by methylphenidate and by cocaine in the baboon brain. |
1999-05-04 |
2023-08-12 |
Not clear |
| N D Volkow, J S Fowler, S J Gatley, S L Dewey, G J Wang, J Logan, Y S Ding, D Franceschi, A Gifford, A Morgan, N Pappas, P Kin. Comparable changes in synaptic dopamine induced by methylphenidate and by cocaine in the baboon brain. Synapse (New York, N.Y.). vol 31. issue 1. 1999-05-04. PMID:10025684. |
though the blockade of dopamine transporters (dat) is associated with cocaine's and methylphenidate's reinforcing effects, it is the stimulation of dopamine (da) receptors, achieved by increases in synaptic da, that enables these effects to occur. |
1999-05-04 |
2023-08-12 |
Not clear |
| N D Volkow, J S Fowler, S J Gatley, S L Dewey, G J Wang, J Logan, Y S Ding, D Franceschi, A Gifford, A Morgan, N Pappas, P Kin. Comparable changes in synaptic dopamine induced by methylphenidate and by cocaine in the baboon brain. Synapse (New York, N.Y.). vol 31. issue 1. 1999-05-04. PMID:10025684. |
positron emission tomography (pet) and [11c]raclopride were used to assess the levels of occupancy of da d2 receptors by dopamine achieved by doses of cocaine or methylphenidate previously documented to block over 70% of dat. |
1999-05-04 |
2023-08-12 |
Not clear |
| S Ghosh, K Grasin. Presynaptic dopaminergic function in the nucleus accumbens following chronic opiate treatment and precipitated withdrawal. Neurochemical research. vol 24. issue 1. 1999-05-03. PMID:9973242. |
fractional dopamine efflux was also diminished after in vitro exposure to rising concentrations of 4-aminopyridine, amphetamine, or cocaine for tissue obtained from the nucleus accumbens, but not for slices from the striatum at six days following morphine pellet implantation. |
1999-05-03 |
2023-08-12 |
Not clear |
| M Jaber, B Bloch, M G Caron, B Giro. [Behavioral, cellular and molecular consequences of the dopamine transporter gene inactivation]. Comptes rendus des seances de la Societe de biologie et de ses filiales. vol 192. issue 6. 1999-05-03. PMID:10101608. |
mice lacking the the plasma membrane dopamine transporter (dat), following gene inactivation or knock out, show an increase in their spontaneous locomotor activity that is of the same magnitude than in normal mice treated with amphetamine or cocaine, known to increase levels of dopamine in the basal ganglia. |
1999-05-03 |
2023-08-12 |
mouse |
| M Jaber, B Bloch, M G Caron, B Giro. [Behavioral, cellular and molecular consequences of the dopamine transporter gene inactivation]. Comptes rendus des seances de la Societe de biologie et de ses filiales. vol 192. issue 6. 1999-05-03. PMID:10101608. |
our results establish not only the central importance of the transporter as the key element controlling dopamine levels in the brain, but also its role in the behavioral and biochemical action of amphetamine, cocaine and morphine. |
1999-05-03 |
2023-08-12 |
mouse |
| b' R Alonso, H Gnanadicom, N Fr\\xc3\\xa9chin, M Fournier, G Le Fur, P Soubri\\xc3\\xa. Blockade of neurotensin receptors suppresses the dopamine D1/D2 synergism on immediate early gene expression in the rat brain. The European journal of neuroscience. vol 11. issue 3. 1999-04-26. PMID:10103090.' |
pretreatment with sr48692 (10 mg/kg) also diminished fos induction by the indirect dopamine agonist, cocaine (25 mg/kg), particularly at the rostral level of the caudate-putamen. |
1999-04-26 |
2023-08-12 |
rat |
| B K Tolliver, A H Newman, J L Katz, L B Ho, L M Fox, K Hsu, S P Berge. Behavioral and neurochemical effects of the dopamine transporter ligand 4-chlorobenztropine alone and in combination with cocaine in vivo. The Journal of pharmacology and experimental therapeutics. vol 289. issue 1. 1999-04-21. PMID:10086994. |
behavioral and neurochemical effects of the dopamine transporter ligand 4-chlorobenztropine alone and in combination with cocaine in vivo. |
1999-04-21 |
2023-08-12 |
rat |
| B K Tolliver, A H Newman, J L Katz, L B Ho, L M Fox, K Hsu, S P Berge. Behavioral and neurochemical effects of the dopamine transporter ligand 4-chlorobenztropine alone and in combination with cocaine in vivo. The Journal of pharmacology and experimental therapeutics. vol 289. issue 1. 1999-04-21. PMID:10086994. |
the current studies evaluated the novel diphenylmethoxytropane analog 4-chlorobenztropine (4-cl-bzt), cocaine, and combinations of the two drugs for their abilities to stimulate locomotor activity, produce cocaine-like discriminative stimulus effects, and elevate extracellular dopamine (da) in the nucleus accumbens (nac) as measured by in vivo microdialysis. |
1999-04-21 |
2023-08-12 |
rat |
| S B Cain. Cocaine abuse: hard knocks for the dopamine hypothesis? Nature neuroscience. vol 1. issue 2. 1999-04-20. PMID:10195118. |
cocaine abuse: hard knocks for the dopamine hypothesis? |
1999-04-20 |
2023-08-12 |
Not clear |
| B A Rocha, F Fumagalli, R R Gainetdinov, S R Jones, R Ator, B Giros, G W Miller, M G Caro. Cocaine self-administration in dopamine-transporter knockout mice. Nature neuroscience. vol 1. issue 2. 1999-04-20. PMID:10195128. |
cocaine blockade of dat leads to increased extracellular dopamine, an effect widely considered to be the primary cause of the reinforcing and addictive properties of cocaine. |
1999-04-20 |
2023-08-12 |
mouse |
| B A Rocha, F Fumagalli, R R Gainetdinov, S R Jones, R Ator, B Giros, G W Miller, M G Caro. Cocaine self-administration in dopamine-transporter knockout mice. Nature neuroscience. vol 1. issue 2. 1999-04-20. PMID:10195128. |
in the absence of dat, these mice exhibit high levels of extracellular dopamine, but paradoxically still self-administer cocaine. |
1999-04-20 |
2023-08-12 |
mouse |
| S Asenbaum, W Pirker, P Angelberger, G Bencsits, M Pruckmayer, T Brück. [123I]beta-CIT and SPECT in essential tremor and Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 105. issue 10-12. 1999-04-15. PMID:9928890. |
the aim of the present study was to investigate the cocaine derivative [123i]beta-cit, which labels striatal dopamine transporters, and spect in differentiating these diseases. |
1999-04-15 |
2023-08-12 |
Not clear |