| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R A Vaughan, G E Agoston, J R Lever, A H Newma. Differential binding of tropane-based photoaffinity ligands on the dopamine transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 2. 1999-02-16. PMID:9880583. |
the maps were compared with those obtained for dopamine transporters photoaffinity labeled with a gbr 12935 analog, [125i]1-[2-(diphenylmethoxy)ethyl]-4-[2-(4-azido-3-iodophenyl)ethy l]p iperazine ([125i]deep), and a cocaine analog, [125i]3beta-(p-chlorophenyl)tropane-2beta-carboxylic acid, 4'-azido-3'-iodophenylethyl ester ([125i]rti 82), which have been shown previously to interact with different regions of the primary sequence of the protein. |
1999-02-16 |
2023-08-12 |
Not clear |
| R A Vaughan, G E Agoston, J R Lever, A H Newma. Differential binding of tropane-based photoaffinity ligands on the dopamine transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 2. 1999-02-16. PMID:9880583. |
thus, although benztropine and cocaine both contain tropane rings, their binding sites are distinct, suggesting that dopamine transport inhibition may occur by different mechanisms. |
1999-02-16 |
2023-08-12 |
Not clear |
| R A Vaughan, G E Agoston, J R Lever, A H Newma. Differential binding of tropane-based photoaffinity ligands on the dopamine transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 2. 1999-02-16. PMID:9880583. |
these results support previously derived structure-activity relationships suggesting that benztropine and cocaine analogs bind to different domains on the dopamine transporter. |
1999-02-16 |
2023-08-12 |
Not clear |
| N D Volkow, G J Wang, J S Fowler, S J Gatley, J Logan, Y S Ding, S L Dewey, R Hitzemann, A N Gifford, N R Pappa. Blockade of striatal dopamine transporters by intravenous methylphenidate is not sufficient to induce self-reports of "high". The Journal of pharmacology and experimental therapeutics. vol 288. issue 1. 1999-02-05. PMID:9862747. |
the reinforcing effects of cocaine and methylphenidate have been linked to their ability to block dopamine transporters (dat). |
1999-02-05 |
2023-08-12 |
human |
| J L Katz, S Izenwasser, R H Kline, A C Allen, A H Newma. Novel 3alpha-diphenylmethoxytropane analogs: selective dopamine uptake inhibitors with behavioral effects distinct from those of cocaine. The Journal of pharmacology and experimental therapeutics. vol 288. issue 1. 1999-02-05. PMID:9862785. |
novel 3alpha-diphenylmethoxytropane analogs: selective dopamine uptake inhibitors with behavioral effects distinct from those of cocaine. |
1999-02-05 |
2023-08-12 |
mouse |
| R S Mansbach, C C Rovetti, C S Freedlan. The role of monoamine neurotransmitter systems in the nicotine discriminative stimulus. Drug and alcohol dependence. vol 52. issue 2. 1999-02-04. PMID:9800142. |
the non-selective dopamine agonists amphetamine, cocaine and apomorphine produced partial substitution for nicotine, while the selective d2/d3 agonists bromocriptine and 7-oh-dpat and the dopamine autoreceptor antagonist (+)-aj-76 had little effect. |
1999-02-04 |
2023-08-12 |
rat |
| N D Volkow, G J Wang, J S Fowler, R Hitzemann, B Angrist, S J Gatley, J Logan, Y S Ding, N Pappa. Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction. The American journal of psychiatry. vol 156. issue 1. 1999-01-27. PMID:9892293. |
the authors have shown that decreases in dopamine d2 receptors in cocaine abusers were associated with decreased metabolism in the cingulate and prefrontal and orbitofrontal cortices. |
1999-01-27 |
2023-08-12 |
Not clear |
| N D Volkow, G J Wang, J S Fowler, R Hitzemann, B Angrist, S J Gatley, J Logan, Y S Ding, N Pappa. Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction. The American journal of psychiatry. vol 156. issue 1. 1999-01-27. PMID:9892293. |
to assess whether increasing dopamine would reverse these metabolic decrements, they measured the effects of methylphenidate, a drug that increases dopamine, on brain glucose metabolism in 20 cocaine abusers. |
1999-01-27 |
2023-08-12 |
Not clear |
| J C Do-Régo, H Hue, J Costentin, J J Bonne. Evidence for the sequential formation of two complexes between an uptake inhibitor, GBR 12783 [1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperazine], and the neuronal transporter of dopamine. Journal of neurochemistry. vol 72. issue 1. 1999-01-21. PMID:9886093. |
the present work gives the first experimental demonstration that dopamine uptake blockers can act according to a two-step mechanism of inhibition; this is of great interest, because these inhibitors can oppose the effects of cocaine or amphetamine on the transporter according to a reaction that is partly nondependent on the concentration of the abused agent. |
1999-01-21 |
2023-08-12 |
rat |
| R M Liao, Y H Chang, S H Wan. Influence of SCH23390 and spiperone on the expression of conditioned place preference induced by d-amphetamine or cocaine in the rat. The Chinese journal of physiology. vol 41. issue 2. 1999-01-19. PMID:9801838. |
the present study investigated the effects of selective dopamine d1 and d2 receptor antagonists, sch23390 and spiperone, on the expression of conditioned place preference (cpp) induced by either d-amphetamine or cocaine. |
1999-01-19 |
2023-08-12 |
rat |
| T V Khroyan, D A Baker, R A Fuchs, N Manders, J L Neisewande. Differential effects of 7-OH-DPAT on amphetamine-induced stereotypy and conditioned place preference. Psychopharmacology. vol 139. issue 4. 1999-01-19. PMID:9809854. |
low doses of the dopamine d3-preferring agonist 7-hydroxy-n,n-di-n-propyl-2-aminotetralin (7-oh-dpat) produce a behavioral profile that is opposite to that produced by the psychomotor stimulants cocaine and amphetamine. |
1999-01-19 |
2023-08-12 |
Not clear |
| C Mitsuhata, S Kitayama, K Morita, D Vandenbergh, G R Uhl, T Doh. Tyrosine-533 of rat dopamine transporter: involvement in interactions with 1-methyl-4-phenylpyridinium and cocaine. Brain research. Molecular brain research. vol 56. issue 1-2. 1999-01-14. PMID:9602072. |
tyrosine-533 of rat dopamine transporter: involvement in interactions with 1-methyl-4-phenylpyridinium and cocaine. |
1999-01-14 |
2023-08-12 |
human |
| C Mitsuhata, S Kitayama, K Morita, D Vandenbergh, G R Uhl, T Doh. Tyrosine-533 of rat dopamine transporter: involvement in interactions with 1-methyl-4-phenylpyridinium and cocaine. Brain research. Molecular brain research. vol 56. issue 1-2. 1999-01-14. PMID:9602072. |
cocaine's potency in inhibiting dopamine uptake was unchanged with y533a, but increased with y533f. |
1999-01-14 |
2023-08-12 |
human |
| P Svensson, Y L Hur. Specific reductions of striatal prodynorphin and D1 dopamine receptor messenger RNAs during cocaine abstinence. Brain research. Molecular brain research. vol 56. issue 1-2. 1999-01-14. PMID:9602109. |
it is well established that the opioid neuropeptide and dopamine systems are altered following the use of cocaine. |
1999-01-14 |
2023-08-12 |
rat |
| P D Mozley, J B Stubbs, K Plössl, S H Dresel, E D Barraclough, A Alavi, L I Araujo, H F Kun. Biodistribution and dosimetry of TRODAT-1: a technetium-99m tropane for imaging dopamine transporters. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 39. issue 12. 1999-01-14. PMID:9867143. |
technetium-99m trodat-1 is an analog of cocaine that selectively binds the presynaptic dopamine transporters. |
1999-01-14 |
2023-08-12 |
human |
| A P Kozikowski, G L Araldi, K R Prakash, M Zhang, K M Johnso. Synthesis and biological properties of new 2beta-alkyl- and 2beta-aryl-3-(substituted phenyl)tropane derivatives: stereochemical effect of C-3 on affinity and selectivity for neuronal dopamine and serotonin transporters. Journal of medicinal chemistry. vol 41. issue 25. 1999-01-07. PMID:9836615. |
in our efforts to identify molecules that might act as cocaine antagonists or cocaine partial agonists, we have been involved in efforts to further elucidate the nature of cocaine's binding to the dopamine transporter (dat) through strategic modifications of its structure. |
1999-01-07 |
2023-08-12 |
Not clear |
| L E Baker, K A Svensson, K J Garner, A K Goodwi. The dopamine D3 receptor antagonist PNU-99194A fails to block (+)-7-OH-DPAT substitution for D-amphetamine or cocaine. European journal of pharmacology. vol 358. issue 2. 1999-01-05. PMID:9808258. |
the dopamine d3 receptor antagonist pnu-99194a fails to block (+)-7-oh-dpat substitution for d-amphetamine or cocaine. |
1999-01-05 |
2023-08-12 |
rat |
| L E Baker, K A Svensson, K J Garner, A K Goodwi. The dopamine D3 receptor antagonist PNU-99194A fails to block (+)-7-OH-DPAT substitution for D-amphetamine or cocaine. European journal of pharmacology. vol 358. issue 2. 1999-01-05. PMID:9808258. |
the present study examined the role of dopamine d3 receptor actions in the stimulus generalization produced by (+)-7-oh-dpat in rats trained to discriminate either d-amphetamine or cocaine from saline. |
1999-01-05 |
2023-08-12 |
rat |
| G Battaglia, T C Napie. The effects of cocaine and the amphetamines on brain and behavior: a conference report. Drug and alcohol dependence. vol 52. issue 1. 1998-12-30. PMID:9788004. |
some of the specific areas discussed were: (a) psychostimulant-induced effects on brain serotonin and dopamine systems, (b) amphetamine-induced neurotoxicity, (c) the long-term consequences of prenatal exposure to cocaine, (d) effects of cocaine withdrawal on hormone responses, and (e) mechanisms underlying drug-taking behavior and dependence. |
1998-12-30 |
2023-08-12 |
Not clear |
| G B Varty, G A Higgin. Dopamine agonist-induced hypothermia and disruption of prepulse inhibition: evidence for a role of D3 receptors? Behavioural pharmacology. vol 9. issue 5-6. 1998-12-29. PMID:9832930. |
in a separate study, the dopamine reuptake inhibitors cocaine and gbr 12909 had no effect on ppi. |
1998-12-29 |
2023-08-12 |
rat |