| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P A Broderick, M F Pierce. Neurochemical and behavioral evidence supporting (+)-AJ 76 as a potential pharmacotherapy for cocaine abuse. Journal of neural transmission (Vienna, Austria : 1996). vol 105. issue 10-12. 1999-04-15. PMID:9928899. |
in vivo microvoltammetry was used to detect synaptic concentrations of dopamine (da) and serotonin (5-ht) from nucleus accumbens (nacc) in awake, freely moving, male, sprague dawley laboratory rats, while their locomotor behavior was monitored, simultaneously, in an open-field paradigm; the purpose was to evaluate the pharmacology of the d3-preferring, dopamine (da) autoreceptor antagonist, (+)-aj 76 [cis-(+)-1s, 2r-5-methoxy-1-methyl-2-(n-propylamino)-tetralin hcl] and its potential use as a pharmacotherapy for cocaine abuse. |
1999-04-15 |
2023-08-12 |
rat |
| M Graziella De Montis, C Co, S I Dworkin, J E Smit. Modifications of dopamine D1 receptor complex in rats self-administering cocaine. European journal of pharmacology. vol 362. issue 1. 1999-04-13. PMID:9865524. |
modifications of dopamine d1 receptor complex in rats self-administering cocaine. |
1999-04-13 |
2023-08-12 |
rat |
| M Graziella De Montis, C Co, S I Dworkin, J E Smit. Modifications of dopamine D1 receptor complex in rats self-administering cocaine. European journal of pharmacology. vol 362. issue 1. 1999-04-13. PMID:9865524. |
animals receiving cocaine (both self-administering and yoked) showed a down-regulation of dopamine d1 receptor number and of dopamine stimulated adenylyl cyclase activity in the nucleus accumbens, as compared to saline rats. |
1999-04-13 |
2023-08-12 |
rat |
| B A Baldo, A Markou, G F Koo. Increased sensitivity to the locomotor depressant effect of a dopamine receptor antagonist during cocaine withdrawal in the rat. Psychopharmacology. vol 141. issue 2. 1999-04-13. PMID:9952037. |
the results of this study support clinical observations of dopamine antagonist-precipitated motor dysfunction in abstinent cocaine abusers, and lend further support to the hypothesis that alterations in dopaminergic neurotransmission consequent to prolonged cocaine exposure are partly responsible for some of the symptoms of cocaine withdrawal. |
1999-04-13 |
2023-08-12 |
rat |
| H M Deutsch, D M Collard, L Zhang, K S Burnham, A K Deshpande, S G Holtzman, M M Schwer. Synthesis and pharmacology of site-specific cocaine abuse treatment agents: 2-(aminomethyl)-3-phenylbicyclo[2.2.2]- and -[2.2.1]alkane dopamine uptake inhibitors. Journal of medicinal chemistry. vol 42. issue 5. 1999-04-13. PMID:10072685. |
synthesis and pharmacology of site-specific cocaine abuse treatment agents: 2-(aminomethyl)-3-phenylbicyclo[2.2.2]- and -[2.2.1]alkane dopamine uptake inhibitors. |
1999-04-13 |
2023-08-12 |
rat |
| H M Deutsch, D M Collard, L Zhang, K S Burnham, A K Deshpande, S G Holtzman, M M Schwer. Synthesis and pharmacology of site-specific cocaine abuse treatment agents: 2-(aminomethyl)-3-phenylbicyclo[2.2.2]- and -[2.2.1]alkane dopamine uptake inhibitors. Journal of medicinal chemistry. vol 42. issue 5. 1999-04-13. PMID:10072685. |
as part of a program to develop site-specific medications for cocaine abuse, a series of 2-(aminomethyl)-3-phenylbicyclo[2.2.2]- and -[2.2.1]alkane derivatives was synthesized and tested for inhibitory potency in [3h]win 35,428 binding and [3h]dopamine uptake assays using rat striatal tissue. |
1999-04-13 |
2023-08-12 |
rat |
| H M Deutsch, D M Collard, L Zhang, K S Burnham, A K Deshpande, S G Holtzman, M M Schwer. Synthesis and pharmacology of site-specific cocaine abuse treatment agents: 2-(aminomethyl)-3-phenylbicyclo[2.2.2]- and -[2.2.1]alkane dopamine uptake inhibitors. Journal of medicinal chemistry. vol 42. issue 5. 1999-04-13. PMID:10072685. |
although the potencies of the bicyclic derivatives in the binding and uptake assays were highly correlated, some of the compounds were 5-7-fold less potent at inhibiting [3h]dopamine uptake than [3h]win 35,428 binding (for comparison, cocaine has a lower discrimination ratio (dr) of 2.5). |
1999-04-13 |
2023-08-12 |
rat |
| M Gasior, M Shoaib, S Yasar, M Jaszyna, S R Goldber. Acquisition of nicotine discrimination and discriminative stimulus effects of nicotine in rats chronically exposed to caffeine. The Journal of pharmacology and experimental therapeutics. vol 288. issue 3. 1999-04-01. PMID:10027843. |
treatment with d-amphetamine, cocaine, the selective dopamine uptake inhibitor gbr-12909, apomorphine, and the selective dopamine d1 receptor agonist skf-82958, but not in caffeine-drinking rats (0-22%). |
1999-04-01 |
2023-08-12 |
rat |
| M A Hebert, G A Larson, N R Zahniser, G A Gerhard. Age-related reductions in [3H]WIN 35,428 binding to the dopamine transporter in nigrostriatal and mesolimbic brain regions of the fischer 344 rat. The Journal of pharmacology and experimental therapeutics. vol 288. issue 3. 1999-04-01. PMID:10027875. |
in the present study, we used the potent cocaine analog [3h]win 35, 428 to map and quantify binding to the dopamine transporter (dat) within the dorsal striatum, nucleus accumbens, substantia nigra, and ventral tegmental area in young (6-month-old), middle-aged (12-month-old), and aged (18- and 24-month-old) fischer 344 rats. |
1999-04-01 |
2023-08-12 |
rat |
| J D Stekete. Repeated injection of GBR 12909, but not cocaine or WIN 35,065-2, into the ventral tegmental area induces behavioral sensitization. Behavioural brain research. vol 97. issue 1-2. 1999-03-29. PMID:9867229. |
in contrast to this, repeated injection of the specific dopamine reuptake inhibitor, gbr 12909 (15 nmol/side) produced behavioral sensitization to a challenge injection of cocaine. |
1999-03-29 |
2023-08-12 |
rat |
| J Poon, M van den Buus. Autonomic mechanisms in the acute cardiovascular effects of cocaine in conscious rats. European journal of pharmacology. vol 363. issue 2-3. 1999-03-25. PMID:9881582. |
however, pretreatment with dopamine d1 receptor antagonist sch 23390 or the d2 receptor antagonist raclopride did not influence the effects of cocaine. |
1999-03-25 |
2023-08-12 |
rat |
| G R King, Z Xiong, E H Ellinwoo. Blockade of accumbens 5-HT3 receptor down-regulation by ondansetron administered during continuous cocaine administration. European journal of pharmacology. vol 364. issue 2-3. 1999-03-24. PMID:9932709. |
continuous cocaine administration significantly attenuated the ability of mcpbg to facilitate k+-induce dopamine overflow compared to saline control rats. |
1999-03-24 |
2023-08-12 |
human |
| G R King, Z Xiong, E H Ellinwoo. Blockade of accumbens 5-HT3 receptor down-regulation by ondansetron administered during continuous cocaine administration. European journal of pharmacology. vol 364. issue 2-3. 1999-03-24. PMID:9932709. |
in addition, the rats that received ondansetron and cocaine during the 14-day pretreatment period, the ability of mcpbg to enhance k+ stimulated dopamine release was not significantly different from the saline control subjects. |
1999-03-24 |
2023-08-12 |
human |
| G R King, Z Xiong, E H Ellinwoo. Blockade of accumbens 5-HT3 receptor down-regulation by ondansetron administered during continuous cocaine administration. European journal of pharmacology. vol 364. issue 2-3. 1999-03-24. PMID:9932709. |
for all groups except the cocaine alone group, the effects of mcpbg on k+ stimulated dopamine release were ca2+ dependent, suggesting that these effects are receptor mediated. |
1999-03-24 |
2023-08-12 |
human |
| I Sziráki, H Sershen, M Benuck, A Hashim, A Lajth. Receptor systems participating in nicotine-specific effects. Neurochemistry international. vol 33. issue 5. 1999-03-18. PMID:9874095. |
in the present paper we compare the effects of receptor-specific antagonists on the increase of dopamine induced by nicotine with that induced by cocaine in the nucleus accumbens in conscious rats. |
1999-03-18 |
2023-08-12 |
rat |
| I Sziráki, H Sershen, M Benuck, A Hashim, A Lajth. Receptor systems participating in nicotine-specific effects. Neurochemistry international. vol 33. issue 5. 1999-03-18. PMID:9874095. |
when administered together the effect of nicotine and cocaine on the level of dopamine in the accumbens was additive. |
1999-03-18 |
2023-08-12 |
rat |
| I Sziráki, H Sershen, M Benuck, A Hashim, A Lajth. Receptor systems participating in nicotine-specific effects. Neurochemistry international. vol 33. issue 5. 1999-03-18. PMID:9874095. |
these three antagonists did not inhibit cocaine-induced dopamine increase in the accumbens, indicating the lack of a role of these receptors in the cocaine effect under our experimental conditions. |
1999-03-18 |
2023-08-12 |
rat |
| I Sziráki, H Sershen, M Benuck, A Hashim, A Lajth. Receptor systems participating in nicotine-specific effects. Neurochemistry international. vol 33. issue 5. 1999-03-18. PMID:9874095. |
the results indicate that there are differences in some of the receptors mediating the central effects of the two compounds examined, nicotine and cocaine, although each influences dopamine levels, and that the two compounds interact. |
1999-03-18 |
2023-08-12 |
rat |
| J L Berfield, L C Wang, M E Reit. Which form of dopamine is the substrate for the human dopamine transporter: the cationic or the uncharged species? The Journal of biological chemistry. vol 274. issue 8. 1999-03-18. PMID:9988729. |
the ki for dopamine in inhibiting the cocaine analog [3h]2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane binding displayed an identical ph dependence, suggesting that changes in uptake result from changes in dopamine recognition. |
1999-03-18 |
2023-08-12 |
human |
| L B Li, M E Reit. Modeling of the interaction of Na+ and K+ with the binding of dopamine and [3H]WIN 35,428 to the human dopamine transporter. Journal of neurochemistry. vol 72. issue 3. 1999-03-18. PMID:10037481. |
this was addressed here by studying the inhibition by dopamine of the binding of [3h]win 35,428 [2beta-carbomethoxy-3beta-(4-fluorophenyl)[3h]tropane], a phenyltropane analogue of cocaine, to the cloned human dopamine transporter expressed in hek-293 cells. |
1999-03-18 |
2023-08-12 |
human |