| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L L Howell, P W Czoty, M J Kuhar, F I Carro. Comparative behavioral pharmacology of cocaine and the selective dopamine uptake inhibitor RTI-113 in the squirrel monkey. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640288. |
the behavioral effects of 3beta-(4-chlorophenyl)tropane-2beta-carboxylic acid phenyl ester hydrochloride (rti-113; 0.03-1.0 mg/kg), a selective dopamine uptake inhibitor, were compared with those of cocaine (0.03-3.0 mg/kg) and 1-(2-[bis(4-fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride (gbr 12909; 0.03-3.0 mg/kg) in squirrel monkeys. |
2000-02-22 |
2023-08-12 |
human |
| L L Howell, P W Czoty, M J Kuhar, F I Carro. Comparative behavioral pharmacology of cocaine and the selective dopamine uptake inhibitor RTI-113 in the squirrel monkey. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640288. |
the results indicate that the behavioral pharmacology of rti-113 is similar to that of cocaine, further implicating a prominent role for dopamine uptake inhibition in the behavioral effects of cocaine. |
2000-02-22 |
2023-08-12 |
human |
| R De La Garza, K A Cunningha. The effects of the 5-hydroxytryptamine(1A) agonist 8-hydroxy-2-(di-n-propylamino)tetralin on spontaneous activity, cocaine-induced hyperactivity and behavioral sensitization: a microanalysis of locomotor activity. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640298. |
the present study implies that the stimulation of 5-hydroxytryptamine(1a) receptors is capable of modulating the hyperactivity evoked by cocaine, possibly via modulation of the mesoaccumbens dopamine circuit thought to mediate the behavioral effects of cocaine. |
2000-02-22 |
2023-08-12 |
rat |
| M Xu, Y Guo, C V Vorhees, J Zhan. Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptor. Brain research. vol 852. issue 1. 2000-02-22. PMID:10661513. |
behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine d1 receptor. |
2000-02-22 |
2023-08-12 |
mouse |
| M Xu, Y Guo, C V Vorhees, J Zhan. Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptor. Brain research. vol 852. issue 1. 2000-02-22. PMID:10661513. |
to determine whether the dopamine d1 receptor plays a crucial role in the behavioral effects of psychostimulants, we tested both the locomotor and stereotyped behaviors in d1 receptor mutant and wild-type control mice after cocaine and amphetamine treatments. |
2000-02-22 |
2023-08-12 |
mouse |
| C Davidson, E H Ellinwood, T H Le. Altered sensitivity of dopamine autoreceptors in rat accumbens 1 and 7 days after intermittent or continuous cocaine withdrawal. Brain research bulletin. vol 51. issue 1. 2000-02-18. PMID:10654586. |
altered sensitivity of dopamine autoreceptors in rat accumbens 1 and 7 days after intermittent or continuous cocaine withdrawal. |
2000-02-18 |
2023-08-12 |
rat |
| C Davidson, E H Ellinwood, T H Le. Altered sensitivity of dopamine autoreceptors in rat accumbens 1 and 7 days after intermittent or continuous cocaine withdrawal. Brain research bulletin. vol 51. issue 1. 2000-02-18. PMID:10654586. |
using slice preparations, we investigated the effects of chronic cocaine treatment on dopamine autoreceptor sensitivity in the nucleus accumbens core. |
2000-02-18 |
2023-08-12 |
rat |
| C Davidson, E H Ellinwood, T H Le. Altered sensitivity of dopamine autoreceptors in rat accumbens 1 and 7 days after intermittent or continuous cocaine withdrawal. Brain research bulletin. vol 51. issue 1. 2000-02-18. PMID:10654586. |
one or 7 days after cocaine withdrawal, we used fast scan cyclic voltammetry (10 hz sampling rate) to measure inhibition of electrically evoked dopamine release by quinpirole (3-300 nm). |
2000-02-18 |
2023-08-12 |
rat |
| C Davidson, E H Ellinwood, T H Le. Altered sensitivity of dopamine autoreceptors in rat accumbens 1 and 7 days after intermittent or continuous cocaine withdrawal. Brain research bulletin. vol 51. issue 1. 2000-02-18. PMID:10654586. |
it is suggested that these cocaine dosing regimes cause differential and dynamic changes in dopamine autoreceptor sensitivity during the early withdrawal phase. |
2000-02-18 |
2023-08-12 |
rat |
| N D Volkow, J S Fowler, G J Wan. Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. Journal of psychopharmacology (Oxford, England). vol 13. issue 4. 2000-02-18. PMID:10667609. |
imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. |
2000-02-18 |
2023-08-12 |
Not clear |
| N D Volkow, J S Fowler, G J Wan. Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. Journal of psychopharmacology (Oxford, England). vol 13. issue 4. 2000-02-18. PMID:10667609. |
we summarize our studies with positron emission tomography investigating the role of dopamine (da) in the reinforcing effects of cocaine and methylphenidate in humans and its involvement in cocaine addiction. |
2000-02-18 |
2023-08-12 |
Not clear |
| N D Volkow, J S Fowler, G J Wan. Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. Journal of psychopharmacology (Oxford, England). vol 13. issue 4. 2000-02-18. PMID:10667609. |
these studies have shown that the rate at which cocaine and methylphenidate enter the brain and block the dopamine transporters (dat) is the variable associated with the 'high', rather than the presence per se of the drug in the brain. |
2000-02-18 |
2023-08-12 |
Not clear |
| D M Donovan, L L Miner, M P Perry, R S Revay, L G Sharpe, S Przedborski, V Kostic, R M Philpot, C L Kirstein, R B Rothman, C W Schindler, G R Uh. Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581396. |
cocaine reward and mptp toxicity: alteration by regional variant dopamine transporter overexpression. |
2000-02-14 |
2023-08-12 |
mouse |
| D M Donovan, L L Miner, M P Perry, R S Revay, L G Sharpe, S Przedborski, V Kostic, R M Philpot, C L Kirstein, R B Rothman, C W Schindler, G R Uh. Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581396. |
the dopamine transporter (dat; slc6a3) is densely expressed by the dopaminergic midbrain neurons that play central roles in drug reward and is believed to be a primary site of action for cocaine reward. |
2000-02-14 |
2023-08-12 |
mouse |
| L Chen, D M Segal, C T Moraes, D C Mas. Dopamine transporter mRNA in autopsy studies of chronic cocaine users. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581411. |
dopamine transporter mrna in autopsy studies of chronic cocaine users. |
2000-02-14 |
2023-08-12 |
human |
| L Chen, D M Segal, C T Moraes, D C Mas. Dopamine transporter mRNA in autopsy studies of chronic cocaine users. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581411. |
the effects of chronic cocaine abuse on transcriptional regulation of human dopamine transporter (dat) mrna in midbrain dopaminergic neurons was assessed by reverse transcription-polymerase chain reaction (rt-pcr). |
2000-02-14 |
2023-08-12 |
human |
| W J Pan, M A Heday. Cocaine and alcohol interactions in the rat: effect of cocaine and alcohol pretreatments on cocaine pharmacokinetics and pharmacodynamics. Journal of pharmaceutical sciences. vol 88. issue 12. 2000-02-01. PMID:10585221. |
a sigmoid-e(max) model was used to describe the brain cocaine concentration-neurochemical effect (dopamine) relationship, and an indirect pharmacodynamic response model was used to describe the plasma cocaine concentration-cardiovascular effect relationships. |
2000-02-01 |
2023-08-12 |
rat |
| W J Pan, M A Heday. Cocaine and alcohol interactions in the rat: effect of cocaine and alcohol pretreatments on cocaine pharmacokinetics and pharmacodynamics. Journal of pharmaceutical sciences. vol 88. issue 12. 2000-02-01. PMID:10585221. |
both cocaine and alcohol pretreatments increased the e(max) for dopamine, with no effect on the ec(50). |
2000-02-01 |
2023-08-12 |
rat |
| W J Pan, M A Heday. Cocaine and alcohol interactions in the rat: effect of cocaine and alcohol pretreatments on cocaine pharmacokinetics and pharmacodynamics. Journal of pharmaceutical sciences. vol 88. issue 12. 2000-02-01. PMID:10585221. |
acute alcohol coadministration with cocaine significantly increased the e(max) for dopamine and reduced the ec(50). |
2000-02-01 |
2023-08-12 |
rat |
| C Hedetoft, H R Christense. [Amphetamine, ecstasy and cocaine. Clinical aspects of acute poisoning]. Ugeskrift for laeger. vol 161. issue 50. 2000-02-01. PMID:10643376. |
amphetamine, ecstasy and cocaine increase the amount of dopamine, norephedrine and serotonine in the nervous system, resulting in cns stimulation and a general sympathomimetic stimulation. |
2000-02-01 |
2023-08-12 |
Not clear |