| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Davidson, E H Ellinwood, T H Le. Altered sensitivity of dopamine autoreceptors in rat accumbens 1 and 7 days after intermittent or continuous cocaine withdrawal. Brain research bulletin. vol 51. issue 1. 2000-02-18. PMID:10654586. |
using slice preparations, we investigated the effects of chronic cocaine treatment on dopamine autoreceptor sensitivity in the nucleus accumbens core. |
2000-02-18 |
2023-08-12 |
rat |
| C Davidson, E H Ellinwood, T H Le. Altered sensitivity of dopamine autoreceptors in rat accumbens 1 and 7 days after intermittent or continuous cocaine withdrawal. Brain research bulletin. vol 51. issue 1. 2000-02-18. PMID:10654586. |
one or 7 days after cocaine withdrawal, we used fast scan cyclic voltammetry (10 hz sampling rate) to measure inhibition of electrically evoked dopamine release by quinpirole (3-300 nm). |
2000-02-18 |
2023-08-12 |
rat |
| C Davidson, E H Ellinwood, T H Le. Altered sensitivity of dopamine autoreceptors in rat accumbens 1 and 7 days after intermittent or continuous cocaine withdrawal. Brain research bulletin. vol 51. issue 1. 2000-02-18. PMID:10654586. |
it is suggested that these cocaine dosing regimes cause differential and dynamic changes in dopamine autoreceptor sensitivity during the early withdrawal phase. |
2000-02-18 |
2023-08-12 |
rat |
| N D Volkow, J S Fowler, G J Wan. Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. Journal of psychopharmacology (Oxford, England). vol 13. issue 4. 2000-02-18. PMID:10667609. |
imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. |
2000-02-18 |
2023-08-12 |
Not clear |
| N D Volkow, J S Fowler, G J Wan. Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. Journal of psychopharmacology (Oxford, England). vol 13. issue 4. 2000-02-18. PMID:10667609. |
we summarize our studies with positron emission tomography investigating the role of dopamine (da) in the reinforcing effects of cocaine and methylphenidate in humans and its involvement in cocaine addiction. |
2000-02-18 |
2023-08-12 |
Not clear |
| N D Volkow, J S Fowler, G J Wan. Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. Journal of psychopharmacology (Oxford, England). vol 13. issue 4. 2000-02-18. PMID:10667609. |
these studies have shown that the rate at which cocaine and methylphenidate enter the brain and block the dopamine transporters (dat) is the variable associated with the 'high', rather than the presence per se of the drug in the brain. |
2000-02-18 |
2023-08-12 |
Not clear |
| D M Donovan, L L Miner, M P Perry, R S Revay, L G Sharpe, S Przedborski, V Kostic, R M Philpot, C L Kirstein, R B Rothman, C W Schindler, G R Uh. Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581396. |
cocaine reward and mptp toxicity: alteration by regional variant dopamine transporter overexpression. |
2000-02-14 |
2023-08-12 |
mouse |
| D M Donovan, L L Miner, M P Perry, R S Revay, L G Sharpe, S Przedborski, V Kostic, R M Philpot, C L Kirstein, R B Rothman, C W Schindler, G R Uh. Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581396. |
the dopamine transporter (dat; slc6a3) is densely expressed by the dopaminergic midbrain neurons that play central roles in drug reward and is believed to be a primary site of action for cocaine reward. |
2000-02-14 |
2023-08-12 |
mouse |
| L Chen, D M Segal, C T Moraes, D C Mas. Dopamine transporter mRNA in autopsy studies of chronic cocaine users. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581411. |
dopamine transporter mrna in autopsy studies of chronic cocaine users. |
2000-02-14 |
2023-08-12 |
human |
| L Chen, D M Segal, C T Moraes, D C Mas. Dopamine transporter mRNA in autopsy studies of chronic cocaine users. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581411. |
the effects of chronic cocaine abuse on transcriptional regulation of human dopamine transporter (dat) mrna in midbrain dopaminergic neurons was assessed by reverse transcription-polymerase chain reaction (rt-pcr). |
2000-02-14 |
2023-08-12 |
human |
| W J Pan, M A Heday. Cocaine and alcohol interactions in the rat: effect of cocaine and alcohol pretreatments on cocaine pharmacokinetics and pharmacodynamics. Journal of pharmaceutical sciences. vol 88. issue 12. 2000-02-01. PMID:10585221. |
a sigmoid-e(max) model was used to describe the brain cocaine concentration-neurochemical effect (dopamine) relationship, and an indirect pharmacodynamic response model was used to describe the plasma cocaine concentration-cardiovascular effect relationships. |
2000-02-01 |
2023-08-12 |
rat |
| W J Pan, M A Heday. Cocaine and alcohol interactions in the rat: effect of cocaine and alcohol pretreatments on cocaine pharmacokinetics and pharmacodynamics. Journal of pharmaceutical sciences. vol 88. issue 12. 2000-02-01. PMID:10585221. |
both cocaine and alcohol pretreatments increased the e(max) for dopamine, with no effect on the ec(50). |
2000-02-01 |
2023-08-12 |
rat |
| W J Pan, M A Heday. Cocaine and alcohol interactions in the rat: effect of cocaine and alcohol pretreatments on cocaine pharmacokinetics and pharmacodynamics. Journal of pharmaceutical sciences. vol 88. issue 12. 2000-02-01. PMID:10585221. |
acute alcohol coadministration with cocaine significantly increased the e(max) for dopamine and reduced the ec(50). |
2000-02-01 |
2023-08-12 |
rat |
| C Hedetoft, H R Christense. [Amphetamine, ecstasy and cocaine. Clinical aspects of acute poisoning]. Ugeskrift for laeger. vol 161. issue 50. 2000-02-01. PMID:10643376. |
amphetamine, ecstasy and cocaine increase the amount of dopamine, norephedrine and serotonine in the nervous system, resulting in cns stimulation and a general sympathomimetic stimulation. |
2000-02-01 |
2023-08-12 |
Not clear |
| H Tsukada, S Nishiyama, T Kakiuchi, H Ohba, K Sato, N Harada, S Nakanish. Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain. Brain research. vol 849. issue 1-2. 2000-01-28. PMID:10592290. |
isoflurane anesthesia enhances the inhibitory effects of cocaine and gbr12909 on dopamine transporter: pet studies in combination with microdialysis in the monkey brain. |
2000-01-28 |
2023-08-12 |
monkey |
| H Tsukada, S Nishiyama, T Kakiuchi, H Ohba, K Sato, N Harada, S Nakanish. Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain. Brain research. vol 849. issue 1-2. 2000-01-28. PMID:10592290. |
the effects of the dopamine transporter (dat) inhibitors cocaine and gbr12909 on dat and dopamine d(2) receptors were evaluated in the brains under awake and isoflurane-anesthetized monkeys using high-resolution positron emission tomography (pet) in combination with microdialysis. |
2000-01-28 |
2023-08-12 |
monkey |
| H Tsukada, S Nishiyama, T Kakiuchi, H Ohba, K Sato, N Harada, S Nakanish. Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain. Brain research. vol 849. issue 1-2. 2000-01-28. PMID:10592290. |
under isoflurane anesthesia, dopamine concentration in the striatal extracellular fluid (ecf), as measured by microdialysis, was markedly increased by cocaine or gbr12909 compared to the awake state. |
2000-01-28 |
2023-08-12 |
monkey |
| H Tsukada, S Nishiyama, T Kakiuchi, H Ohba, K Sato, N Harada, S Nakanish. Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain. Brain research. vol 849. issue 1-2. 2000-01-28. PMID:10592290. |
taken together, these observations indicated that isoflurane anesthesia enhanced not only the direct inhibitory effects of cocaine and gbr12909 on dat, but also their indirect effects on dopamine d(2) receptors. |
2000-01-28 |
2023-08-12 |
monkey |
| N D Volkow, S J Gatley, J S Fowler, J Logan, M Fischman, A N Gifford, N Pappas, P King, S Vitkun, Y S Ding, G J Wan. Cocaine doses equivalent to those abused by humans occupy most of the dopamine transporters. Synapse (New York, N.Y.). vol 24. issue 4. 2000-01-27. PMID:10638828. |
cocaine doses equivalent to those abused by humans occupy most of the dopamine transporters. |
2000-01-27 |
2023-08-12 |
Not clear |
| F Karoum, M E Wolf, A D Mosnai. Effects of the administration of amphetamine, either alone or in combination with reserpine or cocaine, on regional brain beta-phenylethylamine and dopamine release. American journal of therapeutics. vol 4. issue 9-10. 2000-01-24. PMID:10423628. |
effects of the administration of amphetamine, either alone or in combination with reserpine or cocaine, on regional brain beta-phenylethylamine and dopamine release. |
2000-01-24 |
2023-08-12 |
rat |