| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Chen, D M Segal, C T Moraes, D C Mas. Dopamine transporter mRNA in autopsy studies of chronic cocaine users. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581411. |
dopamine transporter mrna in autopsy studies of chronic cocaine users. |
2000-02-14 |
2023-08-12 |
human |
| L Chen, D M Segal, C T Moraes, D C Mas. Dopamine transporter mRNA in autopsy studies of chronic cocaine users. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581411. |
the effects of chronic cocaine abuse on transcriptional regulation of human dopamine transporter (dat) mrna in midbrain dopaminergic neurons was assessed by reverse transcription-polymerase chain reaction (rt-pcr). |
2000-02-14 |
2023-08-12 |
human |
| W J Pan, M A Heday. Cocaine and alcohol interactions in the rat: effect of cocaine and alcohol pretreatments on cocaine pharmacokinetics and pharmacodynamics. Journal of pharmaceutical sciences. vol 88. issue 12. 2000-02-01. PMID:10585221. |
a sigmoid-e(max) model was used to describe the brain cocaine concentration-neurochemical effect (dopamine) relationship, and an indirect pharmacodynamic response model was used to describe the plasma cocaine concentration-cardiovascular effect relationships. |
2000-02-01 |
2023-08-12 |
rat |
| W J Pan, M A Heday. Cocaine and alcohol interactions in the rat: effect of cocaine and alcohol pretreatments on cocaine pharmacokinetics and pharmacodynamics. Journal of pharmaceutical sciences. vol 88. issue 12. 2000-02-01. PMID:10585221. |
both cocaine and alcohol pretreatments increased the e(max) for dopamine, with no effect on the ec(50). |
2000-02-01 |
2023-08-12 |
rat |
| W J Pan, M A Heday. Cocaine and alcohol interactions in the rat: effect of cocaine and alcohol pretreatments on cocaine pharmacokinetics and pharmacodynamics. Journal of pharmaceutical sciences. vol 88. issue 12. 2000-02-01. PMID:10585221. |
acute alcohol coadministration with cocaine significantly increased the e(max) for dopamine and reduced the ec(50). |
2000-02-01 |
2023-08-12 |
rat |
| C Hedetoft, H R Christense. [Amphetamine, ecstasy and cocaine. Clinical aspects of acute poisoning]. Ugeskrift for laeger. vol 161. issue 50. 2000-02-01. PMID:10643376. |
amphetamine, ecstasy and cocaine increase the amount of dopamine, norephedrine and serotonine in the nervous system, resulting in cns stimulation and a general sympathomimetic stimulation. |
2000-02-01 |
2023-08-12 |
Not clear |
| H Tsukada, S Nishiyama, T Kakiuchi, H Ohba, K Sato, N Harada, S Nakanish. Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain. Brain research. vol 849. issue 1-2. 2000-01-28. PMID:10592290. |
isoflurane anesthesia enhances the inhibitory effects of cocaine and gbr12909 on dopamine transporter: pet studies in combination with microdialysis in the monkey brain. |
2000-01-28 |
2023-08-12 |
monkey |
| H Tsukada, S Nishiyama, T Kakiuchi, H Ohba, K Sato, N Harada, S Nakanish. Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain. Brain research. vol 849. issue 1-2. 2000-01-28. PMID:10592290. |
the effects of the dopamine transporter (dat) inhibitors cocaine and gbr12909 on dat and dopamine d(2) receptors were evaluated in the brains under awake and isoflurane-anesthetized monkeys using high-resolution positron emission tomography (pet) in combination with microdialysis. |
2000-01-28 |
2023-08-12 |
monkey |
| H Tsukada, S Nishiyama, T Kakiuchi, H Ohba, K Sato, N Harada, S Nakanish. Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain. Brain research. vol 849. issue 1-2. 2000-01-28. PMID:10592290. |
under isoflurane anesthesia, dopamine concentration in the striatal extracellular fluid (ecf), as measured by microdialysis, was markedly increased by cocaine or gbr12909 compared to the awake state. |
2000-01-28 |
2023-08-12 |
monkey |
| H Tsukada, S Nishiyama, T Kakiuchi, H Ohba, K Sato, N Harada, S Nakanish. Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain. Brain research. vol 849. issue 1-2. 2000-01-28. PMID:10592290. |
taken together, these observations indicated that isoflurane anesthesia enhanced not only the direct inhibitory effects of cocaine and gbr12909 on dat, but also their indirect effects on dopamine d(2) receptors. |
2000-01-28 |
2023-08-12 |
monkey |
| N D Volkow, S J Gatley, J S Fowler, J Logan, M Fischman, A N Gifford, N Pappas, P King, S Vitkun, Y S Ding, G J Wan. Cocaine doses equivalent to those abused by humans occupy most of the dopamine transporters. Synapse (New York, N.Y.). vol 24. issue 4. 2000-01-27. PMID:10638828. |
cocaine doses equivalent to those abused by humans occupy most of the dopamine transporters. |
2000-01-27 |
2023-08-12 |
Not clear |
| F Karoum, M E Wolf, A D Mosnai. Effects of the administration of amphetamine, either alone or in combination with reserpine or cocaine, on regional brain beta-phenylethylamine and dopamine release. American journal of therapeutics. vol 4. issue 9-10. 2000-01-24. PMID:10423628. |
effects of the administration of amphetamine, either alone or in combination with reserpine or cocaine, on regional brain beta-phenylethylamine and dopamine release. |
2000-01-24 |
2023-08-12 |
rat |
| M A Nader, K L Green, R R Luedtke, R H Mac. The effects of benzamide analogues on cocaine self-administration in rhesus monkeys. Psychopharmacology. vol 147. issue 2. 2000-01-24. PMID:10591881. |
based on the differential distribution of dopamine (da) d(3) receptors in mesolimbic regions relative to nigrostriatal regions, the hypothesis was that d(3)-selective antagonists (i.e., higher affinity at d(3)- than d(2)-receptors) would be more potent than d(2)-selective antagonists at decreasing total cocaine intake relative to disrupting rates of responding. |
2000-01-24 |
2023-08-12 |
monkey |
| J Helfenbein, C Loc'h, M Bottlaender, P Emond, C Coulon, M Ottaviani, C Fuseau, S Chalon, I Guenther, J C Besnard, Y Frangin, D Guilloteau, B Mazier. A selective radiobrominated cocaine analogue for imaging of dopamine uptake sites: pharmacological evaluation and PET experiments. Life sciences. vol 65. issue 25. 2000-01-20. PMID:10622281. |
a selective radiobrominated cocaine analogue for imaging of dopamine uptake sites: pharmacological evaluation and pet experiments. |
2000-01-20 |
2023-08-12 |
rat |
| K R Alpe. The EEG and cocaine sensitization: a hypothesis. The Journal of neuropsychiatry and clinical neurosciences. vol 11. issue 2. 1999-12-23. PMID:10333992. |
the author presents the hypothesis that reduced delta eeg power observed in cocaine withdrawal is related to changes in dopamine (da) transmission related to cocaine sensitization. |
1999-12-23 |
2023-08-12 |
Not clear |
| R D Spealman, R L Barrett-Larimore, J K Rowlett, D M Platt, T V Khroya. Pharmacological and environmental determinants of relapse to cocaine-seeking behavior. Pharmacology, biochemistry, and behavior. vol 64. issue 2. 1999-12-20. PMID:10515309. |
drugs that share cocaine's indirect dopamine agonist properties or that act as direct agonists at d2-like dopamine receptors also induce reinstatement of cocaine-seeking behavior, whereas with some exceptions (e.g., caffeine, morphine) drugs from other pharmacological classes do not. |
1999-12-20 |
2023-08-12 |
rat |
| K J Garner, L E Bake. Analysis of D2 and D3 receptor-selective ligands in rats trained to discriminate cocaine from saline. Pharmacology, biochemistry, and behavior. vol 64. issue 2. 1999-12-20. PMID:10515316. |
this study examined the role of dopamine d3 receptors in the stimulus generalization produced by 7-oh-dpat and pd 128907 in rats trained to discriminate cocaine from saline. |
1999-12-20 |
2023-08-12 |
rat |
| M K Romach, P Glue, K Kampman, H L Kaplan, G R Somer, S Poole, L Clarke, V Coffin, J Cornish, C P O'Brien, E M Seller. Attenuation of the euphoric effects of cocaine by the dopamine D1/D5 antagonist ecopipam (SCH 39166) Archives of general psychiatry. vol 56. issue 12. 1999-12-16. PMID:10591286. |
attenuation of the euphoric effects of cocaine by the dopamine d1/d5 antagonist ecopipam (sch 39166) the subjective and reinforcing effects of cocaine in humans are associated with the enhancement of endogenous dopamine function in the mesolimbic system. |
1999-12-16 |
2023-08-12 |
human |
| M K Romach, P Glue, K Kampman, H L Kaplan, G R Somer, S Poole, L Clarke, V Coffin, J Cornish, C P O'Brien, E M Seller. Attenuation of the euphoric effects of cocaine by the dopamine D1/D5 antagonist ecopipam (SCH 39166) Archives of general psychiatry. vol 56. issue 12. 1999-12-16. PMID:10591286. |
this study examined the role of dopamine d1-like receptors in the behavioral and mood effects of cocaine by evaluating the effects of the selective d1/d5 antagonist ecopipam (sch 39166) on subjective responses to intravenous cocaine in 11 subjects with cocaine dependence as defined by dsm-iv. |
1999-12-16 |
2023-08-12 |
human |
| G F Koo. Cocaine reward and dopamine receptors: love at first site. Archives of general psychiatry. vol 56. issue 12. 1999-12-16. PMID:10591287. |
cocaine reward and dopamine receptors: love at first site. |
1999-12-16 |
2023-08-12 |
Not clear |