| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Weiss, C S Maldonado-Vlaar, L H Parsons, T M Kerr, D L Smith, O Ben-Shaha. Control of cocaine-seeking behavior by drug-associated stimuli in rats: effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 8. 2000-05-17. PMID:10760299. |
exposure to the cocaine sdelta significantly increased dopamine efflux in the nacc and amygdala as measured by intracranial microdialysis in a separate group of rats. |
2000-05-17 |
2023-08-12 |
rat |
| D W Johnson, P Eodice, H Winterbottom, D J Mokle. Decreased accumbens dopamine release after cocaine challenge in behaviorally sensitized female rats. Pharmacology, biochemistry, and behavior. vol 65. issue 4. 2000-05-10. PMID:10764919. |
decreased accumbens dopamine release after cocaine challenge in behaviorally sensitized female rats. |
2000-05-10 |
2023-08-12 |
rat |
| D W Johnson, P Eodice, H Winterbottom, D J Mokle. Decreased accumbens dopamine release after cocaine challenge in behaviorally sensitized female rats. Pharmacology, biochemistry, and behavior. vol 65. issue 4. 2000-05-10. PMID:10764919. |
the effects of the competitive nmda receptor antagonist cpp on the initiation of behavioral sensitization to acute cocaine and basal and acute cocaine-induced dopamine (da) release in the nucleus accumbens (nac) were assessed in female sprague-dawley rats. |
2000-05-10 |
2023-08-12 |
rat |
| K G Anderson, F van Haare. Effects of SCH-23390 and raclopride on cocaine discrimination in male and female Wistar rats. Pharmacology, biochemistry, and behavior. vol 65. issue 4. 2000-05-10. PMID:10764921. |
following the determination of the cocaine generalization gradient, the dopamine d(1) antagonist sch-23390 (0.01-0.10 mg/kg) and the dopamine d(2) antagonist raclopride (0.1-1.6 mg/kg) were administered (independently) prior to the injection of the training dose of cocaine (10.0 mg/kg). |
2000-05-10 |
2023-08-12 |
rat |
| Z Lin, M Itokawa, G R Uh. Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 5. 2000-05-01. PMID:10744628. |
dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression. |
2000-05-01 |
2023-08-12 |
Not clear |
| Z Lin, M Itokawa, G R Uh. Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 5. 2000-05-01. PMID:10744628. |
the dopamine transporter (dat) mediates complex actions in recognizing cocaine and in recognizing and translocating dopamine, sodium, and chloride. |
2000-05-01 |
2023-08-12 |
Not clear |
| Z Lin, M Itokawa, G R Uh. Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 5. 2000-05-01. PMID:10744628. |
we examine effects of these modifications on dat expression, dopamine uptake, and cocaine analog binding. |
2000-05-01 |
2023-08-12 |
Not clear |
| Z Lin, M Itokawa, G R Uh. Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 5. 2000-05-01. PMID:10744628. |
five mutations decrease dopamine affinities more than threefold without significantly decreasing cocaine analog affinities. |
2000-05-01 |
2023-08-12 |
Not clear |
| Z Lin, M Itokawa, G R Uh. Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 5. 2000-05-01. PMID:10744628. |
one decreases cocaine analog affinity without decreasing dopamine affinity. |
2000-05-01 |
2023-08-12 |
Not clear |
| Z Lin, M Itokawa, G R Uh. Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 5. 2000-05-01. PMID:10744628. |
two mutations decrease affinities for both dopamine and cocaine analog. |
2000-05-01 |
2023-08-12 |
Not clear |
| Z Lin, M Itokawa, G R Uh. Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 5. 2000-05-01. PMID:10744628. |
these dat proline mutants identify dat regions likely for dopamine translocation and for recognition of dopamine and cocaine. |
2000-05-01 |
2023-08-12 |
Not clear |
| P W Czoty, J B Justice, L L Howel. Cocaine-induced changes in extracellular dopamine determined by microdialysis in awake squirrel monkeys. Psychopharmacology. vol 148. issue 3. 2000-04-27. PMID:10755743. |
the behavioral effects of cocaine have been linked to brain dopamine systems. |
2000-04-27 |
2023-08-12 |
monkey |
| R J Bainton, L T Tsai, C M Singh, M S Moore, W S Neckameyer, U Heberlei. Dopamine modulates acute responses to cocaine, nicotine and ethanol in Drosophila. Current biology : CB. vol 10. issue 4. 2000-04-25. PMID:10704411. |
dopamine modulates acute responses to cocaine, nicotine and ethanol in drosophila. |
2000-04-25 |
2023-08-12 |
drosophila_melanogaster |
| H Li, S Chaney, I J Roberts, M Forte, J Hirs. Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster. Current biology : CB. vol 10. issue 4. 2000-04-25. PMID:10704417. |
ectopic g-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in drosophila melanogaster. |
2000-04-25 |
2023-08-12 |
drosophila_melanogaster |
| H Li, S Chaney, I J Roberts, M Forte, J Hirs. Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster. Current biology : CB. vol 10. issue 4. 2000-04-25. PMID:10704417. |
here, we show that modulated cell signaling in the drosophila dopamine and serotonin neurons plays an essential role in cocaine sensitization. |
2000-04-25 |
2023-08-12 |
drosophila_melanogaster |
| H Li, S Chaney, I J Roberts, M Forte, J Hirs. Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster. Current biology : CB. vol 10. issue 4. 2000-04-25. PMID:10704417. |
targeted expression of either a stimulatory (galpha(s)) or inhibitory (galpha(i)) galpha subunit, or tetanus toxin light chain (tnt) in dopamine and serotonin neurons of living flies blocked behavioral sensitization to repeated cocaine exposures. |
2000-04-25 |
2023-08-12 |
drosophila_melanogaster |
| R M Cowell, L Kantor, G H Hewlett, K A Frey, M E Gneg. Dopamine transporter antagonists block phorbol ester-induced dopamine release and dopamine transporter phosphorylation in striatal synaptosomes. European journal of pharmacology. vol 389. issue 1. 2000-04-20. PMID:10686296. |
the dopamine transporter antagonists, cocaine and gbr 12935 blocked the tpa-mediated dopamine release. |
2000-04-20 |
2023-08-12 |
rat |
| R M Cowell, L Kantor, G H Hewlett, K A Frey, M E Gneg. Dopamine transporter antagonists block phorbol ester-induced dopamine release and dopamine transporter phosphorylation in striatal synaptosomes. European journal of pharmacology. vol 389. issue 1. 2000-04-20. PMID:10686296. |
in addition, cocaine blocked tpa-mediated phosphorylation of the plasmalemmal dopamine transporter. |
2000-04-20 |
2023-08-12 |
rat |
| Y Zhou, S D Schlussman, A Ho, R Spangler, A A Fienberg, P Greengard, M J Kree. Effects of chronic 'Binge' cocaine administration on plasma ACTH and corticosterone levels in mice deficient in DARPP-32. Neuroendocrinology. vol 70. issue 3. 2000-04-14. PMID:10516482. |
cocaine administration leads to increased activation of dopamine receptors, and causes activation of the stress-responsive hypothalamic-pituitary-adrenal (hpa) axis. |
2000-04-14 |
2023-08-12 |
mouse |
| M J Robarge, G E Agoston, S Izenwasser, T Kopajtic, C George, J L Katz, A H Newma. Highly selective chiral N-substituted 3alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues for the dopamine transporter: synthesis and comparative molecular field analysis. Journal of medicinal chemistry. vol 43. issue 6. 2000-04-13. PMID:10737741. |
in a continuing effort to further characterize the role of the dopamine transporter in the pharmacological effects of cocaine, a series of chiral and achiral n-substituted analogues of 3alpha-[bis(4'-fluorophenyl)methoxy]tropane (5) has been prepared as potential selective dopamine transporter ligands. |
2000-04-13 |
2023-08-12 |
rat |