| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z Lin, M Itokawa, G R Uh. Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 5. 2000-05-01. PMID:10744628. |
we examine effects of these modifications on dat expression, dopamine uptake, and cocaine analog binding. |
2000-05-01 |
2023-08-12 |
Not clear |
| Z Lin, M Itokawa, G R Uh. Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 5. 2000-05-01. PMID:10744628. |
five mutations decrease dopamine affinities more than threefold without significantly decreasing cocaine analog affinities. |
2000-05-01 |
2023-08-12 |
Not clear |
| Z Lin, M Itokawa, G R Uh. Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 5. 2000-05-01. PMID:10744628. |
one decreases cocaine analog affinity without decreasing dopamine affinity. |
2000-05-01 |
2023-08-12 |
Not clear |
| Z Lin, M Itokawa, G R Uh. Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 5. 2000-05-01. PMID:10744628. |
two mutations decrease affinities for both dopamine and cocaine analog. |
2000-05-01 |
2023-08-12 |
Not clear |
| Z Lin, M Itokawa, G R Uh. Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 5. 2000-05-01. PMID:10744628. |
these dat proline mutants identify dat regions likely for dopamine translocation and for recognition of dopamine and cocaine. |
2000-05-01 |
2023-08-12 |
Not clear |
| P W Czoty, J B Justice, L L Howel. Cocaine-induced changes in extracellular dopamine determined by microdialysis in awake squirrel monkeys. Psychopharmacology. vol 148. issue 3. 2000-04-27. PMID:10755743. |
the behavioral effects of cocaine have been linked to brain dopamine systems. |
2000-04-27 |
2023-08-12 |
monkey |
| R J Bainton, L T Tsai, C M Singh, M S Moore, W S Neckameyer, U Heberlei. Dopamine modulates acute responses to cocaine, nicotine and ethanol in Drosophila. Current biology : CB. vol 10. issue 4. 2000-04-25. PMID:10704411. |
dopamine modulates acute responses to cocaine, nicotine and ethanol in drosophila. |
2000-04-25 |
2023-08-12 |
drosophila_melanogaster |
| H Li, S Chaney, I J Roberts, M Forte, J Hirs. Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster. Current biology : CB. vol 10. issue 4. 2000-04-25. PMID:10704417. |
ectopic g-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in drosophila melanogaster. |
2000-04-25 |
2023-08-12 |
drosophila_melanogaster |
| H Li, S Chaney, I J Roberts, M Forte, J Hirs. Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster. Current biology : CB. vol 10. issue 4. 2000-04-25. PMID:10704417. |
here, we show that modulated cell signaling in the drosophila dopamine and serotonin neurons plays an essential role in cocaine sensitization. |
2000-04-25 |
2023-08-12 |
drosophila_melanogaster |
| H Li, S Chaney, I J Roberts, M Forte, J Hirs. Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster. Current biology : CB. vol 10. issue 4. 2000-04-25. PMID:10704417. |
targeted expression of either a stimulatory (galpha(s)) or inhibitory (galpha(i)) galpha subunit, or tetanus toxin light chain (tnt) in dopamine and serotonin neurons of living flies blocked behavioral sensitization to repeated cocaine exposures. |
2000-04-25 |
2023-08-12 |
drosophila_melanogaster |
| R M Cowell, L Kantor, G H Hewlett, K A Frey, M E Gneg. Dopamine transporter antagonists block phorbol ester-induced dopamine release and dopamine transporter phosphorylation in striatal synaptosomes. European journal of pharmacology. vol 389. issue 1. 2000-04-20. PMID:10686296. |
the dopamine transporter antagonists, cocaine and gbr 12935 blocked the tpa-mediated dopamine release. |
2000-04-20 |
2023-08-12 |
rat |
| R M Cowell, L Kantor, G H Hewlett, K A Frey, M E Gneg. Dopamine transporter antagonists block phorbol ester-induced dopamine release and dopamine transporter phosphorylation in striatal synaptosomes. European journal of pharmacology. vol 389. issue 1. 2000-04-20. PMID:10686296. |
in addition, cocaine blocked tpa-mediated phosphorylation of the plasmalemmal dopamine transporter. |
2000-04-20 |
2023-08-12 |
rat |
| Y Zhou, S D Schlussman, A Ho, R Spangler, A A Fienberg, P Greengard, M J Kree. Effects of chronic 'Binge' cocaine administration on plasma ACTH and corticosterone levels in mice deficient in DARPP-32. Neuroendocrinology. vol 70. issue 3. 2000-04-14. PMID:10516482. |
cocaine administration leads to increased activation of dopamine receptors, and causes activation of the stress-responsive hypothalamic-pituitary-adrenal (hpa) axis. |
2000-04-14 |
2023-08-12 |
mouse |
| M J Robarge, G E Agoston, S Izenwasser, T Kopajtic, C George, J L Katz, A H Newma. Highly selective chiral N-substituted 3alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues for the dopamine transporter: synthesis and comparative molecular field analysis. Journal of medicinal chemistry. vol 43. issue 6. 2000-04-13. PMID:10737741. |
in a continuing effort to further characterize the role of the dopamine transporter in the pharmacological effects of cocaine, a series of chiral and achiral n-substituted analogues of 3alpha-[bis(4'-fluorophenyl)methoxy]tropane (5) has been prepared as potential selective dopamine transporter ligands. |
2000-04-13 |
2023-08-12 |
rat |
| C Deleuze-Masquefa, M Michaud-Dutreilh, J Vignon, J M Kamenk. 1-[1-(2-Benzo[b]thiopheneyl)cyclohexyl]piperidine hydrochloride (BTCP) yields two active primary metabolites in vivo. Identification and quantification of BTCP primary metabolites in mice plasma, urine, and brain and their affinity for the neuronal dopamine transporter. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 9. issue 4. 2000-04-11. PMID:10664474. |
1-[1-(2-benzo[b]thiopheneyl)cyclohexyl]piperidine hydrochloride (btcp) and cocaine bind to the neuronal dopamine transporter (dat) to strongly inhibit dopamine (da) reuptake. |
2000-04-11 |
2023-08-12 |
mouse |
| C D Fiorillo, J T William. Selective inhibition by adenosine of mGluR IPSPs in dopamine neurons after cocaine treatment. Journal of neurophysiology. vol 83. issue 3. 2000-04-11. PMID:10712458. |
selective inhibition by adenosine of mglur ipsps in dopamine neurons after cocaine treatment. |
2000-04-11 |
2023-08-12 |
rat |
| C D Fiorillo, J T William. Selective inhibition by adenosine of mGluR IPSPs in dopamine neurons after cocaine treatment. Journal of neurophysiology. vol 83. issue 3. 2000-04-11. PMID:10712458. |
one consequence of repeated cocaine treatment is an increase in extracellular adenosine in the ventral tegmental area (vta), which results in tonic inhibition of synaptic input to dopamine neurons. |
2000-04-11 |
2023-08-12 |
rat |
| L B Li, M E Reit. Interaction of Na+, K+, and Cl- with the binding of amphetamine, octopamine, and tyramine to the human dopamine transporter. Journal of neurochemistry. vol 74. issue 4. 2000-04-11. PMID:10737611. |
in this study, substrate recognition was studied via the inhibition of binding of [3h]win 35,428 [2beta-carbomethoxy-3beta-(4-fluorophenyl)[3h]tropane], a cocaine analogue, to the human dopamine transporter in human embryonic kidney 293 cells. |
2000-04-11 |
2023-08-12 |
human |
| E El Daly, V Chefer, S Sandill, T S Shippenber. Modulation of the neurotoxic effects of methamphetamine by the selective kappa-opioid receptor agonist U69593. Journal of neurochemistry. vol 74. issue 4. 2000-04-11. PMID:10737612. |
kappa-opioid receptor agonists prevent alterations in dopamine neurotransmission that occur in response to repeated cocaine administration. |
2000-04-11 |
2023-08-12 |
mouse |
| M Froimowitz, K M Wu, J Rodrigo, C Georg. Conformational preferences of the potent dopamine reuptake blocker BTCP and its analogs and their incorporation into a pharmacophore model. Journal of computer-aided molecular design. vol 14. issue 2. 2000-04-05. PMID:10721502. |
there is excellent agreement between a 'back-bridged' cocaine analog that is optimal as a dopamine reuptake blocker and the previously proposed biologically active conformer of methylphenidate. |
2000-04-05 |
2023-08-12 |
Not clear |