| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Ho, M Segr. Dopamine uptake by mouse neuroblastoma N1E-115 cells stably expressing human dopamine transporter is differentially inhibited by anti-idiotypic ab2beta antibodies mimicking the configuration of cocaine. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924700. |
these findings suggest that the internal images of these antibodies can be used as analog peptides that may compete with cocaine for its binding site on the transporter but not impair dopamine uptake as much as cocaine does. |
2000-09-20 |
2023-08-12 |
mouse |
| D H Feldman, W R Harvey, B R Steven. A novel electrogenic amino acid transporter is activated by K+ or Na+, is alkaline pH-dependent, and is Cl--independent. The Journal of biological chemistry. vol 275. issue 32. 2000-09-14. PMID:10829035. |
amino acids such as l-proline, l-threonine, and l-methionine elicited complex current-voltage relationships in alkaline ph-dependent caatch1 that were reminiscent of the behavior of the dopamine, serotonin, and norepinephrine transporters (dat, sert, net) in the presence of their substrates and pharmacological inhibitors such as cocaine or antidepressants. |
2000-09-14 |
2023-08-12 |
xenopus_laevis |
| L Iverse. Neurotransmitter transporters: fruitful targets for CNS drug discovery. Molecular psychiatry. vol 5. issue 4. 2000-09-14. PMID:10889545. |
the dopamine transporter plays a key role in mediating the actions of cocaine and the amphetamines and in conferring selectivity on dopamine neurotoxins. |
2000-09-14 |
2023-08-12 |
Not clear |
| L G Sharpe, N S Pilotte, T S Shippenberg, C B Goodman, E D Londo. Autoradiographic evidence that prolonged withdrawal from intermittent cocaine reduces mu-opioid receptor expression in limbic regions of the rat brain. Synapse (New York, N.Y.). vol 37. issue 4. 2000-09-14. PMID:10891866. |
the mu-receptor may manifest, as do other neural markers (e.g., dopamine transporter, dopamine efflux), a biphasic temporal pattern with upregulation during early phases of cocaine withdrawal but a downregulation at later times. |
2000-09-14 |
2023-08-12 |
rat |
| M R Gerasimov, W K Schiffer, J D Brodie, I C Lennon, S J Taylor, S L Dewe. gamma-aminobutyric acid mimetic drugs differentially inhibit the dopaminergic response to cocaine. European journal of pharmacology. vol 395. issue 2. 2000-09-06. PMID:10794818. |
we previously demonstrated that increased gamma-aminobutyric acid (gaba)-ergic activity produced by gamma-vinyl gaba [d,l-4-amino-hex-5-enoic acid (vigabatrin(r))], an irreversible inhibitor of gaba-transaminase, attenuated cocaine, nicotine, heroin, alcohol, and methamphetamine-induced increases in extracellular nucleus accumbens dopamine as well as behaviors associated with these biochemical changes. |
2000-09-06 |
2023-08-12 |
Not clear |
| M R Gerasimov, W K Schiffer, J D Brodie, I C Lennon, S J Taylor, S L Dewe. gamma-aminobutyric acid mimetic drugs differentially inhibit the dopaminergic response to cocaine. European journal of pharmacology. vol 395. issue 2. 2000-09-06. PMID:10794818. |
our data demonstrate that the anticonvulsant 1-(2-(((diphenylmethylene)amino)oxy)ethyl)-1,2,5, 6-tetrahydro-3-pyridinecarboxylic acid hydrochloride (nnc-711), a gaba uptake inhibitor, dose and time dependently diminished increases in extracellular dopamine following acute cocaine challenge. |
2000-09-06 |
2023-08-12 |
Not clear |
| J Grabowski, H Rhoades, P Silverman, J M Schmitz, A Stotts, D Creson, R Baile. Risperidone for the treatment of cocaine dependence: randomized, double-blind trial. Journal of clinical psychopharmacology. vol 20. issue 3. 2000-09-01. PMID:10831016. |
risperidone, a 5-hydroxytryptamine and dopamine d2 antagonist, is an atypical antipsychotic and was a candidate medication for the treatment of cocaine dependence. |
2000-09-01 |
2023-08-12 |
human |
| T N Ferraro, G T Golden, W H Berrettini, E Gottheil, C H Yang, G R Cuppels, W H Voge. Cocaine intake by rats correlates with cocaine-induced dopamine changes in the nucleus accumbens shell. Pharmacology, biochemistry, and behavior. vol 66. issue 2. 2000-08-28. PMID:10880696. |
cocaine intake by rats correlates with cocaine-induced dopamine changes in the nucleus accumbens shell. |
2000-08-28 |
2023-08-12 |
rat |
| T N Ferraro, G T Golden, W H Berrettini, E Gottheil, C H Yang, G R Cuppels, W H Voge. Cocaine intake by rats correlates with cocaine-induced dopamine changes in the nucleus accumbens shell. Pharmacology, biochemistry, and behavior. vol 66. issue 2. 2000-08-28. PMID:10880696. |
extracellular dopamine levels were determined by microdialysis in the core and shell of the nucleus accumbens and the frontal cortex of rats before and after an injection of cocaine (20 mg/kg, ip). |
2000-08-28 |
2023-08-12 |
rat |
| T N Ferraro, G T Golden, W H Berrettini, E Gottheil, C H Yang, G R Cuppels, W H Voge. Cocaine intake by rats correlates with cocaine-induced dopamine changes in the nucleus accumbens shell. Pharmacology, biochemistry, and behavior. vol 66. issue 2. 2000-08-28. PMID:10880696. |
baseline dopamine levels and their responses to an injection of cocaine differed among the three brain areas. |
2000-08-28 |
2023-08-12 |
rat |
| T N Ferraro, G T Golden, W H Berrettini, E Gottheil, C H Yang, G R Cuppels, W H Voge. Cocaine intake by rats correlates with cocaine-induced dopamine changes in the nucleus accumbens shell. Pharmacology, biochemistry, and behavior. vol 66. issue 2. 2000-08-28. PMID:10880696. |
no significant correlations were found between baseline dopamine levels in any of the three brain regions and the voluntary cocaine consumption. |
2000-08-28 |
2023-08-12 |
rat |
| T N Ferraro, G T Golden, W H Berrettini, E Gottheil, C H Yang, G R Cuppels, W H Voge. Cocaine intake by rats correlates with cocaine-induced dopamine changes in the nucleus accumbens shell. Pharmacology, biochemistry, and behavior. vol 66. issue 2. 2000-08-28. PMID:10880696. |
a significant negative correlation was found between cocaine-induced increases in extracellular dopamine in the shell of the nucleus accumbens and the voluntary intake of cocaine (r = -0.73, p < 0.01). |
2000-08-28 |
2023-08-12 |
rat |
| T N Ferraro, G T Golden, W H Berrettini, E Gottheil, C H Yang, G R Cuppels, W H Voge. Cocaine intake by rats correlates with cocaine-induced dopamine changes in the nucleus accumbens shell. Pharmacology, biochemistry, and behavior. vol 66. issue 2. 2000-08-28. PMID:10880696. |
these results provide further evidence of the role of the accumbal shell region in cocaine preference, and indicate that cocaine-induced increases in dopamine levels play a role in oral cocaine self-administration or preference. |
2000-08-28 |
2023-08-12 |
rat |
| D A Zachor, J F Moore, C Brezausek, A Theibert, A K Perc. Cocaine inhibits NGF-induced PC12 cells differentiation through D(1)-type dopamine receptors. Brain research. vol 869. issue 1-2. 2000-08-25. PMID:10865062. |
cocaine inhibits ngf-induced pc12 cells differentiation through d(1)-type dopamine receptors. |
2000-08-25 |
2023-08-12 |
Not clear |
| D A Zachor, J F Moore, C Brezausek, A Theibert, A K Perc. Cocaine inhibits NGF-induced PC12 cells differentiation through D(1)-type dopamine receptors. Brain research. vol 869. issue 1-2. 2000-08-25. PMID:10865062. |
to determine if cocaine inhibits neurite outgrowth through the effects of these neurotransmitters, we applied dopamine, norepinephrine, serotonin, and acetylcholine to ngf-induced pc12 cells. |
2000-08-25 |
2023-08-12 |
Not clear |
| D A Zachor, J F Moore, C Brezausek, A Theibert, A K Perc. Cocaine inhibits NGF-induced PC12 cells differentiation through D(1)-type dopamine receptors. Brain research. vol 869. issue 1-2. 2000-08-25. PMID:10865062. |
dopamine uptake measured over time was significantly blocked by cocaine and gbr 12909 which may result in elevated extracellular dopamine. |
2000-08-25 |
2023-08-12 |
Not clear |
| D A Zachor, J F Moore, C Brezausek, A Theibert, A K Perc. Cocaine inhibits NGF-induced PC12 cells differentiation through D(1)-type dopamine receptors. Brain research. vol 869. issue 1-2. 2000-08-25. PMID:10865062. |
these findings suggest that cocaine inhibitory effects on neuronal differentiation are mediated through its binding to the dopamine transporter, resulting in increased dopamine level in the synapses. |
2000-08-25 |
2023-08-12 |
Not clear |
| T M Cabrera-Vera, F Garcia, W Pinto, G Battagli. Neurochemical changes in brain serotonin neurons in immature and adult offspring prenatally exposed to cocaine. Brain research. vol 870. issue 1-2. 2000-08-21. PMID:10869495. |
consistent with the maturational onset of changes in 5-ht, striatal dopamine was significantly reduced (-10%) by prenatal exposure to cocaine only in adult offspring. |
2000-08-21 |
2023-08-12 |
rat |
| N K Mello, S S Negu. Interactions between kappa opioid agonists and cocaine. Preclinical studies. Annals of the New York Academy of Sciences. vol 909. 2000-08-10. PMID:10911926. |
kappa opioid agonists inhibit dopamine release from mesolimbic dopaminergic neurons and attenuate some behavioral effects of cocaine in rodents. |
2000-08-10 |
2023-08-12 |
monkey |
| D W Self, D A Karanian, J J Spence. Effects of the novel D1 dopamine receptor agonist ABT-431 on cocaine self-administration and reinstatement. Annals of the New York Academy of Sciences. vol 909. 2000-08-10. PMID:10911927. |
selective d1 dopamine agonists represent a potential pharmacotherapy for the treatment of cocaine addiction. |
2000-08-10 |
2023-08-12 |
rat |