| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Wirtshafte. A comparison of the patterns of striatal Fos-like immunoreactivity induced by various dopamine agonists in rats. Neuroscience letters. vol 289. issue 2. 2000-10-02. PMID:10904129. |
these findings suggest that the production of relatively 'non-patchy' patterns of immediate early gene expression may be a general property of dopamine transport inhibitors unrelated to any unique pharmacological properties of cocaine. |
2000-10-02 |
2023-08-12 |
rat |
| E A Kiyatkin, D E Kiyatkin, G V Rebe. Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891616. |
phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. |
2000-09-27 |
2023-08-12 |
rat |
| E A Kiyatkin, D E Kiyatkin, G V Rebe. Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891616. |
a new approach combining fast-scan cyclic voltammetry with iontophoretic dopamine delivery was used in freely behaving rats to evaluate the time-course of dopamine uptake inhibition in nucleus accumbens induced by intravenous cocaine at a dose (1.0mg/kg) known to maintain self-administration behavior. |
2000-09-27 |
2023-08-12 |
rat |
| E A Kiyatkin, D E Kiyatkin, G V Rebe. Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891616. |
cocaine significantly increased the decay time of the dopamine response without altering its magnitude or time to peak. |
2000-09-27 |
2023-08-12 |
rat |
| E A Kiyatkin, D E Kiyatkin, G V Rebe. Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891616. |
our data provide direct evidence for a phasic change in dopamine uptake induced by intravenous cocaine under behaviorally relevant conditions. |
2000-09-27 |
2023-08-12 |
rat |
| E A Kiyatkin, D E Kiyatkin, G V Rebe. Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891616. |
the relatively slow and gradual development of dopamine uptake inhibition, which peaks at times when behaving rats self-inject cocaine, is inconsistent with the suggested role of this mechanism in the acute rewarding (euphoric) effects of self-injected cocaine, but supports its role in the activational and motivational aspects of drug-seeking and drug-taking behavior. |
2000-09-27 |
2023-08-12 |
rat |
| E A Kiyatkin, D E Kiyatkin, G V Rebe. Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891616. |
because intravenous cocaine enters the brain rapidly and peaks in neural tissue (1-2 min) long before it effectively inhibits dopamine uptake (6 min), it appears that some of the acute psychoemotional ("rush"), behavioral, autonomic, and neuronal effects of this drug, which are apparently resistant to dopamine receptor blockade, are mediated via rapid central or peripheral mechanisms independent of monoamine uptake. |
2000-09-27 |
2023-08-12 |
rat |
| N D Volkow, G J Wang, M W Fischman, R Foltin, J S Fowler, D Franceschi, M Franceschi, J Logan, S J Gatley, C Wong, Y S Ding, R Hitzemann, N Pappa. Effects of route of administration on cocaine induced dopamine transporter blockade in the human brain. Life sciences. vol 67. issue 12. 2000-09-25. PMID:10983846. |
effects of route of administration on cocaine induced dopamine transporter blockade in the human brain. |
2000-09-25 |
2023-08-12 |
human |
| N D Volkow, G J Wang, M W Fischman, R Foltin, J S Fowler, D Franceschi, M Franceschi, J Logan, S J Gatley, C Wong, Y S Ding, R Hitzemann, N Pappa. Effects of route of administration on cocaine induced dopamine transporter blockade in the human brain. Life sciences. vol 67. issue 12. 2000-09-25. PMID:10983846. |
here we assessed whether there were differences in the efficacy of cocaine to block the dopamine transporters (major target for cocaine's reinforcing effects), as a function of route of administration. |
2000-09-25 |
2023-08-12 |
human |
| N D Volkow, G J Wang, M W Fischman, R Foltin, J S Fowler, D Franceschi, M Franceschi, J Logan, S J Gatley, C Wong, Y S Ding, R Hitzemann, N Pappa. Effects of route of administration on cocaine induced dopamine transporter blockade in the human brain. Life sciences. vol 67. issue 12. 2000-09-25. PMID:10983846. |
positron emission tomography and [11c]cocaine, a dopamine transporter radioligand, were used to compare the levels of dopamine transporter blockade induced by intravenous, smoked and intranasal cocaine in 32 current cocaine abusers. |
2000-09-25 |
2023-08-12 |
human |
| N D Volkow, G J Wang, M W Fischman, R Foltin, J S Fowler, D Franceschi, M Franceschi, J Logan, S J Gatley, C Wong, Y S Ding, R Hitzemann, N Pappa. Effects of route of administration on cocaine induced dopamine transporter blockade in the human brain. Life sciences. vol 67. issue 12. 2000-09-25. PMID:10983846. |
cocaine significantly blocked dopamine transporters. |
2000-09-25 |
2023-08-12 |
human |
| N D Volkow, G J Wang, M W Fischman, R Foltin, J S Fowler, D Franceschi, M Franceschi, J Logan, S J Gatley, C Wong, Y S Ding, R Hitzemann, N Pappa. Effects of route of administration on cocaine induced dopamine transporter blockade in the human brain. Life sciences. vol 67. issue 12. 2000-09-25. PMID:10983846. |
differences in the reinforcing effects of cocaine as a function of the route of administration are not due to differences in the efficacy of cocaine to block the dopamine transporters. |
2000-09-25 |
2023-08-12 |
human |
| A Parada, P Soares-da-Silv. The dopamine antagonist sch 23390 reverses dizocilpine-induced blockade of cocaine sensitization. Neuropharmacology. vol 39. issue 9. 2000-09-20. PMID:10854909. |
the dopamine antagonist sch 23390 reverses dizocilpine-induced blockade of cocaine sensitization. |
2000-09-20 |
2023-08-12 |
rat |
| M Ho, M Segr. Dopamine uptake by mouse neuroblastoma N1E-115 cells stably expressing human dopamine transporter is differentially inhibited by anti-idiotypic ab2beta antibodies mimicking the configuration of cocaine. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924700. |
dopamine uptake by mouse neuroblastoma n1e-115 cells stably expressing human dopamine transporter is differentially inhibited by anti-idiotypic ab2beta antibodies mimicking the configuration of cocaine. |
2000-09-20 |
2023-08-12 |
mouse |
| M Ho, M Segr. Dopamine uptake by mouse neuroblastoma N1E-115 cells stably expressing human dopamine transporter is differentially inhibited by anti-idiotypic ab2beta antibodies mimicking the configuration of cocaine. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924700. |
these findings suggest that the internal images of these antibodies can be used as analog peptides that may compete with cocaine for its binding site on the transporter but not impair dopamine uptake as much as cocaine does. |
2000-09-20 |
2023-08-12 |
mouse |
| D H Feldman, W R Harvey, B R Steven. A novel electrogenic amino acid transporter is activated by K+ or Na+, is alkaline pH-dependent, and is Cl--independent. The Journal of biological chemistry. vol 275. issue 32. 2000-09-14. PMID:10829035. |
amino acids such as l-proline, l-threonine, and l-methionine elicited complex current-voltage relationships in alkaline ph-dependent caatch1 that were reminiscent of the behavior of the dopamine, serotonin, and norepinephrine transporters (dat, sert, net) in the presence of their substrates and pharmacological inhibitors such as cocaine or antidepressants. |
2000-09-14 |
2023-08-12 |
xenopus_laevis |
| L Iverse. Neurotransmitter transporters: fruitful targets for CNS drug discovery. Molecular psychiatry. vol 5. issue 4. 2000-09-14. PMID:10889545. |
the dopamine transporter plays a key role in mediating the actions of cocaine and the amphetamines and in conferring selectivity on dopamine neurotoxins. |
2000-09-14 |
2023-08-12 |
Not clear |
| L G Sharpe, N S Pilotte, T S Shippenberg, C B Goodman, E D Londo. Autoradiographic evidence that prolonged withdrawal from intermittent cocaine reduces mu-opioid receptor expression in limbic regions of the rat brain. Synapse (New York, N.Y.). vol 37. issue 4. 2000-09-14. PMID:10891866. |
the mu-receptor may manifest, as do other neural markers (e.g., dopamine transporter, dopamine efflux), a biphasic temporal pattern with upregulation during early phases of cocaine withdrawal but a downregulation at later times. |
2000-09-14 |
2023-08-12 |
rat |
| M R Gerasimov, W K Schiffer, J D Brodie, I C Lennon, S J Taylor, S L Dewe. gamma-aminobutyric acid mimetic drugs differentially inhibit the dopaminergic response to cocaine. European journal of pharmacology. vol 395. issue 2. 2000-09-06. PMID:10794818. |
we previously demonstrated that increased gamma-aminobutyric acid (gaba)-ergic activity produced by gamma-vinyl gaba [d,l-4-amino-hex-5-enoic acid (vigabatrin(r))], an irreversible inhibitor of gaba-transaminase, attenuated cocaine, nicotine, heroin, alcohol, and methamphetamine-induced increases in extracellular nucleus accumbens dopamine as well as behaviors associated with these biochemical changes. |
2000-09-06 |
2023-08-12 |
Not clear |
| M R Gerasimov, W K Schiffer, J D Brodie, I C Lennon, S J Taylor, S L Dewe. gamma-aminobutyric acid mimetic drugs differentially inhibit the dopaminergic response to cocaine. European journal of pharmacology. vol 395. issue 2. 2000-09-06. PMID:10794818. |
our data demonstrate that the anticonvulsant 1-(2-(((diphenylmethylene)amino)oxy)ethyl)-1,2,5, 6-tetrahydro-3-pyridinecarboxylic acid hydrochloride (nnc-711), a gaba uptake inhibitor, dose and time dependently diminished increases in extracellular dopamine following acute cocaine challenge. |
2000-09-06 |
2023-08-12 |
Not clear |