| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L E Bayer, A Brown, C F Mactutus, R M Booze, B J Strup. Prenatal cocaine exposure increases sensitivity to the attentional effects of the dopamine D1 agonist SKF81297. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 23. 2001-02-08. PMID:11102500. |
sensitivity to the attentional effects of skf81297, a selective full agonist at dopamine d(1) receptors, was assessed in adult rats exposed to cocaine prenatally (via intravenous injections) and controls. |
2001-02-08 |
2023-08-12 |
human |
| J A Lile, D Morgan, C S Freedland, R S Sinnott, H M Davies, M A Nade. Self-administration of two long-acting monoamine transport blockers in rhesus monkeys. Psychopharmacology. vol 152. issue 4. 2001-02-08. PMID:11140334. |
2beta-propanoyl-3beta-(4-tolyl)-tropane (ptt) is a cocaine analog with high affinity at and selectivity for the dopamine transporter (dat). |
2001-02-08 |
2023-08-12 |
monkey |
| H K Wayment, J O Schenk, B A Sor. Characterization of extracellular dopamine clearance in the medial prefrontal cortex: role of monoamine uptake and monoamine oxidase inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 1. 2001-02-08. PMID:11150317. |
rde studies indicate that inhibition by cocaine, specific inhibitors of the dopamine transporter (dat) and norepinephrine transporter (net), and low na(+) produced a 50-70% decrease in the velocity of dopamine clearance. |
2001-02-08 |
2023-08-12 |
rat |
| K K Szumlinski, I M Maisonneuve, S D Glic. Iboga interactions with psychomotor stimulants: panacea in the paradox? Toxicon : official journal of the International Society on Toxinology. vol 39. issue 1. 2001-02-02. PMID:10936624. |
however, this interpretation is contradicted by very recent observations that 18-mc is without effect on the dopamine response to acute cocaine and that both ibogaine and 18-mc block the expression of sensitized levels of dopamine in the nucleus accumbens produced by chronic cocaine administration. |
2001-02-02 |
2023-08-12 |
Not clear |
| E H Ellinwood, G R King, C Davidson, T H Le. The dopamine D2/D3 antagonist DS121 potentiates the effect of cocaine on locomotion and reduces tolerance in cocaine tolerant rats. Behavioural brain research. vol 116. issue 2. 2001-02-02. PMID:11080548. |
the dopamine d2/d3 antagonist ds121 potentiates the effect of cocaine on locomotion and reduces tolerance in cocaine tolerant rats. |
2001-02-02 |
2023-08-12 |
rat |
| E H Ellinwood, G R King, C Davidson, T H Le. The dopamine D2/D3 antagonist DS121 potentiates the effect of cocaine on locomotion and reduces tolerance in cocaine tolerant rats. Behavioural brain research. vol 116. issue 2. 2001-02-02. PMID:11080548. |
to explore the significance of dopamine (da) autoreceptors in cocaine tolerance and cocaine induced locomotor activity rats were treated with saline and cocaine (40 mg/kg per day via osmotic minipump; normal and cocaine tolerant rats, respectively). |
2001-02-02 |
2023-08-12 |
rat |
| Y L Hurd, M Ponté. Cocaine self-administration behavior can be reduced or potentiated by the addition of specific dopamine concentrations in the nucleus accumbens and amygdala using in vivo microdialysis. Behavioural brain research. vol 116. issue 2. 2001-02-02. PMID:11080549. |
cocaine self-administration behavior can be reduced or potentiated by the addition of specific dopamine concentrations in the nucleus accumbens and amygdala using in vivo microdialysis. |
2001-02-02 |
2023-08-12 |
rat |
| Y L Hurd, M Ponté. Cocaine self-administration behavior can be reduced or potentiated by the addition of specific dopamine concentrations in the nucleus accumbens and amygdala using in vivo microdialysis. Behavioural brain research. vol 116. issue 2. 2001-02-02. PMID:11080549. |
potentiation of mesolimbic dopamine levels is generally hypothesized to be reinforcing and contribute to the self-administration of addictive drugs such as cocaine. |
2001-02-02 |
2023-08-12 |
rat |
| Y L Hurd, M Ponté. Cocaine self-administration behavior can be reduced or potentiated by the addition of specific dopamine concentrations in the nucleus accumbens and amygdala using in vivo microdialysis. Behavioural brain research. vol 116. issue 2. 2001-02-02. PMID:11080549. |
in the present study, the in vivo microdialysis technique was used to directly manipulate extracellular dopamine concentrations in the nucleus accumbens (nac) shell and the amygdala (amy) in rats maintaining stable patterns of cocaine (1.5 mg/kg/infusion) intake under a fixed ratio 1 schedule of reinforcement. |
2001-02-02 |
2023-08-12 |
rat |
| Y L Hurd, M Ponté. Cocaine self-administration behavior can be reduced or potentiated by the addition of specific dopamine concentrations in the nucleus accumbens and amygdala using in vivo microdialysis. Behavioural brain research. vol 116. issue 2. 2001-02-02. PMID:11080549. |
in the nac, a perfusate dopamine concentration of 90 nm was found to reduce cocaine self-administration, whereas a perfusate concentration of 450 nm increased the intake of cocaine. |
2001-02-02 |
2023-08-12 |
rat |
| Y L Hurd, M Ponté. Cocaine self-administration behavior can be reduced or potentiated by the addition of specific dopamine concentrations in the nucleus accumbens and amygdala using in vivo microdialysis. Behavioural brain research. vol 116. issue 2. 2001-02-02. PMID:11080549. |
in the amy, 45 nm perfusate dopamine inhibited cocaine self-administration, whereas 90 nm perfusate dopamine enhanced cocaine intake. |
2001-02-02 |
2023-08-12 |
rat |
| Y L Hurd, M Ponté. Cocaine self-administration behavior can be reduced or potentiated by the addition of specific dopamine concentrations in the nucleus accumbens and amygdala using in vivo microdialysis. Behavioural brain research. vol 116. issue 2. 2001-02-02. PMID:11080549. |
the attenuation or potentiation of cocaine intake behavior was maintained throughout the time period (30 or 60 min) of the manipulation of the perfusate dopamine (da) concentrations in the nac and amy. |
2001-02-02 |
2023-08-12 |
rat |
| Y L Hurd, M Ponté. Cocaine self-administration behavior can be reduced or potentiated by the addition of specific dopamine concentrations in the nucleus accumbens and amygdala using in vivo microdialysis. Behavioural brain research. vol 116. issue 2. 2001-02-02. PMID:11080549. |
overall, these experiments show that elevated mesolimbic dopamine concentrations can differentially modulate cocaine self-administration behavior. |
2001-02-02 |
2023-08-12 |
rat |
| M Froimowitz, K M Wu, A Moussa, R M Haidar, J Jurayj, C George, E L Gardne. Slow-onset, long-duration 3-(3',4'-dichlorophenyl)-1-indanamine monoamine reuptake blockers as potential medications to treat cocaine abuse. Journal of medicinal chemistry. vol 43. issue 26. 2001-02-01. PMID:11150168. |
since the effects of cocaine on dopamine (da) and serotonin (5ht) transporters are important components of its pharmacological activity, the focus was on nonselective inhibitors of monoamine transport. |
2001-02-01 |
2023-08-12 |
mouse |
| R B Rothman, M H Baumann, C M Dersch, D V Romero, K C Rice, F I Carroll, J S Partill. Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. Synapse (New York, N.Y.). vol 39. issue 1. 2001-01-25. PMID:11071707. |
a large body of evidence supports the hypothesis that mesolimbic dopamine (da) mediates, in animal models, the reinforcing effects of central nervous system stimulants such as cocaine and amphetamine. |
2001-01-25 |
2023-08-12 |
Not clear |
| Z Lin, W Wang, G R Uh. Dopamine transporter tryptophan mutants highlight candidate dopamine- and cocaine-selective domains. Molecular pharmacology. vol 58. issue 6. 2001-01-18. PMID:11093799. |
cocaine blocks the normal role of the dopamine transporter (dat) in terminating dopamine signaling and in restricting its spatial spread through molecular interactions that remain largely obscure. |
2001-01-18 |
2023-08-12 |
Not clear |
| Z Lin, W Wang, G R Uh. Dopamine transporter tryptophan mutants highlight candidate dopamine- and cocaine-selective domains. Molecular pharmacology. vol 58. issue 6. 2001-01-18. PMID:11093799. |
cocaine analog structure-activity studies suggest roles for cationic and hydrophobic interactions between dat, dopamine, cocaine, and the sodium and chloride ions whose gradients power uptake processes. |
2001-01-18 |
2023-08-12 |
Not clear |
| Z Lin, W Wang, G R Uh. Dopamine transporter tryptophan mutants highlight candidate dopamine- and cocaine-selective domains. Molecular pharmacology. vol 58. issue 6. 2001-01-18. PMID:11093799. |
tryptophan residues lying in putative dat transmembrane domains could contribute to both aromatic and cationic interactions between dat and dopamine or cocaine. |
2001-01-18 |
2023-08-12 |
Not clear |
| Z Lin, W Wang, G R Uh. Dopamine transporter tryptophan mutants highlight candidate dopamine- and cocaine-selective domains. Molecular pharmacology. vol 58. issue 6. 2001-01-18. PMID:11093799. |
we have focused analyses on mutations that exert selective influences on affinities for dopamine or the cocaine analog cft [(-)-2-beta-carbomethoxy-3-beta-(4-fluorophenyl)tropane]. |
2001-01-18 |
2023-08-12 |
Not clear |
| D E Comings, K Blu. Reward deficiency syndrome: genetic aspects of behavioral disorders. Progress in brain research. vol 126. 2001-01-18. PMID:11105655. |
however, the same release of dopamine and production of sensations of pleasure can be produced by 'unnatural rewards' such as alcohol, cocaine, methamphetamine, heroin, nicotine, marijuana, and other drugs, and by compulsive activities such as gambling, eating, and sex, and by risk taking behaviors. |
2001-01-18 |
2023-08-12 |
human |