| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R B Rothman, M H Baumann, C M Dersch, D V Romero, K C Rice, F I Carroll, J S Partill. Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. Synapse (New York, N.Y.). vol 39. issue 1. 2001-01-25. PMID:11071707. |
a large body of evidence supports the hypothesis that mesolimbic dopamine (da) mediates, in animal models, the reinforcing effects of central nervous system stimulants such as cocaine and amphetamine. |
2001-01-25 |
2023-08-12 |
Not clear |
| Z Lin, W Wang, G R Uh. Dopamine transporter tryptophan mutants highlight candidate dopamine- and cocaine-selective domains. Molecular pharmacology. vol 58. issue 6. 2001-01-18. PMID:11093799. |
cocaine blocks the normal role of the dopamine transporter (dat) in terminating dopamine signaling and in restricting its spatial spread through molecular interactions that remain largely obscure. |
2001-01-18 |
2023-08-12 |
Not clear |
| Z Lin, W Wang, G R Uh. Dopamine transporter tryptophan mutants highlight candidate dopamine- and cocaine-selective domains. Molecular pharmacology. vol 58. issue 6. 2001-01-18. PMID:11093799. |
cocaine analog structure-activity studies suggest roles for cationic and hydrophobic interactions between dat, dopamine, cocaine, and the sodium and chloride ions whose gradients power uptake processes. |
2001-01-18 |
2023-08-12 |
Not clear |
| Z Lin, W Wang, G R Uh. Dopamine transporter tryptophan mutants highlight candidate dopamine- and cocaine-selective domains. Molecular pharmacology. vol 58. issue 6. 2001-01-18. PMID:11093799. |
tryptophan residues lying in putative dat transmembrane domains could contribute to both aromatic and cationic interactions between dat and dopamine or cocaine. |
2001-01-18 |
2023-08-12 |
Not clear |
| Z Lin, W Wang, G R Uh. Dopamine transporter tryptophan mutants highlight candidate dopamine- and cocaine-selective domains. Molecular pharmacology. vol 58. issue 6. 2001-01-18. PMID:11093799. |
we have focused analyses on mutations that exert selective influences on affinities for dopamine or the cocaine analog cft [(-)-2-beta-carbomethoxy-3-beta-(4-fluorophenyl)tropane]. |
2001-01-18 |
2023-08-12 |
Not clear |
| D E Comings, K Blu. Reward deficiency syndrome: genetic aspects of behavioral disorders. Progress in brain research. vol 126. 2001-01-18. PMID:11105655. |
however, the same release of dopamine and production of sensations of pleasure can be produced by 'unnatural rewards' such as alcohol, cocaine, methamphetamine, heroin, nicotine, marijuana, and other drugs, and by compulsive activities such as gambling, eating, and sex, and by risk taking behaviors. |
2001-01-18 |
2023-08-12 |
human |
| A Nishi, J A Bibb, G L Snyder, H Higashi, A C Nairn, P Greengar. Amplification of dopaminergic signaling by a positive feedback loop. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 23. 2001-01-11. PMID:11050161. |
we report here that dopamine, in slices, and acute cocaine, in whole animals, decreases the state of phosphorylation of striatal darpp-32 at thr-75 and thereby removes this inhibitory constraint. |
2001-01-11 |
2023-08-12 |
Not clear |
| N H Mutschler, K A Miczek, R P Hamme. Reduction of zif268 messenger RNA expression during prolonged withdrawal following "binge" cocaine self-administration in rats. Neuroscience. vol 100. issue 3. 2001-01-11. PMID:11098116. |
cocaine self-administration increases dopamine efflux and neuronal activity in the mesocorticolimbic dopamine system compared with experimenter-administered cocaine. |
2001-01-11 |
2023-08-12 |
rat |
| N H Mutschler, K A Miczek, R P Hamme. Reduction of zif268 messenger RNA expression during prolonged withdrawal following "binge" cocaine self-administration in rats. Neuroscience. vol 100. issue 3. 2001-01-11. PMID:11098116. |
following a prolonged cocaine self-administration binge, dopamine efflux in the nucleus accumbens is attenuated and behaviors emerge that are indicative of anhedonia and anxiety. |
2001-01-11 |
2023-08-12 |
rat |
| S J Glatt, C A Bolaños, G H Trksak, D Jackso. Effects of prenatal cocaine exposure on dopamine system development: a meta-analysis. Neurotoxicology and teratology. vol 22. issue 5. 2001-01-11. PMID:11106856. |
several studies have investigated the effects of prenatal cocaine (pcoc) exposure on the nigrostriatal dopaminergic system in animal models of maternal drug abuse, yet independent examinations of striatal dopamine (da) receptors and tissue da levels have produced equivocal results. |
2001-01-11 |
2023-08-12 |
Not clear |
| R M Carelli, S Ijames, J Konstantopoulos, S A Deadwyle. Examination of factors mediating the transition to behaviorally correlated nucleus accumbens cell firing during cocaine self-administration sessions in rats. Behavioural brain research. vol 104. issue 1-2. 2001-01-11. PMID:11125731. |
animals were pretreated with either saline, the dopamine d1 receptor antagonist sch23390 (2.5-20 microg/kg, s.c.), or the dopamine d2 receptor antagonist eticlopride (2.5-20 microg/kg, s.c.) 30 min prior to the cocaine (0.33 mg/inf) self-administration session. |
2001-01-11 |
2023-08-12 |
rat |
| S B Caine, S S Negus, N K Mello, J Bergma. Effects of dopamine D1-like and D2-like agonists in rats trained to discriminate cocaine from saline: influence of experimental history. Experimental and clinical psychopharmacology. vol 8. issue 3. 2001-01-09. PMID:10975632. |
effects of dopamine d1-like and d2-like agonists in rats trained to discriminate cocaine from saline: influence of experimental history. |
2001-01-09 |
2023-08-12 |
rat |
| N Chen, M E Reit. Structure and function of the dopamine transporter. European journal of pharmacology. vol 405. issue 1-3. 2001-01-08. PMID:11033338. |
binding domains for dopamine and various blocking drugs including cocaine are likely formed by interactions with multiple amino acid residues, some of which are separate in the primary structure but lie close together in the still unknown tertiary structure. |
2001-01-08 |
2023-08-12 |
Not clear |
| N Chen, M E Reit. Structure and function of the dopamine transporter. European journal of pharmacology. vol 405. issue 1-3. 2001-01-08. PMID:11033338. |
strong evidence for dopamine transporter domains selectively influencing binding of dopamine or cocaine analogs has not yet emerged, although the development of a cocaine antagonist at the level of the transporter remains a possibility. |
2001-01-08 |
2023-08-12 |
Not clear |
| L C Wang, J L Berfield, M J Kuhar, F I Carroll, M E Reit. RTI-76, an isothiocyanate derivative of a phenyltropane cocaine analog, as a tool for irreversibly inactivating dopamine transporter function in vitro. Naunyn-Schmiedeberg's archives of pharmacology. vol 362. issue 3. 2001-01-05. PMID:10997726. |
rti-76, an isothiocyanate derivative of a phenyltropane cocaine analog, as a tool for irreversibly inactivating dopamine transporter function in vitro. |
2001-01-05 |
2023-08-12 |
human |
| L C Wang, J L Berfield, M J Kuhar, F I Carroll, M E Reit. RTI-76, an isothiocyanate derivative of a phenyltropane cocaine analog, as a tool for irreversibly inactivating dopamine transporter function in vitro. Naunyn-Schmiedeberg's archives of pharmacology. vol 362. issue 3. 2001-01-05. PMID:10997726. |
the results are discussed in the context of possible oligomeric assemblies of dopamine transporters carrying multiple recognition sites for cocaine analogs and dopamine. |
2001-01-05 |
2023-08-12 |
human |
| A R Carta, C R Gerfen, H Steine. Cocaine effects on gene regulation in the striatum and behavior: increased sensitivity in D3 dopamine receptor-deficient mice. Neuroreport. vol 11. issue 11. 2001-01-04. PMID:10943692. |
cocaine effects on gene regulation in the striatum and behavior: increased sensitivity in d3 dopamine receptor-deficient mice. |
2001-01-04 |
2023-08-12 |
mouse |
| A R Carta, C R Gerfen, H Steine. Cocaine effects on gene regulation in the striatum and behavior: increased sensitivity in D3 dopamine receptor-deficient mice. Neuroreport. vol 11. issue 11. 2001-01-04. PMID:10943692. |
central effects of psychostimulants such as cocaine are predominantly mediated by dopamine receptors. |
2001-01-04 |
2023-08-12 |
mouse |
| D J Balfour, A E Wright, M E Benwell, C E Birrel. The putative role of extra-synaptic mesolimbic dopamine in the neurobiology of nicotine dependence. Behavioural brain research. vol 113. issue 1-2. 2001-01-03. PMID:10942034. |
as a result, studies with nicotine have the potential to contribute to our understanding of the neurobiology of addiction which cannot easily be explored using drugs, such as cocaine and amphetamine, which invariably increase dopamine overflow in the forebrain. |
2001-01-03 |
2023-08-12 |
Not clear |
| S R Howes, J W Dalley, C H Morrison, T W Robbins, B J Everit. Leftward shift in the acquisition of cocaine self-administration in isolation-reared rats: relationship to extracellular levels of dopamine, serotonin and glutamate in the nucleus accumbens and amygdala-striatal FOS expression. Psychopharmacology. vol 151. issue 1. 2000-12-28. PMID:10958117. |
leftward shift in the acquisition of cocaine self-administration in isolation-reared rats: relationship to extracellular levels of dopamine, serotonin and glutamate in the nucleus accumbens and amygdala-striatal fos expression. |
2000-12-28 |
2023-08-12 |
rat |