| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L R McMahon, K A Cunningha. Antagonism of 5-hydroxytryptamine(2a) receptors attenuates the behavioral effects of cocaine in rats. The Journal of pharmacology and experimental therapeutics. vol 297. issue 1. 2001-05-03. PMID:11259563. |
serotonin (5-hydroxytryptamine; 5-ht) 5-ht(2a) receptors have been shown to modulate dopamine (da) function and a more thorough appreciation of this modulatory interaction between 5-ht2a receptors and da systems may yield insight into novel approaches to treatment of cocaine dependence. |
2001-05-03 |
2023-08-12 |
rat |
| A K Dutta, X S Fei, P M Beardsley, J L Newman, M E Reit. Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters. Journal of medicinal chemistry. vol 44. issue 6. 2001-05-03. PMID:11300876. |
in our effort to develop a pharmacotherapy for the treatment of cocaine addiction, we embarked on synthesizing novel molecules targeting the dopamine transporter (dat) molecule in the brain as dat has been implicated strongly in the reinforcing effect of cocaine. |
2001-05-03 |
2023-08-12 |
mouse |
| R Ciccocioppo, P P Sanna, F Weis. Cocaine-predictive stimulus induces drug-seeking behavior and neural activation in limbic brain regions after multiple months of abstinence: reversal by D(1) antagonists. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11172061. |
the response reinstatement and fos expression induced by the cocaine s(d) were both reversed by selective dopamine d(1) receptor antagonists. |
2001-04-19 |
2023-08-12 |
rat |
| A Pret. Vanoxerine National Institute on Drug Abuse. Current opinion in investigational drugs (London, England : 2000). vol 1. issue 2. 2001-04-19. PMID:11249581. |
it is thought that prolonged treatment with vanoxerine could reverse the addiction process, following studies in rats showing that dopamine transporter levels returned to normal when animals were switched to vanoxerine therapy immediately after cocaine administration [346980]. |
2001-04-19 |
2023-08-12 |
human |
| A Pret. Vanoxerine National Institute on Drug Abuse. Current opinion in investigational drugs (London, England : 2000). vol 1. issue 2. 2001-04-19. PMID:11249581. |
similar studies have shown that, by inhibiting the dopamine transporter, for which vanoxerine has a 500-fold increased affinity in comparison to cocaine, vanoxerine could selectively reduce(1 mg/kg i.v.) |
2001-04-19 |
2023-08-12 |
human |
| A K Dutta, X S Fei, R A Vaughan, J D Gaffaney, N Wang, J R Lever, M E Reit. Design, synthesis, and characterization of a novel, 4-[2-(diphenylmethoxy)ethyl]-1-benzyl piperidine-based, dopamine transporter photoaffinity label. Life sciences. vol 68. issue 16. 2001-04-19. PMID:11292062. |
the dopamine transporter (dat) has been implicated strongly in cocaine's reinforcing effects. |
2001-04-19 |
2023-08-12 |
Not clear |
| A G Jensen, S H Hansen, E O Nielse. Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity. Life sciences. vol 68. issue 14. 2001-04-12. PMID:11263672. |
neither hyperforin nor adhyperforin inhibited binding of the cocaine analogue, [3h]win 35,428 to the dopamine transporter. |
2001-04-12 |
2023-08-12 |
Not clear |
| J A Bibb, J Chen, J R Taylor, P Svenningsson, A Nishi, G L Snyder, Z Yan, Z K Sagawa, C C Ouimet, A C Nairn, E J Nestler, P Greengar. Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature. vol 410. issue 6826. 2001-04-12. PMID:11268215. |
cocaine enhances dopamine-mediated neurotransmission by blocking dopamine re-uptake at axon terminals. |
2001-04-12 |
2023-08-12 |
mouse |
| J A Bibb, J Chen, J R Taylor, P Svenningsson, A Nishi, G L Snyder, Z Yan, Z K Sagawa, C C Ouimet, A C Nairn, E J Nestler, P Greengar. Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature. vol 410. issue 6826. 2001-04-12. PMID:11268215. |
our results suggest that changes in cdk5 levels mediated by deltafosb, and resulting alterations in signalling involving d1 dopamine receptors, contribute to adaptive changes in the brain related to cocaine addiction. |
2001-04-12 |
2023-08-12 |
mouse |
| A N Gifford, M H Park, T L Kash, L M Herman, E H Park, S J Gatley, N D Volko. Effect of amphetamine-induced dopamine release on radiotracer binding to D1 and D2 receptors in rat brain striatal slices. Naunyn-Schmiedeberg's archives of pharmacology. vol 362. issue 4-5. 2001-03-29. PMID:11111836. |
the dopamine uptake blockers, cocaine and methylphenidate, had relatively little effect by themselves on [3h]raclopride binding but, by inhibiting amphetamine-induced dopamine release, significantly reduced inhibition of [3h]raclopride binding by a low (3 microm) amphetamine concentration. |
2001-03-29 |
2023-08-12 |
rat |
| D A Zachor, J F Moore, C M Brezausek, A B Theibert, A K Perc. Cocaine inhibition of neuronal differentiation in NGF-induced PC12 cells is independent of ras signaling. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 18. issue 8. 2001-03-22. PMID:11154845. |
our previous studies demonstrated cocaine inhibits neurite outgrowth in ngf-induced pc12 cells through dopamine, by activation of d1 receptors. |
2001-03-22 |
2023-08-12 |
Not clear |
| D A Zachor, J F Moore, C M Brezausek, A B Theibert, A K Perc. Cocaine inhibition of neuronal differentiation in NGF-induced PC12 cells is independent of ras signaling. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 18. issue 8. 2001-03-22. PMID:11154845. |
morphological differentiation was quantified by counting cells bearing neurite-like processes after 72 h exposure to either dexamethasone or ngf alone, or with cocaine, dopamine or skf-38393. |
2001-03-22 |
2023-08-12 |
Not clear |
| D A Zachor, J F Moore, C M Brezausek, A B Theibert, A K Perc. Cocaine inhibition of neuronal differentiation in NGF-induced PC12 cells is independent of ras signaling. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 18. issue 8. 2001-03-22. PMID:11154845. |
cocaine, dopamine, and the d1 agonist inhibited neurite-like process outgrowth in both dexamethasone and ngf-induced gsras1 cells. |
2001-03-22 |
2023-08-12 |
Not clear |
| D A Zachor, J F Moore, C M Brezausek, A B Theibert, A K Perc. Cocaine inhibition of neuronal differentiation in NGF-induced PC12 cells is independent of ras signaling. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 18. issue 8. 2001-03-22. PMID:11154845. |
these results suggest that cocaine, dopamine and activation of d1 receptors affect the ngf signaling downstream, independent of ras expression, leading to altered neuronal differentiation. |
2001-03-22 |
2023-08-12 |
Not clear |
| R Linke, J Gostomzyk, K Hahn, K Tatsc. [123I]IPT binding to the presynaptic dopamine transporter: variation of intra- and interobserver data evaluation in parkinsonian patients and controls. European journal of nuclear medicine. vol 27. issue 12. 2001-03-22. PMID:11189944. |
imaging the presynaptic dopamine transporter with cocaine analogues and single-photon emission tomography (spet) has proven to be a potential diagnostic tool for classifying the extent and degree of dopaminergic nerve cell loss. |
2001-03-22 |
2023-08-12 |
Not clear |
| R L Cowan, B B Frederick, M Rainey, J M Levin, L C Maas, J Bang, J Hennen, S E Lukas, P F Rensha. Sex differences in response to red and blue light in human primary visual cortex: a bold fMRI study. Psychiatry research. vol 100. issue 3. 2001-03-15. PMID:11120440. |
the discovery of abnormal retinal blue cone, but not red cone, electroretinogram in association with cocaine withdrawal and parkinson's disease suggests that visual system response to blue light might be a marker for cns dopamine tone. |
2001-03-15 |
2023-08-12 |
human |
| C L Duvauchelle, A Ikegami, E Castaned. Conditioned increases in behavioral activity and accumbens dopamine levels produced by intravenous cocaine. Behavioral neuroscience. vol 114. issue 6. 2001-03-15. PMID:11142647. |
conditioned increases in behavioral activity and accumbens dopamine levels produced by intravenous cocaine. |
2001-03-15 |
2023-08-12 |
rat |
| A H Newman, M J Robarge, I M Howard, S L Wittkopp, C George, T Kopajtic, S Izenwasser, J L Kat. Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes. Journal of medicinal chemistry. vol 44. issue 4. 2001-03-15. PMID:11170654. |
furthermore, behavioral evaluation of many of the benztropine analogues in animal models of cocaine abuse has suggested that these two classes of tropane-based dopamine uptake inhibitors have distinct pharmacological profiles. |
2001-03-15 |
2023-08-12 |
mouse |
| A H Newman, M J Robarge, I M Howard, S L Wittkopp, C George, T Kopajtic, S Izenwasser, J L Kat. Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes. Journal of medicinal chemistry. vol 44. issue 4. 2001-03-15. PMID:11170654. |
these compounds are generally more potent than cocaine as dopamine uptake inhibitors in vitro, although their actions in vivo are not consistent with this action. |
2001-03-15 |
2023-08-12 |
mouse |
| J M Brown, G R Hanson, A E Fleckenstei. Regulation of the vesicular monoamine transporter-2: a novel mechanism for cocaine and other psychostimulants. The Journal of pharmacology and experimental therapeutics. vol 296. issue 3. 2001-03-15. PMID:11181904. |
the plasmalemmal dopamine (da) transporter (dat) is a principal site of action for cocaine. |
2001-03-15 |
2023-08-12 |
rat |