| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S A Kushner, E M Unterwal. Chronic cocaine administration decreases the functional coupling of GABA(B) receptors in the rat ventral tegmental area as measured by baclofen-stimulated 35S-GTPgammaS binding. Life sciences. vol 69. issue 9. 2001-08-30. PMID:11508652. |
to determine if chronic cocaine administration alters the functional coupling of gaba(b) receptors to g-proteins in central dopamine systems, male f-344 rats received cocaine (15 mg/kg/injection) or saline three times a day at hourly intervals for fourteen consecutive days. |
2001-08-30 |
2023-08-12 |
rat |
| S A Kushner, E M Unterwal. Chronic cocaine administration decreases the functional coupling of GABA(B) receptors in the rat ventral tegmental area as measured by baclofen-stimulated 35S-GTPgammaS binding. Life sciences. vol 69. issue 9. 2001-08-30. PMID:11508652. |
this finding may have implications in the augmented extracellular dopamine levels seen in the nucleus accumbens of rats that have been sensitized to cocaine. |
2001-08-30 |
2023-08-12 |
rat |
| F Masi, S Scheggi, S Mangiavacchi, P Tolu, A Tagliamonte, M G De Montis, C Gambaran. Dopamine output in the nucleus accumbens shell is related to the acquisition and the retention of a motivated appetitive behavior in rats. Brain research. vol 903. issue 1-2. 2001-08-16. PMID:11382393. |
dopamine output was studied through microdialysis as dopamine accumulation following re-uptake inhibition by cocaine. |
2001-08-16 |
2023-08-12 |
rat |
| R Ranaldi, R A Wis. Blockade of D1 dopamine receptors in the ventral tegmental area decreases cocaine reward: possible role for dendritically released dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 15. 2001-08-16. PMID:11466456. |
blockade of d1 dopamine receptors in the ventral tegmental area decreases cocaine reward: possible role for dendritically released dopamine. |
2001-08-16 |
2023-08-12 |
rat |
| R Ranaldi, R A Wis. Blockade of D1 dopamine receptors in the ventral tegmental area decreases cocaine reward: possible role for dendritically released dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 15. 2001-08-16. PMID:11466456. |
this study was designed to assess the involvement of d1 dopamine actions in the ventral tegmental area (vta) on intravenous cocaine self-administration. |
2001-08-16 |
2023-08-12 |
rat |
| R Ranaldi, R A Wis. Blockade of D1 dopamine receptors in the ventral tegmental area decreases cocaine reward: possible role for dendritically released dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 15. 2001-08-16. PMID:11466456. |
these data suggest a role for dendritically released dopamine, presumably acting through d1 receptors located on the axons of gabaergic or glutamatergic inputs to the vta, in the effectiveness of cocaine reward. |
2001-08-16 |
2023-08-12 |
rat |
| G M Miller, S M Yatin, R De La Garza, M Goulet, B K Madra. Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity. Brain research. Molecular brain research. vol 87. issue 1. 2001-08-09. PMID:11223167. |
cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity. |
2001-08-09 |
2023-08-12 |
human |
| G M Miller, S M Yatin, R De La Garza, M Goulet, B K Madra. Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity. Brain research. Molecular brain research. vol 87. issue 1. 2001-08-09. PMID:11223167. |
variant i displayed dopamine transport kinetics and binding affinities for various dat blockers (including cocaine) versus [3h] cft (win 35, 428) that were identical to wild-type dat (n=7 drugs; r(2)=0.991). |
2001-08-09 |
2023-08-12 |
human |
| D N Ruskin, D A Bergstrom, D Baek, L E Freeman, J R Walter. Cocaine or selective block of dopamine transporters influences multisecond oscillations in firing rate in the globus pallidus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 1. 2001-08-02. PMID:11377917. |
cocaine or selective block of dopamine transporters influences multisecond oscillations in firing rate in the globus pallidus. |
2001-08-02 |
2023-08-12 |
rat |
| D N Ruskin, D A Bergstrom, D Baek, L E Freeman, J R Walter. Cocaine or selective block of dopamine transporters influences multisecond oscillations in firing rate in the globus pallidus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 1. 2001-08-02. PMID:11377917. |
to investigate possible modulation by endogenous dopamine and by other monoamines, and by drugs with abuse potential, cocaine or selective monoamine uptake blockers were injected systemically during extracellular recording of single globus pallidus neurons and the results analyzed with spectral and wavelet methods. |
2001-08-02 |
2023-08-12 |
rat |
| D N Ruskin, D A Bergstrom, D Baek, L E Freeman, J R Walter. Cocaine or selective block of dopamine transporters influences multisecond oscillations in firing rate in the globus pallidus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 1. 2001-08-02. PMID:11377917. |
both cocaine and the selective dopamine uptake blocker gbr-12909 significantly shortened the period of multisecond oscillations, as well as increasing overall firing rate. |
2001-08-02 |
2023-08-12 |
rat |
| D N Ruskin, D A Bergstrom, D Baek, L E Freeman, J R Walter. Cocaine or selective block of dopamine transporters influences multisecond oscillations in firing rate in the globus pallidus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 1. 2001-08-02. PMID:11377917. |
cocaine effects were blocked by dopamine antagonist pretreatment, as well as by n-methyl-d-aspartate receptor antagonist (mk-801) pretreatment. |
2001-08-02 |
2023-08-12 |
rat |
| M Kraft, P Noailles, J A Angul. Substance P modulates cocaine-evoked dopamine overflow in the striatum of the rat brain. Annals of the New York Academy of Sciences. vol 937. 2001-08-02. PMID:11458533. |
in a separate experiment, infusion through the microdialysis probe of the neurokinin-1 receptor antagonist l-733,060 significantly decreased cocaine-evoked striatal dopamine overflow (approximately 50% inhibition at 30 minutes after cocaine administration). |
2001-08-02 |
2023-08-12 |
rat |
| Y Zhang, T M Loonam, P A Noailles, J A Angul. Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions. Annals of the New York Academy of Sciences. vol 937. 2001-08-02. PMID:11458542. |
acute injection of methamphetamine (1 mg/kg of body weight) or cocaine (10 mg/kg) resulted in elevated levels of extracellular dopamine in all brain regions measured, although the magnitude of increase varied between brain regions. |
2001-08-02 |
2023-08-12 |
rat |
| Y Zhang, T M Loonam, P A Noailles, J A Angul. Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions. Annals of the New York Academy of Sciences. vol 937. 2001-08-02. PMID:11458542. |
overall, methamphetamine caused more dopamine to accumulate in the extracellular space than did cocaine when administered to animals during early withdrawal (7 days of daily injections and challenge on day 11). |
2001-08-02 |
2023-08-12 |
rat |
| Y Zhang, T M Loonam, P A Noailles, J A Angul. Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions. Annals of the New York Academy of Sciences. vol 937. 2001-08-02. PMID:11458542. |
by contrast, a challenge injection of cocaine resulted in dopamine levels in the caudate putamen that were lower than those observed for acute exposure. |
2001-08-02 |
2023-08-12 |
rat |
| Y Zhang, T M Loonam, P A Noailles, J A Angul. Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions. Annals of the New York Academy of Sciences. vol 937. 2001-08-02. PMID:11458542. |
in the ventral tegmental area and the substantia nigra compacta, a challenge injection of methamphetamine or cocaine resulted in extracellular dopamine levels that were lower than those for acute exposure. |
2001-08-02 |
2023-08-12 |
rat |
| Y Zhang, T M Loonam, P A Noailles, J A Angul. Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions. Annals of the New York Academy of Sciences. vol 937. 2001-08-02. PMID:11458542. |
thus, it appears that behavioral sensitization to cocaine can be sustained during early withdrawal in the absence of augmented drug-evoked dopamine overflow. |
2001-08-02 |
2023-08-12 |
rat |
| Y Zhang, T M Loonam, P A Noailles, J A Angul. Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions. Annals of the New York Academy of Sciences. vol 937. 2001-08-02. PMID:11458542. |
moreover, the sensitized augmentation of locomotor activity observed by us and others in response to a challenge injection of cocaine is not dependent on elevation of the extracellular concentration of dopamine in the neostriatum. |
2001-08-02 |
2023-08-12 |
rat |
| Y Zhang, T M Loonam, P A Noailles, J A Angul. Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions. Annals of the New York Academy of Sciences. vol 937. 2001-08-02. PMID:11458542. |
we are currently investigating the hypothesis that cocaine activates peptidergic systems of the neostriatum and that these systems modulate the synaptic release of dopamine in response to psychostimulants. |
2001-08-02 |
2023-08-12 |
rat |