| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M E Reith, J L Berfield, L C Wang, J V Ferrer, J A Javitc. The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine transporter. The Journal of biological chemistry. vol 276. issue 31. 2001-09-13. PMID:11395483. |
moreover, whereas cocaine, win, mazindol, and dopamine enhanced the reaction of cys-90 with mtset, benztropine had no effect on this reaction. |
2001-09-13 |
2023-08-12 |
human |
| T H Lee, R Balu, C Davidson, E H Ellinwoo. Differential time-course profiles of dopamine release and uptake changes induced by three dopamine uptake inhibitors. Synapse (New York, N.Y.). vol 41. issue 4. 2001-09-13. PMID:11494401. |
using real-time voltammetry, we compared the effects of cocaine (1.0, 3.0, or 10 microm), win 35428 (0.1, 0.5, or 2.0 microm), and nomifensine (0.2, 1.0, or 5.0 microm) on electrically evoked dopamine release and uptake in the rat accumbens slice. |
2001-09-13 |
2023-08-12 |
rat |
| T H Lee, R Balu, C Davidson, E H Ellinwoo. Differential time-course profiles of dopamine release and uptake changes induced by three dopamine uptake inhibitors. Synapse (New York, N.Y.). vol 41. issue 4. 2001-09-13. PMID:11494401. |
cocaine elicited a rapid, concentration-independent increase in dopamine release and a more gradual, concentration-dependent inhibition of uptake. |
2001-09-13 |
2023-08-12 |
rat |
| T H Lee, R Balu, C Davidson, E H Ellinwoo. Differential time-course profiles of dopamine release and uptake changes induced by three dopamine uptake inhibitors. Synapse (New York, N.Y.). vol 41. issue 4. 2001-09-13. PMID:11494401. |
during the same period, the potentiation of dopamine release exhibited a slower offset for all concentrations and, for 10 microm cocaine, was even greater than that observed during drug perfusion ("rebound" increase). |
2001-09-13 |
2023-08-12 |
rat |
| T H Lee, R Balu, C Davidson, E H Ellinwoo. Differential time-course profiles of dopamine release and uptake changes induced by three dopamine uptake inhibitors. Synapse (New York, N.Y.). vol 41. issue 4. 2001-09-13. PMID:11494401. |
the time-course mismatch between uptake inhibition and da release potentiation as well as release rebound during washout suggests that altered dopamine release might play a role in behavioral effects of cocaine. |
2001-09-13 |
2023-08-12 |
rat |
| B A Morrow, J D Elsworth, R H Rot. Prenatal exposure to cocaine reduces the number and enhances reactivity of A10 dopaminergic neurons to environmental stress. Synapse (New York, N.Y.). vol 41. issue 4. 2001-09-13. PMID:11494404. |
because the exposure to cocaine took place during development, other potential changes in dopaminergic and nondopaminergic neuronal systems could result from the cocaine-induced reduction in numbers of a10 dopamine neurons. |
2001-09-13 |
2023-08-12 |
rat |
| N Tilakaratne, G Cai, E Friedma. Attenuation of cocaine-induced genomic and functional responses in prenatal cocaine-exposed rabbits. Pharmacology, biochemistry, and behavior. vol 69. issue 1-2. 2001-09-06. PMID:11420090. |
the results indicate that in utero cocaine exposure leads to diminished responses to cocaine challenge in the offspring, which may be mediated by prenatal cocaine-induced alterations in one or more components of the d(1) dopamine and/or serotonin receptor signaling systems during early postnatal life. |
2001-09-06 |
2023-08-12 |
Not clear |
| Q Wu, M E Reith, M J Kuhar, F I Carroll, P A Garri. Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 16. 2001-08-30. PMID:11487657. |
preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission. |
2001-08-30 |
2023-08-12 |
Not clear |
| Q Wu, M E Reith, M J Kuhar, F I Carroll, P A Garri. Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 16. 2001-08-30. PMID:11487657. |
in vivo voltammetry was used to investigate the preferential increase of extracellular dopamine in the nucleus accumbens relative to the caudate-putamen after systemic cocaine administration. |
2001-08-30 |
2023-08-12 |
Not clear |
| Q Wu, M E Reith, M J Kuhar, F I Carroll, P A Garri. Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 16. 2001-08-30. PMID:11487657. |
all three drugs robustly increased electrically evoked levels of dopamine, and cocaine elevated dopamine signals to a greater extent in the nucleus accumbens. |
2001-08-30 |
2023-08-12 |
Not clear |
| Q Wu, M E Reith, M J Kuhar, F I Carroll, P A Garri. Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 16. 2001-08-30. PMID:11487657. |
however, kinetic analysis of the evoked dopamine signals indicated that cocaine and nomifensine increased the k(m) for dopamine uptake whereas the dominant effect of rti-76 was a decrease in v(max). |
2001-08-30 |
2023-08-12 |
Not clear |
| Q Wu, M E Reith, M J Kuhar, F I Carroll, P A Garri. Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 16. 2001-08-30. PMID:11487657. |
under the present in vivo conditions, therefore, cocaine is a competitive inhibitor of dopamine uptake in both the nucleus accumbens and caudate-putamen. |
2001-08-30 |
2023-08-12 |
Not clear |
| Q Wu, M E Reith, M J Kuhar, F I Carroll, P A Garri. Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 16. 2001-08-30. PMID:11487657. |
the lower rates for dopamine release and uptake measured in the nucleus accumbens were found to underlie the preferential increase in extracellular dopamine after cocaine. |
2001-08-30 |
2023-08-12 |
Not clear |
| Q Wu, M E Reith, M J Kuhar, F I Carroll, P A Garri. Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 16. 2001-08-30. PMID:11487657. |
this relationship explains the paradox that cocaine more effectively increases accumbal dopamine despite identical effects on the dopamine transporter in the two regions. |
2001-08-30 |
2023-08-12 |
Not clear |
| S A Kushner, E M Unterwal. Chronic cocaine administration decreases the functional coupling of GABA(B) receptors in the rat ventral tegmental area as measured by baclofen-stimulated 35S-GTPgammaS binding. Life sciences. vol 69. issue 9. 2001-08-30. PMID:11508652. |
to determine if chronic cocaine administration alters the functional coupling of gaba(b) receptors to g-proteins in central dopamine systems, male f-344 rats received cocaine (15 mg/kg/injection) or saline three times a day at hourly intervals for fourteen consecutive days. |
2001-08-30 |
2023-08-12 |
rat |
| S A Kushner, E M Unterwal. Chronic cocaine administration decreases the functional coupling of GABA(B) receptors in the rat ventral tegmental area as measured by baclofen-stimulated 35S-GTPgammaS binding. Life sciences. vol 69. issue 9. 2001-08-30. PMID:11508652. |
this finding may have implications in the augmented extracellular dopamine levels seen in the nucleus accumbens of rats that have been sensitized to cocaine. |
2001-08-30 |
2023-08-12 |
rat |
| F Masi, S Scheggi, S Mangiavacchi, P Tolu, A Tagliamonte, M G De Montis, C Gambaran. Dopamine output in the nucleus accumbens shell is related to the acquisition and the retention of a motivated appetitive behavior in rats. Brain research. vol 903. issue 1-2. 2001-08-16. PMID:11382393. |
dopamine output was studied through microdialysis as dopamine accumulation following re-uptake inhibition by cocaine. |
2001-08-16 |
2023-08-12 |
rat |
| R Ranaldi, R A Wis. Blockade of D1 dopamine receptors in the ventral tegmental area decreases cocaine reward: possible role for dendritically released dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 15. 2001-08-16. PMID:11466456. |
blockade of d1 dopamine receptors in the ventral tegmental area decreases cocaine reward: possible role for dendritically released dopamine. |
2001-08-16 |
2023-08-12 |
rat |
| R Ranaldi, R A Wis. Blockade of D1 dopamine receptors in the ventral tegmental area decreases cocaine reward: possible role for dendritically released dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 15. 2001-08-16. PMID:11466456. |
this study was designed to assess the involvement of d1 dopamine actions in the ventral tegmental area (vta) on intravenous cocaine self-administration. |
2001-08-16 |
2023-08-12 |
rat |
| R Ranaldi, R A Wis. Blockade of D1 dopamine receptors in the ventral tegmental area decreases cocaine reward: possible role for dendritically released dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 15. 2001-08-16. PMID:11466456. |
these data suggest a role for dendritically released dopamine, presumably acting through d1 receptors located on the axons of gabaergic or glutamatergic inputs to the vta, in the effectiveness of cocaine reward. |
2001-08-16 |
2023-08-12 |
rat |